EE200300459A - Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena - Google Patents

Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena

Info

Publication number: EE200300459A
Authority: EE; Estonia
Prior art keywords: phosphodiesterase; inhibitors; novel; spirotricyclic; derivatives
Prior art date: 2001-03-21

Application number

EEP200300459A

Other languages

English (en)

Estonian (et)

Inventor

Bernardelli Patrick

Ducrot Pierre

Lorthiois Edwige

Vergne Fabrice

Original Assignee

Warner-Lambert Company Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-21

Filing date

2002-03-18

Publication date

2004-02-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8164349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE200300459(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-03-18 Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc

2004-02-16 Publication of EE200300459A publication Critical patent/EE200300459A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Virology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

EEP200300459A 2001-03-21 2002-03-18 Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena EE200300459A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/EP2001/003355 WO2002076953A1 (fr)	2001-03-21	2001-03-21	Nouveaux derives spirotricycliques et utilisation de ces derives en tant qu'inhibiteurs de la phosphodiesterase-7
PCT/EP2002/003594 WO2002074754A1 (fr)	2001-03-21	2002-03-18	Nouveaux derives spirotricycliques et leur utilisation en tant qu'inhibiteurs de la phosphodiesterase-7

Publications (1)

Publication Number	Publication Date
EE200300459A true EE200300459A (et)	2004-02-16

Family

ID=8164349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300459A EE200300459A (et)	2001-03-21	2002-03-18	Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena

Country Status (46)

