EA201101399A1 - Гетероциклические соединения в качестве ингибиторов аутотаксина - Google Patents
Гетероциклические соединения в качестве ингибиторов аутотаксинаInfo
- Publication number
- EA201101399A1 EA201101399A1 EA201101399A EA201101399A EA201101399A1 EA 201101399 A1 EA201101399 A1 EA 201101399A1 EA 201101399 A EA201101399 A EA 201101399A EA 201101399 A EA201101399 A EA 201101399A EA 201101399 A1 EA201101399 A1 EA 201101399A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- heterocyclic compounds
- autotaxin inhibitors
- autotaxin
- inhibitors
- sup
- Prior art date
Links
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title abstract 2
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09004858 | 2009-04-02 | ||
| PCT/EP2010/001324 WO2010112116A1 (fr) | 2009-04-02 | 2010-03-03 | Composés hétérocycliques comme inhibiteurs de l'autotaxine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201101399A1 true EA201101399A1 (ru) | 2012-08-30 |
Family
ID=42102768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201101399A EA201101399A1 (ru) | 2009-04-02 | 2010-03-03 | Гетероциклические соединения в качестве ингибиторов аутотаксина |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8841324B2 (fr) |
| EP (1) | EP2414327B1 (fr) |
| JP (1) | JP5767205B2 (fr) |
| KR (1) | KR20120027192A (fr) |
| CN (1) | CN102365271B (fr) |
| AR (1) | AR076006A1 (fr) |
| AU (1) | AU2010230646B2 (fr) |
| BR (1) | BRPI1009800A2 (fr) |
| CA (1) | CA2757413C (fr) |
| EA (1) | EA201101399A1 (fr) |
| ES (1) | ES2527788T3 (fr) |
| IL (1) | IL215258A0 (fr) |
| MX (1) | MX2011010207A (fr) |
| SG (1) | SG174520A1 (fr) |
| WO (1) | WO2010112116A1 (fr) |
| ZA (1) | ZA201107986B (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2623491A3 (fr) * | 2009-04-02 | 2014-07-30 | Merck Patent GmbH | Dérivés pipéridines et pipérazines comme inhibiteurs de l'autotaxine |
| HRP20161774T1 (hr) | 2012-06-13 | 2017-02-24 | F. Hoffmann - La Roche Ag | Novi diazaspirocikloalkan i azaspirocikloalkan |
| BR112015004111A2 (pt) * | 2012-09-25 | 2017-07-04 | Hoffmann La Roche | novos derivados bicíclicos |
| ES2715682T3 (es) * | 2012-12-19 | 2019-06-05 | Novartis Ag | Inhibidores de la autotaxina |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| MX368059B (es) | 2013-07-18 | 2019-09-18 | Novartis Ag | Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica. |
| EP3022201A1 (fr) * | 2013-07-18 | 2016-05-25 | Novartis AG | Inhibiteurs de l'autotaxine |
| JP2016530209A (ja) | 2013-09-17 | 2016-09-29 | ファーマケア，インク． | ビニルオートタキシン阻害剤化合物 |
| US9951026B2 (en) | 2013-09-17 | 2018-04-24 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| JP2016531874A (ja) * | 2013-09-26 | 2016-10-13 | ファーマケア，インク． | オートタキシン阻害剤化合物 |
| EA201690880A1 (ru) | 2013-11-22 | 2016-12-30 | Фармакеа, Инк. | Тетрациклические ингибиторы аутотаксина |
| EP3878848A1 (fr) * | 2013-11-22 | 2021-09-15 | Sabre Therapeutics LLC | Composés d'indole inhibant l'autotaxine |
| KR20160087900A (ko) | 2013-11-26 | 2016-07-22 | 에프. 호프만-라 로슈 아게 | 신규한 옥타하이드로-사이클로부타[1,2-c；3,4-c'']다이피롤-2-일 |
| SI3122750T1 (sl) | 2014-03-26 | 2019-12-31 | F. Hoffmann-La Roche Ag | Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA) |
| KR20160128428A (ko) | 2014-03-26 | 2016-11-07 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 및 리소포스파티드산(lpa) 생성 억제제로서의 축합형 [1,4]다이아제핀 화합물 |
| SG11201607920RA (en) | 2014-04-04 | 2016-10-28 | X Rx Inc | Substituted spirocyclic inhibitors of autotaxin |
| EP3134398A1 (fr) | 2014-04-24 | 2017-03-01 | Novartis Ag | Inhibiteurs de l'autotaxine |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| KR20170103960A (ko) * | 2015-01-20 | 2017-09-13 | 노파르티스 아게 | Pet 영상화제 |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| EP4026549A1 (fr) | 2015-05-27 | 2022-07-13 | Sabre Therapeutics LLC | Inhibiteurs de l'autotaxine et leurs utilisations |
| HK1252425A1 (zh) | 2015-06-05 | 2019-05-24 | Vertex Pharmaceuticals Incorporated | 用於治疗脱髓鞘疾病的三唑类药物 |
| JP6886967B2 (ja) | 2015-09-04 | 2021-06-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | フェノキシメチル誘導体 |
| CN107635995B (zh) | 2015-09-24 | 2022-08-19 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
| RU2018112230A (ru) | 2015-09-24 | 2019-10-30 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов atx |
| AU2016328365B2 (en) | 2015-09-24 | 2020-04-23 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| JP6877413B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| WO2018106646A1 (fr) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles pour traiter des maladies démyélinisantes |
| WO2018106643A1 (fr) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Azoles hétérocycliques pour le traitement de maladies de démyélinisation |
| WO2018106641A1 (fr) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles pour le traitement de maladies démyélinisantes |
| EP3596059B1 (fr) | 2017-03-16 | 2024-04-24 | F. Hoffmann-La Roche AG | Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca |
| WO2018167113A1 (fr) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| KR101966286B1 (ko) | 2018-01-26 | 2019-04-05 | 조재석 | 소변의 비산 방지용 양변기 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| EP1187633A4 (fr) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | Utilisation d'anticorps anti-vegf pour accentuer le rayonnement lors d'une therapie anticancereuse |
| DE10050236A1 (de) * | 2000-10-11 | 2002-04-25 | Merck Patent Gmbh | Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen |
| CA2443108A1 (fr) * | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | Antagonistes de nmda/nr2b nonaryl-heterocyclo amidyle n-substitues |
| DE10210779A1 (de) * | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
| JP2006514066A (ja) * | 2003-01-03 | 2006-04-27 | シーブイ・セラピューティクス・インコーポレイテッド | 置換ヘテロ環化合物 |
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
-
2010
- 2010-03-03 BR BRPI1009800A patent/BRPI1009800A2/pt not_active Application Discontinuation
- 2010-03-03 US US13/259,464 patent/US8841324B2/en not_active Expired - Fee Related
- 2010-03-03 MX MX2011010207A patent/MX2011010207A/es not_active Application Discontinuation
- 2010-03-03 ES ES10706554.2T patent/ES2527788T3/es active Active
- 2010-03-03 EP EP10706554.2A patent/EP2414327B1/fr not_active Not-in-force
- 2010-03-03 CA CA2757413A patent/CA2757413C/fr not_active Expired - Fee Related
- 2010-03-03 KR KR1020117025897A patent/KR20120027192A/ko not_active Withdrawn
- 2010-03-03 WO PCT/EP2010/001324 patent/WO2010112116A1/fr not_active Ceased
- 2010-03-03 CN CN201080014895.4A patent/CN102365271B/zh not_active Expired - Fee Related
- 2010-03-03 SG SG2011068640A patent/SG174520A1/en unknown
- 2010-03-03 AU AU2010230646A patent/AU2010230646B2/en not_active Ceased
- 2010-03-03 EA EA201101399A patent/EA201101399A1/xx unknown
- 2010-03-03 JP JP2012502478A patent/JP5767205B2/ja not_active Expired - Fee Related
- 2010-03-31 AR ARP100101048A patent/AR076006A1/es unknown
-
2011
- 2011-09-20 IL IL215258A patent/IL215258A0/en active IP Right Grant
- 2011-11-01 ZA ZA2011/07986A patent/ZA201107986B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2414327A1 (fr) | 2012-02-08 |
| IL215258A0 (en) | 2011-12-29 |
| MX2011010207A (es) | 2011-10-14 |
| EP2414327B1 (fr) | 2014-11-19 |
| AU2010230646A1 (en) | 2011-11-17 |
| WO2010112116A1 (fr) | 2010-10-07 |
| US8841324B2 (en) | 2014-09-23 |
| KR20120027192A (ko) | 2012-03-21 |
| CA2757413C (fr) | 2017-01-10 |
| US20120015959A1 (en) | 2012-01-19 |
| CN102365271A (zh) | 2012-02-29 |
| BRPI1009800A2 (pt) | 2016-03-15 |
| AU2010230646B2 (en) | 2015-11-26 |
| JP2012522733A (ja) | 2012-09-27 |
| SG174520A1 (en) | 2011-10-28 |
| CA2757413A1 (fr) | 2010-10-07 |
| AR076006A1 (es) | 2011-05-11 |
| JP5767205B2 (ja) | 2015-08-19 |
| ZA201107986B (en) | 2012-07-25 |
| CN102365271B (zh) | 2014-05-14 |
| ES2527788T3 (es) | 2015-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201101399A1 (ru) | Гетероциклические соединения в качестве ингибиторов аутотаксина | |
| EA201200119A1 (ru) | Гетероциклические соединения в качестве ингибиторов аутотаксина | |
| EA201100880A1 (ru) | Бензонафтиридиновые соединения в качестве ингибиторов аутотаксина | |
| EA201200653A1 (ru) | Гетариламинохинолины | |
| EA201100125A1 (ru) | Производные пирролопиридинилпиримидин-2-иламина | |
| EA201300873A1 (ru) | Производные 7-азаиндола | |
| EA201000558A1 (ru) | Производные имидазола | |
| EA201201170A1 (ru) | Гетариламинонафтиридины | |
| EA201000004A1 (ru) | Производные 6-(пирролопиридинил)пиримидин-2-иламина и их применение для лечения злокачественного новообразования и спида | |
| EA201000549A1 (ru) | Производные пиперидина и пиперазина | |
| EA201300282A1 (ru) | Производные триазолопиразина | |
| EA201101585A1 (ru) | 3-(1,2,3-триазол-4-ил)пирроло[2,3-b]пиридинпроизводные | |
| EA201000094A1 (ru) | Производные пиримидинил-пиридазинона | |
| EA201100966A1 (ru) | Производные пиридазинона | |
| EA201001005A1 (ru) | Производные 2-бензилпиридазинона в качестве ингибиторов мет киназы | |
| EA201001359A1 (ru) | Гетероциклические соединения в качестве ингибиторов cxcr2 | |
| EA200901611A1 (ru) | Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей | |
| EA201171210A1 (ru) | Производные оксадиазола | |
| EA200901601A1 (ru) | Производные пиридазинона | |
| EA201000550A1 (ru) | Производные тиазола | |
| EA201201081A1 (ru) | Производные гетарил[1,8]нафтиридина | |
| EA201401081A1 (ru) | Циклические амиды в качестве ингибиторов метар-2 | |
| EA201300442A1 (ru) | ПИРРОЛИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ MetAP-2 | |
| EA201001648A1 (ru) | Производные пиридазинона | |
| EA201001358A1 (ru) | Активаторы глюкокиназы |