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ECSP12011740A - ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME - Google Patents

ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME

Info

Publication number
ECSP12011740A
ECSP12011740A ECSP12011740A ECSP12011740A EC SP12011740 A ECSP12011740 A EC SP12011740A EC SP12011740 A ECSP12011740 A EC SP12011740A EC SP12011740 A ECSP12011740 A EC SP12011740A
Authority
EC
Ecuador
Prior art keywords
erbb3
antibodies
antigen
receptor
binding fragments
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Birgit Schoeberl
Ulrik Nielsen
Michael Feldhaus
Original Assignee
Merrimack Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011740(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrimack Pharmaceuticals Inc filed Critical Merrimack Pharmaceuticals Inc
Publication of ECSP12011740A publication Critical patent/ECSP12011740A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona una nueva clase de anticuerpos y fragmentos de unión a antígeno de los mismos que se unen al dominio extracelular del receptor ErbB3 e inhiben diversas funciones de ErbB3. Por ejemplo, los anticuerpos y fragmentos de unión a antígeno descritos en la presente son capaces de unirse al receptor designado ErbB3 e inhibir la fosforilación mediada por ligando similar a EGF del receptor. Dichos anticuerpos y fragmentos de unión a antígeno de los mismos tiene la característica útil de inhibir la proliferación de células cancerígenas que expresan ErbB3.The present invention provides a new class of antibodies and antigen-binding fragments thereof that bind to the extracellular domain of the ErbB3 receptor and inhibit various functions of ErbB3. For example, the antibodies and antigen-binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand-mediated phosphorylation of the receptor. Said antibodies and antigen-binding fragments thereof have the useful feature of inhibiting the proliferation of cancer cells expressing ErbB3.

ECSP12011740 2009-08-21 2012-03-21 ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME ECSP12011740A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23579909P 2009-08-21 2009-08-21

Publications (1)

Publication Number Publication Date
ECSP12011740A true ECSP12011740A (en) 2013-02-28

Family

ID=43607614

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011740 ECSP12011740A (en) 2009-08-21 2012-03-21 ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME

Country Status (21)

