EE04582B1 - Farnesüülproteiintransferaasi inhibiitorite kasutamine radiosensibiliseerimisomadustega farmatseutilise kompositsiooni valmistamiseks, mis on ette nähtud kasutamiseks vähi kiiritusravis - Google Patents

Farnesüülproteiintransferaasi inhibiitorite kasutamine radiosensibiliseerimisomadustega farmatseutilise kompositsiooni valmistamiseks, mis on ette nähtud kasutamiseks vähi kiiritusravis

Info

Publication number: EE04582B1
Authority: EE; Estonia
Prior art keywords: radiotherapy; cancer; preparation; pharmaceutical composition; protein transferase
Prior art date: 1998-07-06

Application number

EEP200000794A

Other languages

English (en)

Estonian (et)

Inventor

Franciscus Van Ginckel Robert

Joanna Floren Wim

William End David

Boudewijn Leopold Wouters Walter

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-06-30

Publication date

2006-02-15

1999-06-30 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2002-06-17 Publication of EE200000794A publication Critical patent/EE200000794A/xx

2006-02-15 Publication of EE04582B1 publication Critical patent/EE04582B1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

EEP200000794A 1998-07-06 1999-06-30 Farnesüülproteiintransferaasi inhibiitorite kasutamine radiosensibiliseerimisomadustega farmatseutilise kompositsiooni valmistamiseks, mis on ette nähtud kasutamiseks vähi kiiritusravis EE04582B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (2)

Publication Number	Publication Date
EE200000794A EE200000794A (et)	2002-06-17
EE04582B1 true EE04582B1 (et)	2006-02-15

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000794A EE04582B1 (et)	1998-07-06	1999-06-30	Farnesüülproteiintransferaasi inhibiitorite kasutamine radiosensibiliseerimisomadustega farmatseutilise kompositsiooni valmistamiseks, mis on ette nähtud kasutamiseks vähi kiiritusravis

Country Status (30)

Country	Link
US (1)	US6545020B1 (bg)
EP (1)	EP1094839B1 (bg)
JP (1)	JP4530537B2 (bg)
KR (1)	KR100591603B1 (bg)
CN (1)	CN1152716C (bg)
AP (1)	AP1599A (bg)
AT (1)	ATE238811T1 (bg)
AU (1)	AU762423B2 (bg)
BG (1)	BG64941B1 (bg)
BR (1)	BR9911861A (bg)
CA (1)	CA2336624C (bg)
CZ (1)	CZ300968B6 (bg)
DE (1)	DE69907461T2 (bg)
DK (1)	DK1094839T3 (bg)
EA (1)	EA003877B1 (bg)
EE (1)	EE04582B1 (bg)
ES (1)	ES2199579T3 (bg)
HR (1)	HRP20000903A2 (bg)
HU (1)	HU229076B1 (bg)
ID (1)	ID26987A (bg)
IL (2)	IL140721A0 (bg)
MY (1)	MY126519A (bg)
NO (1)	NO328178B1 (bg)
PL (1)	PL193464B1 (bg)
PT (1)	PT1094839E (bg)
SI (1)	SI1094839T1 (bg)
SK (1)	SK284723B6 (bg)
TR (1)	TR200003879T2 (bg)
TW (1)	TW586937B (bg)
WO (1)	WO2000001411A1 (bg)

