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EE03829B1 - Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim - Google Patents

Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim

Info

Publication number
EE03829B1
EE03829B1 EEP199900105A EE9900105A EE03829B1 EE 03829 B1 EE03829 B1 EE 03829B1 EE P199900105 A EEP199900105 A EE P199900105A EE 9900105 A EE9900105 A EE 9900105A EE 03829 B1 EE03829 B1 EE 03829B1
Authority
EE
Estonia
Prior art keywords
benzonaphthyridines
medicament
manufacture
product containing
medicinal product
Prior art date
Application number
EEP199900105A
Other languages
English (en)
Estonian (et)
Other versions
EE9900105A (et
Inventor
Gutterer Beate
Amschler Hermann
Ulrich Wolf-R�diger
Martin Thomas
B�r Thomas
Hatzelmann Armin
Sanders Karl
Beume Rolf
Boss Hildegard
H�fner Dietrich
Kley Hans-Peter
Goebel Karl-Josef
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9900105A publication Critical patent/EE9900105A/xx
Publication of EE03829B1 publication Critical patent/EE03829B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP199900105A 1996-11-11 1997-11-05 Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim EE03829B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Publications (2)

Publication Number Publication Date
EE9900105A EE9900105A (et) 1999-10-15
EE03829B1 true EE03829B1 (et) 2002-08-15

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900105A EE03829B1 (et) 1996-11-11 1997-11-05 Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim

Country Status (30)

Country Link
US (1) US6008215A (ja)
EP (1) EP0937074B1 (ja)
JP (1) JP4223075B2 (ja)
KR (1) KR100484045B1 (ja)
CN (1) CN1090188C (ja)
AT (1) ATE234300T1 (ja)
AU (1) AU733129B2 (ja)
BG (1) BG63695B1 (ja)
BR (1) BR9713338B1 (ja)
CA (1) CA2270964C (ja)
CY (1) CY2476B1 (ja)
CZ (1) CZ288752B6 (ja)
DE (1) DE69719778T2 (ja)
DK (1) DK0937074T3 (ja)
EA (1) EA001551B1 (ja)
EE (1) EE03829B1 (ja)
ES (1) ES2195189T3 (ja)
GE (1) GEP20012390B (ja)
HU (1) HU226981B1 (ja)
ID (1) ID22042A (ja)
IL (1) IL129054A (ja)
NO (1) NO312764B1 (ja)
NZ (1) NZ334976A (ja)
PL (1) PL189641B1 (ja)
PT (1) PT937074E (ja)
RS (1) RS49607B (ja)
SI (1) SI0937074T1 (ja)
SK (1) SK283269B6 (ja)
TR (1) TR199900856T2 (ja)
WO (1) WO1998021208A1 (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306869B1 (en) 1998-05-05 2001-10-23 Byk Gulden Lomberg Chemische Febrik Gmbh N-oxides
ES2224745T3 (es) 1998-08-31 2005-03-01 Altana Pharma Ag N-oxidos de benzonaftiridina con actividad inhibidora de pde3 y pde4.
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
DK1147089T3 (da) * 1999-01-15 2006-04-10 Altana Pharma Ag Phenylphenanthridiner med PDE-IV-inhiberende virkning
CA2359449A1 (en) 1999-01-15 2000-07-20 Beate Gutterer Phenanthridine-n-oxides with pde-iv inhibiting activity
WO2000042017A1 (en) * 1999-01-15 2000-07-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity
AU2904300A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
AU777012B2 (en) * 1999-08-21 2004-09-30 Takeda Gmbh Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
DK1377574T3 (da) 2001-02-21 2005-04-25 Altana Pharma Ag 6-phenylbenzonaphtyridiner
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
WO2004018465A2 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Benzonaphthyridines with pde 3/4 inhibiting activity
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
PL373989A1 (en) * 2002-09-04 2005-09-19 Altana Pharma Ag Novel benzonaphthyridines
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CN104761545A (zh) 2004-03-03 2015-07-08 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
BRPI0508481A (pt) * 2004-03-10 2007-07-31 Altana Pharma Ag hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4
CA2559200A1 (en) 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
JP4960870B2 (ja) * 2004-09-08 2012-06-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−チア−１０−アザ−フェナントレン誘導体
WO2006027344A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
NZ589278A (en) 2005-03-02 2012-04-27 Nycomed Gmbh Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
ES2528316T3 (es) * 2006-09-01 2015-02-06 Senhwa Biosciences, Inc. Moduladores de la serina-treonina proteína quinasa y de PARP
CN112079769A (zh) 2008-04-23 2020-12-15 里格尔药品股份有限公司 用于治疗代谢障碍的甲酰胺化合物
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
WO1998021208A1 (en) 1998-05-22
AU733129B2 (en) 2001-05-10
CA2270964A1 (en) 1998-05-22
ATE234300T1 (de) 2003-03-15
HUP0000426A2 (hu) 2001-02-28
YU19499A (sh) 2001-09-28
DE69719778T2 (de) 2004-02-05
BG63695B1 (bg) 2002-09-30
IL129054A (en) 2002-07-25
NO992282D0 (no) 1999-05-11
GEP20012390B (en) 2001-03-25
EA001551B1 (ru) 2001-04-23
NO312764B1 (no) 2002-07-01
TR199900856T2 (xx) 1999-07-21
EE9900105A (et) 1999-10-15
SK283269B6 (sk) 2003-04-01
RS49607B (sr) 2007-06-04
BR9713338A (pt) 2000-05-09
KR100484045B1 (ko) 2005-04-20
HK1022151A1 (en) 2000-07-28
HU226981B1 (hu) 2010-04-28
US6008215A (en) 1999-12-28
DK0937074T3 (da) 2003-06-23
PL333429A1 (en) 1999-12-06
PL189641B1 (pl) 2005-09-30
KR20000053100A (ko) 2000-08-25
EP0937074A1 (en) 1999-08-25
IL129054A0 (en) 2000-02-17
HUP0000426A3 (en) 2001-04-28
SK62399A3 (en) 1999-10-08
ES2195189T3 (es) 2003-12-01
CA2270964C (en) 2007-07-31
JP4223075B2 (ja) 2009-02-12
PT937074E (pt) 2003-07-31
CY2476B1 (en) 2005-05-03
AU5317098A (en) 1998-06-03
NO992282L (no) 1999-05-11
JP2001503442A (ja) 2001-03-13
DE69719778D1 (de) 2003-04-17
EP0937074B1 (en) 2003-03-12
CN1090188C (zh) 2002-09-04
BR9713338B1 (pt) 2009-12-01
EA199900421A1 (ru) 1999-10-28
NZ334976A (en) 2000-10-27
CZ167599A3 (cs) 1999-11-17
CN1236367A (zh) 1999-11-24
ID22042A (id) 1999-08-26
CZ288752B6 (cs) 2001-08-15
SI0937074T1 (en) 2003-08-31
BG103310A (en) 2000-05-31

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

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Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

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HC1A Change of owner name
KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20151105