EE03697B1 - Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm - Google Patents

Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm

Info

Publication number: EE03697B1
Authority: EE; Estonia
Prior art keywords: interleukin; antagonist; receptor antagonist; new; intracellular isoform
Prior art date: 1994-10-13

Application number

EE9700090A

Other languages

English (en)

Other versions

EE9700090A (et

Inventor

Colotta Francesco

Muzio Marta

Mantovani Alberto

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-12

Publication date

2002-04-15

1995-10-12 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

1997-10-15 Publication of EE9700090A publication Critical patent/EE9700090A/et

2002-04-15 Publication of EE03697B1 publication Critical patent/EE03697B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Oncology (AREA)
Virology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physics & Mathematics (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)

EE9700090A 1994-10-13 1995-10-12 Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm EE03697B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942097A IT1270662B (it)	1994-10-13	1994-10-13	Antagonista della interleuchina-1
PCT/EP1995/004023 WO1996012022A1 (en)	1994-10-13	1995-10-12	Intracellular isoform of the interleukin-1 receptor antagonist

Publications (2)

Publication Number	Publication Date
EE9700090A EE9700090A (et)	1997-10-15
EE03697B1 true EE03697B1 (et)	2002-04-15

Family

ID=11369705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700090A EE03697B1 (et)	1994-10-13	1995-10-12	Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm

Country Status (18)

Country	Link
US (1)	US5739282A (et)
EP (1)	EP0786002B1 (et)
JP (1)	JPH10509306A (et)
KR (1)	KR100237936B1 (et)
CN (2)	CN100363053C (et)
AT (1)	ATE303439T1 (et)
BR (1)	BR9509317A (et)
CA (1)	CA2202470C (et)
DE (1)	DE69534419T2 (et)
EE (1)	EE03697B1 (et)
ES (1)	ES2243942T3 (et)
IT (1)	IT1270662B (et)
MX (1)	MX9702616A (et)
NO (1)	NO320494B1 (et)
PT (1)	PT786002E (et)
RU (1)	RU2193064C2 (et)
UA (1)	UA65522C2 (et)
WO (1)	WO1996012022A1 (et)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5075222A (en) *	1988-05-27	1991-12-24	Synergen, Inc.	Interleukin-1 inhibitors
US5872095A (en) *	1990-05-01	1999-02-16	Chiron Corporation	IL-1 receptor antagonists medicaments
UA70291C2 (en) *	1996-10-31	2004-10-15	Applied Research Systems	PEPTIDE CAPABLE OF BINDING TO INTERLEUKIN-1b-CONVEPEPTIDE CAPABLE OF BINDING TO INTERLEUKIN-1b-CONVERTING FERMENT (ICE) AND A PHARMACEUTICAL COMPOSITIRTING FERMENT (ICE) AND A PHARMACEUTICAL COMPOSITION CONTAINING IT ON CONTAINING IT
AU736876B2 (en) *	1996-12-06	2001-08-02	Amgen, Inc.	Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases
US6294170B1 (en)	1997-08-08	2001-09-25	Amgen Inc.	Composition and method for treating inflammatory diseases
IL126562A0 (en) *	1998-10-14	1999-08-17	Interpharm Lab Ltd	Expression and secretion of icil-1 receptor antagonist type ii
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders
US7166712B2 (en) *	2000-07-12	2007-01-23	Philadelphia, Health And Education Corporation	Mammalian MDM2 binding proteins and uses thereof
ES2385038T3 (es) *	2003-12-23	2012-07-17	Genentech, Inc.	Nuevos anticuerpos Anti-IL 13 y usos de los mismos
ES2706848T3 (es)	2004-07-06	2019-04-01	Zymogenetics Inc	Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
RU2326947C2 (ru) *	2004-11-23	2008-06-20	Общество с ограниченной ответственностью "ЦИТОКИН"	Способ получения рекомбинантного антагониста рецептора интерлейкина-1 человека "арил"
KR20080099290A (ko) *	2006-01-31	2008-11-12	노파르티스 아게	암 치료용 ｉｌ-17 길항 항체
US8323635B2 (en)	2007-11-14	2012-12-04	General Regeneratives, Ltd.	Methods of using interleukin-1 receptor antagonist as a myeloprotective agent
CN101690801B (zh)	2009-10-26	2012-08-01	上海交通大学	白细胞介素-1受体拮抗剂的用途及其药物组合物
MX2013010171A (es)	2011-03-14	2013-11-20	Serodus Asa	Antagonistas del receptor de interleucina-1.
CA2869674A1 (en)	2012-06-08	2013-12-12	Alkermes, Inc.	Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide
US20160000936A1 (en)	2014-06-10	2016-01-07	Abbvie Inc.	Biomarkers for inflammatory disease and methods of using same
JP7657714B2 (ja) *	2018-11-15	2025-04-07	ヤンセンバイオテツク，インコーポレーテツド	炎症性腸疾患の治療に対する応答を予測するための方法及び組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0148009B1 (ko) *	1988-05-27	1998-08-01	그래고리 비. 아보트	인터루킨-1 억제제
BR9007883A (pt) *	1989-11-29	1992-09-29	Synergen Inc	Producao de inibidor de interleucina-1 humana recombinante
AU649245B2 (en) *	1990-04-02	1994-05-19	Amgen, Inc.	Methods for treating interleukin-1 mediated diseases
WO1991017184A1 (en) *	1990-04-27	1991-11-14	The Upjohn Company	Modified interleukin-1 inhibitors
ATE178094T1 (de) *	1990-05-01	1999-04-15	Chiron Corp	Interleukin-i antagonist und seine verwendung

