EA201000803A1 - Производные хинолина и их применение - Google Patents
Производные хинолина и их применениеInfo
- Publication number
- EA201000803A1 EA201000803A1 EA201000803A EA201000803A EA201000803A1 EA 201000803 A1 EA201000803 A1 EA 201000803A1 EA 201000803 A EA201000803 A EA 201000803A EA 201000803 A EA201000803 A EA 201000803A EA 201000803 A1 EA201000803 A1 EA 201000803A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- application
- quinoline derivatives
- psoriasis
- atherosclerosis
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000001344 Macular Edema Diseases 0.000 abstract 1
- 206010025415 Macular oedema Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 201000010230 macular retinal edema Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Соединение формулы (I)а также его фармацевтически приемлемые соли. Фармацевтическая композиция, содержащая терапевтически эффективное количество соединения. Соединение является применимым для лечения рака, диабетической ретинопатии, связанной с возрастом дегенерации желтого пятна, воспаления, "удара" (мозгового кровоизлияния), ишемии миокарда, атеросклероза, макулярного отека или псориаза.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98814707P | 2007-11-15 | 2007-11-15 | |
| EP07120799 | 2007-11-15 | ||
| PCT/EP2008/065596 WO2009063070A2 (en) | 2007-11-15 | 2008-11-14 | Quinoline derivatives and their use as tyrosine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201000803A1 true EA201000803A1 (ru) | 2011-02-28 |
| EA018798B1 EA018798B1 (ru) | 2013-10-30 |
Family
ID=39295948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201000803A EA018798B1 (ru) | 2007-11-15 | 2008-11-14 | Производные хинолина и их применение |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8557843B2 (ru) |
| EP (1) | EP2220047B1 (ru) |
| JP (1) | JP5565841B2 (ru) |
| KR (1) | KR101572929B1 (ru) |
| CN (1) | CN103476755B (ru) |
| AU (1) | AU2008322858B2 (ru) |
| BR (1) | BRPI0820210A2 (ru) |
| CA (1) | CA2705820C (ru) |
| DK (1) | DK2220047T3 (ru) |
| EA (1) | EA018798B1 (ru) |
| ES (1) | ES2540219T3 (ru) |
| HR (1) | HRP20150583T1 (ru) |
| HU (1) | HUE025421T2 (ru) |
| IL (1) | IL205308A (ru) |
| MX (1) | MX2010005039A (ru) |
| NZ (1) | NZ585090A (ru) |
| PL (1) | PL2220047T3 (ru) |
| PT (1) | PT2220047E (ru) |
| RS (1) | RS54061B1 (ru) |
| SI (1) | SI2220047T1 (ru) |
| WO (1) | WO2009063070A2 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592592B2 (en) | 2010-04-02 | 2013-11-26 | Senomyx, Inc. | Sweet flavor modifier |
| AU2012295255B2 (en) | 2011-08-12 | 2016-04-21 | Senomyx, Inc. | Sweet flavor modifier |
| US9376393B2 (en) | 2012-01-05 | 2016-06-28 | Clanotech Ab | Quinoline compounds which are anti-angiogenic integrin alpha5 beta1 inhibitors for use in the treatment of fibrosis or fibrosis-related diseases |
| CA2963901A1 (en) | 2014-11-07 | 2016-05-12 | Senomyx, Inc. | Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
| GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| GB0324270D0 (en) * | 2003-10-16 | 2003-11-19 | Univ Edinburgh | Improved control of ES cell self-renewal and lineage specification, and medium therefor |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| WO2007139496A1 (en) * | 2006-05-30 | 2007-12-06 | Clanotech Ab | Quinoline derivatives acting as tyrosine kinase inhibitors |
| WO2008119771A2 (en) * | 2007-03-30 | 2008-10-09 | Clanotech Ab | Quinoline-s-carboxylic acid derivatives as tyrosine kinase inhibitors |
-
2008
- 2008-11-14 AU AU2008322858A patent/AU2008322858B2/en active Active
- 2008-11-14 BR BRPI0820210A patent/BRPI0820210A2/pt not_active Application Discontinuation
- 2008-11-14 EA EA201000803A patent/EA018798B1/ru not_active IP Right Cessation
- 2008-11-14 CN CN200880116202.5A patent/CN103476755B/zh active Active
- 2008-11-14 EP EP20080850996 patent/EP2220047B1/en active Active
- 2008-11-14 NZ NZ585090A patent/NZ585090A/en not_active IP Right Cessation
- 2008-11-14 CA CA2705820A patent/CA2705820C/en active Active
- 2008-11-14 KR KR1020107013103A patent/KR101572929B1/ko not_active Expired - Fee Related
- 2008-11-14 JP JP2010533600A patent/JP5565841B2/ja not_active Expired - Fee Related
- 2008-11-14 SI SI200831443T patent/SI2220047T1/sl unknown
- 2008-11-14 DK DK08850996.3T patent/DK2220047T3/en active
- 2008-11-14 US US12/742,944 patent/US8557843B2/en active Active
- 2008-11-14 RS RS20150411A patent/RS54061B1/sr unknown
- 2008-11-14 HU HUE08850996A patent/HUE025421T2/en unknown
- 2008-11-14 MX MX2010005039A patent/MX2010005039A/es active IP Right Grant
- 2008-11-14 HR HRP20150583TT patent/HRP20150583T1/hr unknown
- 2008-11-14 PT PT88509963T patent/PT2220047E/pt unknown
- 2008-11-14 WO PCT/EP2008/065596 patent/WO2009063070A2/en not_active Ceased
- 2008-11-14 PL PL08850996T patent/PL2220047T3/pl unknown
- 2008-11-14 ES ES08850996.3T patent/ES2540219T3/es active Active
-
2010
- 2010-04-25 IL IL205308A patent/IL205308A/en active IP Right Grant
-
2013
- 2013-08-30 US US14/014,867 patent/US8957092B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2705820C (en) | 2016-06-07 |
| EP2220047A2 (en) | 2010-08-25 |
| SI2220047T1 (sl) | 2015-07-31 |
| KR101572929B1 (ko) | 2015-11-30 |
| JP5565841B2 (ja) | 2014-08-06 |
| AU2008322858B2 (en) | 2013-05-02 |
| ES2540219T3 (es) | 2015-07-09 |
| CA2705820A1 (en) | 2009-05-22 |
| JP2011503151A (ja) | 2011-01-27 |
| IL205308A0 (en) | 2010-12-30 |
| WO2009063070A2 (en) | 2009-05-22 |
| CN103476755A (zh) | 2013-12-25 |
| WO2009063070A3 (en) | 2009-07-23 |
| HRP20150583T1 (hr) | 2015-07-31 |
| NZ585090A (en) | 2011-09-30 |
| RS54061B1 (sr) | 2015-10-30 |
| EA018798B1 (ru) | 2013-10-30 |
| PT2220047E (pt) | 2015-07-30 |
| AU2008322858A1 (en) | 2009-05-22 |
| HUE025421T2 (en) | 2016-02-29 |
| DK2220047T3 (en) | 2015-06-29 |
| US8557843B2 (en) | 2013-10-15 |
| US8957092B2 (en) | 2015-02-17 |
| KR20100097158A (ko) | 2010-09-02 |
| US20140018388A1 (en) | 2014-01-16 |
| BRPI0820210A2 (pt) | 2017-05-09 |
| MX2010005039A (es) | 2010-07-30 |
| PL2220047T3 (pl) | 2015-08-31 |
| EP2220047B1 (en) | 2015-05-06 |
| US20110053976A1 (en) | 2011-03-03 |
| IL205308A (en) | 2015-03-31 |
| CN103476755B (zh) | 2015-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |