ECSP17038668A - Formulaciones inyectables de paracetamol - Google Patents
Formulaciones inyectables de paracetamolInfo
- Publication number
- ECSP17038668A ECSP17038668A ECIEPI201738668A ECPI201738668A ECSP17038668A EC SP17038668 A ECSP17038668 A EC SP17038668A EC IEPI201738668 A ECIEPI201738668 A EC IEPI201738668A EC PI201738668 A ECPI201738668 A EC PI201738668A EC SP17038668 A ECSP17038668 A EC SP17038668A
- Authority
- EC
- Ecuador
- Prior art keywords
- paracetamol
- injectable formulations
- pharmaceutically acceptable
- acceptable salt
- slow
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005489 paracetamol Drugs 0.000 title abstract 3
- 239000007972 injectable composition Substances 0.000 title abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000001297 phlebitis Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a inyecciones intravenosas de bajo volumen de paracetamol o su sal farmacéuticamente aceptable y el método de preparación del mismo. Las formulaciones proporcionan una alta concentración de paracetamol o su sal farmacéuticamente aceptable en un sistema disolvente de la presente invención que puede administrarse no sólo a través de la vía de infusión intramuscular e intravenosa, sino también para la administración de bolo IV lento después de la dilución con fluidos acuosos hasta el volumen final de no más de 20 ml. Estas formulaciones inyectables permanecen estables y también son adecuadas para administración a través de una vía intravenosa lenta con efectos secundarios minimizados (tales como flebitis, dolor, etc.)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4102MU2014 | 2014-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP17038668A true ECSP17038668A (es) | 2017-12-01 |
Family
ID=55022620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201738668A ECSP17038668A (es) | 2014-12-20 | 2017-06-20 | Formulaciones inyectables de paracetamol |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20180000940A1 (es) |
| EP (1) | EP3233055B1 (es) |
| JP (1) | JP2017538762A (es) |
| KR (1) | KR20170099911A (es) |
| CN (1) | CN107205924A (es) |
| AR (1) | AR103188A1 (es) |
| AU (1) | AU2015365533A1 (es) |
| BR (1) | BR112017012975B1 (es) |
| CA (1) | CA2969303A1 (es) |
| CL (1) | CL2017001629A1 (es) |
| CO (1) | CO2017006268A2 (es) |
| CU (1) | CU20170088A7 (es) |
| DO (1) | DOP2017000134A (es) |
| EA (1) | EA201791409A1 (es) |
| EC (1) | ECSP17038668A (es) |
| ES (1) | ES3009433T3 (es) |
| HU (1) | HUE070091T2 (es) |
| IL (1) | IL252729A0 (es) |
| JO (1) | JO3689B1 (es) |
| MA (1) | MA40599A1 (es) |
| MD (1) | MD20170071A2 (es) |
| MX (1) | MX383557B (es) |
| MY (1) | MY203965A (es) |
| PE (1) | PE20171305A1 (es) |
| PH (1) | PH12017501005B1 (es) |
| PL (1) | PL3233055T3 (es) |
| SG (1) | SG11201704435PA (es) |
| TN (1) | TN2017000232A1 (es) |
| TW (1) | TWI649097B (es) |
| UA (1) | UA122136C2 (es) |
| UY (1) | UY36466A (es) |
| WO (1) | WO2016097899A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107229455B (zh) | 2016-03-24 | 2019-09-17 | 阿里巴巴集团控股有限公司 | 一种业务处理方法、装置及系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751875B1 (fr) * | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
| IT1301976B1 (it) * | 1998-07-31 | 2000-07-20 | Angelini Ricerche Spa | Composizione farmaceutica iniettabile a base di paracetamolo |
| IT1313579B1 (it) | 1999-07-30 | 2002-09-09 | Acraf | Composizione farmaceutica liquida a base di paracetamolo. |
| ITMI20012135A1 (it) | 2001-10-16 | 2003-04-16 | Bioren S A | Soluzioni iniettabili pronte all'uso di paracetamolo |
| MX2007014862A (es) * | 2005-05-27 | 2008-02-21 | Panacea Biotec Ltd | Composiciones inyectables y procedimiento para la preparacion de dichas composiciones. |
| WO2007070852A2 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for parenteral administration |
| AR067048A1 (es) | 2007-06-18 | 2009-09-30 | Combino Pharm Sl | Formulaciones acuosas de acetaminofen para inyeccion. |
| WO2009098716A2 (en) | 2008-01-17 | 2009-08-13 | Aptuit Laurus Private Limited | Stable pharmaceutical aqueous compositions |
| MX2011003695A (es) * | 2008-10-09 | 2011-08-17 | A F S P A Aziende Chimiche Riunite Angelini Francesco A C R | Formulacion farmaceutica liquida con contenido de paracetamol. |
| UA109544C2 (uk) * | 2010-06-30 | 2015-09-10 | Фармацевтична композиція, що містить парацетамол, та спосіб її виготовлення | |
| TWI577377B (zh) * | 2010-09-16 | 2017-04-11 | Ｖｉｉｖ醫療保健公司 | 醫藥組合物 |
| CN102258485A (zh) * | 2011-01-11 | 2011-11-30 | 北京润德康医药技术有限公司 | 一种含对乙酰氨基酚的注射用制剂及其应用 |
| CN102600068A (zh) * | 2011-01-24 | 2012-07-25 | 联康药业克雷恩特塞提斯制药实验室有限责任公司 | 稳定即用的可注射扑热息痛制剂 |
-
2015
- 2015-11-17 HU HUE15816228A patent/HUE070091T2/hu unknown
- 2015-11-17 WO PCT/IB2015/058876 patent/WO2016097899A1/en not_active Ceased
- 2015-11-17 ES ES15816228T patent/ES3009433T3/es active Active
- 2015-11-17 MD MDA20170071A patent/MD20170071A2/ro not_active Application Discontinuation
- 2015-11-17 CN CN201580069391.5A patent/CN107205924A/zh active Pending
- 2015-11-17 PH PH1/2017/501005A patent/PH12017501005B1/en unknown
- 2015-11-17 MA MA40599A patent/MA40599A1/fr unknown
- 2015-11-17 JP JP2017533277A patent/JP2017538762A/ja active Pending
- 2015-11-17 AU AU2015365533A patent/AU2015365533A1/en not_active Abandoned
- 2015-11-17 EP EP15816228.9A patent/EP3233055B1/en active Active
- 2015-11-17 KR KR1020177017759A patent/KR20170099911A/ko not_active Ceased
- 2015-11-17 BR BR112017012975-2A patent/BR112017012975B1/pt active IP Right Grant
- 2015-11-17 EA EA201791409A patent/EA201791409A1/ru unknown
- 2015-11-17 US US15/537,642 patent/US20180000940A1/en not_active Abandoned
- 2015-11-17 PL PL15816228.9T patent/PL3233055T3/pl unknown
- 2015-11-17 MY MYPI2017701979A patent/MY203965A/en unknown
- 2015-11-17 PE PE2017001066A patent/PE20171305A1/es unknown
- 2015-11-17 CU CUP2017000088A patent/CU20170088A7/es unknown
- 2015-11-17 MX MX2017008264A patent/MX383557B/es unknown
- 2015-11-17 UA UAA201706668A patent/UA122136C2/uk unknown
- 2015-11-17 SG SG11201704435PA patent/SG11201704435PA/en unknown
- 2015-11-17 TN TN2017000232A patent/TN2017000232A1/en unknown
- 2015-11-17 CA CA2969303A patent/CA2969303A1/en not_active Abandoned
- 2015-11-27 TW TW104139783A patent/TWI649097B/zh not_active IP Right Cessation
- 2015-12-09 JO JOP/2015/0303A patent/JO3689B1/ar active
- 2015-12-21 UY UY0001036466A patent/UY36466A/es unknown
- 2015-12-21 AR ARP150104211A patent/AR103188A1/es unknown
-
2017
- 2017-06-06 IL IL252729A patent/IL252729A0/en unknown
- 2017-06-09 DO DO2017000134A patent/DOP2017000134A/es unknown
- 2017-06-20 EC ECIEPI201738668A patent/ECSP17038668A/es unknown
- 2017-06-20 CL CL2017001629A patent/CL2017001629A1/es unknown
- 2017-06-23 CO CONC2017/0006268A patent/CO2017006268A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202303593B (en) | Liquid protein formulations containing viscosity-lowering agents | |
| MX2015012559A (es) | Novedosos fármacos de alta penetración y sus composiciones para el tratamiento de enfermedades de parkinson. | |
| CL2019002190A1 (es) | Reducción de la viscosidad de formulaciones farmacéuticas que comprende una proteína terapéutica a una concentración de al menos 70 mg/ml, donde la proteína terapéutica no es un anticuerpo (divisional solicitud 201700984) | |
| AR107014A1 (es) | Formulación farmacéutica acuosa | |
| AR098386A1 (es) | Formulación para gonadotropinas | |
| PE20170426A1 (es) | Composiciones farmaceuticas que consisten de paracetamol y el proceso para la preparacion del mismo | |
| ECSP17038668A (es) | Formulaciones inyectables de paracetamol | |
| UA115333C2 (uk) | Склад есмололу для парентерального введення | |
| EA201391512A1 (ru) | Твердая фармацевтическая композиция | |
| MX372644B (es) | Una combinacion de unidades de dosificacion para su uso en el tratamiento del parto prematuro. | |
| HK1226310A1 (en) | Liquid protein formulations containing water soluble organic dyes | |
| RU2014142874A (ru) | Способ лечения похмельного синдрома у лиц, не относящихся к больным алкоголизмом | |
| RU2013143983A (ru) | Способ коррекции иммунной недостаточности у инфицированного вирусом лейкоза крупного рогатого скота | |
| TH154084A (th) | สารละลายอะเซทามิโนเฟนที่ฉีดได้สำหรับการให้ทางไขสันหลัง | |
| AR091633A1 (es) | Solucion inyectable de acetaminofen para su administracion por via espinal | |
| TH155633A (th) | สูตรผสมแบบฉีดของเอสโมลอล |