Country	Link
US (3)	US20020198198A1 (fr)
EP (2)	EP1373224B1 (fr)
JP (1)	JP4086663B2 (fr)
KR (1)	KR100617435B1 (fr)
CN (1)	CN100447136C (fr)
AP (1)	AP1699A (fr)
AR (1)	AR033617A1 (fr)
AT (1)	ATE367381T1 (fr)
AU (1)	AU2002304800B2 (fr)
BG (1)	BG108181A (fr)
BR (1)	BR0208192A (fr)
CA (1)	CA2441313C (fr)
CU (1)	CU23218A3 (fr)
CY (1)	CY1106829T1 (fr)
CZ (1)	CZ20032451A3 (fr)
DE (1)	DE60221233T2 (fr)
DK (1)	DK1373224T3 (fr)
EA (1)	EA006815B1 (fr)
EC (1)	ECSP034750A (fr)
EE (1)	EE200300459A (fr)
ES (1)	ES2288552T3 (fr)
GE (1)	GEP20053631B (fr)
GT (1)	GT200200053A (fr)
HR (1)	HRP20030740A2 (fr)
HU (1)	HUP0303637A3 (fr)
IL (2)	IL157659A0 (fr)
IS (1)	IS2529B (fr)
MA (1)	MA27001A1 (fr)
MX (1)	MXPA03008485A (fr)
MY (1)	MY142045A (fr)
NO (1)	NO326086B1 (fr)
NZ (1)	NZ527847A (fr)
OA (1)	OA12454A (fr)
PA (1)	PA8541601A1 (fr)
PE (1)	PE20021010A1 (fr)
PL (1)	PL367058A1 (fr)
PT (1)	PT1373224E (fr)
RS (1)	RS50429B (fr)
SI (1)	SI1373224T1 (fr)
SK (1)	SK11562003A3 (fr)
SV (1)	SV2003000925A (fr)
TN (1)	TNSN03076A1 (fr)
TW (1)	TWI267509B (fr)
UA (1)	UA74243C2 (fr)
WO (2)	WO2002076953A1 (fr)
ZA (1)	ZA200306601B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1400244A1 (fr) *	2002-09-17	2004-03-24	Warner-Lambert Company LLC	Nouveaux quinazolinones spirocondensés et leur utilisation comme inhibiteurs de la phosphodiesterase
GB0230195D0 (en) *	2002-12-24	2003-02-05	Biofocus Plc	Compound Libraries
HUE026904T2 (en)	2003-04-24	2016-08-29	Incyte Holdings Corp	Aza-spiroalkane derivatives as inhibitors of metalloproteases
JP2006219374A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
JP2006219373A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
CN1835753A (zh) *	2003-08-12	2006-09-20	弗·哈夫曼-拉罗切有限公司	作为促皮质释放素(cfr)拮抗剂的螺－取代的四氢喹唑啉
CN102827082B (zh)	2004-07-01	2015-01-07	第一三共株式会社	具有pde7抑制活性的噻吩并吡唑衍生物
WO2006092692A1 (fr) *	2005-03-01	2006-09-08	Pfizer Limited	Utilisation d'associations d’inhibiteurs de pde7 et de ligands alpha-2-delta pour le traitement de la douleur neuropathique
GB0504209D0 (en) *	2005-03-01	2005-04-06	Pfizer Ltd	New use of PDE7 inhibitors
CA2599662A1 (fr) *	2005-03-01	2006-09-08	Pfizer Limited	Utilisation des inhibiteurs de pde7 pour le traitement de la douleur neuropathique
KR100680497B1 (ko) *	2005-07-25	2007-02-08	엘지전자 주식회사	근거리통신 시스템에서 단말기가 액세스 포인트에 접속하는방법
EP2258359A3 (fr)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
CA2620333A1 (fr)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenese par modulation du recepteur muscarinique
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
EP2314289A1 (fr)	2005-10-31	2011-04-27	Braincells, Inc.	Modulation de la neurogenese dont la médiation est assurée par récepteur gaba
KR20080065704A (ko)	2005-11-09	2008-07-14	콤비네이토릭스, 인코포레이티드	의학적 이상의 치료 방법들, 조성물들, 및 키트들
MEP0408A (xx)	2005-12-02	2010-02-10	Pfizer Ltd	Derivati hinociklicnog hinazolina kao inhibitori pde7
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2021000A2 (fr)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenèse par modulation de l'angiotensine
JP2009536667A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	５ｈｔ受容体介在性の神経新生
MX2009002496A (es) *	2006-09-08	2009-07-10	Braincells Inc	Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
NZ580413A (en) *	2007-03-27	2012-11-30	Omeros Corp	The use of pde7 inhibitors for the treatment of movement disorders
WO2008142550A2 (fr) *	2007-05-24	2008-11-27	Pfizer Limited	Dérivés spirocycliques
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
NZ610925A (en)	2010-11-08	2015-10-30	Omeros Corp	Treatment of addiction and impulse-control disorders using pde7 inhibitors
US8754114B2 (en)	2010-12-22	2014-06-17	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
WO2013106547A1 (fr)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
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US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
JP6449244B2 (ja)	2013-04-19	2019-01-09	インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅＨｏｌｄｉｎｇｓＣｏｒｐｏｒａｔｉｏｎ	Ｆｇｆｒ抑制剤としての二環式複素環
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (fr)	2015-02-20	2016-08-25	Incyte Corporation	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
ES2751669T3 (es)	2015-02-20	2020-04-01	Incyte Corp	Heterociclos bicíclicos como inhibidores FGFR
CN108602815B (zh) *	2015-12-16	2020-07-28	正大天晴药业集团股份有限公司	吡啶并[1,2-a]嘧啶酮类似物、其晶型、其中间体及其制备方法
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN107382976A (zh) *	2017-07-04	2017-11-24	孙秀芹	一种治疗盆腔炎的化合物及制备方法和应用
EP3652180B1 (fr) *	2017-07-12	2023-11-29	Dart NeuroScience, LLC	Composés de benzoxazole et de benzofurane substitués utilisés en tant qu'inhibiteurs de pde7
CN119241541A (zh)	2018-05-04	2025-01-03	因赛特公司	Fgfr抑制剂的固体形式和其制备方法
PE20210919A1 (es)	2018-05-04	2021-05-19	Incyte Corp	Sales de un inhibidor de fgfr
WO2020185532A1 (fr)	2019-03-08	2020-09-17	Incyte Corporation	Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (fr)	2019-10-01	2021-04-08	Incyte Corporation	Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
GEP20247679B (en)	2019-10-14	2024-10-10	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
IL293001A (en)	2019-12-04	2022-07-01	Incyte Corp	Derivatives of fgfr repressors
CA3163875A1 (fr)	2019-12-04	2021-06-10	Incyte Corporation	Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
JP2024513575A (ja)	2021-04-12	2024-03-26	インサイト・コーポレイション	Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
WO2022261160A1 (fr)	2021-06-09	2022-12-15	Incyte Corporation	Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
AR126101A1 (es)	2021-06-09	2023-09-13	Incyte Corp	Heterociclos tricíclicos como inhibidores de fgfr
IL318817A (en)	2022-08-18	2025-04-01	Mitodicure Gmbh	Use of a therapeutic agent with PHOSPHODIESTERASE-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exercise intolerance

