EE05316B1 - Crystalline anticholinergic, a process for its preparation and its use in the manufacture of a medicament - Google Patents

Crystalline anticholinergic, a process for its preparation and its use in the manufacture of a medicament

Info

Publication number: EE05316B1
Authority: EE; Estonia
Prior art keywords: medicament; manufacture; preparation; anticholinergic; crystalline
Prior art date: 2001-06-22

Application number

EEP200400029A

Other languages

Estonian (et)

Inventor

Sieger Peter

Werthmann Ulrike

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-22

Filing date

2002-06-08

Publication date

2010-08-16

2002-06-08 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg

2004-04-15 Publication of EE200400029A publication Critical patent/EE200400029A/en

2010-08-16 Publication of EE05316B1 publication Critical patent/EE05316B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

EEP200400029A 2001-06-22 2002-06-08 Crystalline anticholinergic, a process for its preparation and its use in the manufacture of a medicament EE05316B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10129710		2001-06-22
DE10215436		2002-04-08
PCT/EP2002/006291 WO2003000265A1 (en)	2001-06-22	2002-06-08	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Publications (2)

Publication Number	Publication Date
EE200400029A EE200400029A (en)	2004-04-15
EE05316B1 true EE05316B1 (en)	2010-08-16

Family

ID=26009556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200400029A EE05316B1 (en)	2001-06-22	2002-06-08	Crystalline anticholinergic, a process for its preparation and its use in the manufacture of a medicament

Country Status (37)

Country	Link
EP (1)	EP1401445B1 (en)
JP (1)	JP2005504015A (en)
KR (2)	KR100971616B1 (en)
CN (1)	CN100586948C (en)
AR (1)	AR037491A1 (en)
AT (1)	ATE337006T1 (en)
AU (1)	AU2002345016B2 (en)
BG (1)	BG66303B1 (en)
BR (1)	BR0210537A (en)
CA (1)	CA2450961C (en)
CO (1)	CO5550423A2 (en)
CY (1)	CY1105223T1 (en)
CZ (1)	CZ302786B6 (en)
DE (1)	DE50207943D1 (en)
DK (1)	DK1401445T3 (en)
EA (1)	EA005813B1 (en)
EE (1)	EE05316B1 (en)
EG (1)	EG24851A (en)
ES (1)	ES2271280T3 (en)
HR (1)	HRP20031066B1 (en)
HU (1)	HUP0400333A3 (en)
IL (2)	IL159238A0 (en)
ME (1)	ME00412B (en)
MX (1)	MXPA03011718A (en)
MY (1)	MY122779A (en)
NO (1)	NO334301B1 (en)
NZ (1)	NZ530690A (en)
PE (2)	PE20030130A1 (en)
PL (1)	PL208137B1 (en)
PT (1)	PT1401445E (en)
RS (1)	RS50441B (en)
SA (1)	SA02230255B1 (en)
SI (1)	SI1401445T1 (en)
SK (1)	SK287262B6 (en)
TW (2)	TWI261589B (en)
UY (1)	UY27342A1 (en)
WO (1)	WO2003000265A1 (en)

