ECSP21085693A - Moléculas de unión a tigit y pd-1/tigit - Google Patents
Moléculas de unión a tigit y pd-1/tigitInfo
- Publication number
- ECSP21085693A ECSP21085693A ECSENADI202185693A ECDI202185693A ECSP21085693A EC SP21085693 A ECSP21085693 A EC SP21085693A EC SENADI202185693 A ECSENADI202185693 A EC SENADI202185693A EC DI202185693 A ECDI202185693 A EC DI202185693A EC SP21085693 A ECSP21085693 A EC SP21085693A
- Authority
- EC
- Ecuador
- Prior art keywords
- tigit
- binding molecules
- chemotherapy
- bind
- human
- Prior art date
Links
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 title abstract 4
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 title 2
- 238000002512 chemotherapy Methods 0.000 abstract 2
- 102000049823 human TIGIT Human genes 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000048362 human PDCD1 Human genes 0.000 abstract 1
- 230000005865 ionizing radiation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a las moléculas de polipéptidos que se unen a TIGIT humano, y a las moléculas de polipéptidos que se unen a PD-1 humano y a TIGIT humano, y son útiles para tratar tumores sólidos, solas y en combinación con quimioterapia y/o radiación ionizante.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962853816P | 2019-05-29 | 2019-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP21085693A true ECSP21085693A (es) | 2021-12-30 |
Family
ID=71070067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202185693A ECSP21085693A (es) | 2019-05-29 | 2021-11-26 | Moléculas de unión a tigit y pd-1/tigit |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20220227860A1 (es) |
| EP (1) | EP3976652A1 (es) |
| JP (2) | JP7241207B2 (es) |
| KR (1) | KR20220004120A (es) |
| CN (1) | CN113939536B (es) |
| AR (1) | AR118980A1 (es) |
| AU (1) | AU2020283817A1 (es) |
| BR (1) | BR112021021795A2 (es) |
| CA (1) | CA3139025A1 (es) |
| CL (1) | CL2021003039A1 (es) |
| CO (1) | CO2021015610A2 (es) |
| CR (1) | CR20210573A (es) |
| DO (1) | DOP2021000241A (es) |
| EA (1) | EA202192796A1 (es) |
| EC (1) | ECSP21085693A (es) |
| IL (1) | IL287765A (es) |
| JO (1) | JOP20210314A1 (es) |
| MA (1) | MA56029A (es) |
| MX (1) | MX2021014472A (es) |
| PE (1) | PE20220505A1 (es) |
| PH (1) | PH12021552970A1 (es) |
| SG (1) | SG11202112725XA (es) |
| TW (1) | TWI760751B (es) |
| WO (1) | WO2020242919A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
| CN110536693B (zh) | 2017-01-05 | 2023-12-22 | 卡尔医学有限公司 | Pd1-41bbl融合蛋白及使用其的方法 |
| CA3047708A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirpalpha-41bbl fusion protein and methods of use thereof |
| US12134638B2 (en) | 2018-07-11 | 2024-11-05 | Kahr Medical Ltd. | SIRPalpha-4-1BBL variant fusion protein and methods of use thereof |
| MX2021000047A (es) | 2018-07-11 | 2021-05-12 | Kahr Medical Ltd | Proteina de fusion variante pd1-4-1bbl y procedimientos de uso de la misma. |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| US20240076346A1 (en) * | 2021-01-13 | 2024-03-07 | Kahr Medical Ltd. | Type i membrane proteins heterodimers and methods of use thereof |
| CN117202933A (zh) * | 2021-04-30 | 2023-12-08 | 免疫医疗有限责任公司 | 双特异性pd-1和tigit结合蛋白及其用途 |
| TW202304965A (zh) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法 |
| WO2023034336A2 (en) * | 2021-08-30 | 2023-03-09 | G1 Therapeutics, Inc. | Improved treatments for advanced/metastatic cancers with checkpoint inhibitor resistance or resistance susceptibility |
| TW202337897A (zh) * | 2021-11-18 | 2023-10-01 | 大陸商信達生物製藥（蘇州）有限公司 | 抗ｐｄ－１抗體和抗ｖｅｇｆ－ａ抗體的藥物組合及其使用方法 |
| US20250179176A1 (en) | 2022-05-02 | 2025-06-05 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160030936A (ko) * | 2013-07-16 | 2016-03-21 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 tigit 억제제를 사용한 암을 치료하는 방법 |
| MA40437A (fr) | 2014-07-16 | 2017-05-24 | Hoffmann La Roche | Méthodes de traitement du cancer faisant appel à des inhibiteurs de tigit et à des agents anticancéreux |
| SG11201701161QA (en) | 2014-08-19 | 2017-03-30 | Merck Sharp & Dohme | Anti-tigit antibodies |
| MA40662B1 (fr) | 2014-12-23 | 2020-12-31 | Bristol Myers Squibb Co | Anticorps contre tigit |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| NZ739750A (en) | 2015-09-25 | 2019-11-29 | Genentech Inc | Anti-tigit antibodies and methods of use |
| KR20230145510A (ko) | 2016-08-17 | 2023-10-17 | 컴퓨젠 엘티디. | 항-tigit 항체, 항-pvrig 항체 및 이들의 조합 |
| JOP20190133A1 (ar) * | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1 |
| US10537637B2 (en) * | 2017-01-05 | 2020-01-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| WO2018204363A1 (en) * | 2017-05-01 | 2018-11-08 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
| AR112603A1 (es) * | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| IL272227B2 (en) | 2017-07-27 | 2025-09-01 | iTeos Belgium SA | Anti-tigit antibodies |
| SG11202004158QA (en) * | 2017-12-28 | 2020-06-29 | Nanjing Legend Biotech Co Ltd | Single-domain antibodies and variants thereof against tigit |
| JP2021529556A (ja) * | 2018-06-29 | 2021-11-04 | ジェンサン バイオファーマ、 インコーポレイテッドＧｅｎｓｕｎ Ｂｉｏｐｈａｒｍａ， Ｉｎｃ． | 抗腫瘍アンタゴニスト |
-
2020
- 2020-05-19 TW TW109116479A patent/TWI760751B/zh not_active IP Right Cessation
- 2020-05-21 AR ARP200101441A patent/AR118980A1/es not_active Application Discontinuation
- 2020-05-22 JP JP2021569860A patent/JP7241207B2/ja active Active
- 2020-05-22 CR CR20210573A patent/CR20210573A/es unknown
- 2020-05-22 PH PH1/2021/552970A patent/PH12021552970A1/en unknown
- 2020-05-22 AU AU2020283817A patent/AU2020283817A1/en not_active Abandoned
- 2020-05-22 PE PE2021001860A patent/PE20220505A1/es unknown
- 2020-05-22 CN CN202080039788.0A patent/CN113939536B/zh active Active
- 2020-05-22 SG SG11202112725XA patent/SG11202112725XA/en unknown
- 2020-05-22 CA CA3139025A patent/CA3139025A1/en active Pending
- 2020-05-22 KR KR1020217038318A patent/KR20220004120A/ko not_active Withdrawn
- 2020-05-22 EA EA202192796A patent/EA202192796A1/ru unknown
- 2020-05-22 JO JOP/2021/0314A patent/JOP20210314A1/ar unknown
- 2020-05-22 MX MX2021014472A patent/MX2021014472A/es unknown
- 2020-05-22 BR BR112021021795A patent/BR112021021795A2/pt not_active IP Right Cessation
- 2020-05-22 EP EP20731763.7A patent/EP3976652A1/en active Pending
- 2020-05-22 US US17/613,675 patent/US20220227860A1/en not_active Abandoned
- 2020-05-22 MA MA056029A patent/MA56029A/fr unknown
- 2020-05-22 WO PCT/US2020/034158 patent/WO2020242919A1/en not_active Ceased
-
2021
- 2021-11-01 IL IL287765A patent/IL287765A/en unknown
- 2021-11-17 CL CL2021003039A patent/CL2021003039A1/es unknown
- 2021-11-22 CO CONC2021/0015610A patent/CO2021015610A2/es unknown
- 2021-11-25 DO DO2021000241A patent/DOP2021000241A/es unknown
- 2021-11-26 EC ECSENADI202185693A patent/ECSP21085693A/es unknown
-
2023
- 2023-03-06 JP JP2023033480A patent/JP2023071889A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CL2021003039A1 (es) | 2022-08-05 |
| PH12021552970A1 (en) | 2022-07-25 |
| MX2021014472A (es) | 2022-01-06 |
| DOP2021000241A (es) | 2021-12-30 |
| JP2022533457A (ja) | 2022-07-22 |
| TW202110884A (zh) | 2021-03-16 |
| JP2023071889A (ja) | 2023-05-23 |
| JP7241207B2 (ja) | 2023-03-16 |
| CO2021015610A2 (es) | 2021-11-30 |
| PE20220505A1 (es) | 2022-04-07 |
| EP3976652A1 (en) | 2022-04-06 |
| CA3139025A1 (en) | 2020-12-03 |
| SG11202112725XA (en) | 2021-12-30 |
| CN113939536B (zh) | 2024-05-14 |
| AR118980A1 (es) | 2021-11-17 |
| EA202192796A1 (ru) | 2022-03-03 |
| AU2020283817A1 (en) | 2021-11-25 |
| CN113939536A (zh) | 2022-01-14 |
| BR112021021795A2 (pt) | 2022-01-04 |
| US20220227860A1 (en) | 2022-07-21 |
| IL287765A (en) | 2022-01-01 |
| WO2020242919A1 (en) | 2020-12-03 |
| MA56029A (fr) | 2022-04-06 |
| TWI760751B (zh) | 2022-04-11 |
| KR20220004120A (ko) | 2022-01-11 |
| CR20210573A (es) | 2021-12-15 |
| JOP20210314A1 (ar) | 2023-01-30 |
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