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ECSP17073650A - Proteínas de fusión - Google Patents

Proteínas de fusión

Info

Publication number
ECSP17073650A
ECSP17073650A ECIEPI201773650A ECPI201773650A ECSP17073650A EC SP17073650 A ECSP17073650 A EC SP17073650A EC IEPI201773650 A ECIEPI201773650 A EC IEPI201773650A EC PI201773650 A ECPI201773650 A EC PI201773650A EC SP17073650 A ECSP17073650 A EC SP17073650A
Authority
EC
Ecuador
Prior art keywords
fusion proteins
present
diabetes
useful
treatment
Prior art date
Application number
ECIEPI201773650A
Other languages
English (en)
Inventor
Gregory Alan Lazar
Craig Duane Dickinson
David Bruce Baldwin
Jonathan Wesley Day
Andrew Ihor Korytko
John Michael Beals
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55953435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP17073650(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP17073650A publication Critical patent/ECSP17073650A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

La presente invención se refiere a proteínas de fusión que comprenden un agonista del receptor de insulina fusionado a una región Fc de IgG humana mediante el uso de un enlazante de péptido, y el uso de tales proteínas de fusión en el tratamiento de diabetes. La proteína de fusión de la presente invención tiene un perfil de acción de tiempo prolongado y es útil para proporcionar un control de glucosa basal durante un período de tiempo prolongado.
ECIEPI201773650A 2015-05-07 2017-11-06 Proteínas de fusión ECSP17073650A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562158079P 2015-05-07 2015-05-07

Publications (1)

Publication Number Publication Date
ECSP17073650A true ECSP17073650A (es) 2018-02-28

Family

ID=55953435

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201773650A ECSP17073650A (es) 2015-05-07 2017-11-06 Proteínas de fusión

Country Status (40)

Country Link
US (5) US9855318B2 (es)
EP (1) EP3292141B1 (es)
JP (1) JP6591562B2 (es)
KR (1) KR102059736B1 (es)
CN (1) CN107531806B (es)
AR (1) AR105616A1 (es)
AU (1) AU2016257659B2 (es)
CA (1) CA2981102A1 (es)
CL (1) CL2017002761A1 (es)
CO (1) CO2017011301A2 (es)
CR (1) CR20170469A (es)
CY (1) CY1122929T1 (es)
DK (1) DK3292141T3 (es)
DO (1) DOP2017000258A (es)
EA (1) EA039770B1 (es)
EC (1) ECSP17073650A (es)
ES (1) ES2799099T3 (es)
HR (1) HRP20200503T1 (es)
IL (1) IL254965B (es)
JO (1) JO3658B1 (es)
LT (1) LT3292141T (es)
MA (1) MA42037B1 (es)
MD (1) MD3292141T2 (es)
ME (1) ME03709B (es)
MX (1) MX388594B (es)
MY (1) MY183025A (es)
NZ (1) NZ736470A (es)
PE (1) PE20180507A1 (es)
PH (1) PH12017502025A1 (es)
PL (1) PL3292141T3 (es)
PT (1) PT3292141T (es)
RS (1) RS60044B1 (es)
SG (1) SG11201708194WA (es)
SI (1) SI3292141T1 (es)
SV (1) SV2017005548A (es)
TN (1) TN2018000059A1 (es)
TW (1) TWI656132B (es)
UA (1) UA122146C2 (es)
WO (1) WO2016178905A1 (es)
ZA (1) ZA201706334B (es)

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Also Published As

Publication number Publication date
TN2018000059A1 (en) 2019-07-08
CR20170469A (es) 2017-11-14
JP6591562B2 (ja) 2019-10-16
WO2016178905A1 (en) 2016-11-10
JP2018515088A (ja) 2018-06-14
MD3292141T2 (ro) 2020-07-31
LT3292141T (lt) 2020-03-25
CL2017002761A1 (es) 2018-05-18
CO2017011301A2 (es) 2018-03-20
DK3292141T3 (da) 2020-04-20
JO3658B1 (ar) 2020-08-27
US9855318B2 (en) 2018-01-02
HRP20200503T1 (hr) 2020-06-26
EP3292141B1 (en) 2020-02-12
PL3292141T3 (pl) 2020-06-29
US10709766B2 (en) 2020-07-14
CY1122929T1 (el) 2021-10-29
UA122146C2 (uk) 2020-09-25
SI3292141T1 (sl) 2020-04-30
PE20180507A1 (es) 2018-03-09
BR112017020502A2 (pt) 2018-07-03
US20250032588A1 (en) 2025-01-30
IL254965B (en) 2021-03-25
AU2016257659A1 (en) 2017-10-12
US20160324932A1 (en) 2016-11-10
EP3292141A1 (en) 2018-03-14
ME03709B (me) 2021-01-20
RS60044B1 (sr) 2020-04-30
CN107531806B (zh) 2022-06-07
MY183025A (en) 2021-02-07
ES2799099T3 (es) 2020-12-14
SV2017005548A (es) 2018-04-24
PH12017502025B1 (en) 2018-04-02
AU2016257659B2 (en) 2018-08-09
DOP2017000258A (es) 2017-12-31
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US11253574B2 (en) 2022-02-22
TW201712029A (zh) 2017-04-01
MA42037B1 (fr) 2020-03-31
AR105616A1 (es) 2017-10-25
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US20220211818A1 (en) 2022-07-07
IL254965A0 (en) 2017-12-31
PH12017502025A1 (en) 2018-04-02
EA039770B1 (ru) 2022-03-11
US20200390865A1 (en) 2020-12-17
HK1244019A1 (en) 2018-07-27
TWI656132B (zh) 2019-04-11
NZ736470A (en) 2019-04-26
MX388594B (es) 2025-03-20
ZA201706334B (en) 2020-01-29
CA2981102A1 (en) 2016-11-10
KR20170134614A (ko) 2017-12-06
KR102059736B1 (ko) 2019-12-26
EA201792199A1 (ru) 2018-03-30
US20180177851A1 (en) 2018-06-28
US12059452B2 (en) 2024-08-13
PT3292141T (pt) 2020-04-22
MX2017014284A (es) 2018-03-23

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