EA201900326A1 - Усовершенствованные способы повышения продуктивности антител в культурах клеток млекопитающих и сведения к минимуму агрегации в процессах выделения и очистки, получения композиций и стабильные композиции антител, полученные этими способами - Google Patents
Усовершенствованные способы повышения продуктивности антител в культурах клеток млекопитающих и сведения к минимуму агрегации в процессах выделения и очистки, получения композиций и стабильные композиции антител, полученные этими способамиInfo
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Abstract
Изобретение относится к эффективной платформе для производства и получения композиций антител, которая обеспечивает: i) технологию культивирования клеток с усовершенствованной стратегией подпитки, которая обеспечивает повышенный титр антител от 2 до 5 г/л; ii) усовершенствованный процесс очистки, демонстрирующий оптимальную степень извлечения антител в процентах, высокое содержание мономеров, минимальную агрегацию/образование частиц, минимальные уровни примесей; iii) высококонцентрированную стабильную жидкую композицию с оптимальной осмоляльностью и низкой вязкостью при различных колебаниях температуры, не подверженную агрегации. Предпочтительные антитела включают моноклональные антитела IgG1, специфичные к эпитопу вируса денге в домене III белка E, и моноклональные антитела IgG1, специфичные к поверхностному гликопротеину G вируса бешенства.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201621044139 | 2016-12-23 | ||
| PCT/IB2017/058194 WO2018116198A1 (en) | 2016-12-23 | 2017-12-20 | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201900326A1 true EA201900326A1 (ru) | 2019-11-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201900326A EA201900326A1 (ru) | 2016-12-23 | 2017-12-20 | Усовершенствованные способы повышения продуктивности антител в культурах клеток млекопитающих и сведения к минимуму агрегации в процессах выделения и очистки, получения композиций и стабильные композиции антител, полученные этими способами |
Country Status (27)
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| EP (1) | EP3559027B1 (ru) |
| JP (1) | JP7265477B6 (ru) |
| KR (1) | KR102595080B1 (ru) |
| CN (1) | CN110337445B (ru) |
| AR (1) | AR110584A1 (ru) |
| AU (1) | AU2017380842B2 (ru) |
| BR (1) | BR112019011900A2 (ru) |
| CO (1) | CO2019006289A2 (ru) |
| CR (1) | CR20190291A (ru) |
| DK (1) | DK3559027T3 (ru) |
| EA (1) | EA201900326A1 (ru) |
| ES (1) | ES2926028T3 (ru) |
| GE (2) | GEP20237513B (ru) |
| HR (1) | HRP20221071T1 (ru) |
| MX (1) | MX2019007564A (ru) |
| MY (1) | MY197200A (ru) |
| PE (1) | PE20191436A1 (ru) |
| PH (1) | PH12019501472A1 (ru) |
| PT (1) | PT3559027T (ru) |
| RS (1) | RS63533B1 (ru) |
| SA (1) | SA519402010B1 (ru) |
| TW (2) | TWI830692B (ru) |
| UA (1) | UA128200C2 (ru) |
| UY (1) | UY37547A (ru) |
| WO (1) | WO2018116198A1 (ru) |
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