EE04432B1 - Substituted indolinones inhibit kinases and cyclin / CDK complexes - Google Patents

Substituted indolinones inhibit kinases and cyclin / CDK complexes

Info

Publication number: EE04432B1
Authority: EE; Estonia
Prior art keywords: cyclin; cdk complexes; inhibit kinases; substituted indolinones; indolinones
Prior art date: 1998-04-15

Application number

EEP200000598A

Other languages

Estonian (et)

Inventor

Heckel Armin

Walter Rainer

Grell Wolfgang

C. A. Van Meel Jacobus

Redemann Norbert

Original Assignee

Boehringer Ingelheim Pharma Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-10

Publication date

2005-02-15

1999-04-10 Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg

2002-04-15 Publication of EE200000598A publication Critical patent/EE200000598A/en

2005-02-15 Publication of EE04432B1 publication Critical patent/EE04432B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

EEP200000598A 1998-04-15 1999-04-10 Substituted indolinones inhibit kinases and cyclin / CDK complexes EE04432B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19816624A DE19816624A1 (en)	1998-04-15	1998-04-15	Novel substituted indolinones, their preparation and their use as pharmaceuticals
PCT/EP1999/002436 WO1999052869A1 (en)	1998-04-15	1999-04-10	Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes

Publications (2)

Publication Number	Publication Date
EE200000598A EE200000598A (en)	2002-04-15
EE04432B1 true EE04432B1 (en)	2005-02-15

Family

ID=7864562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000598A EE04432B1 (en)	1998-04-15	1999-04-10	Substituted indolinones inhibit kinases and cyclin / CDK complexes

Country Status (31)

Country	Link
EP (1)	EP1071665B1 (en)
JP (1)	JP4015365B2 (en)
KR (1)	KR100588250B1 (en)
CN (1)	CN100338036C (en)
AR (1)	AR015763A1 (en)
AT (1)	ATE251138T1 (en)
AU (1)	AU749829B2 (en)
BG (1)	BG64443B1 (en)
BR (1)	BR9909688A (en)
CA (1)	CA2323111C (en)
CO (1)	CO5011040A1 (en)
DE (2)	DE19816624A1 (en)
DK (1)	DK1071665T3 (en)
EA (1)	EA003532B1 (en)
EE (1)	EE04432B1 (en)
ES (1)	ES2207209T3 (en)
HU (1)	HUP0101568A3 (en)
ID (1)	ID26420A (en)
IL (1)	IL138036A0 (en)
MY (1)	MY122357A (en)
NO (1)	NO317298B1 (en)
NZ (1)	NZ507967A (en)
PL (1)	PL343314A1 (en)
PT (1)	PT1071665E (en)
SK (1)	SK283824B6 (en)
TR (1)	TR200002980T2 (en)
TW (1)	TW510897B (en)
UA (1)	UA63009C2 (en)
WO (1)	WO1999052869A1 (en)
YU (1)	YU59800A (en)
ZA (1)	ZA200004623B (en)

Families Citing this family (39)