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DE10212264A1 (en)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
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RS20060291A (en) *	2003-11-03	2008-06-05	Boehringer Ingelheim International Gmbh.,	Novel crystalline anhydride with anticholinergic effect
DE102004016179A1 (en) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Compounds for the treatment of proliferative processes
NZ550797A (en)	2004-04-22	2010-08-27	Boehringer Ingelheim Int	Pharmaceutical combinations containing 6-hydroxy-8-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1,1-dimethylethylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one for treating respiratory diseases
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (en)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
ES2322148T3 (en)	2004-08-11	2009-06-17	BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG	MEDICINES CONTAINING ANTI-POLINERGIC FOR TREATMENT IN URINARY ROADS.
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modification of surfaces of lactose as adjuvant for use with powder inhalants
CN101163706A (en)	2005-04-21	2008-04-16	贝林格尔·英格海姆国际有限公司	Dihydrothienopyrimidines for the treatment of inflammatory diseases
MX2007012907A (en)	2005-04-28	2008-03-14	Boehringer Ingelheim Int	Novel compounds for treating inflammatory diseases.
EP1879888A2 (en) *	2005-05-02	2008-01-23	Boehringer Ingelheim International GmbH	Crystalline forms of tiotropium bromide
NZ563596A (en) *	2005-05-02	2011-01-28	Boehringer Ingelheim Int	Crystalline form of tiotropium bromide anhydrate
DE102005030733A1 (en)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
DK1917253T3 (en)	2005-08-15	2015-03-30	Boehringer Ingelheim Int	Method of Preparation of Beta Mimetics
TWI396541B (en) *	2005-10-10	2013-05-21	Boehringer Ingelheim Int	Novel combinations of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
MX2007009988A (en)	2005-12-19	2008-02-22	Sicor Inc	Novel forms of tiotropium bromide and processes for preparation thereof.
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (en) *	2006-01-13	2010-12-08	江苏正大天晴药业股份有限公司	crystalline anticholinergic tiotropium bromide
EP1847543A1 (en)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidines for the treatment of inflammatory diseases
EP2051714B1 (en)	2006-08-07	2011-04-13	Boehringer Ingelheim International GmbH	Drug combinations for the treatment of respiratory tract diseases
UY30550A1 (en)	2006-08-22	2008-03-31	Boehringer Ingelheim Int	NEW BETA-AGANISTAS ENANTIOMÉRICAMENTE PUROS, PROCEDURES FOR ITS PREPARATION AND ITS USE AS MEDICATIONS
GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
EP2610258B1 (en)	2007-10-19	2014-08-27	Boehringer Ingelheim International Gmbh	Substituted piperidino dihydrothieno pyrimidines
EP2093219A1 (en)	2008-02-22	2009-08-26	Boehringer Ingelheim International Gmbh	Crystalline enantiomer free salt form of a betamimetic and its use as medicine
US20120053164A1 (en)	2008-12-19	2012-03-01	Boehringer Ingelheim International Gmbh	Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
WO2010101538A2 (en)	2009-03-06	2010-09-10	Bilgic Mahmut	New crystal forms
EP2513093B1 (en)	2009-12-17	2014-08-27	Boehringer Ingelheim International GmbH	New ccr2 receptor antagonists and uses thereof
EP2513086B1 (en)	2009-12-17	2015-04-29	Boehringer Ingelheim International GmbH	Novel antagonists for ccr2 and uses thereof
JP5629331B2 (en)	2010-01-29	2014-11-19	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Substituted naphthyridines and their use as SYK kinase inhibitors
WO2011141474A1 (en)	2010-05-12	2011-11-17	Boehringer Ingelheim International Gmbh	Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8946218B2 (en)	2010-05-12	2015-02-03	Boehringer Ingelheim International Gmbh	CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (en)	2010-05-17	2015-01-21	Boehringer Ingelheim International GmbH	Ccr2 antagonists and uses thereof
US9018212B2 (en)	2010-05-25	2015-04-28	Boehringer Ingelheim International Gmbh	Pyridazine carboxamides as CCR2 receptor antagonists
EP2576538B1 (en)	2010-06-01	2015-10-28	Boehringer Ingelheim International GmbH	New CCR2 antagonists
TR201007108A2 (en) *	2010-08-25	2012-03-21	B�Lg�� Mahmut	New tiotropium bromide crystal and production method.
JP5959537B2 (en)	2011-01-28	2016-08-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Substituted pyridinyl-pyrimidines and their use as pharmaceuticals
TR201101897A2 (en)	2011-02-28	2012-09-21	Bi̇lgi̇ç Mahmut	Crystal material containing tiotropium bromide
