EE9800335A - Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid - Google Patents

Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid

Info

Publication number: EE9800335A
Authority: EE; Estonia
Prior art keywords: inhibitors; neutrophil elastase; pyrrolopyrrolone; derivatives; pyrrolopyrrolone derivatives
Prior art date: 1996-03-28

Application number

EE9800335A

Other languages

English (en)

Inventor

Andrew Harrison Lee

George Adam Inglis Graham

Redpath Johnson Martin

John Fawcett Macdonald Simon

Andrew Smith Robin

Dennis Dowle Michael

Finch Harry

Shah Pritom

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-28

Filing date

1997-03-26

Publication date

1999-04-15

1996-03-28 Priority claimed from GBGB9606508.1A external-priority patent/GB9606508D0/en

1996-11-05 Priority claimed from GBGB9623001.6A external-priority patent/GB9623001D0/en

1997-03-26 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

1999-04-15 Publication of EE9800335A publication Critical patent/EE9800335A/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

EE9800335A 1996-03-28 1997-03-26 Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid EE9800335A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9606508.1A GB9606508D0 (en)	1996-03-28	1996-03-28	Chemical componds
GBGB9623001.6A GB9623001D0 (en)	1996-11-05	1996-11-05	Chemical compounds
PCT/EP1997/001530 WO1997036903A1 (en)	1996-03-28	1997-03-26	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number	Publication Date
EE9800335A true EE9800335A (et)	1999-04-15

Family

ID=26309008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800335A EE9800335A (et)	1996-03-28	1997-03-26	Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid

Country Status (30)

Country	Link
US (3)	US5994344A (et)
EP (1)	EP0891362B1 (et)
JP (1)	JP4118337B2 (et)
KR (1)	KR20000005039A (et)
CN (1)	CN1067075C (et)
AP (1)	AP823A (et)
AR (1)	AR006401A1 (et)
AT (1)	ATE261969T1 (et)
AU (1)	AU726649B2 (et)
BR (1)	BR9708449A (et)
CA (1)	CA2250209A1 (et)
CO (1)	CO4790152A1 (et)
CZ (1)	CZ309798A3 (et)
DE (1)	DE69728139T2 (et)
DK (1)	DK0891362T3 (et)
EA (1)	EA001437B1 (et)
EE (1)	EE9800335A (et)
ES (1)	ES2217404T3 (et)
HU (1)	HUP9900567A3 (et)
IL (1)	IL125859A0 (et)
IS (1)	IS4837A (et)
NO (1)	NO984470L (et)
NZ (1)	NZ331490A (et)
PE (1)	PE55298A1 (et)
PL (1)	PL329153A1 (et)
PT (1)	PT891362E (et)
SK (1)	SK132498A3 (et)
TR (1)	TR199801935T2 (et)
WO (1)	WO1997036903A1 (et)
YU (1)	YU41198A (et)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9719189D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	New therapeutic method
GB9719172D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
PE107899A1 (es) *	1997-09-09	1999-11-17	Glaxo Group Ltd	Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9719187D0 (en)	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
GB9821199D0 (en) *	1998-09-30	1998-11-25	Glaxo Group Ltd	Chemical compounds
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
AU2003216707A1 (en) *	2003-03-10	2004-09-30	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
KR101078505B1 (ko)	2003-03-14	2011-10-31	오노 야꾸힝 고교 가부시키가이샤	질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제
US8530509B2 (en)	2003-06-20	2013-09-10	Siga Technologies, Inc.	Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
US7692037B2 (en) *	2004-09-02	2010-04-06	Eastman Chemical Company	Optimized liquid-phase oxidation
PE20090123A1 (es)	2004-09-13	2009-03-10	Ono Pharmaceutical Co	Un derivado heterociclico conteniendo nitrogeno y un farmaco conteniendo el mismo como el ingrediente activo
GB0512238D0 (en) *	2005-06-15	2005-07-27	Univ Cambridge Tech	Anti-inflammatory agents
MX2008011414A (es)	2006-03-10	2008-09-22	Ono Pharmaceutical Co	Derivado heterociclico nitrogenado y agente farmaceutico que comprende el derivado como ingrediente activo.
MX363189B (es) *	2007-04-23	2019-03-14	Siga Tech Inc	Productos químicos, composiciones y métodos para tratamiento y prevención de infecciones de virus orthopox y enfermedades asociadas.
AU2008322426C1 (en)	2007-11-16	2014-10-23	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds for metabolic disorders
ES2553340T3 (es)	2007-12-12	2015-12-07	Rigel Pharmaceuticals, Inc.	Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
CN104016980B (zh)	2008-04-23	2016-12-07	里格尔药品股份有限公司	用于治疗代谢障碍的甲酰胺化合物
DK2935274T3 (en) *	2012-12-18	2018-11-26	Chiesi Farm Spa	3-OXO-2,3,5,8-TETRAHYDRO- [1,2,4] TRIAZOLO [4,3-A] PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AIR TRACT
CN114650819A (zh)	2019-09-17	2022-06-21	美莱奥生物制药第四有限公司	用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
PT4106757T (pt)	2020-04-16	2023-11-17	Mereo Biopharma 5 Inc	Métodos que envolvem o inibidor da elastase neutrofílica alvelestat para o tratamento de doenças respiratórias mediadas pela deficiência de alfa 1 antitripsina
JP2024540952A (ja)	2021-10-20	2024-11-06	メレオバイオファーマ４リミテッド	線維化の治療における使用のための好中球エラスターゼ阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2932650A (en) *	1957-11-19	1960-04-12	Arthur C Cope	2-6-diazabicyclo (3. 3. 0) octanes
US4997950A (en) *	1989-04-20	1991-03-05	Richard Finbar Murphy	Novel C-terminal gastrin antagonists
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
US5610296A (en) *	1994-12-05	1997-03-11	G. D. Searle & Co.	Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

1997
- 1997-03-26 EA EA199800773A patent/EA001437B1/ru not_active IP Right Cessation
- 1997-03-26 CN CN97194959A patent/CN1067075C/zh not_active Expired - Lifetime
- 1997-03-26 PL PL97329153A patent/PL329153A1/xx unknown
- 1997-03-26 PE PE1997000244A patent/PE55298A1/es not_active Application Discontinuation
- 1997-03-26 CA CA002250209A patent/CA2250209A1/en not_active Abandoned
- 1997-03-26 TR TR1998/01935T patent/TR199801935T2/xx unknown
- 1997-03-26 NZ NZ331490A patent/NZ331490A/en unknown
- 1997-03-26 CZ CZ983097A patent/CZ309798A3/cs unknown
- 1997-03-26 US US09/155,323 patent/US5994344A/en not_active Expired - Fee Related
- 1997-03-26 AR ARP970101212A patent/AR006401A1/es not_active Application Discontinuation
- 1997-03-26 PT PT97915439T patent/PT891362E/pt unknown
- 1997-03-26 EE EE9800335A patent/EE9800335A/et unknown
- 1997-03-26 EP EP97915439A patent/EP0891362B1/en not_active Expired - Lifetime
- 1997-03-26 SK SK1324-98A patent/SK132498A3/sk unknown
- 1997-03-26 DK DK97915439T patent/DK0891362T3/da active
- 1997-03-26 BR BR9708449A patent/BR9708449A/pt unknown
- 1997-03-26 WO PCT/EP1997/001530 patent/WO1997036903A1/en not_active Ceased
- 1997-03-26 ES ES97915439T patent/ES2217404T3/es not_active Expired - Lifetime
- 1997-03-26 DE DE69728139T patent/DE69728139T2/de not_active Expired - Fee Related
- 1997-03-26 HU HU9900567A patent/HUP9900567A3/hu unknown
- 1997-03-26 AU AU22917/97A patent/AU726649B2/en not_active Ceased
- 1997-03-26 KR KR1019980707664A patent/KR20000005039A/ko not_active Withdrawn
- 1997-03-26 JP JP53490797A patent/JP4118337B2/ja not_active Expired - Fee Related
- 1997-03-26 AT AT97915439T patent/ATE261969T1/de not_active IP Right Cessation
- 1997-03-26 AP APAP/P/1998/001351A patent/AP823A/en active
- 1997-03-26 IL IL12585997A patent/IL125859A0/xx unknown
- 1997-03-31 CO CO97015902A patent/CO4790152A1/es unknown
1998
- 1998-08-28 IS IS4837A patent/IS4837A/is unknown
- 1998-09-23 YU YU41198A patent/YU41198A/sh unknown
- 1998-09-25 NO NO984470A patent/NO984470L/no not_active Application Discontinuation
1999
- 1999-10-15 US US09/418,644 patent/US6057457A/en not_active Expired - Fee Related
2000
- 2000-03-03 US US09/517,963 patent/US6215002B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0891362B1 (en)	2004-03-17
YU41198A (sh)	1999-09-27
SK132498A3 (en)	1999-08-06
AU2291797A (en)	1997-10-22
PE55298A1 (es)	1998-09-19
DK0891362T3 (da)	2004-07-12
NO984470D0 (no)	1998-09-25
AP823A (en)	2000-04-25
JP2000507950A (ja)	2000-06-27
IS4837A (is)	1998-08-28
KR20000005039A (ko)	2000-01-25
TR199801935T2 (xx)	1999-03-22
HUP9900567A3 (en)	2001-02-28
CN1067075C (zh)	2001-06-13
ATE261969T1 (de)	2004-04-15
NO984470L (no)	1998-11-25
BR9708449A (pt)	1999-08-03
CN1219935A (zh)	1999-06-16
PL329153A1 (en)	1999-03-15
EA001437B1 (ru)	2001-02-26
WO1997036903A1 (en)	1997-10-09
EP0891362A1 (en)	1999-01-20
IL125859A0 (en)	1999-04-11
CO4790152A1 (es)	1999-05-31
AP9801351A0 (en)	1998-09-30
AR006401A1 (es)	1999-08-25
JP4118337B2 (ja)	2008-07-16
HUP9900567A2 (hu)	1999-06-28
CA2250209A1 (en)	1997-10-09
DE69728139D1 (de)	2004-04-22
US6057457A (en)	2000-05-02
EA199800773A1 (ru)	1999-06-24
ES2217404T3 (es)	2004-11-01
US6215002B1 (en)	2001-04-10
US5994344A (en)	1999-11-30
DE69728139T2 (de)	2004-10-21
PT891362E (pt)	2004-08-31
CZ309798A3 (cs)	1999-02-17
NZ331490A (en)	2000-06-23
AU726649B2 (en)	2000-11-16

Publication	Publication Date	Title
EE9800335A (et)	1999-04-15	Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid
FI944804L (fi)	1994-10-12	Pyrimidinyyliasetamideja elastaasin estäjinä
DE69725465D1 (de)	2003-11-13	6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
DE69716615D1 (de)	2002-11-28	Heterozyklische metalloproteaseinhibitoren
ID19198A (id)	1998-06-28	Inhibitor metaloprotease heterosiklik
DE122007000005I1 (de)	2007-04-26	Apolipoprotein-B Syntheseinhibitoren
EE200000138A (et)	2001-02-15	Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
FI973211A0 (fi)	1997-08-01	Ihmisen leukosyyttielastaasin inhibiittoreina hyödylliset proliinijohdannaiset
EE200100039A (et)	2002-06-17	Ftalasiinderivaadid kui fosfodiesteraas-4 inhibiitorid
DE69736109D1 (de)	2006-07-27	Differenzierungsinhibitor
EE9700093A (et)	1997-10-15	Apolipoproteiin-B sünteesi inhiibitorid
DE69733263D1 (de)	2005-06-16	Markierte elastase-inhibitoren
EE200000137A (et)	2001-02-15	Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
FI964749A7 (fi)	1996-11-28	Asyloituja enolijohdannaisia elastaasi-inhibiittoreiden lääkkeen esias teina
SI0891362T1 (en)	2004-08-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
ZA988160B (en)	2000-03-22	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
HK1016170A (en)	1999-10-29	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
HK1026420A (en)	2000-12-15	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
HK1026210A (en)	2000-12-08	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
BR9704770A (pt)	1998-11-03	Derivados de 1-carba-(detia)-cefalosporina
KR960031416U (ko)	1996-10-22	투포원연사기의 스핀들
PT1062392E (pt)	2006-05-31	Obra de passagem sob terrapleno
FI941265A7 (fi)	1995-09-18	Heterosyklisiä sulfoniamidotrombiini-inhibiittoreita
KR960023128U (ko)	1996-07-20	머플러의 배출통로
NO940997D0 (no)	1994-03-18	Guanidinyl-substituerte heterocykliske trombin-inhibitorer