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HUP0300227A2 - Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására - Google Patents

Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Info

Publication number
HUP0300227A2
HUP0300227A2 HU0300227A HUP0300227A HUP0300227A2 HU P0300227 A2 HUP0300227 A2 HU P0300227A2 HU 0300227 A HU0300227 A HU 0300227A HU P0300227 A HUP0300227 A HU P0300227A HU P0300227 A2 HUP0300227 A2 HU P0300227A2
Authority
HU
Hungary
Prior art keywords
salts
substituted
hidroxyetylidene
preparing
high purity
Prior art date
Application number
HU0300227A
Other languages
English (en)
Inventor
József Neu
János Fischer
Tamás Fodor
József Thörley
Tibor Gizur
Sándor Lévai
Ádám Demeter
Éva Perényi
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0300227A priority Critical patent/HUP0300227A2/hu
Publication of HU0300227D0 publication Critical patent/HU0300227D0/hu
Priority to PL378438A priority patent/PL214441B1/pl
Priority to DE602004019047T priority patent/DE602004019047D1/de
Priority to EP04705466A priority patent/EP1587814B1/en
Priority to AT04705466T priority patent/ATE420885T1/de
Priority to UAA200508269A priority patent/UA80023C2/uk
Priority to PCT/HU2004/000009 priority patent/WO2004067541A1/en
Priority to US10/541,866 priority patent/US7612229B2/en
Priority to EA200501188A priority patent/EA007947B1/ru
Publication of HUP0300227A2 publication Critical patent/HUP0300227A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Eljárás az I általános képletű 2-szubsztituált-l-(hidroxi-etilidén)-1,1-biszfoszfonsavak azok sói és hidrátjai - ahol R jelentése 3'-piridil, vagy 2'amino-etilidén - előállítására a II általános képletű- ahol a képletben R jelentése a fenti - vegyületekből vagy azoksóiból kiindulva metánszulfonsav jelenlétében foszforossavval úgy,hogy reagensként foszfor-pontoxidot alkalmaznak, majd kívánt esetben akapott savat lúggal sóvá alakítják. Ó
HU0300227A 2003-01-28 2003-01-28 Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására HUP0300227A2 (hu)

Priority Applications (9)

Application Number Priority Date Filing Date Title
HU0300227A HUP0300227A2 (hu) 2003-01-28 2003-01-28 Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
PL378438A PL214441B1 (pl) 2003-01-28 2004-01-27 Sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych i ich soli
DE602004019047T DE602004019047D1 (de) 2003-01-28 2004-01-27 Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)-1,1-bisphosphonsäuren und deren salzen
EP04705466A EP1587814B1 (en) 2003-01-28 2004-01-27 Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosphonic acids of high purity and the salts thereof
AT04705466T ATE420885T1 (de) 2003-01-28 2004-01-27 Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen
UAA200508269A UA80023C2 (en) 2003-01-28 2004-01-27 Process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosfonic acid and salt thereof or hydrate
PCT/HU2004/000009 WO2004067541A1 (en) 2003-01-28 2004-01-27 Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosphonic acids of high purity and the salts thereof
US10/541,866 US7612229B2 (en) 2003-01-28 2004-01-27 Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosfi- conic acids of high purity and the salts thereof
EA200501188A EA007947B1 (ru) 2003-01-28 2004-01-27 Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0300227A HUP0300227A2 (hu) 2003-01-28 2003-01-28 Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Publications (2)

Publication Number Publication Date
HU0300227D0 HU0300227D0 (en) 2003-03-28
HUP0300227A2 true HUP0300227A2 (hu) 2004-09-28

Family

ID=89981108

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300227A HUP0300227A2 (hu) 2003-01-28 2003-01-28 Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Country Status (9)

Country Link
US (1) US7612229B2 (hu)
EP (1) EP1587814B1 (hu)
AT (1) ATE420885T1 (hu)
DE (1) DE602004019047D1 (hu)
EA (1) EA007947B1 (hu)
HU (1) HUP0300227A2 (hu)
PL (1) PL214441B1 (hu)
UA (1) UA80023C2 (hu)
WO (1) WO2004067541A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
ES2324015T1 (es) * 2005-05-06 2009-07-29 Medichem, S.A. Proceso de sintesis de acidos bisfosfonicos geminales o de sus sales farmaceuticamente aceptables o de sus hidratos.
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
US8076483B2 (en) 2006-05-11 2011-12-13 M/S. Ind Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
WO2008152518A2 (en) * 2007-05-16 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
MX2012003914A (es) * 2009-10-02 2012-05-08 Metodo para la fabricacion de acidos aminohidroxi difosfonicos.
EP2665734B1 (en) * 2011-01-21 2016-06-29 Straitmark Holding AG METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN alpha-OXY PHOSPHORUS GROUP
CN121203646A (zh) * 2025-11-28 2025-12-26 四川雷驰力奥石油科技有限公司 一种防垢交联聚合物压裂液体及其制备方法

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Publication number Priority date Publication date Assignee Title
DE2702631A1 (de) 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
IT1246992B (it) 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
CA2197267C (en) 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5908859A (en) * 1997-08-11 1999-06-01 Eli Lilly And Company Benzothiophenes for inhibiting hyperlipidemia
NZ513551A (en) * 1999-02-17 2003-02-28 Teva Pharma Novel process for preparing alendronic acid
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
ES2311142T3 (es) * 2003-01-17 2009-02-01 Teva Pharmaceutical Industries Limited Procedimiento para reducir el contenido de hierro del risedronato sodico.
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005044831A2 (en) * 2003-08-21 2005-05-19 Sun Pharmaceutical Industries Limited A process for preparation of bisphosphonic acid compounds

Also Published As

Publication number Publication date
WO2004067541A1 (en) 2004-08-12
US20060122395A1 (en) 2006-06-08
PL214441B1 (pl) 2013-08-30
EA200501188A1 (ru) 2005-12-29
EP1587814B1 (en) 2009-01-14
EA007947B1 (ru) 2007-02-27
US7612229B2 (en) 2009-11-03
PL378438A1 (pl) 2006-04-03
UA80023C2 (en) 2007-08-10
DE602004019047D1 (de) 2009-03-05
ATE420885T1 (de) 2009-01-15
HU0300227D0 (en) 2003-03-28
EP1587814A1 (en) 2005-10-26

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU