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EE9900079A - Meetod 21-atsüüloksüpregna-1,4-dieen-11ß,16a,17a-triool-3,20-diooni derivaatide 16,17-atsetaalderivaatide R-epimeerseks rikastamiseks - Google Patents

Meetod 21-atsüüloksüpregna-1,4-dieen-11ß,16a,17a-triool-3,20-diooni derivaatide 16,17-atsetaalderivaatide R-epimeerseks rikastamiseks

Info

Publication number
EE9900079A
EE9900079A EEP199900079A EE9900079A EE9900079A EE 9900079 A EE9900079 A EE 9900079A EE P199900079 A EEP199900079 A EE P199900079A EE 9900079 A EE9900079 A EE 9900079A EE 9900079 A EE9900079 A EE 9900079A
Authority
EE
Estonia
Prior art keywords
derivatives
triol
acyloxypregna
diene
acetal
Prior art date
Application number
EEP199900079A
Other languages
English (en)
Other versions
EE03927B1 (et
Inventor
Amschler Hermann
Flockerzi Dieter
Gutterer Beate
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE9900079(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9900079A publication Critical patent/EE9900079A/et
Publication of EE03927B1 publication Critical patent/EE03927B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
EEP199900079A 1996-09-03 1997-08-29 Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod EE03927B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (2)

Publication Number Publication Date
EE9900079A true EE9900079A (et) 1999-10-15
EE03927B1 EE03927B1 (et) 2002-12-16

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900079A EE03927B1 (et) 1996-09-03 1997-08-29 Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod

Country Status (18)

Country Link
US (1) US6787533B1 (et)
EP (1) EP0929566B1 (et)
JP (1) JP3807509B2 (et)
AT (1) ATE229539T1 (et)
AU (1) AU736840B2 (et)
CA (1) CA2264863C (et)
CL (1) CL2004001297A1 (et)
CY (2) CY2454B1 (et)
CZ (1) CZ298789B6 (et)
DE (2) DE19635498A1 (et)
DK (1) DK0929566T3 (et)
EE (1) EE03927B1 (et)
ES (1) ES2188984T3 (et)
HU (1) HU228766B1 (et)
IL (1) IL128535A (et)
PL (1) PL186063B1 (et)
PT (1) PT929566E (et)
WO (1) WO1998009982A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
CZ303885B6 (cs) 2000-11-10 2013-06-12 Takeda Gmbh Zpusob výroby 16,17-[(cyklohexylmethylen)bis(oxy)]-11,21-dihydroxypregna-1,4-dien-3,20-dionu nebo jeho 21-isobutyrátu
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
AU2003291634A1 (en) 2002-10-08 2004-05-04 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
RS51707B (sr) 2002-12-12 2011-10-31 Nycomed Gmbh. Kombinacija leka sastavljena od r, r - formoterola i ciklezonida
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
DK1670482T4 (da) 2003-09-16 2022-08-22 Covis Pharma B V Anvendelse af ciclesonid til behandlingen af respiratoriske sygdomme
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
EP1869064A2 (en) * 2005-11-02 2007-12-26 Sicor, Inc. Improved process for the preparation of ciclesonide
WO2007092574A2 (en) * 2006-02-08 2007-08-16 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
KR20090078329A (ko) 2006-09-19 2009-07-17 씨아이피엘에이 엘티디. 시클레소니드의 제조방법 및 그의 결정형
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
PE20190622A1 (es) 2016-06-02 2019-04-26 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
HUE054428T2 (hu) 2017-12-01 2021-09-28 Abbvie Inc Glükokortikoid receptor agonista és annak immunkonjugátumai
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (et) * 1972-05-19 1975-08-18 Bofors Ab
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
HU220868B1 (en) 1993-04-02 2002-06-29 Byk Gulden Lomberg Chem Fab New prednisolone derivative, process for its production, use of the same and pharmaceutical composition containing the same
PT749438E (pt) * 1994-03-09 2001-05-31 Byk Gulden Lomberg Chem Fab Novos compostos sililo e sua utilizacao

Also Published As

Publication number Publication date
ATE229539T1 (de) 2002-12-15
CZ298789B6 (cs) 2008-01-30
PL331699A1 (en) 1999-08-02
DE19635498A1 (de) 1998-03-26
CL2004001297A1 (es) 2005-04-15
US6787533B1 (en) 2004-09-07
DE69717836D1 (de) 2003-01-23
EP0929566B1 (en) 2002-12-11
HUP9904127A3 (en) 2001-02-28
HU228766B1 (hu) 2013-05-28
CA2264863A1 (en) 1998-03-12
DE69717836T2 (de) 2003-09-18
DK0929566T3 (da) 2003-04-07
IL128535A0 (en) 2000-01-31
AU4456797A (en) 1998-03-26
WO1998009982A1 (en) 1998-03-12
PL186063B1 (pl) 2003-09-30
CA2264863C (en) 2007-07-31
HUP9904127A2 (hu) 2000-04-28
JP2000517330A (ja) 2000-12-26
ES2188984T3 (es) 2003-07-01
PT929566E (pt) 2003-04-30
IL128535A (en) 2003-07-06
CY2009010I2 (el) 2010-07-28
CY2454B1 (en) 2005-06-03
AU736840B2 (en) 2001-08-02
CY2009010I1 (el) 2010-07-28
JP3807509B2 (ja) 2006-08-09
EP0929566A1 (en) 1999-07-21
EE03927B1 (et) 2002-12-16
CZ72799A3 (cs) 1999-09-15

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Free format text: PRODUCT NAME: ALVESCO 40 INHALAATOR; REG NO/DATE: 459605 04.02.2005

Spc suppl protection certif: C20050003

Filing date: 20050718

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