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JP4974437B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−［（置換フェニル）メチル］−キノリンおよびキナゾリン誘導体
US7196094B2 (en)	2000-09-25	2007-03-27	Janssen Pharmaceutica, N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
EP1322644A1 (en)	2000-09-25	2003-07-02	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
JP4348080B2 (ja)	2000-11-21	2009-10-21	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体
ES2260316T3 (es)	2000-12-27	2006-11-01	Janssen Pharmaceutica N.V.	Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
PT1351954E (pt) *	2000-12-27	2006-09-29	Janssen Pharmaceutica Nv	Derivados 4-heterociclil-quinolina e quinazolina inibidores da farnesil-transferase
EP1408971A4 (en)	2001-06-21	2006-01-25	Ariad Pharma Inc	NEW QUINOLINES AND THEIR USES
CA2469275C (en)	2001-12-19	2011-09-06	Janssen Pharmaceutica N.V.	1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
AU2003223970B2 (en)	2002-03-22	2008-03-06	Janssen Pharmaceutica N.V.	Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors
EP1497295B1 (en)	2002-04-15	2006-08-16	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
US7517890B2 (en)	2003-11-20	2009-04-14	Children's Hospital Medical Center	GTPase inhibitors and methods of use
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WO2005089518A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Uch-l1 expression and cancer therapy
WO2005089504A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
EP1920048A4 (en)	2005-07-29	2009-12-09	Childrens Hosp Medical Center	GTASE INHIBITORS AND USE METHOD AND CRYSTAL STRUCTURE OF RAC-1 GTASE
EP2545919A1 (en)	2005-12-23	2013-01-16	Link Medicine Corporation	Treatment of synucleinopathies
WO2008147788A1 (en) *	2007-05-23	2008-12-04	Allergan, Inc.	Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
US8232402B2 (en) *	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2138844B1 (en)	2008-06-26	2012-04-25	SpheroTec GmbH	Method for testing the response of cells to exposures with therapeutics
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
JP2012508768A (ja) *	2008-11-13	2012-04-12	リンク・メディスン・コーポレーション	アザキノリノン誘導体及びその使用
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
MY189505A (en)	2012-10-16	2022-02-16	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of roryt
PE20151203A1 (es)	2012-10-16	2015-08-31	Janssen Pharmaceutica Nv	MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t
HK1213250A1 (zh)	2012-10-16	2016-06-30	Janssen Pharmaceutica, N.V.	RORγT的雜芳基連接的喹啉基調節劑
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
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US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
CA2927182A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	Quinolinyl modulators of ror.gamma.t
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
TWI621437B (zh)	2015-08-17	2018-04-21	庫拉腫瘤技術股份有限公司	以法呢基轉移酶（farnesyltransferase）抑制劑治療癌症病患之方法
US20190119758A1 (en)	2016-04-22	2019-04-25	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
LT3534885T (lt)	2016-11-03	2021-07-12	Kura Oncology, Inc.	Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui
US9956215B1 (en)	2017-02-21	2018-05-01	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2018156609A1 (en)	2017-02-21	2018-08-30	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
CN111182899A (zh)	2017-08-07	2020-05-19	库拉肿瘤学公司	使用法尼基转移酶抑制剂治疗癌症的方法
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
TW202031259A (zh)	2018-11-01	2020-09-01	美商庫拉腫瘤技術股份有限公司	以法尼基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
WO2020180663A1 (en)	2019-03-01	2020-09-10	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220143006A1 (en)	2019-03-15	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
KR20210144778A (ko)	2019-03-29	2021-11-30	쿠라 온콜로지, 인크.	파르네실트랜스퍼라제 억제제를 사용한 편평 세포 암종의 치료 방법
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1999
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active Expired - Lifetime
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en not_active Ceased
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 EP EP99931229A patent/EP1094839B1/en not_active Expired - Lifetime
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9911861A (pt)	2001-03-20
NO328178B1 (no)	2009-12-28
WO2000001411A1 (en)	2000-01-13
MY126519A (en)	2006-10-31
SK19862000A3 (sk)	2001-12-03
TW586937B (en)	2004-05-11
NO20010082D0 (no)	2001-01-05
CN1152716C (zh)	2004-06-09
CZ20004777A3 (en)	2001-05-16
AU762423B2 (en)	2003-06-26
CA2336624A1 (en)	2000-01-13
SI1094839T1 (en)	2003-12-31
IL140721A0 (en)	2002-02-10
PL193464B1 (pl)	2007-02-28
AP2001002057A0 (en)	2001-03-31
NO20010082L (no)	2001-01-05
BG105108A (bg)	2001-11-30
CN1311692A (zh)	2001-09-05
ATE238811T1 (de)	2003-05-15
ID26987A (id)	2001-02-22
ES2199579T3 (es)	2004-02-16
HRP20000903A2 (en)	2001-12-31
PL347979A1 (en)	2002-05-06
HU229076B1 (en)	2013-07-29
TR200003879T2 (tr)	2007-01-22
DK1094839T3 (da)	2003-08-18
HK1034451A1 (en)	2001-10-26
DE69907461D1 (de)	2003-06-05
JP4530537B2 (ja)	2010-08-25
HUP0103689A3 (en)	2003-01-28
KR100591603B1 (ko)	2006-06-20
CA2336624C (en)	2008-10-21
DE69907461T2 (de)	2004-02-19
AU4780599A (en)	2000-01-24
KR20010052770A (ko)	2001-06-25
EP1094839A1 (en)	2001-05-02
CZ300968B6 (cs)	2009-09-30
PT1094839E (pt)	2003-09-30
EA003877B1 (ru)	2003-10-30
SK284723B6 (sk)	2005-10-06
BG64941B1 (bg)	2006-10-31
EA200100111A1 (ru)	2001-06-25
EP1094839B1 (en)	2003-05-02
AP1599A (en)	2006-04-27
HUP0103689A2 (hu)	2002-02-28
JP2002519389A (ja)	2002-07-02
IL140721A (en)	2008-11-26
EE200000794A (et)	2002-06-17
US6545020B1 (en)	2003-04-08

Publication	Publication Date	Title
EE04582B1 (et)	2006-02-15	Farnesüülproteiintransferaasi inhibiitorite kasutamine radiosensibiliseerimisomadustega farmatseutilise kompositsiooni valmistamiseks, mis on ette nähtud kasutamiseks vähi kiiritusravis
EE04579B1 (et)	2006-02-15	Farnesüülproteiintransferaasi inhibiitorite kasutamine farmatseutilise kompositsiooni valmistamiseks, mis on ette nähtud artropaatiate raviks
HUP0200403A2 (en)	2002-06-29	Pyrrolopyrimidines as protein kinase inhibitors, pharmaceutical compositions containing them and their use
EE200200622A (et)	2004-06-15	Aromataasi inhibiitori kasutamine farmatseutilisekompositsiooni valmistamiseks, mis on ette nähtudHER2 valgu liigse avaldumisega hormoon-sõltuva häire raviks, ja meetod vähivastase ravi kõrvaltoimete vähendamiseks
HUP0202490A3 (en)	2003-01-28	Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
MY117961A (en)	2004-08-30	Inhibitors of farnesyl protein transferase
WO2002028832A3 (en)	2003-01-16	Diindolylmethane and c-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
HUP0202708A3 (en)	2004-12-28	Cyclic protein tyrosine kinase inhibitors, pharmaceutical compositions containing them and their use
NO973608D0 (no)	1997-08-05	Nye farnesyl-transferaseinhibitorer, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
HUP0203054A3 (en)	2004-01-28	Farnesyl protein transferase inhibitors, pharmaceutical compositions containing them and their use
NO20023713D0 (no)	2002-08-06	2-benzotiazolyl-urea-derivater samt anvendelse derav som proteinkinaseinhibitorer
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