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EE05333B1 - Makroliidhendite konjugaadid p?letikuvastaste henditega ja nende kasutamine - Google Patents

Makroliidhendite konjugaadid p?letikuvastaste henditega ja nende kasutamine

Info

Publication number
EE05333B1
EE05333B1 EEP200300293A EEP200300293A EE05333B1 EE 05333 B1 EE05333 B1 EE 05333B1 EE P200300293 A EEP200300293 A EE P200300293A EE P200300293 A EEP200300293 A EE P200300293A EE 05333 B1 EE05333 B1 EE 05333B1
Authority
EE
Estonia
Prior art keywords
conjugates
inflammatory agents
macrolide compounds
macrolide
compounds
Prior art date
Application number
EEP200300293A
Other languages
English (en)
Estonian (et)
Inventor
Mercep Mladen
Mesic Milan
Tomaskovic Linda
Komac Marijana
Hrvacic Boska
Markovic Stribor
Original Assignee
Pliva D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D.D. filed Critical Pliva D.D.
Publication of EE200300293A publication Critical patent/EE200300293A/xx
Publication of EE05333B1 publication Critical patent/EE05333B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200300293A 2001-01-09 2002-01-03 Makroliidhendite konjugaadid p?letikuvastaste henditega ja nende kasutamine EE05333B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20010018A HRP20010018A2 (en) 2001-01-09 2001-01-09 Novel anti-inflammatory compounds
PCT/HR2002/000001 WO2002055531A1 (en) 2001-01-09 2002-01-03 Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy

Publications (2)

Publication Number Publication Date
EE200300293A EE200300293A (et) 2003-10-15
EE05333B1 true EE05333B1 (et) 2010-08-16

Family

ID=10947235

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300293A EE05333B1 (et) 2001-01-09 2002-01-03 Makroliidhendite konjugaadid p?letikuvastaste henditega ja nende kasutamine

Country Status (23)

Country Link
US (2) US7446097B2 (es)
EP (1) EP1351973B1 (es)
JP (1) JP4474101B2 (es)
CN (1) CN1269836C (es)
AR (1) AR035727A1 (es)
AT (1) ATE462713T1 (es)
BG (1) BG108073A (es)
BR (1) BR0206347A (es)
CA (1) CA2434009C (es)
CZ (1) CZ20031825A3 (es)
DE (1) DE60235794D1 (es)
EA (1) EA007061B1 (es)
EE (1) EE05333B1 (es)
ES (1) ES2342364T3 (es)
GE (1) GEP20053607B (es)
HR (1) HRP20010018A2 (es)
HU (1) HUP0500180A3 (es)
IL (1) IL156673A0 (es)
PL (1) PL207636B1 (es)
RS (1) RS51308B (es)
SK (1) SK9792003A3 (es)
UA (1) UA77166C2 (es)
WO (1) WO2002055531A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002109169A (ja) * 2000-09-29 2002-04-12 Hitachi Ltd 作業支援方法並びにシステム及び作業支援方法を記録した記録媒体
EP1483277A4 (en) * 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
NZ535355A (en) 2002-02-15 2007-09-28 Merckle Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
HRP20050002A2 (en) * 2002-07-08 2006-03-31 Pliva-Istra�iva�ki institut d.o.o. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
JP2005536488A (ja) * 2002-07-08 2005-12-02 プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー 新規な非ステロイド抗炎症物質、組成物、およびその使用方法
BR0312634A (pt) * 2002-07-08 2005-05-10 Pliva Istrazivacki Inst D O O Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias
HRP20030324A2 (en) * 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
JP4737495B2 (ja) * 2004-01-14 2011-08-03 塩野義製薬株式会社 エリスロマイシン誘導体
RU2007108544A (ru) * 2004-08-12 2008-09-20 Глаксосмитклайн Истраживацки Центар Загреб Д.О.О.(Hr) Применение клеточно-специфических конъюгатов для лечения воспалительных заболеваний желудочно-кишечного тракта
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
CN101090908A (zh) * 2004-10-27 2007-12-19 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 具有抗炎活性的共轭物
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
WO2011116312A1 (en) * 2010-03-19 2011-09-22 Catabasis Pharmaceuticals, Inc. Fatty acid macrolide derivatives and their uses
CN112552364A (zh) * 2013-01-23 2021-03-26 司菲埃拉制药私人有限公司 用于线粒体生物发生和与线粒体功能障碍或耗竭相关的疾病的新颖11β-羟基类固醇化合物
CN106714770B (zh) 2014-07-23 2024-04-19 斯法尔制药私人有限公司 羟基类固醇化合物、其中间体、制备方法、组合物及其用途
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
WO2023248010A2 (en) * 2022-06-23 2023-12-28 Synovo Gmbh Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
DE3860503D1 (de) 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
JPH01163124A (ja) * 1987-12-21 1989-06-27 Yamayuu Seikatsushiya:Kk 外用鎮痛消炎消腫消膿剤
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
FI953130A0 (fi) 1992-12-24 1995-06-22 Rhone Poulenc Rorer Ltd Uudet steroidit
CN1159756A (zh) 1994-08-12 1997-09-17 大正制药株式会社 抑制白细胞介素5的产生的抑制剂
KR970704455A (ko) 1994-08-12 1997-09-06 우에하라 아끼라 인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor)
DE19542949A1 (de) 1995-11-17 1997-07-17 Hilti Ag Bolzen zum Eintreiben in harte Aufnahmewerkstoffe
US5928868A (en) * 1996-04-26 1999-07-27 Massachusetts Institute Of Technology Three hybrid screening assay
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
AU4549999A (en) 1998-06-08 1999-12-30 Advanced Medicine, Inc. Novel polyene macrolide compounds and uses
AU4543899A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS

Also Published As

Publication number Publication date
CN1491230A (zh) 2004-04-21
EP1351973B1 (en) 2010-03-31
EE200300293A (et) 2003-10-15
US20090105163A1 (en) 2009-04-23
RS51308B (sr) 2010-12-31
HRP20010018A2 (en) 2002-12-31
ES2342364T3 (es) 2010-07-06
CA2434009C (en) 2009-09-29
JP2004518670A (ja) 2004-06-24
EP1351973A1 (en) 2003-10-15
IL156673A0 (en) 2004-01-04
WO2002055531A1 (en) 2002-07-18
AR035727A1 (es) 2004-07-07
CA2434009A1 (en) 2002-07-18
BG108073A (bg) 2005-05-31
PL207636B1 (pl) 2011-01-31
CZ20031825A3 (cs) 2003-11-12
EA007061B1 (ru) 2006-06-30
HUP0500180A2 (en) 2006-09-28
DE60235794D1 (de) 2010-05-12
BR0206347A (pt) 2004-02-10
HUP0500180A3 (en) 2009-12-28
SK9792003A3 (en) 2004-01-08
US7446097B2 (en) 2008-11-04
US20040198677A1 (en) 2004-10-07
ATE462713T1 (de) 2010-04-15
HK1065320A1 (en) 2005-02-18
YU55203A (sh) 2006-03-03
US7928078B2 (en) 2011-04-19
GEP20053607B (en) 2005-09-12
EA200300781A1 (ru) 2003-12-25
CN1269836C (zh) 2006-08-16
UA77166C2 (en) 2006-11-15
JP4474101B2 (ja) 2010-06-02
PL363478A1 (en) 2004-11-15

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
HB1A Correction of owner name or address
KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20120103