DE60235794D1 - Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie - Google Patents

Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie

Info

Publication number: DE60235794D1
Authority: DE; Germany
Prior art keywords: phlogistic; compounds; immunetic; conjugates; therapy
Prior art date: 2001-01-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60235794T

Other languages

English (en)

Inventor

Mladen Mercep

Milan Mesic

Linda Tomaskovic

Marijana Komac

Boska Hrvacic

Stribor Markovic

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fidelta doo

Original Assignee

GlaxoSmithKline Istrazivacki Centar Zagreb doo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-09

Filing date

2002-01-03

Publication date

2010-05-12

2002-01-03 Application filed by GlaxoSmithKline Istrazivacki Centar Zagreb doo filed Critical GlaxoSmithKline Istrazivacki Centar Zagreb doo

2010-05-12 Application granted granted Critical

2010-05-12 Publication of DE60235794D1 publication Critical patent/DE60235794D1/de

2022-01-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60235794T 2001-01-09 2002-01-03 Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie Expired - Lifetime DE60235794D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HR20010018A HRP20010018A2 (en)	2001-01-09	2001-01-09	Novel anti-inflammatory compounds
PCT/HR2002/000001 WO2002055531A1 (en)	2001-01-09	2002-01-03	Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy

Publications (1)

Publication Number	Publication Date
DE60235794D1 true DE60235794D1 (de)	2010-05-12

Family

ID=10947235

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60235794T Expired - Lifetime DE60235794D1 (de)	2001-01-09	2002-01-03	Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie

Country Status (23)

Country	Link
US (2)	US7446097B2 (de)
EP (1)	EP1351973B1 (de)
JP (1)	JP4474101B2 (de)
CN (1)	CN1269836C (de)
AR (1)	AR035727A1 (de)
AT (1)	ATE462713T1 (de)
BG (1)	BG108073A (de)
BR (1)	BR0206347A (de)
CA (1)	CA2434009C (de)
CZ (1)	CZ20031825A3 (de)
DE (1)	DE60235794D1 (de)
EA (1)	EA007061B1 (de)
EE (1)	EE05333B1 (de)
ES (1)	ES2342364T3 (de)
GE (1)	GEP20053607B (de)
HR (1)	HRP20010018A2 (de)
HU (1)	HUP0500180A3 (de)
IL (1)	IL156673A0 (de)
PL (1)	PL207636B1 (de)
RS (1)	RS51308B (de)
SK (1)	SK9792003A3 (de)
UA (1)	UA77166C2 (de)
WO (1)	WO2002055531A1 (de)

