NO20005151L - Substituted indolines with an inhibitory effect on kinases and cyclin / CDK complexes - Google Patents

Substituted indolines with an inhibitory effect on kinases and cyclin / CDK complexes

Info

Publication number: NO20005151L
Authority: NO; Norway
Prior art keywords: cyclin; kinases; inhibitory effect; cdk complexes; substituted indolines
Prior art date: 1998-04-15

Application number

NO20005151A

Other languages

Norwegian (no)

Other versions

NO20005151D0 (en

NO317298B1 (en

Inventor

Armin Heckel

Rainer Walter

Wolfgang Gress

Jacobus C A Van Meel

Norbert Redemann

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

2000-10-13

Publication date

2000-10-13

2000-10-13 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2000-10-13 Publication of NO20005151D0 publication Critical patent/NO20005151D0/en

2000-10-13 Publication of NO20005151L publication Critical patent/NO20005151L/en

2004-10-04 Publication of NO317298B1 publication Critical patent/NO317298B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Neurosurgery (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

NO20005151A 1998-04-15 2000-10-13 Substituted indolines with an inhibitory effect on kinases and cyclin / CDK complexes NO317298B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19816624A DE19816624A1 (en)	1998-04-15	1998-04-15	Novel substituted indolinones, their preparation and their use as pharmaceuticals
PCT/EP1999/002436 WO1999052869A1 (en)	1998-04-15	1999-04-10	Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes

Publications (3)

Publication Number	Publication Date
NO20005151D0 NO20005151D0 (en)	2000-10-13
NO20005151L true NO20005151L (en)	2000-10-13
NO317298B1 NO317298B1 (en)	2004-10-04

Family

ID=7864562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005151A NO317298B1 (en)	1998-04-15	2000-10-13	Substituted indolines with an inhibitory effect on kinases and cyclin / CDK complexes

Country Status (31)

Country	Link
EP (1)	EP1071665B1 (en)
JP (1)	JP4015365B2 (en)
KR (1)	KR100588250B1 (en)
CN (1)	CN100338036C (en)
AR (1)	AR015763A1 (en)
AT (1)	ATE251138T1 (en)
AU (1)	AU749829B2 (en)
BG (1)	BG64443B1 (en)
BR (1)	BR9909688A (en)
CA (1)	CA2323111C (en)
CO (1)	CO5011040A1 (en)
DE (2)	DE19816624A1 (en)
DK (1)	DK1071665T3 (en)
EA (1)	EA003532B1 (en)
EE (1)	EE04432B1 (en)
ES (1)	ES2207209T3 (en)
HU (1)	HUP0101568A3 (en)
ID (1)	ID26420A (en)
IL (1)	IL138036A0 (en)
MY (1)	MY122357A (en)
NO (1)	NO317298B1 (en)
NZ (1)	NZ507967A (en)
PL (1)	PL343314A1 (en)
PT (1)	PT1071665E (en)
SK (1)	SK283824B6 (en)
TR (1)	TR200002980T2 (en)
TW (1)	TW510897B (en)
UA (1)	UA63009C2 (en)
WO (1)	WO1999052869A1 (en)
YU (1)	YU59800A (en)
ZA (1)	ZA200004623B (en)

Families Citing this family (39)

