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EA201000106A1 - Соли периндоприла - Google Patents

Соли периндоприла

Info

Publication number
EA201000106A1
EA201000106A1 EA201000106A EA201000106A EA201000106A1 EA 201000106 A1 EA201000106 A1 EA 201000106A1 EA 201000106 A EA201000106 A EA 201000106A EA 201000106 A EA201000106 A EA 201000106A EA 201000106 A1 EA201000106 A1 EA 201000106A1
Authority
EA
Eurasian Patent Office
Prior art keywords
perindopril
salts
new
salt
salt perindopril
Prior art date
Application number
EA201000106A
Other languages
English (en)
Other versions
EA017835B1 (ru
Inventor
Марьо Мирславиц
Сергея Бомбек
Урска Гояк
Матей Смрколь
Рок Зупет
Original Assignee
Крка, Товарна Здравил, Д.Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Крка, Товарна Здравил, