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EA201300074A1 - Способ получения представляющего интерес соединения - Google Patents

Способ получения представляющего интерес соединения

Info

Publication number
EA201300074A1
EA201300074A1 EA201300074A EA201300074A EA201300074A1 EA 201300074 A1 EA201300074 A1 EA 201300074A1 EA 201300074 A EA201300074 A EA 201300074A EA 201300074 A EA201300074 A EA 201300074A EA 201300074 A1 EA201300074 A1 EA 201300074A1
Authority
EA
Eurasian Patent Office
Prior art keywords
interest
obtaining
connection
relates
defect
Prior art date
Application number
EA201300074A
Other languages
English (en)
Inventor
Ноэль Николас Мария Элизабет Пейдж Ван
Маркус Ханс
Мартина Бейсхёйзен
Дик Схиппер
Робертус Антониус Мийндерт Хувен Ван Дер
Олаф Леонардус Схаутен
Original Assignee
ДСМ АйПи АССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДСМ АйПи АССЕТС Б.В. filed Critical ДСМ АйПи АССЕТС Б.В.
Publication of EA201300074A1 publication Critical patent/EA201300074A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Изобретение относится к способу получения микробной ферментацией представляющего интерес соединения, где модификация генома используемой микробной клетки-хозяина приводит к дефекту выработки по меньшей мере одной нерибосомной пептидсинтазы. Настоящее изобретение также относится к микробной клетке-хозяину, модификация генома которой приводит к дефекту выработки по меньшей мере одной нерибосомной пептидсинтазы. Изобретение также относится к представляющему интерес соединению.
EA201300074A 2010-07-01 2011-07-01 Способ получения представляющего интерес соединения EA201300074A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10168174 2010-07-01
EP11151308 2011-01-18
PCT/EP2011/061163 WO2012001169A1 (en) 2010-07-01 2011-07-01 A method for the production of a compound of interest

Publications (1)

Publication Number Publication Date
EA201300074A1 true EA201300074A1 (ru) 2013-06-28

Family

ID=45401419

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300074A EA201300074A1 (ru) 2010-07-01 2011-07-01 Способ получения представляющего интерес соединения

Country Status (8)

Country Link
US (1) US8945898B2 (ru)
EP (1) EP2588616B1 (ru)
CN (1) CN103459600B (ru)
AU (1) AU2011273351A1 (ru)
CA (1) CA2803222A1 (ru)
DK (1) DK2588616T3 (ru)
EA (1) EA201300074A1 (ru)
WO (1) WO2012001169A1 (ru)

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US10918113B2 (en) 2016-12-21 2021-02-16 Dsm Ip Assets B.V. Lipolytic enzyme variants
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WO2018114912A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018166943A1 (en) 2017-03-13 2018-09-20 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
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EP3809852A1 (en) 2018-06-19 2021-04-28 DSM IP Assets B.V. Lipolytic enzyme variants
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CN114350692B (zh) * 2021-10-21 2024-03-26 浙江工业大学 一种全细胞催化制备脱羧肌肽的方法
CN116003542B (zh) * 2021-10-22 2025-03-14 中国科学院天津工业生物技术研究所 生产柠檬酸的微生物及其构建方法和应用
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Also Published As

Publication number Publication date
US20130144034A1 (en) 2013-06-06
DK2588616T3 (en) 2019-03-11
US8945898B2 (en) 2015-02-03
EP2588616B1 (en) 2018-11-14
WO2012001169A1 (en) 2012-01-05
AU2011273351A1 (en) 2013-01-17
CN103459600A (zh) 2013-12-18
EP2588616A1 (en) 2013-05-08
CN103459600B (zh) 2016-10-19
CA2803222A1 (en) 2012-01-05

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