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US6569868B2 (en)	1998-04-16	2003-05-27	Sugen, Inc.	2-indolinone derivatives as modulators of protein kinase activity
GB9904995D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Substituted aza-oxindole derivatives
GB9904932D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
DE19924401A1 (en) *	1999-05-27	2000-11-30	Boehringer Ingelheim Pharma	Novel substituted indolinones, their preparation and their use as pharmaceuticals
DE50012136D1 (en) *	1999-08-27	2006-04-13	Boehringer Ingelheim Pharma	Substituierte indolinone als tyrosinkinase inhibitoren
UA75054C2 (en) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Substituted in position 6 indolinones, producing and use thereof as medicament
US6762180B1 (en)	1999-10-13	2004-07-13	Boehringer Ingelheim Pharma Kg	Substituted indolines which inhibit receptor tyrosine kinases
SK287142B6 (en)	2000-02-15	2010-01-07	Sugen, Inc.	Pyrrole substituted 2-indolinone protein kinase inhibitors, pharmacutical composition and use
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
TWI270545B (en)	2000-05-24	2007-01-11	Sugen Inc	Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2001094312A2 (en)	2000-06-02	2001-12-13	Sugen, Inc.	Indolinone derivatives as protein kinase/phosphatase inhibitors
AU2002215053A1 (en) *	2000-11-27	2002-06-24	Pharmacia Italia S.P.A.	Phenylacetamido- pyrazole derivatives and their use as antitumor agents
AR042586A1 (en)	2001-02-15	2005-06-29	Sugen Inc	3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
DE10117204A1 (en)	2001-04-06	2002-10-10	Boehringer Ingelheim Pharma	Indolinones substituted in the 6-position, their preparation and their use as medicaments
AR036042A1 (en)	2001-05-30	2004-08-04	Sugen Inc	DERIVATIVES ARALQUILSUFONIL-3- (PIRROL-2-ILMETILIDEN) -2-INDOLINONA, ITS PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF A KINASE PROTEIN
PL373043A1 (en)	2002-03-26	2005-08-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7169936B2 (en)	2002-07-23	2007-01-30	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (en) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z- [1- (4- (N - ((4-methyl-piperazin-1-yl) -methylcarbonyl) -N-methyl-amino) -anilino) -1-phenyl-methylene] -6-methoxycarbonyl- 2-indolinone monoethanesulfonate and its use as a medicament
DE10237423A1 (en) *	2002-08-16	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound
JP4879492B2 (en) *	2002-11-27	2012-02-22	アラーガン、インコーポレイテッド	Kinase inhibitors for the treatment of diseases
US20050043233A1 (en)	2003-04-29	2005-02-24	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (en)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
WO2005033330A2 (en) *	2003-10-03	2005-04-14	Boehringer Ingelheim Pharmaceuticals, Inc.	Fluorescent probes for use in protein kinase inhibitor binding assay
DE102004012070A1 (en) *	2004-03-12	2005-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (en)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
WO2006071609A2 (en)	2004-12-27	2006-07-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP5519932B2 (en) *	2005-06-10	2014-06-11	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	Oxindoles as kinase inhibitors
WO2007057399A2 (en) *	2005-11-15	2007-05-24	Boehringer Ingelheim International Gmbh	Treatment of cancer with indole derivatives
CN101547909A (en)	2006-12-06	2009-09-30	贝林格尔.英格海姆国际有限公司	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
BRPI0915680A2 (en)	2008-06-06	2019-09-24	Boehringer Ingelheim Int	glucocorticoid mimetics, methods of preparing them, pharmaceutical compositions, and uses thereof
WO2011032320A1 (en) *	2009-09-21	2011-03-24	F. Hoffmann-La Roche Ag	Novel alkene oxindole derivatives
CN104039761A (en) *	2011-11-14	2014-09-10	利亘制药公司	Methods and compositions related to granulocyte colony stimulating factor receptor
WO2014150252A1 (en) *	2013-03-15	2014-09-25	Ligand Pharmaceuticals Incorporated	Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN107033064B (en) *	2017-04-28	2019-07-09	西安医学院	A kind of 3- (morpholine replaces fragrant imido grpup) Benzazole compounds and its preparation method and application
CN111285872B (en) *	2018-12-06	2022-05-17	北京志健金瑞生物医药科技有限公司	Indole-2-ketone derivative and preparation method and application thereof

Family Cites Families (5)

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GB9501567D0 (en) *	1995-01-26	1995-03-15	Pharmacia Spa	Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
GB9718913D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
DE19824922A1 (en) *	1998-06-04	1999-12-09	Boehringer Ingelheim Pharma	Novel substituted indolinones, their preparation and their use as pharmaceuticals
UA75054C2 (en) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Substituted in position 6 indolinones, producing and use thereof as medicament

1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/en not_active Withdrawn
1999
- 1999-04-10 EP EP99920635A patent/EP1071665B1/en not_active Expired - Lifetime
- 1999-04-10 NZ NZ507967A patent/NZ507967A/en unknown
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 EE EEP200000598A patent/EE04432B1/en not_active IP Right Cessation
- 1999-04-10 ES ES99920635T patent/ES2207209T3/en not_active Expired - Lifetime
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/en unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/en not_active Expired - Fee Related
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/en unknown
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/en not_active Expired - Lifetime
- 1999-04-10 PL PL99343314A patent/PL343314A1/en not_active Application Discontinuation
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/en not_active Expired - Fee Related
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/en not_active Ceased
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/en not_active Application Discontinuation
- 1999-04-10 ID IDW20002062A patent/ID26420A/en unknown
- 1999-04-10 EA EA200001021A patent/EA003532B1/en not_active IP Right Cessation
- 1999-04-10 IL IL13803699A patent/IL138036A0/en not_active IP Right Cessation
- 1999-04-10 YU YU59800A patent/YU59800A/en unknown
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/en unknown
- 1999-04-10 DE DE59907199T patent/DE59907199D1/en not_active Expired - Lifetime
- 1999-04-10 PT PT99920635T patent/PT1071665E/en unknown
- 1999-04-10 DK DK99920635T patent/DK1071665T3/en active
- 1999-04-10 AT AT99920635T patent/ATE251138T1/en active
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 AR ARP990101700A patent/AR015763A1/en active IP Right Grant
- 1999-04-14 TW TW088105963A patent/TW510897B/en active
- 1999-04-14 CO CO99022218A patent/CO5011040A1/en unknown
- 1999-10-04 UA UA2000116456A patent/UA63009C2/en unknown
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/en unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/en unknown
- 2000-10-13 NO NO20005151A patent/NO317298B1/en unknown