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5815979A (ja)	1981-07-11	1983-01-29	Kyowa Hakko Kogyo Co Ltd	新規なピペリジン誘導体およびその製造法
US4764512A (en)	1986-08-27	1988-08-16	Rorer Pharmaceutical Corporation	Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses
GR1000821B (el) *	1988-11-22	1993-01-25	Tanabe Seiyaku Co	Μεθοδος παραγωγης παραγωγων κιναζολινονης.
US5536716A (en)	1992-12-11	1996-07-16	Merck & Co., Inc.	Spiro piperidines and homologs which promote release of growth hormone
RO115804B1 (ro)	1992-12-11	2000-06-30	Merck & Co Inc	Derivati de spiropiperidine, procedee de preparare si compozitii farmaceutice ale acestora
US5602143A (en) *	1994-12-08	1997-02-11	Allergan	Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors
NZ319673A (en) *	1995-10-17	2000-06-23	Astra Pharma Prod	Quinazoline compounds for inflammatory disorders such rheumatoid arthritis or osteoarthritis
CN1205008A (zh) *	1996-08-30	1999-01-13	协和发酵工业株式会社	咪唑并喹唑啉衍生物
WO2000066560A1 (fr) *	1999-05-04	2000-11-09	American Home Products Corporation	Derives de quinazolinone et de benzoxazine tenant lieu de modulateurs du recepteur de progesterone
US6358948B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
CN1179753C (zh)	1999-05-04	2004-12-15	惠氏公司	含有抗孕激素和孕激素的避孕组合物
US6498154B1 (en)	1999-05-04	2002-12-24	Wyeth	Cyclic regimens using quinazolinone and benzoxazine derivatives
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
AU2274101A (en)	1999-12-21	2001-07-03	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
UA73119C2 (en)	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors

2001
- 2001-03-21 AP APAP/P/2003/002857A patent/AP1699A/en active
- 2001-03-21 WO PCT/EP2001/003355 patent/WO2002076953A1/fr not_active Ceased
2002
- 2002-03-05 TW TW091104028A patent/TWI267509B/zh not_active IP Right Cessation
- 2002-03-18 AU AU2002304800A patent/AU2002304800B2/en not_active Ceased
- 2002-03-18 TN TNPCT/EP2002/003594A patent/TNSN03076A1/fr unknown
- 2002-03-18 PT PT02732544T patent/PT1373224E/pt unknown
- 2002-03-18 CZ CZ20032451A patent/CZ20032451A3/cs unknown
- 2002-03-18 MX MXPA03008485A patent/MXPA03008485A/es active IP Right Grant
- 2002-03-18 UA UA2003098601A patent/UA74243C2/uk unknown
- 2002-03-18 EA EA200300906A patent/EA006815B1/ru unknown
- 2002-03-18 SK SK1156-2003A patent/SK11562003A3/sk not_active Application Discontinuation
- 2002-03-18 MY MYPI20020954A patent/MY142045A/en unknown
- 2002-03-18 WO PCT/EP2002/003594 patent/WO2002074754A1/fr not_active Ceased
- 2002-03-18 AT AT02732544T patent/ATE367381T1/de not_active IP Right Cessation
- 2002-03-18 DK DK02732544T patent/DK1373224T3/da active
- 2002-03-18 EE EEP200300459A patent/EE200300459A/xx unknown
- 2002-03-18 NZ NZ527847A patent/NZ527847A/en unknown
- 2002-03-18 EP EP02732544A patent/EP1373224B1/fr not_active Expired - Lifetime
- 2002-03-18 IL IL15765902A patent/IL157659A0/xx active IP Right Grant
- 2002-03-18 PL PL02367058A patent/PL367058A1/xx not_active Application Discontinuation
- 2002-03-18 ES ES02732544T patent/ES2288552T3/es not_active Expired - Lifetime
- 2002-03-18 HU HU0303637A patent/HUP0303637A3/hu unknown
- 2002-03-18 KR KR1020037012247A patent/KR100617435B1/ko not_active Expired - Fee Related
- 2002-03-18 DE DE60221233T patent/DE60221233T2/de not_active Expired - Lifetime
- 2002-03-18 CA CA002441313A patent/CA2441313C/fr not_active Expired - Fee Related
- 2002-03-18 JP JP2002573763A patent/JP4086663B2/ja not_active Expired - Fee Related
- 2002-03-18 EP EP07104642A patent/EP1801106A3/fr not_active Withdrawn
- 2002-03-18 HR HR20030740A patent/HRP20030740A2/hr not_active Application Discontinuation
- 2002-03-18 GE GE5294A patent/GEP20053631B/en unknown
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- 2002-03-18 CN CNB028069714A patent/CN100447136C/zh not_active Expired - Fee Related
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- 2002-03-18 SI SI200230587T patent/SI1373224T1/sl unknown
- 2002-03-18 BR BR0208192-0A patent/BR0208192A/pt not_active IP Right Cessation
- 2002-03-19 US US10/101,996 patent/US20020198198A1/en not_active Abandoned
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2003
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- 2003-09-12 MA MA27310A patent/MA27001A1/fr unknown
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- 2003-09-19 NO NO20034187A patent/NO326086B1/no not_active IP Right Cessation
2004
- 2004-05-24 US US10/852,404 patent/US7214676B2/en not_active Expired - Fee Related
2006
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Also Published As

Publication number	Publication date
CA2441313A1 (fr)	2002-09-26
ATE367381T1 (de)	2007-08-15
DE60221233D1 (de)	2007-08-30
BG108181A (bg)	2004-09-30
IL157659A0 (en)	2004-03-28
EA006815B1 (ru)	2006-04-28
NZ527847A (en)	2005-06-24
PL367058A1 (en)	2005-02-21
TWI267509B (en)	2006-12-01
SK11562003A3 (sk)	2005-01-03
IS2529B (is)	2009-07-15
US7214676B2 (en)	2007-05-08
KR100617435B1 (ko)	2006-08-31
BR0208192A (pt)	2004-03-02
AP2003002857A0 (en)	2003-09-30
EP1373224A1 (fr)	2004-01-02
AU2002304800B2 (en)	2007-08-30
ZA200306601B (en)	2004-08-25
SV2003000925A (es)	2003-05-20
PA8541601A1 (es)	2003-05-14
UA74243C2 (uk)	2005-11-15
EP1801106A3 (fr)	2007-07-04
TNSN03076A1 (fr)	2005-12-23
DK1373224T3 (da)	2007-10-15
EP1373224B1 (fr)	2007-07-18
JP4086663B2 (ja)	2008-05-14
CA2441313C (fr)	2009-03-31
EP1801106A2 (fr)	2007-06-27
CN100447136C (zh)	2008-12-31
HUP0303637A3 (en)	2004-07-28
PT1373224E (pt)	2007-09-25
PE20021010A1 (es)	2003-02-01
GEP20053631B (en)	2005-10-10
HK1061854A1 (zh)	2004-10-08
SI1373224T1 (sl)	2007-10-31
CU23218A3 (es)	2007-07-20
CN1498212A (zh)	2004-05-19
IS6934A (is)	2003-08-29
AP1699A (en)	2006-12-26
EA200300906A1 (ru)	2004-02-26
MA27001A1 (fr)	2004-12-20
US20020198198A1 (en)	2002-12-26
NO326086B1 (no)	2008-09-15
DE60221233T2 (de)	2008-04-03
JP2004529123A (ja)	2004-09-24
IL157659A (en)	2008-08-07
CY1106829T1 (el)	2012-05-23
AR033617A1 (es)	2003-12-26
MY142045A (en)	2010-08-30
NO20034187D0 (no)	2003-09-19
ECSP034750A (es)	2003-10-28
GT200200053A (es)	2003-02-12
ES2288552T3 (es)	2008-01-16
YU74003A (sh)	2006-05-25
WO2002076953A1 (fr)	2002-10-03
NO20034187L (no)	2003-10-15
KR20030086315A (ko)	2003-11-07
US20040214843A1 (en)	2004-10-28
CZ20032451A3 (cs)	2004-09-15
MXPA03008485A (es)	2003-12-08
OA12454A (en)	2004-09-30
RS50429B (sr)	2009-12-31
WO2002074754A1 (fr)	2002-09-26
HUP0303637A2 (hu)	2004-03-01
HRP20030740A2 (en)	2005-06-30
US20070049558A1 (en)	2007-03-01

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