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EE200200353A - Inimese heparanaasisarnane polüpeptiid ja nukleiinhape - Google Patents

Inimese heparanaasisarnane polüpeptiid ja nukleiinhape

Info

Publication number
EE200200353A
EE200200353A EEP200200353A EEP200200353A EE200200353A EE 200200353 A EE200200353 A EE 200200353A EE P200200353 A EEP200200353 A EE P200200353A EE P200200353 A EEP200200353 A EE P200200353A EE 200200353 A EE200200353 A EE 200200353A
Authority
EE
Estonia
Prior art keywords
polypeptide
nucleic acid
human heparanase
heparanase
human
Prior art date
Application number
EEP200200353A
Other languages
English (en)
Inventor
Siemeister Gerhard
Weiss Bertram
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of EE200200353A publication Critical patent/EE200200353A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01139—Alpha-glucuronidase (3.2.1.139)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP200200353A 1999-12-23 2000-12-18 Inimese heparanaasisarnane polüpeptiid ja nukleiinhape EE200200353A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99125831 1999-12-23
PCT/EP2000/012909 WO2001048161A2 (en) 1999-12-23 2000-12-18 Human heparanase-related polypeptide and nucleic acid

Publications (1)

Publication Number Publication Date
EE200200353A true EE200200353A (et) 2003-10-15

Family

ID=8239724

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200353A EE200200353A (et) 1999-12-23 2000-12-18 Inimese heparanaasisarnane polüpeptiid ja nukleiinhape

Country Status (20)

Country Link
US (1) US20040161745A1 (et)
EP (1) EP1244778A2 (et)
JP (1) JP2003518381A (et)
KR (1) KR20020062375A (et)
CN (1) CN1413249A (et)
AU (1) AU3013901A (et)
BG (1) BG106842A (et)
BR (1) BR0016703A (et)
CA (1) CA2392703A1 (et)
CZ (1) CZ20022147A3 (et)
EE (1) EE200200353A (et)
HU (1) HUP0203724A2 (et)
IL (1) IL149506A0 (et)
MX (1) MXPA02005077A (et)
NO (1) NO20023015L (et)
PL (1) PL362867A1 (et)
RU (1) RU2002119561A (et)
SK (1) SK8882002A3 (et)
WO (1) WO2001048161A2 (et)
ZA (1) ZA200205852B (et)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072973A2 (en) * 2000-02-24 2001-10-04 Bayer Aktiengesellschaft Regulation of human heparanase-like enzyme
GB0008912D0 (en) * 2000-04-11 2000-05-31 Janssen Pharmaceutica Nv Mammalian heparanase
US20020064853A1 (en) * 2000-04-20 2002-05-30 Heinrikson Robert Leroy Heparanase II, a novel human heparanase paralog
WO2002004645A2 (en) * 2000-07-12 2002-01-17 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas
FR2818131B1 (fr) * 2000-12-14 2005-02-11 Oreal Composition cosmetique comprenant de l'heparanase
CN101311188B (zh) * 2007-05-21 2010-12-29 中国人民解放军军事医学科学院生物工程研究所 人乙酰肝素酶的小分子多肽抑制剂
CN101670115B (zh) * 2009-07-31 2011-07-27 中国人民解放军第三军医大学 乙酰肝素酶与热休克蛋白的复合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
BR9813296A (pt) * 1997-10-28 2000-08-22 Univ Australian Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula
CA2377498A1 (en) * 1999-06-25 2001-01-04 Insight Strategy & Marketing Ltd. Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
WO2001021814A1 (en) * 1999-09-23 2001-03-29 Merck Patent Gmbh Heparanase-2, a member of the heparanase protein family

Also Published As

Publication number Publication date
WO2001048161A2 (en) 2001-07-05
US20040161745A1 (en) 2004-08-19
NO20023015D0 (no) 2002-06-21
SK8882002A3 (en) 2002-11-06
AU3013901A (en) 2001-07-09
BG106842A (en) 2003-05-30
MXPA02005077A (es) 2002-11-07
CN1413249A (zh) 2003-04-23
HUP0203724A2 (hu) 2003-03-28
CZ20022147A3 (cs) 2002-09-11
CA2392703A1 (en) 2001-07-05
KR20020062375A (ko) 2002-07-25
BR0016703A (pt) 2002-09-24
WO2001048161A3 (en) 2002-02-14
PL362867A1 (en) 2004-11-02
EP1244778A2 (en) 2002-10-02
IL149506A0 (en) 2002-11-10
RU2002119561A (ru) 2004-02-10
ZA200205852B (en) 2003-10-22
JP2003518381A (ja) 2003-06-10
NO20023015L (no) 2002-06-21

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