TR201111589A2 (en) *	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropium bromide anhydrous crystal form.
TR201102068A2 (en)	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Crystalline substances containing tiotropium bromide
JP5786257B2 (en)	2011-06-16	2015-09-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Novel selective CCR2 antagonist
EP2731941B1 (en)	2011-07-15	2019-05-08	Boehringer Ingelheim International GmbH	Novel and selective ccr2 antagonists
JP5860960B2 (en)	2011-07-26	2016-02-16	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Substituted quinolines and their use as pharmaceuticals
US20130059866A1 (en)	2011-08-24	2013-03-07	Boehringer Ingelheim International Gmbh	Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
EA031602B1 (en)	2011-11-25	2019-01-31	Адверио Фарма Гмбх	Processes for preraring aldehydes
CZ304368B6 (en)	2011-11-28	2014-04-02	Zentiva, K.S.	Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
PT106142B (en) *	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
US9096579B2 (en)	2012-04-20	2015-08-04	Boehringer Ingelheim International Gmbh	Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EP2897955B1 (en) *	2012-09-11	2019-11-06	Bilgic, Mahmut	New tiotropium bromide crystalline form
SI2914593T1 (en)	2012-11-05	2017-05-31	Zentiva, K.S.	Stabilization of tiotropium solvates
CN104341412A (en) *	2013-07-29	2015-02-11	天津金耀集团有限公司	Anhydrous tiotropium bromide crystal preparation method
ME03472B (en)	2014-03-19	2020-01-20	Boehringer Ingelheim Int	Heteroaryl sik inhibitors
US10034866B2 (en)	2014-06-19	2018-07-31	Teva Branded Pharmaceutical Products R&D, Inc.	Inhalable medicament comprising tiotropium
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2002
- 2002-06-08 IL IL15923802A patent/IL159238A0/en unknown
- 2002-06-08 SI SI200230431T patent/SI1401445T1/en unknown
- 2002-06-08 DK DK02743165T patent/DK1401445T3/en active
- 2002-06-08 AU AU2002345016A patent/AU2002345016B2/en not_active Expired
- 2002-06-08 CN CN02812303A patent/CN100586948C/en not_active Expired - Lifetime
- 2002-06-08 BR BR0210537-3A patent/BR0210537A/en not_active Application Discontinuation
- 2002-06-08 PT PT02743165T patent/PT1401445E/en unknown
- 2002-06-08 AT AT02743165T patent/ATE337006T1/en active
- 2002-06-08 KR KR1020037016769A patent/KR100971616B1/en not_active Expired - Lifetime
- 2002-06-08 KR KR1020097004823A patent/KR101011353B1/en not_active Expired - Lifetime
- 2002-06-08 MX MXPA03011718A patent/MXPA03011718A/en active IP Right Grant
- 2002-06-08 CZ CZ20040120A patent/CZ302786B6/en not_active IP Right Cessation
- 2002-06-08 ES ES02743165T patent/ES2271280T3/en not_active Expired - Lifetime
- 2002-06-08 HR HR20031066A patent/HRP20031066B1/en not_active IP Right Cessation
- 2002-06-08 PL PL364489A patent/PL208137B1/en unknown
- 2002-06-08 ME MEP-2008-620A patent/ME00412B/en unknown
- 2002-06-08 NZ NZ530690A patent/NZ530690A/en not_active IP Right Cessation
- 2002-06-08 WO PCT/EP2002/006291 patent/WO2003000265A1/en not_active Ceased
- 2002-06-08 JP JP2003506910A patent/JP2005504015A/en active Pending
- 2002-06-08 HU HU0400333A patent/HUP0400333A3/en unknown
- 2002-06-08 DE DE50207943T patent/DE50207943D1/en not_active Expired - Lifetime
- 2002-06-08 EE EEP200400029A patent/EE05316B1/en unknown
- 2002-06-08 SK SK52-2004A patent/SK287262B6/en unknown
- 2002-06-08 EA EA200301293A patent/EA005813B1/en not_active IP Right Cessation
- 2002-06-08 CA CA2450961A patent/CA2450961C/en not_active Expired - Fee Related
- 2002-06-08 RS YUP-997/03A patent/RS50441B/en unknown
- 2002-06-08 EP EP02743165A patent/EP1401445B1/en not_active Expired - Lifetime
- 2002-06-19 EG EG2002060698A patent/EG24851A/en active
- 2002-06-19 TW TW091113373A patent/TWI261589B/en not_active IP Right Cessation
- 2002-06-19 TW TW095100968A patent/TW200617007A/en unknown
- 2002-06-20 MY MYPI20022316A patent/MY122779A/en unknown
- 2002-06-20 UY UY27342A patent/UY27342A1/en not_active Application Discontinuation
- 2002-06-21 PE PE2002000538A patent/PE20030130A1/en active IP Right Grant
- 2002-06-21 AR ARP020102337A patent/AR037491A1/en not_active Application Discontinuation
- 2002-06-21 PE PE2007000660A patent/PE20081305A1/en not_active Application Discontinuation
- 2002-08-19 SA SA2230255A patent/SA02230255B1/en unknown
2003
- 2003-12-08 IL IL159238A patent/IL159238A/en active IP Right Grant
- 2003-12-12 BG BG108440A patent/BG66303B1/en unknown
- 2003-12-19 NO NO20035696A patent/NO334301B1/en not_active IP Right Cessation
2004
- 2004-01-20 CO CO04003764A patent/CO5550423A2/en not_active Application Discontinuation
2006
- 2006-09-20 CY CY20061101339T patent/CY1105223T1/en unknown

Also Published As

Publication number	Publication date
KR100971616B1 (en)	2010-07-22
EA200301293A1 (en)	2004-08-26
PT1401445E (en)	2006-10-31
EP1401445B1 (en)	2006-08-23
RS50441B (en)	2010-03-02
PL364489A1 (en)	2004-12-13
CN1520294A (en)	2004-08-11
PE20081305A1 (en)	2008-10-01
MY122779A (en)	2006-05-31
EP1401445A1 (en)	2004-03-31
ME00412B (en)	2011-10-10
AU2002345016B2 (en)	2008-04-17
CA2450961A1 (en)	2003-01-03
PL208137B1 (en)	2011-03-31
IL159238A (en)	2010-04-15
CZ302786B6 (en)	2011-11-09
UY27342A1 (en)	2003-02-28
MXPA03011718A (en)	2004-12-06
KR101011353B1 (en)	2011-01-28
EE200400029A (en)	2004-04-15
DE50207943D1 (en)	2006-10-05
HUP0400333A3 (en)	2012-10-29
CN100586948C (en)	2010-02-03
YU99703A (en)	2006-05-25
WO2003000265A1 (en)	2003-01-03
DK1401445T3 (en)	2006-11-27
KR20040018285A (en)	2004-03-02
HK1068540A1 (en)	2005-04-29
EG24851A (en)	2010-10-27
SA02230255B1 (en)	2006-10-31
CY1105223T1 (en)	2010-03-03
JP2005504015A (en)	2005-02-10
PE20030130A1 (en)	2003-04-02
BG66303B1 (en)	2013-03-29
MEP62008A (en)	2011-05-10
CO5550423A2 (en)	2005-08-31
SK522004A3 (en)	2004-06-08
KR20090031638A (en)	2009-03-26
HRP20031066A2 (en)	2004-04-30
HUP0400333A2 (en)	2004-12-28
BG108440A (en)	2004-08-31
NO20035696D0 (en)	2003-12-19
TW200617007A (en)	2006-06-01
CZ2004120A3 (en)	2004-05-12
EA005813B1 (en)	2005-06-30
SI1401445T1 (en)	2007-02-28
ATE337006T1 (en)	2006-09-15
HRP20031066B1 (en)	2011-10-31
TWI261589B (en)	2006-09-11
SK287262B6 (en)	2010-04-07
NZ530690A (en)	2005-05-27
NO334301B1 (en)	2014-02-03
CA2450961C (en)	2010-03-30
AR037491A1 (en)	2004-11-17
ES2271280T3 (en)	2007-04-16
IL159238A0 (en)	2004-06-01
BR0210537A (en)	2004-06-22

Publication	Publication Date	Title
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2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231