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EA201800064A1 - 1,1,1-трифтор-3-гидроксипропан-2-ил карбаматные производные и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматные производные в качестве ингибиторов magl - Google Patents

1,1,1-трифтор-3-гидроксипропан-2-ил карбаматные производные и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматные производные в качестве ингибиторов magl

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Publication number
EA201800064A1
EA201800064A1 EA201800064A EA201800064A EA201800064A1 EA 201800064 A1 EA201800064 A1 EA 201800064A1 EA 201800064 A EA201800064 A EA 201800064A EA 201800064 A EA201800064 A EA 201800064A EA 201800064 A1 EA201800064 A1 EA 201800064A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbamate derivatives
triftor
hydroxybutan
hydroxypropan
inhibitors
Prior art date
Application number
EA201800064A
Other languages
English (en)
Other versions
EA035823B1 (ru
Inventor
Элизабет Мэри Бек
Майкл Аарон Бродний
Кристофер Райан Батлер
Адам Мэтью Гилберт
Кристофер Джон Хелал
Дуглас Скотт Джонсон
Лаура Энн Макалистер
Джастин Иан Монтгомери
Стивен Виктор О'Нил
Брюс Нельсон Роджерс
Патрик Роберт Верхоист
Дэмиен Уэбб
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201800064A1 publication Critical patent/EA201800064A1/ru
Publication of EA035823B1 publication Critical patent/EA035823B1/ru

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Представленное изобретение относится к области фармацевтики, а именно касается новых 1,1,1-трифтор-3-гидроксипропан-2-ил карбаматных производных и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматных производных, которые являются ингибиторами моноацилглицерол-липазы (MAGL), их фармацевтических композиций и их применения для лечения MAGL-опосредованных расстройств, таких как боль, воспалительное заболевание, травматическое повреждение мозга, депрессия, тревога, болезнь Альцгеймера, нарушение обмена веществ, инсульт или рак. Данное изобретение предусматривает соединения формулы Iи их фармацевтически приемлемые соли; способы их получения; промежуточные соединения, используемые при получении; и композиции, содержащие такие соединения или соли, и их применение для лечения MAGL-опосредованных заболеваний и расстройств, включая, например, боль, воспалительное заболевание, травматическое повреждение мозга, депрессию, тревогу, болезнь Альцгеймера, нарушение обмена веществ, инсульт или рак.
EA201800064A 2015-07-31 2016-07-18 1,1,1-трифтор-3-гидроксипропан-2-ил карбаматные производные и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматные производные в качестве ингибиторов magl EA035823B1 (ru)

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