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EA201070898A1 - Новое производное хиназолин-2,4-диона и лекарственные композиции на его основе для профилактики и лечения заболевания, обусловленного поражением черепно-мозгового нерва - Google Patents

Новое производное хиназолин-2,4-диона и лекарственные композиции на его основе для профилактики и лечения заболевания, обусловленного поражением черепно-мозгового нерва

Info

Publication number
EA201070898A1
EA201070898A1 EA201070898A EA201070898A EA201070898A1 EA 201070898 A1 EA201070898 A1 EA 201070898A1 EA 201070898 A EA201070898 A EA 201070898A EA 201070898 A EA201070898 A EA 201070898A EA 201070898 A1 EA201070898 A1 EA 201070898A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivative
disease
hinazolin
diona
prevention
Prior art date
Application number
EA201070898A
Other languages
English (en)
Other versions
EA018142B1 (ru
Inventor
Ил Хван Чо
Еун Банг Ли
Син Чеол Канг
Вон Сеок Ким
Чул Киу Ли
Original Assignee
Син Поонг Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Син Поонг Фармасьютикал Ко., Лтд. filed Critical Син Поонг Фармасьютикал Ко., Лтд.
Publication of EA201070898A1 publication Critical patent/EA201070898A1/ru
Publication of EA018142B1 publication Critical patent/EA018142B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новому производному хиназолин-2-4-диона формулы (I), к его фармацевтически приемлемой соли и к фармацевтической композиции, содержащей соединение формулы (I) в качестве активного ингредиента для предотвращения или лечения неврологического заболевания мозга.
EA201070898A 2008-01-30 2009-01-08 Производное хиназолин-2,4-диона и лекарственные композиции на его основе для профилактики и лечения заболевания, обусловленного поражением черепно-мозгового нерва EA018142B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080009390 2008-01-30
PCT/KR2009/000083 WO2009096667A2 (ko) 2008-01-30 2009-01-08 신규한 퀴나졸린-2,4-디온 유도체 및 이를 함유하는 뇌신경질환 예방 및 치료용 의약 조성물

Publications (2)

Publication Number Publication Date
EA201070898A1 true EA201070898A1 (ru) 2011-02-28
EA018142B1 EA018142B1 (ru) 2013-05-30

Family

ID=40913386

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070898A EA018142B1 (ru) 2008-01-30 2009-01-08 Производное хиназолин-2,4-диона и лекарственные композиции на его основе для профилактики и лечения заболевания, обусловленного поражением черепно-мозгового нерва

Country Status (20)

Country Link
US (2) US8404696B2 (ru)
EP (1) EP2239257B1 (ru)
JP (1) JP5291124B2 (ru)
KR (1) KR101075435B1 (ru)
CN (1) CN101925585B (ru)
AR (1) AR074372A1 (ru)
AU (1) AU2009209811B2 (ru)
BR (1) BRPI0906996B1 (ru)
CA (1) CA2712819C (ru)
CO (1) CO6290762A2 (ru)
DK (1) DK2239257T3 (ru)
EA (1) EA018142B1 (ru)
ES (1) ES2387539T3 (ru)
IL (1) IL206738A (ru)
MY (1) MY153733A (ru)
NZ (1) NZ586552A (ru)
PL (1) PL2239257T3 (ru)
PT (1) PT2239257E (ru)
WO (1) WO2009096667A2 (ru)
ZA (1) ZA201004546B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY153733A (en) 2008-01-30 2015-03-13 Shin Poong Pharmaceutical Co Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same
US8337902B2 (en) * 2008-09-25 2012-12-25 Wisconsin Alumni Research Foundation Degradation of prion protein and reduced prion infectivity by earthworm homogenates
SG194154A1 (en) * 2011-05-02 2013-11-29 Fina Technology Process for ethylbenzene production
RU2708673C2 (ru) * 2014-01-20 2019-12-11 Велл Стоун Ко. Ускоритель продуцирования катехоламина и терапевтическое и профилактическое средство и терапевтическая и профилактическая пищевая композиция для заболеваний, обусловленных недостаточностью катехоламина
WO2016203327A1 (en) * 2015-06-15 2016-12-22 Koninklijke Philips N.V. Oral cleaning device with improved nozzle design

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9400680D0 (en) * 1994-01-14 1994-03-09 Sandoz Ltd Improvements in or relating to organic compounds
CZ295565B6 (cs) 1996-05-15 2005-08-17 Pfizer Inc. 2,3-Disubstituované 4(3H)-chinazolinony, jejich použití a farmaceutické kompozice na jejich bázi
US6060479A (en) 1997-06-09 2000-05-09 Pfizer Inc Quinazoline-4-one AMPA antagonists
HUP0104952A3 (en) * 1999-11-01 2006-02-28 Daiichi Asubio Pharma Co Ltd Inhibitors against vascular lipid deposition containing chymase-inhibiting substances
OA12316A (en) * 2000-01-24 2006-05-15 Warner Lambert Co 3-Aminoquinazolin-2,4-dione antibacterial agents.
WO2002083651A2 (en) * 2001-04-11 2002-10-24 Queen's University At Kingston Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
DE10201240A1 (de) * 2002-01-15 2003-07-24 Bayer Ag Substituierte Alkyluracile und ihre Verwendung
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
TWI396543B (zh) * 2005-05-12 2013-05-21 Sankyo Co 取代丙烯醯胺衍生物及含有它之醫藥組成物
WO2008112715A2 (en) 2007-03-12 2008-09-18 Vm Discovery Inc. Novel agents of calcium ion channel modulators
MY153733A (en) 2008-01-30 2015-03-13 Shin Poong Pharmaceutical Co Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same

Also Published As

Publication number Publication date
EP2239257B1 (en) 2012-06-06
IL206738A0 (en) 2010-12-30
JP5291124B2 (ja) 2013-09-18
CA2712819A1 (en) 2009-08-06
US9290480B2 (en) 2016-03-22
CN101925585B (zh) 2013-04-17
AR074372A1 (es) 2011-01-12
KR101075435B1 (ko) 2011-10-24
PT2239257E (pt) 2012-09-12
US8404696B2 (en) 2013-03-26
DK2239257T3 (da) 2012-08-13
PL2239257T3 (pl) 2012-10-31
US20130102622A1 (en) 2013-04-25
CO6290762A2 (es) 2011-06-20
WO2009096667A4 (ko) 2009-12-03
BRPI0906996A2 (pt) 2015-07-07
CN101925585A (zh) 2010-12-22
AU2009209811A1 (en) 2009-08-06
EP2239257A4 (en) 2011-06-22
KR20090083848A (ko) 2009-08-04
IL206738A (en) 2014-05-28
NZ586552A (en) 2012-06-29
WO2009096667A3 (ko) 2009-10-08
US20100311769A1 (en) 2010-12-09
BRPI0906996B1 (pt) 2021-06-22
WO2009096667A2 (ko) 2009-08-06
AU2009209811B2 (en) 2011-07-21
CA2712819C (en) 2013-07-23
HK1149263A1 (en) 2011-09-30
MY153733A (en) 2015-03-13
EA018142B1 (ru) 2013-05-30
JP2011510978A (ja) 2011-04-07
EP2239257A2 (en) 2010-10-13
ES2387539T3 (es) 2012-09-25
ZA201004546B (en) 2011-04-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM