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EE04237B1 - 4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm, selle kasutamine ja valmistamise meetod - Google Patents

4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm, selle kasutamine ja valmistamise meetod

Info

Publication number
EE04237B1
EE04237B1 EEP199900053A EE9900053A EE04237B1 EE 04237 B1 EE04237 B1 EE 04237B1 EE P199900053 A EEP199900053 A EE P199900053A EE 9900053 A EE9900053 A EE 9900053A EE 04237 B1 EE04237 B1 EE 04237B1
Authority
EE
Estonia
Prior art keywords
phenylisoxazol
benzenesulfonamide
methyl
preparation
crystalline form
Prior art date
Application number
EEP199900053A
Other languages
English (en)
Other versions
EE9900053A (et
Inventor
J. Talley John
R. Medich John
T. Mclaughlin Kathleen
T. Gaud Henry
E. Yonan Edward
Original Assignee
G.D. Searle & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.
Priority to EEP200400073A priority Critical patent/EE200400073A/et
Publication of EE9900053A publication Critical patent/EE9900053A/et
Publication of EE04237B1 publication Critical patent/EE04237B1/et

Links

Classifications

    • H10W40/611—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • H10W40/73—

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Power Engineering (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Liquid Crystal Substances (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
EEP199900053A 1996-08-14 1997-08-12 4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm, selle kasutamine ja valmistamise meetod EE04237B1 (et)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EEP200400073A EE200400073A (et) 1996-08-14 1997-08-12 4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm ja selle kasutamine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2437896P 1996-08-14 1996-08-14
PCT/US1997/015126 WO1998006708A1 (en) 1996-08-14 1997-08-12 Crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide

Publications (2)

Publication Number Publication Date
EE9900053A EE9900053A (et) 1999-08-16
EE04237B1 true EE04237B1 (et) 2004-02-16

Family

ID=21820280

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900053A EE04237B1 (et) 1996-08-14 1997-08-12 4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm, selle kasutamine ja valmistamise meetod

Country Status (38)

Country Link
US (2) US6441014B2 (et)
EP (2) EP1283203A1 (et)
JP (2) JP3631763B2 (et)
KR (1) KR100383148B1 (et)
CN (1) CN1205193C (et)
AP (1) AP1055A (et)
AR (1) AR009244A1 (et)
AT (1) ATE228117T1 (et)
AU (1) AU722072B2 (et)
BG (1) BG64259B1 (et)
BR (1) BR9711151A (et)
CA (1) CA2264104A1 (et)
CZ (1) CZ297679B6 (et)
DE (1) DE69717281T2 (et)
DK (1) DK0920422T3 (et)
EA (2) EA003754B1 (et)
EE (1) EE04237B1 (et)
ES (1) ES2188971T3 (et)
GE (1) GEP20022636B (et)
HU (1) HUP0400923A3 (et)
IL (2) IL128255A (et)
IS (1) IS1989B (et)
LT (1) LT4551B (et)
LV (1) LV12274B (et)
NO (1) NO312461B1 (et)
NZ (1) NZ334132A (et)
OA (1) OA11298A (et)
PL (1) PL191313B1 (et)
PT (1) PT920422E (et)
RO (1) RO120771B1 (et)
RS (1) RS49671B (et)
SI (1) SI9720059B (et)
SK (1) SK283558B6 (et)
TR (1) TR199900298T2 (et)
TW (1) TW527350B (et)
UA (1) UA52684C2 (et)
WO (1) WO1998006708A1 (et)
ZA (1) ZA977314B (et)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU722072B2 (en) * 1996-08-14 2000-07-20 G.D. Searle & Co. Crytalline form of 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
NZ333399A (en) * 1997-12-24 2000-05-26 Sankyo Co Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
GB9810920D0 (en) * 1998-05-21 1998-07-22 Merck Sharp & Dohme Therapeutic use
ES2255294T3 (es) * 1998-08-07 2006-06-16 Chiron Corporation Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos.
AU1398899A (en) * 1998-11-12 2000-06-05 Algos Pharmaceutical Corporation Cox-2 inhibitors in combination with centrally acting analgesics
WO2000051685A1 (en) * 1999-03-01 2000-09-08 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
ATE284223T1 (de) * 1999-08-20 2004-12-15 Ortho Mcneil Pharm Inc Zusammensetzung enthaltend ein tramadol und ein antikonvulsives arzneimittel
CA2381895A1 (en) * 1999-08-27 2001-03-08 Merck & Co., Inc. Method for treating or preventing chronic prostatitis or chronic pelvic pain syndrome
US7172769B2 (en) 1999-12-08 2007-02-06 Pharmacia Corporation Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
DE10032132A1 (de) * 2000-07-01 2002-01-17 Lohmann Therapie Syst Lts Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
CA2455050C (en) * 2001-08-15 2007-02-20 Pharmacia & Upjohn Company Crystals including a malic acid salt of n-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene) methyl]-2, 4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
US20070072921A1 (en) * 2002-07-26 2007-03-29 Talley John J Crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl] benzenesulfonamide
AU2003238668A1 (en) 2003-04-04 2004-10-25 Hetero Drugs Limited Novel crystalline forms of valdecoxib
WO2004098619A2 (en) 2003-05-07 2004-11-18 Osteologix A/S Treating cartilage / bone conditions with water-soluble strontium salts
US20050182113A1 (en) * 2003-12-30 2005-08-18 Venkataraman Sundaram Method for preparing diaryl-substituted isoxazole compounds
US20050272787A1 (en) * 2004-05-19 2005-12-08 Eswaraiah Sajja Process for preparing crystalline form A of valdecoxib
WO2005120499A1 (en) * 2004-06-10 2005-12-22 Chandiran Thakashinamoorthy Form a of valdecoxib suitable for pharmaceutical formulations
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
PL1612203T3 (pl) * 2004-06-28 2007-12-31 Gruenenthal Gmbh Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylo-propylo)fenolu
KR100591786B1 (ko) 2004-10-19 2006-06-26 휴먼팜 주식회사 프란루카스트를 함유하는 약학적 조성물 및 이의 제조 방법
JP2008545650A (ja) 2005-05-20 2008-12-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ スルファミド誘導体の製造方法
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
WO2007137167A2 (en) 2006-05-19 2007-11-29 Janssen Pharmaceutica N.V. Co-therapy for the treatment of epilepsy
PE20110060A1 (es) 2008-06-23 2011-01-31 Janssen Pharmaceutica Nv Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]dioxin-2-ilmetil)-sulfamida
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CN103172583A (zh) * 2013-03-07 2013-06-26 深圳市资福药业有限公司 一种制备帕瑞昔布的方法
US9375417B2 (en) 2014-12-04 2016-06-28 Mary's Medicinals LLC Transdermal cannabinoid formulations
US10028904B2 (en) 2014-12-04 2018-07-24 Wisconsin Alumni Research Foundation Transdermal cannabinoid formulations
CN114441666B (zh) * 2020-11-05 2024-02-27 成都百裕制药股份有限公司 一种4-(5-甲基-3-苯基-4-异恶唑)苯磺酰氯中杂质的检测方法
US20240165148A1 (en) 2021-03-15 2024-05-23 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
AU699593B2 (en) * 1995-02-13 1998-12-10 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US5633272A (en) 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
AU722072B2 (en) * 1996-08-14 2000-07-20 G.D. Searle & Co. Crytalline form of 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
AU2003238668A1 (en) * 2003-04-04 2004-10-25 Hetero Drugs Limited Novel crystalline forms of valdecoxib
US20050272787A1 (en) * 2004-05-19 2005-12-08 Eswaraiah Sajja Process for preparing crystalline form A of valdecoxib

