[go: up one dir, main page]

CO2017011301A2 - Proteínas de fusión - Google Patents

Proteínas de fusión

Info

Publication number
CO2017011301A2
CO2017011301A2 CONC2017/0011301A CO2017011301A CO2017011301A2 CO 2017011301 A2 CO2017011301 A2 CO 2017011301A2 CO 2017011301 A CO2017011301 A CO 2017011301A CO 2017011301 A2 CO2017011301 A2 CO 2017011301A2
Authority
CO
Colombia
Prior art keywords
fusion proteins
present
diabetes
useful
treatment
Prior art date
Application number
CONC2017/0011301A
Other languages
English (en)
Inventor
David Bruce Baldwin
John Michael Beals
Jonathan Wesley Day
Craig Duane Dickinson
Andrew Ihor Korytko
Gregory Alan Lazar
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55953435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2017011301(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO2017011301A2 publication Critical patent/CO2017011301A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

La presente invención se refiere a proteínas de fusión que comprenden un agonista del receptor de insulina fusionado a una región Fc de IgG humana mediante el uso de un enlazante de péptido, y el uso de tales proteínas de fusión en el tratamiento de diabetes. La proteína de fusión de la presente invención tiene un perfil de acción de tiempo prolongado y es útil para proporcionar un control de glucosa basal durante un período de tiempo prolongado.
CONC2017/0011301A 2015-05-07 2017-11-02 Proteínas de fusión CO2017011301A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562158079P 2015-05-07 2015-05-07
PCT/US2016/029807 WO2016178905A1 (en) 2015-05-07 2016-04-28 Fusion proteins

Publications (1)

Publication Number Publication Date
CO2017011301A2 true CO2017011301A2 (es) 2018-03-20

Family

ID=55953435

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0011301A CO2017011301A2 (es) 2015-05-07 2017-11-02 Proteínas de fusión

Country Status (40)

Country Link
US (5) US9855318B2 (es)
EP (1) EP3292141B1 (es)
JP (1) JP6591562B2 (es)
KR (1) KR102059736B1 (es)
CN (1) CN107531806B (es)
AR (1) AR105616A1 (es)
AU (1) AU2016257659B2 (es)
CA (1) CA2981102A1 (es)
CL (1) CL2017002761A1 (es)
CO (1) CO2017011301A2 (es)
CR (1) CR20170469A (es)
CY (1) CY1122929T1 (es)
DK (1) DK3292141T3 (es)
DO (1) DOP2017000258A (es)
EA (1) EA039770B1 (es)
EC (1) ECSP17073650A (es)
ES (1) ES2799099T3 (es)
HR (1) HRP20200503T1 (es)
IL (1) IL254965B (es)
JO (1) JO3658B1 (es)
LT (1) LT3292141T (es)
MA (1) MA42037B1 (es)
MD (1) MD3292141T2 (es)
ME (1) ME03709B (es)
MX (1) MX388594B (es)
MY (1) MY183025A (es)
NZ (1) NZ736470A (es)
PE (1) PE20180507A1 (es)
PH (1) PH12017502025A1 (es)
PL (1) PL3292141T3 (es)
PT (1) PT3292141T (es)
RS (1) RS60044B1 (es)
SG (1) SG11201708194WA (es)
SI (1) SI3292141T1 (es)
SV (1) SV2017005548A (es)
TN (1) TN2018000059A1 (es)
TW (1) TWI656132B (es)
UA (1) UA122146C2 (es)
WO (1) WO2016178905A1 (es)
ZA (1) ZA201706334B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016193380A1 (en) 2015-06-02 2016-12-08 Novo Nordisk A/S Insulins with polar recombinant extensions
MA43348A (fr) 2015-10-01 2018-08-08 Novo Nordisk As Conjugués de protéines
MX2019001079A (es) 2016-07-27 2019-09-18 Hewlett Packard Development Co Interfaz horizontal para cartucho de suministro de fluido que tiene sensores digitales de nivel de fluido.
EP3939605A1 (en) 2016-12-09 2022-01-19 Akston Biosciences Corporation Insulin-fc fusions and methods of use
TR201703622A1 (tr) * 2017-03-09 2018-09-21 Univ Yeditepe Obezi̇te tedavi̇si̇ i̇çi̇n bi̇r ürün
EP3606560A2 (en) 2017-04-05 2020-02-12 Novo Nordisk A/S Oligomer extended insulin-fc conjugates
KR20200125590A (ko) 2018-01-26 2020-11-04 제넨테크, 인크. 조성물 및 사용 방법
SG11202011460YA (en) 2018-06-25 2020-12-30 Univ Washington De novo design of potent and selective interleukin mimetics
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
DK4186920T5 (da) 2018-06-29 2024-07-22 Akston Biosciences Corp Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse
WO2020074544A1 (en) 2018-10-10 2020-04-16 Novo Nordisk A/S Oligomer extended insulin-fc conjugates and their medical use
US12234572B2 (en) 2018-11-20 2025-02-25 University Of Washington Split interleukin mimetics and their use
JP7728176B2 (ja) * 2019-03-15 2025-08-22 イーライ リリー アンド カンパニー 保存製剤
WO2021011827A1 (en) * 2019-07-16 2021-01-21 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
TW202434620A (zh) 2019-07-31 2024-09-01 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
AU2020368369A1 (en) 2019-10-15 2022-05-12 Eli Lilly And Company Recombinantly engineered, lipase/esterase-deficient mammalian cell lines
LT4073098T (lt) * 2019-12-19 2023-12-11 Akston Biosciences Corporation Itin ilgai veikiantys insulino-fc sulieti baltymai ir jų naudojimo būdai
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
WO2021188374A2 (en) 2020-03-16 2021-09-23 Neoleukin Therapeutics, Inc. Interleukin-2 receptor βeta (il-2rβ) binding polypeptides
WO2021207207A2 (en) 2020-04-07 2021-10-14 Neoleukin Therapeutics, Inc. De novo protein decoys of angiotensin-converting enzyme 2 (ace2)
LT3972987T (lt) 2020-04-10 2023-09-25 Akston Biosciences Corporation Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
JP7532638B2 (ja) * 2020-07-24 2024-08-13 チアンスー ジェンサイエンス インコーポレイテッド インスリン－Ｆｃ融合タンパク質及びその応用
EP4240407A1 (en) * 2020-11-06 2023-09-13 Amgen Inc. Antigen binding domain with reduced clipping rate
KR20230118648A (ko) * 2020-12-14 2023-08-11 일라이 릴리 앤드 캄파니 당뇨병을 치료하는 방법
US11667689B2 (en) 2021-07-23 2023-06-06 Akston Biosciences Corporation Insulin-Fc fusion proteins and methods of use to treat cancer
WO2023044318A2 (en) 2021-09-15 2023-03-23 Neoleukin Therapeutics, Inc. Interleukin-2 receptor βeta (il-2rβ) binding polypeptides
AR127619A1 (es) * 2021-11-15 2024-02-14 Lilly Co Eli FORMULACIONES CONSERVADAS DE FUSIONES DE INSULINA-Fc
JP2025509433A (ja) * 2022-03-16 2025-04-11 北京拓界生物医薬科技有限公司 ヒトインスリン類似体、その融合タンパク質及び医薬的使用
CN119677541A (zh) 2022-05-18 2025-03-21 原聚体科技公司 芳族含硼化合物和相关的胰岛素类似物
JP2025522529A (ja) 2022-06-23 2025-07-15 サノフイ 一本鎖インスリン及びそのＦｃ結合体
WO2024137820A1 (en) * 2022-12-20 2024-06-27 The Board Of Trustees Of The Leland Stanford Junior University Insulin receptor antagonist
CN115894720B (zh) * 2023-01-16 2024-07-09 中国科学院上海药物研究所 一种长效胰岛素-Fc融合蛋白
AU2024265269A1 (en) 2023-05-03 2025-11-06 Eli Lilly And Company Methods and systems for managing diabetes
WO2025059010A1 (en) 2023-09-11 2025-03-20 Eli Lilly And Company Methods and systems for managing diabetes
WO2025061146A1 (zh) * 2023-09-20 2025-03-27 上海迈晋生物医药科技有限公司 一种人胰岛素类似物融合蛋白的药物组合物及其医药用途
WO2025080923A1 (en) 2023-10-13 2025-04-17 Eli Lilly And Company Insulin-fc fusion proteins
EP4669757A1 (en) 2024-03-21 2025-12-31 Akston Biosciences Corporation PD-L1 ANALOGUE FUSION PROTEINS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY AND METHODS OF USE