Country Link
EP (1) EP2467164A2 (en)
JP (1) JP5752687B2 (en)
KR (1) KR20120059568A (en)
CN (1) CN103002912A (en)
AU (1) AU2010284018C1 (en)
BR (1) BR112012003809A2 (en)
CA (1) CA2771744A1 (en)
CR (1) CR20120108A (en)
DO (1) DOP2012000044A (en)
EA (1) EA201200195A1 (en)
EC (1) ECSP12011740A (en)
IL (1) IL218097A0 (en)
IN (1) IN2012DN01518A (en)
MA (1) MA33582B1 (en)
MX (1) MX336091B (en)
NI (1) NI201200027A (en)
PE (1) PE20121585A1 (en)
SG (1) SG178509A1 (en)
TN (1) TN2012000057A1 (en)
WO (1) WO2011022727A2 (en)
ZA (1) ZA201201195B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2631727T3 (en) 2007-02-16 2017-09-04 Merrimack Pharmaceuticals, Inc. Antibodies against ErbB3 and their uses
CN105999263B (en) * 2009-11-13 2021-06-29 第一三共欧洲有限公司 Materials and methods for treating or preventing human epidermal growth factor receptor-3 (HER-3) related diseases
CN102822201B (en) 2009-12-22 2014-09-24 罗切格利卡特公司 Anti-HER3 antibodies and uses thereof
EP2544680B1 (en) 2010-03-11 2015-01-14 Merrimack Pharmaceuticals, Inc. Use of erbb3 inhibitors in the treatment of triple negative breast cancer
BR112012025730B1 (en) 2010-04-09 2020-12-08 Aveo Pharmaceuticals, Inc isolated antibody that binds to human erbb3, its uses, its production process and expression vector
BR112013004012B1 (en) 2010-08-20 2021-03-23 Novartis Ag ISOLATED MONOCLONAL ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THE SAME TO THE HER3 RECEPTOR, ITS USE AND PHARMACEUTICAL COMPOSITION
TW201302793A (en) 2010-09-03 2013-01-16 Glaxo Group Ltd Novel antigen binding protein
IT1402149B1 (en) * 2010-10-04 2013-08-28 Ist Fisioterap Ospitalroma USE OF A PHOSPHOPEPTIDE WHICH IS ABLE TO BLOCK THE HER3 / P85 INTERACTION FOR THE TREATMENT OF HER2 EXPRESSION TUMORS.
MX348637B (en) 2010-11-01 2017-06-22 Symphogen As Anti-her3 antibodies and compositions.
KR101517320B1 (en) 2011-04-19 2015-05-28 메리맥 파마슈티컬즈, 인크. Monospecific and bispecific anti-igf-1r and anti-erbb3 antibodies
AU2012274461A1 (en) 2011-06-20 2014-01-16 Kyowa Hakko Kirin Co., Ltd. Anti-erbB3 antibody
MX357391B (en) 2011-09-30 2018-07-06 Regeneron Pharma Anti-erbb3 antibodies and uses thereof.
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
CN103959065B (en) 2011-10-06 2018-07-17 Aveo制药公司 Predicting Tumor Responses to Anti-ERBB3 Antibodies
EP2788377B1 (en) * 2011-11-09 2019-01-23 The UAB Research Foundation Her3 antibodies and uses thereof
WO2013084147A2 (en) 2011-12-05 2013-06-13 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
WO2013124297A1 (en) * 2012-02-22 2013-08-29 U3 Pharma Gmbh Combination of hb-egf binding protein and egfr inhibitor
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
US20160232293A1 (en) * 2013-10-17 2016-08-11 Sanford-Burnham Medical Research Institute Drug sensitivity biomarkers and methods of identifying and using drug sensitivity biomarkers
WO2015100459A2 (en) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
CA2941030C (en) 2014-02-28 2025-05-13 Merus N.V. Antibodies that bind egfr and erbb3
CN110642952B (en) * 2014-08-14 2021-05-25 上海生物制品研究所有限责任公司 anti-HER 3 antibody, preparation method and application thereof
WO2016038610A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
WO2016038609A1 (en) * 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
EP3365373B1 (en) 2015-10-23 2021-03-10 Merus N.V. Binding molecules that inhibit cancer growth
KR102905513B1 (en) 2017-03-31 2026-01-02 메뤼스 엔.페. ErbB-2 and ErbB-3 binding bispecific antibodies for treating cells harboring the NRG1 fusion gene
JP7296891B2 (en) 2017-05-17 2023-06-23 メルス ナムローゼ フェンノートシャップ Combining ErbB-2/ErbB-3 bispecific antibodies with endocrine therapy for breast cancer
FI3665198T3 (en) 2017-08-09 2025-04-25 Merus Nv Antibodies that bind egfr and cmet
EP3665200B1 (en) 2017-08-09 2025-04-16 University of Saskatchewan Her3 binding agents and uses thereof
GB201804094D0 (en) * 2018-03-14 2018-04-25 Ultrahuman Thirteen Ltd ERBB3 Binding agents
JP2021534811A (en) * 2018-06-22 2021-12-16 シーアールディー ファーマシューティカルズ インコーポレイティド Anti-HER3 antibody and its uses
KR20230086702A (en) * 2020-10-14 2023-06-15 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Anti-HER3 antibodies and anti-HER3 antibody-drug conjugates and their medical uses
EP4247430A4 (en) * 2020-11-20 2024-12-11 Actinium Pharmaceuticals, Inc. HER3 RADIOIMMUNOTHERAPY FOR THE TREATMENT OF SOLID CANCERS
AU2022293634A1 (en) * 2021-06-15 2024-01-18 Beijing Sinotau Bio-Pharmaceuticals Technology Co., Ltd. Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof
CN119013307A (en) * 2022-04-13 2024-11-22 上海翰森生物医药科技有限公司 Antibodies or antigen binding fragments thereof and medical uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2631727T3 (en) * 2007-02-16 2017-09-04 Merrimack Pharmaceuticals, Inc. Antibodies against ErbB3 and their uses

Also Published As

Publication number Publication date
IL218097A0 (en) 2012-04-30
ZA201201195B (en) 2015-07-29
MX336091B (en) 2016-01-08
CA2771744A1 (en) 2011-02-24
EP2467164A2 (en) 2012-06-27
KR20120059568A (en) 2012-06-08
EA201200195A1 (en) 2012-12-28
JP5752687B2 (en) 2015-07-22
BR112012003809A2 (en) 2019-09-24
WO2011022727A3 (en) 2013-06-27
AU2010284018A1 (en) 2012-03-22
MA33582B1 (en) 2012-09-01
AU2010284018C1 (en) 2015-10-15
CR20120108A (en) 2012-06-05
CN103002912A (en) 2013-03-27
WO2011022727A2 (en) 2011-02-24
MX2012002172A (en) 2012-05-29
PE20121585A1 (en) 2012-11-29
AU2010284018B2 (en) 2014-06-05
SG178509A1 (en) 2012-04-27
NI201200027A (en) 2013-01-29
DOP2012000044A (en) 2012-06-30
TN2012000057A1 (en) 2013-09-19
JP2013506622A (en) 2013-02-28
IN2012DN01518A (en) 2015-06-05

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