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EE200100436A - Alendroonhappe uus valmistamismeetod - Google Patents

Alendroonhappe uus valmistamismeetod

Info

Publication number
EE200100436A
EE200100436A EEP200100436A EEP200100436A EE200100436A EE 200100436 A EE200100436 A EE 200100436A EE P200100436 A EEP200100436 A EE P200100436A EE P200100436 A EEP200100436 A EE P200100436A EE 200100436 A EE200100436 A EE 200100436A
Authority
EE
Estonia
Prior art keywords
alendronic acid
preparation
new method
reacting
group
Prior art date
Application number
EEP200100436A
Other languages
English (en)
Inventor
Lidor-Hadas Ramy
Lifshitz Revital
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of EE200100436A publication Critical patent/EE200100436A/et
Publication of EE04593B1 publication Critical patent/EE04593B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
EEP200100436A 1999-02-17 2000-02-11 Alendroonhappe valmistamismeetod EE04593B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25163499A 1999-02-17 1999-02-17
PCT/US2000/003586 WO2000049026A1 (en) 1999-02-17 2000-02-11 Novel process for preparing alendronic acid

Publications (2)

Publication Number Publication Date
EE200100436A true EE200100436A (et) 2002-12-16
EE04593B1 EE04593B1 (et) 2006-02-15

Family

ID=22952795

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100436A EE04593B1 (et) 1999-02-17 2000-02-11 Alendroonhappe valmistamismeetod

Country Status (29)

Country Link
US (2) US6201148B1 (et)
EP (1) EP1169326B1 (et)
JP (1) JP3930251B2 (et)
KR (1) KR100665633B1 (et)
AT (1) ATE271057T1 (et)
AU (1) AU770312B2 (et)
BG (1) BG64851B1 (et)
BR (1) BR0010112A (et)
CA (1) CA2363317C (et)
CZ (1) CZ296921B6 (et)
DE (1) DE60012165T2 (et)
DK (1) DK1169326T3 (et)
EA (1) EA003861B1 (et)
EE (1) EE04593B1 (et)
ES (1) ES2222188T3 (et)
HK (1) HK1041004B (et)
HR (1) HRP20010606B1 (et)
HU (1) HUP0200342A3 (et)
IL (1) IL144941A0 (et)
IS (1) IS6050A (et)
MX (1) MXPA01008332A (et)
NO (1) NO20013984L (et)
NZ (1) NZ513551A (et)
PL (1) PL350126A1 (et)
PT (1) PT1169326E (et)
SK (1) SK285163B6 (et)
WO (1) WO2000049026A1 (et)
YU (1) YU59401A (et)
ZA (1) ZA200106816B (et)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1169326E (pt) * 1999-02-17 2004-10-29 Teva Pharma Novo processo para a preparacao de acido alendronico
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
WO2003057136A2 (en) 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US562A (en) * 1838-01-09 Scale beam and weight
US22A (en) * 1836-09-05 Spbcificatioh
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4621107A (en) * 1982-08-12 1986-11-04 Lagow Richard J Fluorinated elastomeric materials
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
GB2248063A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Phthalimido alkanoyl phosphonates
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PT1169326E (pt) * 1999-02-17 2004-10-29 Teva Pharma Novo processo para a preparacao de acido alendronico

Also Published As

Publication number Publication date
ATE271057T1 (de) 2004-07-15
CZ20012942A3 (cs) 2002-01-16
EA200100894A1 (ru) 2002-04-25
JP3930251B2 (ja) 2007-06-13
NO20013984D0 (no) 2001-08-16
EA003861B1 (ru) 2003-10-30
HRP20010606A2 (en) 2002-10-31
IS6050A (is) 2001-08-16
DE60012165D1 (de) 2004-08-19
AU3488600A (en) 2000-09-04
US6201148B1 (en) 2001-03-13
AU770312B2 (en) 2004-02-19
EE04593B1 (et) 2006-02-15
EP1169326A4 (en) 2002-05-22
BR0010112A (pt) 2001-12-26
EP1169326B1 (en) 2004-07-14
CA2363317C (en) 2008-04-29
BG105825A (en) 2002-04-30
YU59401A (sh) 2004-05-12
ES2222188T3 (es) 2005-02-01
HRP20010606B1 (en) 2005-08-31
CA2363317A1 (en) 2000-08-24
ZA200106816B (en) 2002-08-19
US20020052527A1 (en) 2002-05-02
HK1041004B (en) 2005-01-21
HK1041004A1 (en) 2002-06-28
NZ513551A (en) 2003-02-28
WO2000049026A1 (en) 2000-08-24
BG64851B1 (bg) 2006-06-30
PT1169326E (pt) 2004-10-29
IL144941A0 (en) 2002-06-30
HUP0200342A3 (en) 2005-02-28
JP2002537303A (ja) 2002-11-05
HUP0200342A2 (en) 2002-06-29
EP1169326A1 (en) 2002-01-09
PL350126A1 (en) 2002-11-04
MXPA01008332A (es) 2003-01-08
NO20013984L (no) 2001-10-17
KR20010102162A (ko) 2001-11-15
DK1169326T3 (da) 2004-10-04
SK11862001A3 (sk) 2002-02-05
SK285163B6 (sk) 2006-07-07
CZ296921B6 (cs) 2006-07-12
KR100665633B1 (ko) 2007-01-10
DE60012165T2 (de) 2005-08-25

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Legal Events

Date Code Title Description
HD1A Correction of address
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090211