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
HU225496B1 (en) 1993-04-07 2007-01-29 Scios Inc Pharmaceutical compositions of prolonged delivery, containing peptides
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
AU5724996A (en) 1995-05-05 1996-11-21 Eli Lilly And Company Single chain insulin with high bioactivity
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
AU5760900A (en) 1999-06-25 2001-01-31 Minimed, Inc. Multiple agent diabetes therapy
KR100449454B1 (ko) 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
JP2004528014A (ja) 2000-12-07 2004-09-16 イーライ・リリー・アンド・カンパニー Ｇｌｐ−１融合タンパク質
HUP0700126A2 (en) 2001-12-20 2007-06-28 Lilly Co Eli Insulin molecule having protracted time action
US7452966B2 (en) * 2003-06-12 2008-11-18 Eli Lilly And Company GLP-1 analog fusion proteins
JP4237755B2 (ja) 2003-10-02 2009-03-11 カール・ツァイス・エスエムティー・アーゲー 半導体リソグラフィにおける光学的半組立品及び投射対物レンズ
ATE517119T1 (de) 2003-12-03 2011-08-15 Novo Nordisk As Einzelketteninsulin
WO2006097521A1 (en) 2005-03-18 2006-09-21 Novo Nordisk A/S Pegylated single-chain insulin
EP1991575A1 (en) 2006-02-21 2008-11-19 Novo Nordisk A/S Single-chain insulin analogues and pharmaceutical formulations thereof
EP1996223A1 (en) 2006-03-13 2008-12-03 Novo Nordisk A/S Acylated single chain insulin
EP1996709A2 (en) 2006-03-13 2008-12-03 Novo Nordisk A/S Acylated single chain insulin
AU2007298919C1 (en) 2006-09-22 2014-02-06 Novo Nordisk A/S Protease resistant insulin analogues
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
JP5577243B2 (ja) * 2007-05-30 2014-08-20 ポステク アカデミー−インダストリー ファウンデイション 免疫グロブリン融合タンパク質
CN101730523A (zh) 2007-07-10 2010-06-09 伊莱利利公司 GLP-1-Fc融合蛋白质制剂
EP2254905B1 (en) 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
KR101755434B1 (ko) * 2008-03-18 2017-07-10 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
NZ588857A (en) 2008-04-22 2012-07-27 Univ Case Western Reserve Isoform-specific insulin analogue for control blood sugar levels
GB0812019D0 (en) 2008-07-02 2008-08-06 Asterion Ltd Insulin
CA2731546C (en) 2008-07-23 2013-11-19 Hanmi Holdings Co., Ltd. A polypeptide complex comprising non-peptidyl polymer having three functional ends
AR081066A1 (es) 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
KR101324828B1 (ko) * 2010-06-08 2013-11-01 한미사이언스 주식회사 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체
CA2802485C (en) 2010-06-16 2019-09-17 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
SG192671A1 (en) 2011-02-09 2013-09-30 Glaxosmithkline Llc Lyophilized formulations
CN102718870B (zh) * 2011-05-24 2014-04-30 马鞍山中美德康生物科技有限公司 一种胰岛素生物增敏剂及其应用
UA113626C2 (xx) 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
CN102516393B (zh) * 2011-11-30 2017-03-15 北京康明百奥新药研发有限公司 胰岛素模拟肽融合蛋白和突变体及其应用
CN103509118B (zh) * 2012-06-15 2016-03-23 郭怀祖 胰岛素-Fc融合蛋白
EP2869830B1 (en) 2012-07-09 2016-10-12 Novo Nordisk A/S Novel use of insulin derivatives
AR091902A1 (es) 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
AR092862A1 (es) 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
CA2886228A1 (en) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers
BR112015010194B1 (pt) 2012-11-05 2022-03-22 Case Western Reserve University Análogo de insulina de cadeia única, sequência de ácido nucleico e uso do mesmo
JP6465817B2 (ja) 2013-02-26 2019-02-06 ハンミ ファーム．カンパニー リミテッドＨａｎｍｉ Ｐｈａｒｍ．Ｃｏ．，Ｌｔｄ． インスリン位置特異的結合体
HK1220466A1 (zh) * 2013-03-14 2017-05-05 Regeneron Pharmaceuticals, Inc. 爱帕琳融合蛋白和其用途
RS57004B1 (sr) 2013-10-07 2018-05-31 Novo Nordisk As Novi derivat analoga insulina
EP3098235A4 (en) 2014-01-20 2017-10-18 Hanmi Pharm. Co., Ltd. Long-acting insulin and use thereof
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
KR20160001391A (ko) 2014-06-27 2016-01-06 한미약품 주식회사 신규한 지속형 인슐린 아날로그 결합체 및 이의 용도
KR20160007295A (ko) 2014-07-11 2016-01-20 한미약품 주식회사 인슐린 아날로그
JP6829928B2 (ja) 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体
CR20170208A (es) 2014-11-21 2017-07-17 Merck Sharp & Dohme Agonistas parciales del receptor de insulina
US10894089B2 (en) 2015-02-17 2021-01-19 Hanmi Pharm. Co., Ltd. Long-acting insulin or insulin analogue conjugate
CN110134210A (zh) 2019-04-16 2019-08-16 深圳市国鑫恒宇科技有限公司 一种服务器一体机的温度控制方法、系统、装置及存储介质