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US6569868B2 (en)	1998-04-16	2003-05-27	Sugen, Inc.	2-indolinone derivatives as modulators of protein kinase activity
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
GB9904995D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Substituted aza-oxindole derivatives
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
GB9904932D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
DE19924401A1 (en) *	1999-05-27	2000-11-30	Boehringer Ingelheim Pharma	Novel substituted indolinones, their preparation and their use as pharmaceuticals
EP1212318B1 (en)	1999-08-27	2006-01-25	Boehringer Ingelheim Pharma GmbH & Co.KG	Substituted indolinones as tyrosine kinase inhibitors
UA75054C2 (en) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Substituted in position 6 indolinones, producing and use thereof as medicament
US6762180B1 (en)	1999-10-13	2004-07-13	Boehringer Ingelheim Pharma Kg	Substituted indolines which inhibit receptor tyrosine kinases
PT1255752E (en)	2000-02-15	2007-10-17	Pharmacia & Upjohn Co Llc	Pyrrole substituted 2-indolinone protein kinase inhibitors
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en)	2000-05-24	2007-02-28	Upjohn Co	1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
EP1294688A2 (en)	2000-06-02	2003-03-26	Sugen, Inc.	Indolinone derivatives as protein kinase/phosphatase inhibitors
JP2004517840A (en) *	2000-11-27	2004-06-17	フアルマシア・イタリア・エツセ・ピー・アー	Phenylacetamide-pyrazole derivatives and their use as antitumor agents
AR042586A1 (en)	2001-02-15	2005-06-29	Sugen Inc	3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
DE10117204A1 (en)	2001-04-06	2002-10-10	Boehringer Ingelheim Pharma	Indolinones substituted in the 6-position, their preparation and their use as medicaments
PE20030062A1 (en)	2001-05-30	2003-02-08	Sugen Inc	ARALKYLSULFONIL-3- (PYRROL-2-ILMETILIDEN) -2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS
KR101022977B1 (en)	2002-03-26	2011-03-18	베링거 인겔하임 파마슈티칼즈, 인코포레이티드	Glucocorticoid mimetics, preparation methods thereof, pharmaceutical compositions and uses thereof
US7169936B2 (en)	2002-07-23	2007-01-30	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (en) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z- [1- (4- (N - ((4-methyl-piperazin-1-yl) -methylcarbonyl) -N-methyl-amino) -anilino) -1-phenyl-methylene] -6-methoxycarbonyl- 2-indolinone monoethanesulfonate and its use as a medicament
DE10237423A1 (en)	2002-08-16	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound
JP4879492B2 (en) *	2002-11-27	2012-02-22	アラーガン、インコーポレイテッド	Kinase inhibitors for the treatment of diseases
US20050043233A1 (en)	2003-04-29	2005-02-24	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (en)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
JP4949845B2 (en)	2003-10-03	2012-06-13	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	Fluorescent probes for use in protein kinase inhibitor binding assays
DE102004012070A1 (en) *	2004-03-12	2005-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (en)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
US7741361B2 (en)	2004-12-27	2010-06-22	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2006254758B2 (en) *	2005-06-10	2012-04-05	Merck Patent Gmbh	Oxindoles as kinase inhibitors
WO2007057399A2 (en) *	2005-11-15	2007-05-24	Boehringer Ingelheim International Gmbh	Treatment of cancer with indole derivatives
JP2010512331A (en)	2006-12-06	2010-04-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Glucocorticoid mimetics, methods for their production, pharmaceutical compositions, and uses thereof
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
ATE541846T1 (en)	2008-06-06	2012-02-15	Boehringer Ingelheim Int	GLUCOCORTICOID MIMETICS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS AND APPLICATIONS THEREOF
WO2011032320A1 (en) *	2009-09-21	2011-03-24	F. Hoffmann-La Roche Ag	Novel alkene oxindole derivatives
CN104039761A (en)	2011-11-14	2014-09-10	利亘制药公司	Methods and compositions related to granulocyte colony stimulating factor receptor
WO2014150252A1 (en) *	2013-03-15	2014-09-25	Ligand Pharmaceuticals Incorporated	Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN107033064B (en) *	2017-04-28	2019-07-09	西安医学院	A kind of 3- (morpholine replaces fragrant imido grpup) Benzazole compounds and its preparation method and application
CN111285872B (en) *	2018-12-06	2022-05-17	北京志健金瑞生物医药科技有限公司	Indole-2-ketone derivative and preparation method and application thereof

Family Cites Families (5)

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GB9501567D0 (en) *	1995-01-26	1995-03-15	Pharmacia Spa	Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
GB9718913D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
DE19824922A1 (en) *	1998-06-04	1999-12-09	Boehringer Ingelheim Pharma	Novel substituted indolinones, their preparation and their use as pharmaceuticals
UA75054C2 (en) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Substituted in position 6 indolinones, producing and use thereof as medicament

1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/en not_active Withdrawn
1999
- 1999-04-10 ES ES99920635T patent/ES2207209T3/en not_active Expired - Lifetime
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/en unknown
- 1999-04-10 PT PT99920635T patent/PT1071665E/en unknown
- 1999-04-10 ID IDW20002062A patent/ID26420A/en unknown
- 1999-04-10 IL IL13803699A patent/IL138036A0/en not_active IP Right Cessation
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/en unknown
- 1999-04-10 EP EP99920635A patent/EP1071665B1/en not_active Expired - Lifetime
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/en not_active Ceased
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/en not_active Expired - Fee Related
- 1999-04-10 AT AT99920635T patent/ATE251138T1/en active
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/en not_active Application Discontinuation
- 1999-04-10 EE EEP200000598A patent/EE04432B1/en not_active IP Right Cessation
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/en unknown
- 1999-04-10 NZ NZ507967A patent/NZ507967A/en unknown
- 1999-04-10 EA EA200001021A patent/EA003532B1/en not_active IP Right Cessation
- 1999-04-10 YU YU59800A patent/YU59800A/en unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/en not_active Expired - Fee Related
- 1999-04-10 DK DK99920635T patent/DK1071665T3/en active
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/en not_active Expired - Lifetime
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 DE DE59907199T patent/DE59907199D1/en not_active Expired - Lifetime
- 1999-04-10 PL PL99343314A patent/PL343314A1/en not_active Application Discontinuation
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 TW TW088105963A patent/TW510897B/en active
- 1999-04-14 CO CO99022218A patent/CO5011040A1/en unknown
- 1999-04-14 AR ARP990101700A patent/AR015763A1/en active IP Right Grant
- 1999-10-04 UA UA2000116456A patent/UA63009C2/en unknown
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/en unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/en unknown
- 2000-10-13 NO NO20005151A patent/NO317298B1/en unknown