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* Cited by examiner, † Cited by third party
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JP2002109169A (ja) *	2000-09-29	2002-04-12	Hitachi Ltd	作業支援方法並びにシステム及び作業支援方法を記録した記録媒体
EP1483277A4 (de) *	2002-02-15	2007-10-03	Merckle Gmbh	Konjugate biologisch aktiver verbindungen, verfahren zu deren herstellung und anwendung, formulierung und pharmazeutische anwendungen davon
NZ535355A (en)	2002-02-15	2007-09-28	Merckle Gmbh	Antibiotic conjugates
WO2003070173A2 (en)	2002-02-15	2003-08-28	Sympore Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
HRP20050002A2 (en) *	2002-07-08	2006-03-31	Pliva-Istra�iva�ki institut d.o.o.	Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
JP2005536488A (ja) *	2002-07-08	2005-12-02	プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー	新規な非ステロイド抗炎症物質、組成物、およびその使用方法
BR0312634A (pt) *	2002-07-08	2005-05-10	Pliva Istrazivacki Inst D O O	Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias
HRP20030324A2 (en) *	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect
US7276487B2 (en)	2003-09-23	2007-10-02	Enanta Pharmaceuticals, Inc.	9a, 11-3C-bicyclic 9a-azalide derivatives
JP4737495B2 (ja) *	2004-01-14	2011-08-03	塩野義製薬株式会社	エリスロマイシン誘導体
RU2007108544A (ru) *	2004-08-12	2008-09-20	Глаксосмитклайн Истраживацки Центар Загреб Д.О.О.(Hr)	Применение клеточно-специфических конъюгатов для лечения воспалительных заболеваний желудочно-кишечного тракта
US20060183696A1 (en) *	2004-08-12	2006-08-17	Pliva-Istrazivacki Institut D.O.O.	Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
US7402568B2 (en)	2004-09-29	2008-07-22	Enanta Pharmaceuticals, Inc.	Bicyclic 9a-azalide derivatives
CN101090908A (zh) *	2004-10-27	2007-12-19	葛兰素伊斯特拉齐瓦基森塔萨格勒布公司	具有抗炎活性的共轭物
US7271155B2 (en)	2005-01-07	2007-09-18	Enanta Pharmaceuticals, Inc.	9A, 11-2C-bicyclic 9a-azalide derivatives
US20080249034A1 (en) *	2005-03-21	2008-10-09	Zambon S.P.A.	Use of Macrolides for Treating Intestinal Inflammation
WO2011116312A1 (en) *	2010-03-19	2011-09-22	Catabasis Pharmaceuticals, Inc.	Fatty acid macrolide derivatives and their uses
CN112552364A (zh) *	2013-01-23	2021-03-26	司菲埃拉制药私人有限公司	用于线粒体生物发生和与线粒体功能障碍或耗竭相关的疾病的新颖11β-羟基类固醇化合物
CN106714770B (zh)	2014-07-23	2024-04-19	斯法尔制药私人有限公司	羟基类固醇化合物、其中间体、制备方法、组合物及其用途
GB201520419D0 (en)	2015-11-19	2016-01-06	Epi Endo Pharmaceuticals Ehf	Compounds
WO2023248010A2 (en) *	2022-06-23	2023-12-28	Synovo Gmbh	Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4710495A (en) *	1980-07-10	1987-12-01	Otsuka Pharmaceutical Co., Ltd.	Soft steroids having anti-inflammatory activity
DE3860503D1 (de)	1987-09-03	1990-10-04	Pliva Pharm & Chem Works	10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
JPH01163124A (ja) *	1987-12-21	1989-06-27	Yamayuu Seikatsushiya:Kk	外用鎮痛消炎消腫消膿剤
SE9100342D0 (sv)	1991-02-04	1991-02-04	Astra Ab	Novel steroid esters
SE9100341D0 (sv)	1991-02-04	1991-02-04	Astra Ab	Novel steroids
GB9225923D0 (en)	1992-12-11	1993-02-03	Rhone Poulenc Rorer Ltd	New compositions of matter
FI953130A0 (fi)	1992-12-24	1995-06-22	Rhone Poulenc Rorer Ltd	Uudet steroidit
CN1159756A (zh)	1994-08-12	1997-09-17	大正制药株式会社	抑制白细胞介素5的产生的抑制剂
KR970704455A (ko)	1994-08-12	1997-09-06	우에하라 아끼라	인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor)
DE19542949A1 (de)	1995-11-17	1997-07-17	Hilti Ag	Bolzen zum Eintreiben in harte Aufnahmewerkstoffe
US5928868A (en) *	1996-04-26	1999-07-27	Massachusetts Institute Of Technology	Three hybrid screening assay
FR2776927B1 (fr) *	1998-04-07	2002-07-05	Univ Paris Curie	Compositions pour la vectorisation de molecules
AU4549999A (en)	1998-06-08	1999-12-30	Advanced Medicine, Inc.	Novel polyene macrolide compounds and uses
AU4543899A (en) *	1998-06-08	1999-12-30	Advanced Medicine, Inc.	Multibinding inhibitors of microsomal triglyceride transferase protein
IT1306205B1 (it)	1999-01-15	2001-05-30	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.
EP1483277A4 (de)	2002-02-15	2007-10-03	Merckle Gmbh	Konjugate biologisch aktiver verbindungen, verfahren zu deren herstellung und anwendung, formulierung und pharmazeutische anwendungen davon

2001
- 2001-01-09 HR HR20010018A patent/HRP20010018A2/hr not_active Application Discontinuation
2002
- 2002-01-03 WO PCT/HR2002/000001 patent/WO2002055531A1/en not_active Ceased
- 2002-01-03 ES ES02729470T patent/ES2342364T3/es not_active Expired - Lifetime
- 2002-01-03 EA EA200300781A patent/EA007061B1/ru not_active IP Right Cessation
- 2002-01-03 IL IL15667302A patent/IL156673A0/xx unknown
- 2002-01-03 DE DE60235794T patent/DE60235794D1/de not_active Expired - Lifetime
- 2002-01-03 EE EEP200300293A patent/EE05333B1/xx not_active IP Right Cessation
- 2002-01-03 GE GE5260A patent/GEP20053607B/en unknown
- 2002-01-03 US US10/250,934 patent/US7446097B2/en not_active Expired - Fee Related
- 2002-01-03 CZ CZ20031825A patent/CZ20031825A3/cs unknown
- 2002-01-03 SK SK979-2003A patent/SK9792003A3/sk unknown
- 2002-01-03 JP JP2002556599A patent/JP4474101B2/ja not_active Expired - Fee Related
- 2002-01-03 RS YUP-552/03A patent/RS51308B/sr unknown
- 2002-01-03 HU HU0500180A patent/HUP0500180A3/hu unknown
- 2002-01-03 CN CNB02804715XA patent/CN1269836C/zh not_active Expired - Fee Related
- 2002-01-03 CA CA002434009A patent/CA2434009C/en not_active Expired - Fee Related
- 2002-01-03 AT AT02729470T patent/ATE462713T1/de not_active IP Right Cessation
- 2002-01-03 EP EP02729470A patent/EP1351973B1/de not_active Expired - Lifetime
- 2002-01-03 BR BR0206347-6A patent/BR0206347A/pt not_active Application Discontinuation
- 2002-01-03 PL PL363478A patent/PL207636B1/pl unknown
- 2002-01-08 AR ARP020100040A patent/AR035727A1/es active IP Right Grant
- 2002-03-01 UA UA2003076135A patent/UA77166C2/uk unknown
2003
- 2003-08-07 BG BG108073A patent/BG108073A/bg unknown
2008
- 2008-09-16 US US12/211,213 patent/US7928078B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1491230A (zh)	2004-04-21
EP1351973B1 (de)	2010-03-31
EE200300293A (et)	2003-10-15
US20090105163A1 (en)	2009-04-23
RS51308B (sr)	2010-12-31
HRP20010018A2 (en)	2002-12-31
ES2342364T3 (es)	2010-07-06
CA2434009C (en)	2009-09-29
JP2004518670A (ja)	2004-06-24
EP1351973A1 (de)	2003-10-15
IL156673A0 (en)	2004-01-04
WO2002055531A1 (en)	2002-07-18
AR035727A1 (es)	2004-07-07
CA2434009A1 (en)	2002-07-18
BG108073A (bg)	2005-05-31
PL207636B1 (pl)	2011-01-31
CZ20031825A3 (cs)	2003-11-12
EA007061B1 (ru)	2006-06-30
HUP0500180A2 (en)	2006-09-28
BR0206347A (pt)	2004-02-10
HUP0500180A3 (en)	2009-12-28
SK9792003A3 (en)	2004-01-08
US7446097B2 (en)	2008-11-04
US20040198677A1 (en)	2004-10-07
ATE462713T1 (de)	2010-04-15
HK1065320A1 (en)	2005-02-18
EE05333B1 (et)	2010-08-16
YU55203A (sh)	2006-03-03
US7928078B2 (en)	2011-04-19
GEP20053607B (en)	2005-09-12
EA200300781A1 (ru)	2003-12-25
CN1269836C (zh)	2006-08-16
UA77166C2 (en)	2006-11-15
JP4474101B2 (ja)	2010-06-02
PL363478A1 (en)	2004-11-15

Publication	Publication Date	Title
DE60235794D1 (de)	2010-05-12	Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie
EP1296698A4 (de)	2005-02-16	Therapeutische verbindungen
ATE430570T1 (de)	2009-05-15	Synergistische kombinationstherapie zur krebsbehandlung
IS6891A (is)	2003-07-24	Aðferðir við gjöf epóþílon hliðstæðna við meðferðkrabbameins
DE60237823D1 (de)	2010-11-11	Medizinisches behandlungsinstrument
DK1335678T3 (da)	2009-02-09	Oralt behandlingssystem
DE60016794D1 (de)	2005-01-20	Intraspinale botulinus-toxin-enthaltende verbindungen zur schmerzbehandlung
DK1446012T3 (da)	2013-10-14	Bakteriolytisk kombinationsterapi til behandling af tumorer
NO20035773L (no)	2004-02-27	Ny konstruert superantigen for human terapi
KR100695846B9 (ko)	2021-09-30	암 치료
EP1446129A4 (de)	2006-05-10	Polynucleotid-therapie
ATE358674T1 (de)	2007-04-15	4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung
ATE269324T1 (de)	2004-07-15	Hydroxyphenyl-piperidin-4-ylidene-methyl- benzamidderivate zur schmerzbekämpfung
NO20033205D0 (no)	2003-07-15	Terapeutiske kromanforbindelser
DE60223576D1 (de)	2007-12-27	Hautbehandlungszusammensetzung
EP1429659A4 (de)	2009-11-11	Ultraschalltherapie
DE60227963D1 (de)	2008-09-11	Behandlungssystem
ATE297914T1 (de)	2005-07-15	Hydroxyphenyl-piperazinyl-methyl-benzamid- derivate zur schmerzbehandlung
EP1357919A4 (de)	2008-02-27	Glucan zur verbesserung der therapie
DE60220220D1 (de)	2007-07-05	Blutbehandlungssystem
ATE289603T1 (de)	2005-03-15	Chinolinyl-piperidin-4-yliden-methyl-benzamid- derivate zur schmerzbekämpfung
DK1553950T3 (da)	2007-10-15	Terapeutisk behandling
EP1478356A4 (de)	2005-03-16	Therapeutische verbindungen
DE60221068D1 (de)	2007-08-23	Gerät zur tiefenwirksamen Hauttherapie
FI20002473L (fi)	2002-05-11	Hammasimplanttikiinnike

Legal Events

Date	Code	Title	Description
2011-04-21	8364	No opposition during term of opposition