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EE200200464A - Meetod LH puhastamiseks - Google Patents

Meetod LH puhastamiseks

Info

Publication number
EE200200464A
EE200200464A EEP200200464A EEP200200464A EE200200464A EE 200200464 A EE200200464 A EE 200200464A EE P200200464 A EEP200200464 A EE P200200464A EE P200200464 A EEP200200464 A EE P200200464A EE 200200464 A EE200200464 A EE 200200464A
Authority
EE
Estonia
Prior art keywords
purification
ion
reverse phase
phase hplc
exchange chromatography
Prior art date
Application number
EEP200200464A
Other languages
English (en)
Inventor
Paradisi Gianfranco
Rossi Mara
Scaglia Laura
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200200464A publication Critical patent/EE200200464A/et
Publication of EE04932B1 publication Critical patent/EE04932B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Semiconductor Lasers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EEP200200464A 2000-02-22 2001-01-22 Meetod LH puhastamiseks, rekombinantne hLH ning seda sisaldav ravimkoostis EE04932B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00103692 2000-02-22
PCT/EP2001/000666 WO2001062774A2 (en) 2000-02-22 2001-01-22 Purified lh

Publications (2)

Publication Number Publication Date
EE200200464A true EE200200464A (et) 2003-12-15
EE04932B1 EE04932B1 (et) 2007-12-17

Family

ID=8167926

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200464A EE04932B1 (et) 2000-02-22 2001-01-22 Meetod LH puhastamiseks, rekombinantne hLH ning seda sisaldav ravimkoostis

Country Status (30)

Country Link
US (2) US7053054B2 (et)
EP (2) EP1777231A3 (et)
JP (1) JP4959898B2 (et)
KR (1) KR100808149B1 (et)
CN (1) CN100480258C (et)
AT (1) ATE356138T1 (et)
AU (1) AU780377B2 (et)
BG (1) BG65761B1 (et)
BR (2) BRPI0108553B8 (et)
CA (1) CA2399100C (et)
CY (1) CY1108056T1 (et)
CZ (1) CZ303274B6 (et)
DE (1) DE60127100T2 (et)
DK (1) DK1261622T3 (et)
EA (1) EA004385B1 (et)
EE (1) EE04932B1 (et)
ES (1) ES2278722T3 (et)
HR (1) HRP20020651B1 (et)
HU (1) HU227007B1 (et)
IL (2) IL151309A0 (et)
MX (1) MXPA02007867A (et)
NO (1) NO328693B1 (et)
PL (1) PL207728B1 (et)
PT (1) PT1261622E (et)
RS (1) RS50416B (et)
SI (1) SI1261622T1 (et)
SK (1) SK287041B6 (et)
UA (2) UA78676C2 (et)
WO (1) WO2001062774A2 (et)
ZA (1) ZA200206108B (et)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2278722T3 (es) * 2000-02-22 2007-08-16 Applied Research Systems Ars Holding N.V. Hlh purificada recombinante que tiene una bioactividad especifica y procedimiento para su purificacion.
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
CA2518268C (en) * 2003-03-04 2013-12-10 Aspenbio, Inc. Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone
CN1283792C (zh) * 2003-11-14 2006-11-08 余伟明 生物大分子组分相分离法
AU2004309040B2 (en) * 2003-12-22 2010-12-16 Ares Trading S.A. Method for purifying FSH
EP1709065B1 (en) * 2004-10-04 2010-06-02 Novetide Ltd. A counterion exchange process for peptides
KR101173717B1 (ko) * 2004-11-09 2012-08-13 아레스 트레이딩 에스.에이. Ｆｓｈ를 정제하는 방법
SG155183A1 (en) 2005-08-26 2009-09-30 Ares Trading Sa Process for the preparation of glycosylated interferon beta
US8604175B2 (en) * 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CA2701221A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying an fc-containing protein
WO2009053358A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying fc-fusion proteins
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
WO2015168622A1 (en) * 2014-05-01 2015-11-05 Virginia Tech Intellectual Properties, Inc. Keratin nanomaterials and methods of production
CN104569441B (zh) * 2015-01-19 2016-02-03 成都大熊猫繁育研究基地 大熊猫尿液促黄体素的酶联检测方法及其应用
WO2020229699A1 (en) 2019-05-16 2020-11-19 Ceva Sante Animale Compositions and methods for increasing reproduction performance in non human mammals using recombinant luteinizing hormone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002757A1 (en) * 1988-09-02 1990-03-22 Integrated Genetics, Inc. Heteropolymeric protein
JP3045539B2 (ja) * 1989-02-21 2000-05-29 ワシントン ユニバーシティ 改変型生殖ホルモン
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
HU227908B1 (en) * 1997-06-25 2012-05-29 Serono Lab Disulfide cross-linked glycoprotein hormones, their preparation and use thereof
ES2278722T3 (es) * 2000-02-22 2007-08-16 Applied Research Systems Ars Holding N.V. Hlh purificada recombinante que tiene una bioactividad especifica y procedimiento para su purificacion.

Also Published As

Publication number Publication date
HUP0301814A3 (en) 2004-10-28
HUP0301814A2 (hu) 2003-08-28
EA004385B1 (ru) 2004-04-29
JP2003532636A (ja) 2003-11-05
ZA200206108B (en) 2003-07-31
JP4959898B2 (ja) 2012-06-27
PT1261622E (pt) 2007-04-30
CN1404486A (zh) 2003-03-19
CA2399100A1 (en) 2001-08-30
BR122012018280B8 (pt) 2021-05-25
ATE356138T1 (de) 2007-03-15
HRP20020651A2 (en) 2004-12-31
NO20023963D0 (no) 2002-08-20
US20030186893A1 (en) 2003-10-02
EE04932B1 (et) 2007-12-17
BG65761B1 (bg) 2009-10-30
UA78676C2 (en) 2007-04-25
SK12052002A3 (sk) 2002-12-03
MXPA02007867A (es) 2003-02-10
EA200200893A1 (ru) 2003-02-27
CZ20022856A3 (cs) 2003-01-15
HRP20020651B1 (en) 2011-01-31
US7053054B2 (en) 2006-05-30
UA92145C2 (en) 2010-10-11
NO328693B1 (no) 2010-04-26
EP1261622B1 (en) 2007-03-07
DE60127100T2 (de) 2007-06-28
EP1261622A2 (en) 2002-12-04
KR100808149B1 (ko) 2008-02-29
IL151309A0 (en) 2003-04-10
NO20023963L (no) 2002-08-20
AU780377B2 (en) 2005-03-17
DK1261622T3 (da) 2007-05-29
RS50416B (sr) 2009-12-31
CY1108056T1 (el) 2013-09-04
CZ303274B6 (cs) 2012-07-11
CA2399100C (en) 2011-11-08
BG107001A (bg) 2003-04-30
HK1052014A1 (zh) 2003-08-29
AU3543601A (en) 2001-09-03
EP1777231A2 (en) 2007-04-25
SK287041B6 (sk) 2009-10-07
BR0108553A (pt) 2003-12-23
DE60127100D1 (de) 2007-04-19
PL207728B1 (pl) 2011-01-31
BR122012018280B1 (pt) 2018-01-09
KR20030001358A (ko) 2003-01-06
EP1777231A3 (en) 2007-11-07
SI1261622T1 (sl) 2007-06-30
PL362891A1 (en) 2004-11-02
WO2001062774A3 (en) 2002-03-14
ES2278722T3 (es) 2007-08-16
YU60302A (sh) 2005-09-19
HU227007B1 (en) 2010-04-28
BRPI0108553B1 (pt) 2016-06-14
US20060079460A1 (en) 2006-04-13
BRPI0108553B8 (pt) 2021-05-25
WO2001062774A2 (en) 2001-08-30
CN100480258C (zh) 2009-04-22
IL151309A (en) 2010-11-30

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

HC1A Change of owner name