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ECSP11011172A - Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer. - Google Patents

Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer.

Info

Publication number
ECSP11011172A
ECSP11011172A EC2011011172A ECSP11011172A ECSP11011172A EC SP11011172 A ECSP11011172 A EC SP11011172A EC 2011011172 A EC2011011172 A EC 2011011172A EC SP11011172 A ECSP11011172 A EC SP11011172A EC SP11011172 A ECSP11011172 A EC SP11011172A
Authority
EC
Ecuador
Prior art keywords
tieno
piridine
derivatives
kinase inhibitors
cancer treatment
Prior art date
Application number
EC2011011172A
Other languages
English (en)
Inventor
L Michael Curtin
Michael R Michaelides
Robin R Frey
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ECSP11011172A publication Critical patent/ECSP11011172A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos que inhiben proteína quinasas, tales como aurora-quinasas y las familias de quinasas VEGFR y PDGFR, con un perfil de seguridad mejorado debido a una baja inhibición de CYP3A4, composiciones que contienen los compuestos y métodos de tratamiento de enfermedades usando los compuestos.
EC2011011172A 2008-12-05 2011-07-01 Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer. ECSP11011172A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12028108P 2008-12-05 2008-12-05
US22376009P 2009-07-08 2009-07-08

Publications (1)

Publication Number Publication Date
ECSP11011172A true ECSP11011172A (es) 2011-08-31

Family

ID=41559043

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011172A ECSP11011172A (es) 2008-12-05 2011-07-01 Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer.

Country Status (25)

Country Link
US (2) US20100144783A1 (es)
EP (1) EP2373662B1 (es)
JP (1) JP5588458B2 (es)
KR (1) KR101639642B1 (es)
CN (1) CN102239171B (es)
AR (1) AR074481A1 (es)
AU (1) AU2009322270B2 (es)
BR (1) BRPI0921392A2 (es)
CA (1) CA2743592A1 (es)
CL (1) CL2011001312A1 (es)
CO (1) CO6382131A2 (es)
DO (1) DOP2011000153A (es)
EC (1) ECSP11011172A (es)
ES (1) ES2524966T3 (es)
IL (1) IL212716A (es)
MX (1) MX2011005943A (es)
MY (1) MY179042A (es)
NZ (1) NZ592714A (es)
PA (1) PA8852401A1 (es)
PE (1) PE20110830A1 (es)
RU (2) RU2480472C2 (es)
TW (2) TWI441827B (es)
UA (1) UA103351C2 (es)
UY (1) UY32291A (es)
WO (1) WO2010065825A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202363B2 (en) * 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
BRPI0921392A2 (pt) * 2008-12-05 2016-04-26 Abbott Lab inibidores quinase com perfil de segurança cyp aperfeiçoado
TWI482770B (zh) 2010-06-09 2015-05-01 Abbvie Bahamas Ltd 結晶型激酶抑制劑
CN103003283A (zh) * 2010-06-09 2013-03-27 Abbvie公司 激酶抑制剂的结晶形式
WO2011156361A2 (en) * 2010-06-09 2011-12-15 Abbott Laboratories Solid dispersions containing kinase inhibitors
TWI492949B (zh) * 2010-06-09 2015-07-21 Abbvie Bahamas Ltd 結晶型激酶抑制劑
US8911725B2 (en) 2010-06-23 2014-12-16 University Of Central Florida Research Foundation, Inc. Co-targeting of aurora A kinase and LIM kinase 1 for cancer therapy
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
JP2015500343A (ja) 2011-12-14 2015-01-05 アッヴィ・インコーポレイテッド キナーゼ阻害剤を含有する組成物
HK1209104A1 (en) * 2012-08-17 2016-03-24 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
US20160009686A1 (en) * 2012-08-17 2016-01-14 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
CN103012428A (zh) * 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
WO2015157360A1 (en) 2014-04-08 2015-10-15 Abbvie Inc. Processes to make protein kinase inhibitors
US20170197980A1 (en) * 2014-06-25 2017-07-13 Abbvie Inc. N-(4-phenyl)-n'-(3-fluorophenyl)urea docusate
KR20210107069A (ko) 2018-12-21 2021-08-31 다이이찌 산쿄 가부시키가이샤 항체-약물 컨쥬게이트와 키나아제 저해제의 조합
WO2020252353A1 (en) * 2019-06-12 2020-12-17 Vanderbilt University Amino acid transport inhibitors and the uses thereof
CN115803330B (zh) * 2020-05-11 2025-07-04 大学健康网络 4-氨基-5-(6-(4-甲基哌嗪-1-基)-1H-苯并[d]咪唑-2-基)噻吩并[2,3-b]吡啶-6(7H)-酮的盐和晶型

