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EE03927B1 - Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod - Google Patents

Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod

Info

Publication number
EE03927B1
EE03927B1 EEP199900079A EE9900079A EE03927B1 EE 03927 B1 EE03927 B1 EE 03927B1 EE P199900079 A EEP199900079 A EE P199900079A EE 9900079 A EE9900079 A EE 9900079A EE 03927 B1 EE03927 B1 EE 03927B1
Authority
EE
Estonia
Prior art keywords
mixture
pregna
dione
cyclohexylmethylene
oxopropoxy
Prior art date
Application number
EEP199900079A
Other languages
English (en)
Other versions
EE9900079A (et
Inventor
Amschler Hermann
Flockerzi Dieter
Gutterer Beate
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03927(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9900079A publication Critical patent/EE9900079A/et
Publication of EE03927B1 publication Critical patent/EE03927B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
EEP199900079A 1996-09-03 1997-08-29 Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod EE03927B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (2)

Publication Number Publication Date
EE9900079A EE9900079A (et) 1999-10-15
EE03927B1 true EE03927B1 (et) 2002-12-16

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900079A EE03927B1 (et) 1996-09-03 1997-08-29 Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod

Country Status (18)

Country Link
US (1) US6787533B1 (et)
EP (1) EP0929566B1 (et)
JP (1) JP3807509B2 (et)
AT (1) ATE229539T1 (et)
AU (1) AU736840B2 (et)
CA (1) CA2264863C (et)
CL (1) CL2004001297A1 (et)
CY (2) CY2454B1 (et)
CZ (1) CZ298789B6 (et)
DE (2) DE19635498A1 (et)
DK (1) DK0929566T3 (et)
EE (1) EE03927B1 (et)
ES (1) ES2188984T3 (et)
HU (1) HU228766B1 (et)
IL (1) IL128535A (et)
PL (1) PL186063B1 (et)
PT (1) PT929566E (et)
WO (1) WO1998009982A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
CA2430196C (en) 2000-11-10 2010-01-26 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
WO2004033478A2 (en) 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
US7879833B2 (en) 2002-12-12 2011-02-01 Nycomed Gmbh Combination medicament
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
WO2005025578A1 (en) 2003-09-16 2005-03-24 Altana Pharma Ag Use of ciclesonide for the treatment of respiratory diseases
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
US20070135398A1 (en) * 2005-11-02 2007-06-14 Pierluigi Rossetto Process for the preparation of ciclesonide
WO2007092574A2 (en) * 2006-02-08 2007-08-16 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
NZ575549A (en) 2006-09-19 2012-06-29 Cipla Ltd Processes for the preparation of ciclesonide and its crystal form
ES2401057T3 (es) * 2008-03-13 2013-04-16 Farmabios S.P.A. Procedimiento para la preparación de derivados de pregnano
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
SG10202001787QA (en) 2016-06-02 2020-04-29 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
PE20201286A1 (es) 2017-12-01 2020-11-24 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados de este
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (et) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
WO1994022899A1 (de) 1993-04-02 1994-10-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue prednisolonderivate
DE59508898D1 (de) 1994-03-09 2001-01-18 Byk Gulden Lomberg Chem Fab Neue silylverbindungen und ihre verwendung

Also Published As

Publication number Publication date
CY2009010I2 (el) 2010-07-28
CY2454B1 (en) 2005-06-03
CA2264863C (en) 2007-07-31
DK0929566T3 (da) 2003-04-07
HUP9904127A3 (en) 2001-02-28
CZ72799A3 (cs) 1999-09-15
ES2188984T3 (es) 2003-07-01
PT929566E (pt) 2003-04-30
PL186063B1 (pl) 2003-09-30
DE69717836T2 (de) 2003-09-18
DE19635498A1 (de) 1998-03-26
CZ298789B6 (cs) 2008-01-30
ATE229539T1 (de) 2002-12-15
WO1998009982A1 (en) 1998-03-12
JP3807509B2 (ja) 2006-08-09
DE69717836D1 (de) 2003-01-23
CY2009010I1 (el) 2010-07-28
EE9900079A (et) 1999-10-15
EP0929566A1 (en) 1999-07-21
EP0929566B1 (en) 2002-12-11
AU736840B2 (en) 2001-08-02
HUP9904127A2 (hu) 2000-04-28
PL331699A1 (en) 1999-08-02
IL128535A (en) 2003-07-06
CA2264863A1 (en) 1998-03-12
JP2000517330A (ja) 2000-12-26
IL128535A0 (en) 2000-01-31
HU228766B1 (hu) 2013-05-28
US6787533B1 (en) 2004-09-07
CL2004001297A1 (es) 2005-04-15
AU4456797A (en) 1998-03-26

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Filing date: 20050718

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