Also Published As

Publication number	Publication date
BG64443B1 (en)	2005-02-28
NZ507967A (en)	2003-04-29
PT1071665E (en)	2004-02-27
KR100588250B1 (en)	2006-06-13
DK1071665T3 (en)	2004-01-05
SK283824B6 (en)	2004-02-03
NO20005151L (en)	2000-10-13
PL343314A1 (en)	2001-08-13
WO1999052869A1 (en)	1999-10-21
SK15132000A3 (en)	2001-03-12
ZA200004623B (en)	2001-05-30
NO317298B1 (en)	2004-10-04
ES2207209T3 (en)	2004-05-16
AU749829B2 (en)	2002-07-04
CA2323111A1 (en)	1999-10-21
HUP0101568A2 (en)	2001-09-28
MY122357A (en)	2006-04-29
CO5011040A1 (en)	2001-02-28
BR9909688A (en)	2000-12-19
ATE251138T1 (en)	2003-10-15
YU59800A (en)	2003-04-30
EA003532B1 (en)	2003-06-26
ID26420A (en)	2000-12-21
AR015763A1 (en)	2001-05-16
EA200001021A1 (en)	2001-06-25
TW510897B (en)	2002-11-21
DE59907199D1 (en)	2003-11-06
BG104813A (en)	2001-08-31
EE200000598A (en)	2002-04-15
AU3814999A (en)	1999-11-01
DE19816624A1 (en)	1999-10-21
CN1297438A (en)	2001-05-30
JP2002511449A (en)	2002-04-16
EP1071665B1 (en)	2003-10-01
NO20005151D0 (en)	2000-10-13
KR20010042731A (en)	2001-05-25
IL138036A0 (en)	2001-10-31
JP4015365B2 (en)	2007-11-28
CA2323111C (en)	2009-09-15
UA63009C2 (en)	2004-01-15
TR200002980T2 (en)	2001-02-21
HUP0101568A3 (en)	2002-12-28
CN100338036C (en)	2007-09-19
EP1071665A1 (en)	2001-01-31

Publication	Publication Date	Title
EE200000598A (en)	2002-04-15	Substituted indolinones inhibit kinases and cyclin / CDK complexes
DK1115704T3 (en)	2003-09-29	Substituted indolinones with inhibitory effect for various kinases and cyclin / CDK complexes
EE200000622A (en)	2002-02-15	Transmitter-receiver for GMSK and offset-QAM
DK0877845T3 (en)	2003-08-11	Reversible inserts lock
PT904774E (en)	2003-08-29	RESORCINOL DERIVATIVES
DE69916691D1 (en)	2004-06-03	Pacemaker
ID26130A (en)	2000-11-23	IMPROVEMENTS IN MEDICAL INTRODUCTION TOOLS
FI981653L (en)	2000-01-24	Method and arrangement for managing connections
FI982525A0 (en)	1998-11-23	Security arrangement
NO20003154L (en)	2000-06-16	Insert the plug
DE69906152D1 (en)	2003-04-24	4-ALKENYL (AND ALKINYL) OXOINDOLE AS INHIBITORS CYCLINE-DEPENDENT KINASES, ESPECIALLY CDK2
DE59810269D1 (en)	2004-01-08	Self-calibrating rate-adaptive pacemaker
EE200100347A (en)	2002-12-16	3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
NO20010200D0 (en)	2001-01-12	Organic phosphorus compounds and their use
MA26613A1 (en)	2004-12-20	SUBSTITUTED PYRROLES
DE69926591D1 (en)	2005-09-15	Fail-safe defibrillator
FR2776660B1 (en)	2000-05-12	DIAZEPINO-INDOLES OF PHOSPHODIESTERASES IV
FR2774599B1 (en)	2001-10-05	POULTICE
ZA200102260B (en)	2004-04-19	Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes.
DE69920224D1 (en)	2004-10-21	Urea derivatives for pain relief
DE59911871D1 (en)	2005-05-12	Dual-chamber pacemakers
DE69803818D1 (en)	2002-03-21	connector lock
DE59813079D1 (en)	2006-02-09	Milling tooth for earthworking
DE59900924D1 (en)	2002-04-11	Self-calibrating rate-adaptive pacemaker
FI980566L (en)	1999-09-14	New filler and pigment

Legal Events

Date	Code	Title	Description
2003-06-16	HC1A	Change of owner name
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-12-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20070410