Also Published As

Publication number Publication date
AR009244A1 (es) 2000-04-12
LV12274A (lv) 1999-05-20
UA52684C2 (uk) 2003-01-15
IL128255A (en) 2004-06-20
WO1998006708A1 (en) 1998-02-19
DE69717281D1 (de) 2003-01-02
SI9720059B (sl) 2011-11-30
EP0920422B1 (en) 2002-11-20
RS49671B (sr) 2007-11-15
SI9720059A (sl) 1999-12-31
HUP0400923A3 (en) 2007-11-28
SK13699A3 (en) 1999-07-12
PL191313B1 (pl) 2006-04-28
KR20000029994A (ko) 2000-05-25
PT920422E (pt) 2003-03-31
JP2000506542A (ja) 2000-05-30
AU722072B2 (en) 2000-07-20
CZ297679B6 (cs) 2007-03-07
PL331607A1 (en) 1999-08-02
LT4551B (lt) 1999-10-25
US20010003752A1 (en) 2001-06-14
JP3631763B2 (ja) 2005-03-23
IL128255A0 (en) 1999-11-30
RO120771B1 (ro) 2006-07-28
KR100383148B1 (ko) 2003-05-09
EA199900200A1 (ru) 1999-06-24
EA200000891A1 (ru) 2001-02-26
DK0920422T3 (da) 2003-03-17
CA2264104A1 (en) 1998-02-19
HUP0400923A2 (hu) 2004-08-30
EP0920422A1 (en) 1999-06-09
HK1023125A1 (en) 2000-09-01
CN1205193C (zh) 2005-06-08
BG64259B1 (bg) 2004-07-30
US6441014B2 (en) 2002-08-27
NO312461B1 (no) 2002-05-13
IL161224A0 (en) 2004-09-27
YU7499A (sh) 2000-03-21
EP1283203A1 (en) 2003-02-12
AP1055A (en) 2002-04-04
NO990541D0 (no) 1999-02-05
EA003754B1 (ru) 2003-08-28
GEP20022636B (en) 2002-02-25
TW527350B (en) 2003-04-11
NZ334132A (en) 2000-06-23
ES2188971T3 (es) 2003-07-01
SK283558B6 (sk) 2003-09-11
LV12274B (en) 1999-09-20
AU4093697A (en) 1998-03-06
TR199900298T2 (xx) 1999-05-21
IS4961A (is) 1999-01-29
IS1989B (is) 2005-02-15
BG103155A (bg) 1999-11-30
DE69717281T2 (de) 2003-09-04
CN1233243A (zh) 1999-10-27
ZA977314B (en) 1998-08-14
LT99024A (en) 1999-07-26
CZ33499A3 (cs) 1999-06-16
EA001472B1 (ru) 2001-04-23
AP9901458A0 (en) 1999-03-31
JP2005015497A (ja) 2005-01-20
BR9711151A (pt) 1999-08-17
US7135489B2 (en) 2006-11-14
NO990541L (no) 1999-02-05
ATE228117T1 (de) 2002-12-15
US20030004200A1 (en) 2003-01-02
OA11298A (en) 2003-10-22
EE9900053A (et) 1999-08-16

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