Also Published As

Publication number	Publication date
NO20005151D0 (en)	2000-10-13
HUP0101568A3 (en)	2002-12-28
KR20010042731A (en)	2001-05-25
EE200000598A (en)	2002-04-15
EP1071665A1 (en)	2001-01-31
PT1071665E (en)	2004-02-27
TR200002980T2 (en)	2001-02-21
NZ507967A (en)	2003-04-29
JP2002511449A (en)	2002-04-16
CA2323111C (en)	2009-09-15
DE59907199D1 (en)	2003-11-06
CA2323111A1 (en)	1999-10-21
EP1071665B1 (en)	2003-10-01
EA200001021A1 (en)	2001-06-25
DE19816624A1 (en)	1999-10-21
PL343314A1 (en)	2001-08-13
SK15132000A3 (en)	2001-03-12
KR100588250B1 (en)	2006-06-13
BG104813A (en)	2001-08-31
YU59800A (en)	2003-04-30
JP4015365B2 (en)	2007-11-28
WO1999052869A1 (en)	1999-10-21
AU749829B2 (en)	2002-07-04
ES2207209T3 (en)	2004-05-16
ID26420A (en)	2000-12-21
UA63009C2 (en)	2004-01-15
NO317298B1 (en)	2004-10-04
EE04432B1 (en)	2005-02-15
TW510897B (en)	2002-11-21
BR9909688A (en)	2000-12-19
CN100338036C (en)	2007-09-19
EA003532B1 (en)	2003-06-26
CN1297438A (en)	2001-05-30
MY122357A (en)	2006-04-29
IL138036A0 (en)	2001-10-31
ZA200004623B (en)	2001-05-30
ATE251138T1 (en)	2003-10-15
AR015763A1 (en)	2001-05-16
AU3814999A (en)	1999-11-01
BG64443B1 (en)	2005-02-28
SK283824B6 (en)	2004-02-03
CO5011040A1 (en)	2001-02-28
DK1071665T3 (en)	2004-01-05
HUP0101568A2 (en)	2001-09-28

Publication	Publication Date	Title
NO20005151L (en)	2000-10-13	Substituted indolines with an inhibitory effect on kinases and cyclin / CDK complexes
NO20011477D0 (en)	2001-03-22	Novel substituted indolinones with inhibitory effect on various kinases and cyclin / CDK complexes
NO20015045D0 (en)	2001-10-17	Diaminothiazoles and their use in inhibiting protein kinases
NO20014659L (en)	2001-11-01	Aryl-substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles and their use
PT1157019E (en)	2003-06-30	4-Alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinase in particular CDK2
NO20014114D0 (en)	2001-08-24	4-Amino-quinazoline and quinoline derivatives with inhibitory effect on signal transduction mediated by tyrosine kinases
DK1117669T3 (en)	2003-05-26	Antivirus purine derivatives
NO20004787D0 (en)	2000-09-25	Indole derivatives with antiviral activity
DE69920697D1 (en)	2004-11-04	ADENOSINE DERIVATIVES
NO991150D0 (en)	1999-03-10	Pyrazolopyrimidines and pyrazolotriazines
PT900210E (en)	2005-06-30	HETEROCYCLIC AZAHEXAN DERIVATIVES WITH ANTVIRAL ACTIVITY
DE69716615D1 (en)	2002-11-28	HETEROCYCLIC METALOPROTEAS INHIBITORS
DK1104422T3 (en)	2004-06-14	phenyl xanthine derivatives
NO980718D0 (en)	1998-02-20	Bicyclic 4-aralkylaminopyrimidine derivatives and tyrosine kinase inhibitors
NO20003916L (en)	2000-09-28	Benzothiadiazoles and derivatives
NO990053D0 (en)	1999-01-07	Milling control with orientation and depth determination
NO986174L (en)	1999-07-05	Triazine derivatives and their use
NO20012606L (en)	2001-11-08	Compound having inhibitory effect on cholesterol-transferring protein and preparation thereof
SI1071665T1 (en)	2004-02-29	Substituted indolinones having an inhibitory effect on kinases and cyclin / CDK complexes
DE69911455D1 (en)	2003-10-23	Hydrazine derivatives
ES1035703Y (en)	1997-11-16	PERFECTED PLUG.
ES1042708Y (en)	2000-02-16	PERFECTED CROWN PLUG.
ES1039353Y (en)	1999-05-16	PERFECTED PLUG.
ES1039069Y (en)	1999-03-16	PERFECTED PLUG.
ES1043985Y (en)	2000-08-01	PERFECTED PLUG.