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1188529A (en) 1966-06-09 1970-04-15 Wellcome Found Pyramidine Derivatives
US4357535A (en) 1980-04-30 1982-11-02 North American Philips Corporation Apparatus for inspecting hand-held articles and persons carrying same
GB8307154D0 (en) 1983-03-15 1983-04-20 Mk Electric Ltd Terminals
US4767766A (en) 1987-01-30 1988-08-30 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
EP0300688A1 (en) 1987-07-21 1989-01-25 FISONS plc Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
JPH0436810Y2 (es) 1987-12-29 1992-08-31
US4843949A (en) 1988-08-29 1989-07-04 Pneumo Abex Corporation Fluid control valve with variable pressure gain
GB8912498D0 (en) 1989-05-31 1989-07-19 De Beers Ind Diamond Diamond growth
EP0438261A3 (en) 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
DE4129603A1 (de) 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0630031B1 (en) 1993-06-16 2002-08-14 E.I. Du Pont De Nemours And Company Water cleanable thick film paste composition
IL112759A0 (en) 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
DE29511756U1 (de) 1995-07-20 1995-09-28 Ferco International Usine de Ferrures de Bâtiment S.A.R.L., Sarrebourg Flügelseitiges Ecklagerbeschlagteil für Drehkippfenster
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
DE19620508A1 (de) 1996-05-22 1997-11-27 Hoechst Ag Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
CA2285424A1 (en) 1997-04-22 1998-10-29 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
TR200001079T2 (tr) 1997-10-20 2000-07-21 F.Hoffmann-La Roche Ag Bisiklik kinaz inhibitörleri.
WO2000039102A1 (en) 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
AU7491400A (en) 1999-09-17 2001-04-17 Abbott Gmbh & Co. Kg Kinase inhibitors as therapeutic agents
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
US20020004511A1 (en) 2000-06-28 2002-01-10 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents
US7447791B2 (en) 2000-12-15 2008-11-04 British Telecommunications Public Limited Company Transmission and reception of audio and/or video material
MXPA03007779A (es) 2001-03-14 2004-11-12 Lilly Co Eli Moduladores de los receptores de retinoides x.
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7427623B2 (en) 2001-09-11 2008-09-23 Smithkline Beecham Corporation 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof
MXPA04005561A (es) 2001-12-21 2004-12-06 Bayer Pharmaceuticals Corp Terapias de combinacion anti-angiogenesis que comprenden derivados de piridazina o piridina.
JP4564952B2 (ja) 2003-01-17 2010-10-20 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
DE10303311A1 (de) * 2003-01-28 2004-07-29 Basf Ag Addukte auf Basis cyclischer Verbindungen und ihre Verwendung als Gerbstoffe und Konservierungsmittel
WO2004100947A2 (en) 2003-05-06 2004-11-25 Smithkline Beecham Corporation Novel chemical compounds
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US7202363B2 (en) * 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
BRPI0514476A (pt) 2004-11-11 2008-06-17 Achillion Pharmaceuticals Inc inibidores da formação de cápsideo hiv-1: aril aminometil tiazol uréias substituìdas e análogos destas
DK1904504T3 (da) 2005-05-20 2014-06-23 Methylgene Inc Inhibitorer af vegf-receptor- og hgf-receptorsignalering
US7566721B2 (en) 2005-08-08 2009-07-28 Osi Pharmaceuticals, Inc. Substituted thienol[2,3-d]pyrimidines as kinase inhibitors
EP1940819A1 (en) 2005-08-16 2008-07-09 Memory Pharmaceuticals Corporation Phosphodiesterase 10 inhibitors
US20080255184A1 (en) 2005-11-04 2008-10-16 Smithkline Beecham Corporation Thienopyridine B-Raf Kinase Inhibitors
EP1968979A2 (en) * 2005-12-08 2008-09-17 Abbott Laboratories 9-membered heterobicyclic compounds as inhibitors of protein kinases
BRPI0713187A2 (pt) 2006-07-20 2012-10-16 Mehmet Kahraman método de inibir rho-quinase, método de tratamento de doença mediada por rho-quinase, composto e composição farmacêutica
BRPI0921392A2 (pt) * 2008-12-05 2016-04-26 Abbott Lab inibidores quinase com perfil de segurança cyp aperfeiçoado

Also Published As

Publication number Publication date
CN102239171B (zh) 2014-06-11
US20100144783A1 (en) 2010-06-10
CA2743592A1 (en) 2010-06-10
TWI500621B (zh) 2015-09-21
CL2011001312A1 (es) 2011-10-07
TW201026706A (en) 2010-07-16
BRPI0921392A2 (pt) 2016-04-26
MY179042A (en) 2020-10-26
DOP2011000153A (es) 2011-06-30
RU2011127451A (ru) 2013-01-10
PA8852401A1 (es) 2010-07-27
AR074481A1 (es) 2011-01-19
PE20110830A1 (es) 2011-12-14
RU2480472C2 (ru) 2013-04-27
WO2010065825A2 (en) 2010-06-10
AU2009322270B2 (en) 2014-12-18
TWI441827B (zh) 2014-06-21
WO2010065825A3 (en) 2010-08-26
EP2373662A2 (en) 2011-10-12
EP2373662B1 (en) 2014-09-24
JP5588458B2 (ja) 2014-09-10
MX2011005943A (es) 2011-06-27
KR101639642B1 (ko) 2016-07-14
US8722890B2 (en) 2014-05-13
IL212716A0 (en) 2011-07-31
KR20110091577A (ko) 2011-08-11
US20120309783A1 (en) 2012-12-06
UA103351C2 (uk) 2013-10-10
JP2012511016A (ja) 2012-05-17
AU2009322270A1 (en) 2011-07-14
RU2012156958A (ru) 2014-06-27
UY32291A (es) 2010-07-30
CN102239171A (zh) 2011-11-09
TW201431862A (zh) 2014-08-16
HK1159628A1 (en) 2012-08-03
IL212716A (en) 2013-10-31
NZ592714A (en) 2013-03-28
CO6382131A2 (es) 2012-02-15
ES2524966T3 (es) 2014-12-16

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