1994
- 1994-10-13 IT ITMI942097A patent/IT1270662B/it active IP Right Grant
1995
- 1995-06-07 US US08/476,860 patent/US5739282A/en not_active Expired - Fee Related
- 1995-10-12 RU RU97107461/13A patent/RU2193064C2/ru not_active IP Right Cessation
- 1995-10-12 PT PT95936482T patent/PT786002E/pt unknown
- 1995-10-12 BR BR9509317A patent/BR9509317A/pt not_active Application Discontinuation
- 1995-10-12 MX MX9702616A patent/MX9702616A/es not_active IP Right Cessation
- 1995-10-12 EP EP95936482A patent/EP0786002B1/en not_active Expired - Lifetime
- 1995-10-12 AT AT95936482T patent/ATE303439T1/de not_active IP Right Cessation
- 1995-10-12 ES ES95936482T patent/ES2243942T3/es not_active Expired - Lifetime
- 1995-10-12 DE DE69534419T patent/DE69534419T2/de not_active Expired - Fee Related
- 1995-10-12 EE EE9700090A patent/EE03697B1/et not_active IP Right Cessation
- 1995-10-12 CN CNB200510053993XA patent/CN100363053C/zh not_active Expired - Fee Related
- 1995-10-12 KR KR1019970701931A patent/KR100237936B1/ko not_active Expired - Fee Related
- 1995-10-12 JP JP8512932A patent/JPH10509306A/ja active Pending
- 1995-10-12 CA CA002202470A patent/CA2202470C/en not_active Expired - Fee Related
- 1995-10-12 CN CNB951956647A patent/CN1224707C/zh not_active Expired - Fee Related
- 1995-10-12 WO PCT/EP1995/004023 patent/WO1996012022A1/en not_active Ceased
- 1995-12-10 UA UA97052129A patent/UA65522C2/uk unknown
1997
- 1997-04-09 NO NO19971624A patent/NO320494B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9509317A (pt)	1997-10-14
CN100363053C (zh)	2008-01-23
UA65522C2 (en)	2004-04-15
NO320494B1 (no)	2005-12-12
EP0786002B1 (en)	2005-08-31
HK1081124A1 (zh)	2006-05-12
PT786002E (pt)	2005-11-30
ATE303439T1 (de)	2005-09-15
DE69534419T2 (de)	2006-06-14
KR100237936B1 (ko)	2000-01-15
DE69534419D1 (de)	2005-10-06
NO971624L (no)	1997-05-30
MX9702616A (es)	1998-04-30
AU701471B2 (en)	1999-01-28
EP0786002A1 (en)	1997-07-30
CN1161058A (zh)	1997-10-01
CA2202470C (en)	2008-09-16
CN1224707C (zh)	2005-10-26
ES2243942T3 (es)	2005-12-01
US5739282A (en)	1998-04-14
IT1270662B (it)	1997-05-07
AU3841795A (en)	1996-05-06
HK1002659A1 (en)	1998-09-11
CN1679919A (zh)	2005-10-12
CA2202470A1 (en)	1996-04-25
EE9700090A (et)	1997-10-15
JPH10509306A (ja)	1998-09-14
KR970706391A (ko)	1997-11-03
NO971624D0 (no)	1997-04-09
ITMI942097A1 (it)	1996-04-13
WO1996012022A1 (en)	1996-04-25
ITMI942097A0 (it)	1994-10-13
RU2193064C2 (ru)	2002-11-20

Publication	Publication Date	Title
EE9700090A (et)	1997-10-15	Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm
PT735818E (pt)	2004-07-30	Proteinas inflamatorias de macrofagos pim-3 pim-4 e pim-1y
FI960727A0 (fi)	1996-02-16	Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
DK0669979T3 (da)	2006-03-06	C-C CKR-1, kemokinreceptor
DE69839992D1 (de)	2008-10-23	Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff
NO900227L (no)	1990-07-18	Ekstruderbar elastisk gel for anvendelse som baerer for terapeutisk middel.
NO975716L (no)	1998-02-04	Imidazolforbindelser
ES2180665T3 (es)	2003-02-16	Uso de factor de celulas madre y de receptor soluble de interleuquina-6 para la expansion ex-vivo de celulas hematopoyeticas multipotenciales.
TR199900318T2 (xx)	1999-05-21	IL-8 resept�r antagonistleri.
BR0113213A (pt)	2003-07-08	Método para diagnosticar uma doença auto-imune, anticorpo, composição de diagnóstico, e, uso do anticorpo
ATE245196T1 (de)	2003-08-15	Regulierung der fruchtbarkeit mit transformierendem wachstumfaktor beta
IT1090154B (it)	1985-06-18	Dispositivo vibratore per sedie poltrone letti e simili
TR200103448T2 (tr)	2002-06-21	IL-8 reseptör antagonistleri.
ITFI990094A0 (it)	1999-04-20	Metodo diagnostico per il riconoscimento di neoplasie umane attraverso la determinazione dell'isoforma ctn-c della tn-c,frammenti di
EA199800959A1 (ru)	1999-06-24	ПРИМЕНЕНИЕ ГЕНЕТИЧЕСКОЙ МОДИФИКАЦИИ В ГЕНЕ b3- СУБЪЕДИНИЦЫ ЧЕЛОВЕЧЕСКОГО G-ПРОТЕИНА ДЛЯ ДИАГНОСТИКИ ЗАБОЛЕВАНИЙ
IT1294932B1 (it)	1999-04-23	Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT1207619B (it)	1989-05-25	Apparecchiatura ad ingombro ridotto per il supporto di strumenti operativi pendenti, in particolare per strumenti odontoiatrici
IT8430790U1 (it)	1986-01-12	Dispositivo orientabile per i comandi di movimento delle poltrone particolarmente per dentisti.
IT1277556B1 (it)	1997-11-11	Dispositivo di raccordo regolabile e amovibile, particolarmente adatto per contatori del gas e simili
IT8921151A0 (it)	1989-07-11	Dispositivo per la determinazione della regolazione di altezza ottimale dello schienale di una sedia per ufficio, in funzione della statura dell'utilizzatore.
ITCT920022A0 (it)	1992-07-27	Test immunoenzimatico competitivo per il rilievo quantitativo del frammento secretorio presente nel siero, nella saliva, nell'urina, nelle lacrime, nel succo gastrico, nel secreto vaginale, nelle feci.
NO880522D0 (no)	1988-02-05	Brille for toalettsete.
IT8920060A0 (it)	1989-04-07	Impianto per la riduzione di pressione del gas metano tra le centrali di pompaggio e le reti di distribuzione all'utenza.
IT1189760B (it)	1988-02-04	Dispositivo per il supporto e la regolazione del poggiatesta di una poltrona particolarmente ad uso odontoiatrico
IT8841683A0 (it)	1988-09-30	Dispositivo oftalmologico in particolare per l'asportazione di umore vitreo, cateratte molli e membrane preretinali.

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-10-15	GB1A	Change in the ownership or in the address of the owner
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2010-06-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20091012