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BRPI0907844B8 - compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos - Google Patents

compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos

Info

Publication number
BRPI0907844B8
BRPI0907844B8 BRPI0907844A BRPI0907844A BRPI0907844B8 BR PI0907844 B8 BRPI0907844 B8 BR PI0907844B8 BR PI0907844 A BRPI0907844 A BR PI0907844A BR PI0907844 A BRPI0907844 A BR PI0907844A BR PI0907844 B8 BRPI0907844 B8 BR PI0907844B8
Authority
BR
Brazil
Prior art keywords
compounds
androgen receptor
modulating
formulas
pharmaceutical composition
Prior art date
Application number
BRPI0907844A
Other languages
English (en)
Inventor
P Miller Chris
Original Assignee
Radius Health Inc
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Health Inc, Radius Pharmaceuticals Inc filed Critical Radius Health Inc
Publication of BRPI0907844A2 publication Critical patent/BRPI0907844A2/pt
Publication of BRPI0907844B1 publication Critical patent/BRPI0907844B1/pt
Publication of BRPI0907844B8 publication Critical patent/BRPI0907844B8/pt

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Abstract

moduladores seletivos do receptor de andrógeno. a presente invenção refere-se a compostos de formulas (i), la, ib, ic, id, le e ou seus sais, composições farmacêuticas que compreendem um composto de fórmulas i, la, ib, ic, id, le e um excipiente farmaceuticamente aceitável,métodos para modular o receptor de andrógeno, métodos para tratar doenças beneficamente tratadas por um modulador de andrógeno (por exemplo, sarcopenia, câncer da próstata, anticoncepção, distúrbios ou doenças relacionadas com a diabetes tipo 2, anemia, depressão e doença renal) e processos para preparar os compostos de fórmulas (i), la, ib, ic, id,le e intermediários úteis na preparação dos mesmos.
BRPI0907844A 2008-02-22 2009-02-19 compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos BRPI0907844B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6669708P 2008-02-22 2008-02-22
US61/066,697 2008-02-22
US13235308P 2008-06-18 2008-06-18
US61/132,353 2008-06-18
US20572709P 2009-01-21 2009-01-21
US61/205,727 2009-01-21
PCT/US2009/001035 WO2009105214A2 (en) 2008-02-22 2009-02-19 Selective androgen receptor modulators

Publications (3)

Publication Number Publication Date
BRPI0907844A2 BRPI0907844A2 (pt) 2018-01-30
BRPI0907844B1 BRPI0907844B1 (pt) 2020-08-18
BRPI0907844B8 true BRPI0907844B8 (pt) 2021-05-25

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BRPI0907844A BRPI0907844B8 (pt) 2008-02-22 2009-02-19 compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos

Country Status (9)

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US (2) US8067448B2 (pt)
EP (1) EP2260028B1 (pt)
JP (1) JP5308458B2 (pt)
AU (1) AU2009215843B2 (pt)
BR (1) BRPI0907844B8 (pt)
CA (1) CA2716320C (pt)
ES (1) ES2488990T3 (pt)
MX (1) MX2010009162A (pt)
WO (1) WO2009105214A2 (pt)

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US8268872B2 (en) * 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
CA2788907A1 (en) 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
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AU2011258009B2 (en) * 2010-05-28 2016-04-21 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds and their use
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
FI20105806A0 (fi) * 2010-07-15 2010-07-15 Medeia Therapeutics Ltd Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia
JP5965909B2 (ja) 2010-09-28 2016-08-10 ラジウス ヘルス，インコーポレイテッド 選択的アンドロゲン受容体モジュレーター
WO2013042782A1 (ja) 2011-09-22 2013-03-28 武田薬品工業株式会社 縮合複素環化合物
AR088082A1 (es) 2011-10-13 2014-05-07 Lilly Co Eli Moduladores selectivos del receptor androgeno
WO2014087298A1 (en) * 2012-12-03 2014-06-12 Pfizer Inc. Novel selective androgen receptor modulators
CA2943611A1 (en) 2014-03-28 2015-10-01 Duke University Method of treating cancer using selective estrogen receptor modulators
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MX2016015467A (es) * 2014-05-30 2017-03-23 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos.
CA3027563C (en) 2016-06-22 2024-07-02 Ellipses Pharma Ltd AR+ METHODS FOR BREAST CANCER TREATMENT
DE112017003415T5 (de) 2016-07-07 2019-03-28 Mark, S. Stern Dornfortsatz-laminaklemmvorrichtung
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US20090253758A1 (en) 2009-10-08
CA2716320A1 (en) 2009-08-27
BRPI0907844B1 (pt) 2020-08-18
JP2011513219A (ja) 2011-04-28
AU2009215843A1 (en) 2009-08-27
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US8067448B2 (en) 2011-11-29
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