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ECSP13012390A - Método para diagnosticar una respuesta al tratamiento en sujetos con esclerosis múltiple - Google Patents

Método para diagnosticar una respuesta al tratamiento en sujetos con esclerosis múltiple

Info

Publication number
ECSP13012390A
ECSP13012390A ECSP13012390A ECSP13012390A EC SP13012390 A ECSP13012390 A EC SP13012390A EC SP13012390 A ECSP13012390 A EC SP13012390A EC SP13012390 A ECSP13012390 A EC SP13012390A
Authority
EC
Ecuador
Prior art keywords
treatment
multiple sclerosis
subject
diagnosing
subjects
Prior art date
Application number
Other languages
English (en)
Inventor
Richard A Rudick
Richard M Ransohoff
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45348885&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012390(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cleveland Clinic Foundation filed Critical Cleveland Clinic Foundation
Publication of ECSP13012390A publication Critical patent/ECSP13012390A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se provee un método para determinar la eficiencia del tratamiento con interferón beta (IFN-ß) en un sujeto con esclerosis múltiple. Un paso del método puede incluir la obtención de una muestra biológica tomada del sujeto. Después de obtener la muestra biológica, puede determinarse el nivel de expresión de al menos un gen regulado por interferón (IRG) y/o su variante. Una expresión aumentada o reducida del al menos un IRG y/o su variante en comparación con un control puede indicar que el sujeto responderá mal al tratamiento con interferón beta.
ECSP13012390 2010-06-18 2013-01-16 Método para diagnosticar una respuesta al tratamiento en sujetos con esclerosis múltiple ECSP13012390A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35626510P 2010-06-18 2010-06-18
PCT/US2011/040810 WO2011159970A2 (en) 2010-06-18 2011-06-17 Method for predicting a therapy response in subjects with multiple sclerosis

Publications (1)

Publication Number Publication Date
ECSP13012390A true ECSP13012390A (es) 2013-04-30

Family

ID=45348885

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012390 ECSP13012390A (es) 2010-06-18 2013-01-16 Método para diagnosticar una respuesta al tratamiento en sujetos con esclerosis múltiple

Country Status (23)

Country Link
US (1) US20130089519A1 (es)
EP (1) EP2585100A4 (es)
JP (1) JP2013534419A (es)
KR (1) KR20130036046A (es)
CN (1) CN103140235A (es)
AU (1) AU2011268223B2 (es)
BR (1) BR112012032344A2 (es)
CA (1) CA2802999A1 (es)
CL (1) CL2012003571A1 (es)
CO (1) CO6670574A2 (es)
CR (1) CR20130018A (es)
DO (1) DOP2012000316A (es)
EA (1) EA201370003A1 (es)
EC (1) ECSP13012390A (es)
MA (1) MA34381B1 (es)
MX (1) MX2012015028A (es)
NI (1) NI201200188A (es)
PE (1) PE20130645A1 (es)
PH (1) PH12012502501A1 (es)
SG (1) SG186393A1 (es)
TN (1) TN2012000607A1 (es)
WO (1) WO2011159970A2 (es)
ZA (1) ZA201300019B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160265058A1 (en) * 2013-11-01 2016-09-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Diagnostic methods and kits for determining a personalized treatment regimen for a subject suffering from a pathologic disorder
BR112018007474A2 (pt) * 2015-10-14 2018-10-30 Novozymes A/S ?limpeza de membranas de filtração de água?
CN108304912B (zh) * 2017-12-29 2020-12-29 北京理工大学 一种运用抑制信号实现脉冲神经网络监督学习的系统和方法
CN116068473A (zh) * 2021-10-29 2023-05-05 通用电气精准医疗有限责任公司 生成磁共振图像的方法和磁共振成像系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60209832T2 (de) * 2002-05-29 2007-01-25 Charité - Universitätsmedizin Berlin Verfahren zur Identifizierung von auf Ifn-Beta ansprechenden multiple Sklerose Patienten, durch die Bestimmung der Expression von Trail
WO2005108610A2 (en) * 2004-04-05 2005-11-17 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for the selection of subjects for multiple sclerosis therapy
US20100209914A1 (en) * 2007-05-25 2010-08-19 Ore Pharmaceuticals , Inc. Methods, systems, and kits for evaluating multiple sclerosis
EP2009440A1 (en) * 2007-06-01 2008-12-31 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Means and methods for classifying samples of multiple sclerosis patients.
CN102197143A (zh) * 2008-09-16 2011-09-21 拜耳医药保健有限公司 临床样品中的干扰素响应(iris)

Also Published As

Publication number Publication date
CR20130018A (es) 2013-04-26
MA34381B1 (fr) 2013-07-03
CA2802999A1 (en) 2011-12-22
CO6670574A2 (es) 2013-05-15
EP2585100A4 (en) 2013-11-06
TN2012000607A1 (en) 2014-04-01
WO2011159970A3 (en) 2012-04-19
WO2011159970A2 (en) 2011-12-22
MX2012015028A (es) 2013-06-13
SG186393A1 (en) 2013-01-30
ZA201300019B (en) 2014-03-26
JP2013534419A (ja) 2013-09-05
EP2585100A2 (en) 2013-05-01
AU2011268223A1 (en) 2013-01-31
CL2012003571A1 (es) 2013-08-23
EA201370003A1 (ru) 2013-06-28
DOP2012000316A (es) 2013-07-31
PH12012502501A1 (en) 2013-02-11
US20130089519A1 (en) 2013-04-11
CN103140235A (zh) 2013-06-05
BR112012032344A2 (pt) 2017-05-30
NI201200188A (es) 2013-04-15
AU2011268223B2 (en) 2014-05-29
PE20130645A1 (es) 2013-07-03
KR20130036046A (ko) 2013-04-09

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