ECSP11010839A - Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1 - Google Patents
Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1Info
- Publication number
- ECSP11010839A ECSP11010839A EC2011010839A ECSP11010839A ECSP11010839A EC SP11010839 A ECSP11010839 A EC SP11010839A EC 2011010839 A EC2011010839 A EC 2011010839A EC SP11010839 A ECSP11010839 A EC SP11010839A EC SP11010839 A ECSP11010839 A EC SP11010839A
- Authority
- EC
- Ecuador
- Prior art keywords
- 11beta
- cycle inhibitors
- hydroxiesteroid
- dehydrogenase
- cortisol
- Prior art date
Links
- 101710088194 Dehydrogenase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960000890 hydrocortisone Drugs 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229960004544 cortisone Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Esta invención se refiere a nuevos compuestos de la Fórmula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, a sales farmacéuticamente aceptables de los mismos y a composiciones farmacéuticas de los mismos, que son útiles para el tratamiento terapéutico de enfermedades asociadas con la modulación o inhibición de 11 -HSD1 en mamíferos. La invención también se refiere a composiciones farmacéuticas de los nuevos compuestos y métodos para su uso en la reducción o control de la producción de cortisol en una célula o la inhibición de la conversión de cortisona en cortisol en una célula.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/004261 WO2010011314A1 (en) | 2008-07-25 | 2009-07-23 | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11010839A true ECSP11010839A (es) | 2011-03-31 |
Family
ID=44583523
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011010839A ECSP11010839A (es) | 2009-07-23 | 2011-02-18 | Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1 |
| EC2011011413A ECSP11011413A (es) | 2009-04-30 | 2011-10-21 | Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011413A ECSP11011413A (es) | 2009-04-30 | 2011-10-21 | Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2424865B1 (es) |
| AR (1) | AR076492A1 (es) |
| AU (1) | AU2010242876B2 (es) |
| EC (2) | ECSP11010839A (es) |
| NZ (1) | NZ618741A (es) |
| TN (1) | TN2011000031A1 (es) |
| TW (1) | TW201040167A (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2183229B1 (en) * | 2007-07-26 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| US8846668B2 (en) * | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
-
2010
- 2010-04-29 AR ARP100101447A patent/AR076492A1/es unknown
- 2010-04-29 TW TW099113647A patent/TW201040167A/zh unknown
- 2010-04-30 NZ NZ618741A patent/NZ618741A/en not_active IP Right Cessation
- 2010-04-30 EP EP10721215.1A patent/EP2424865B1/en active Active
- 2010-04-30 AU AU2010242876A patent/AU2010242876B2/en not_active Ceased
-
2011
- 2011-01-25 TN TN2011000031A patent/TN2011000031A1/fr unknown
- 2011-02-18 EC EC2011010839A patent/ECSP11010839A/es unknown
- 2011-10-21 EC EC2011011413A patent/ECSP11011413A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201040167A (en) | 2010-11-16 |
| NZ618741A (en) | 2015-05-29 |
| AU2010242876B2 (en) | 2015-06-18 |
| EP2424865A2 (en) | 2012-03-07 |
| ECSP11011413A (es) | 2012-01-31 |
| TN2011000031A1 (en) | 2012-09-05 |
| EP2424865B1 (en) | 2017-01-18 |
| AU2010242876A1 (en) | 2011-10-20 |
| AR076492A1 (es) | 2011-06-15 |
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