Also Published As

Publication number Publication date
AR105616A1 (es) 2017-10-25
JO3658B1 (ar) 2020-08-27
MX388594B (es) 2025-03-20
TW201712029A (zh) 2017-04-01
US12059452B2 (en) 2024-08-13
PT3292141T (pt) 2020-04-22
HRP20200503T1 (hr) 2020-06-26
US20160324932A1 (en) 2016-11-10
EP3292141A1 (en) 2018-03-14
US20200390865A1 (en) 2020-12-17
AU2016257659A1 (en) 2017-10-12
NZ736470A (en) 2019-04-26
CY1122929T1 (el) 2021-10-29
MX2017014284A (es) 2018-03-23
SI3292141T1 (sl) 2020-04-30
CR20170469A (es) 2017-11-14
AU2016257659B2 (en) 2018-08-09
MY183025A (en) 2021-02-07
PH12017502025B1 (en) 2018-04-02
ME03709B (me) 2021-01-20
LT3292141T (lt) 2020-03-25
CN107531806A (zh) 2018-01-02
SV2017005548A (es) 2018-04-24
US9855318B2 (en) 2018-01-02
CA2981102A1 (en) 2016-11-10
UA122146C2 (uk) 2020-09-25
US20250032588A1 (en) 2025-01-30
HK1244019A1 (en) 2018-07-27
EP3292141B1 (en) 2020-02-12
IL254965A0 (en) 2017-12-31
MA42037B1 (fr) 2020-03-31
EA039770B1 (ru) 2022-03-11
RS60044B1 (sr) 2020-04-30
TN2018000059A1 (en) 2019-07-08
PL3292141T3 (pl) 2020-06-29
DOP2017000258A (es) 2017-12-31
WO2016178905A1 (en) 2016-11-10
KR20170134614A (ko) 2017-12-06
CN107531806B (zh) 2022-06-07
TWI656132B (zh) 2019-04-11
ES2799099T3 (es) 2020-12-14
BR112017020502A2 (pt) 2018-07-03
IL254965B (en) 2021-03-25
ECSP17073650A (es) 2018-02-28
CL2017002761A1 (es) 2018-05-18
JP6591562B2 (ja) 2019-10-16
US10709766B2 (en) 2020-07-14
ZA201706334B (en) 2020-01-29
US20220211818A1 (en) 2022-07-07
SG11201708194WA (en) 2017-11-29
KR102059736B1 (ko) 2019-12-26
US11253574B2 (en) 2022-02-22
DK3292141T3 (da) 2020-04-20
PH12017502025A1 (en) 2018-04-02
PE20180507A1 (es) 2018-03-09
US20180177851A1 (en) 2018-06-28
EA201792199A1 (ru) 2018-03-30
MD3292141T2 (ro) 2020-07-31
JP2018515088A (ja) 2018-06-14

Similar Documents

Publication Publication Date Title
ECSP17073650A (es) Proteínas de fusión
PH12020550205A1 (en) IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE
EA201790063A1 (ru) Слитые белки интерлейкин-2/рецептор интерлейкина-2 альфа и способы применения
CL2018002687A1 (es) Proteínas de unión y métodos de uso de las mismas
CR20180378A (es) Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agosnistas de glp-1
CL2019001465A1 (es) Nuevos compuestos como agonistas peptídicos trigonales de los receptores de glp1/glucagón/gip.
AR106144A1 (es) Un conjugado de proteína que comprende polipéptidos fisiológicos y una región fc inmunoglobulina
UY36370A (es) Polipéptidos fgf-21 modificados y sus usos
MX2017014822A (es) Composiciones y métodos para la reprogramación del tcr con proteínas de fusión.
EA201790213A1 (ru) Молекулы, которые избирательно активируют регуляторные t-клетки, для лечения аутоиммунных заболеваний
PL3765489T3 (pl) Terapeutyczne połączenie agonistów 4-1BB z przeciwciałami anty-CD20
MX387560B (es) Procedimiento para mejorar la solubilidad de proteínas y péptidos usando un enlace del fragmento fc de inmunoglobulina.
IL276616A (en) Dosage for treatment with IL-22 Fc fusion proteins
BR112021011595A2 (pt) Proteína biespecífica
EA202090582A3 (ru) Полипептиды il-22, химерные белки il-22 fc и их применение
AR099080A1 (es) Variantes de región fc con propiedades de unión a fcrn (receptor fc neonatal) modificadas y de unión a proteína a mantenidas
TH177202A (th) โพลีเปปไทด์ IL-22 และฟิวชันโปรตีน IL-22 Fc และวิธีการใช้
AR090915A1 (es) Proteina de fusion de proteina linfopoyetina estromal timica canina con la region fc de igg
TH1501005499A (th) โพลีเปปไทด์ IL-22 และฟิวชันโปรตีน IL-22 Fc และวิธีการใช้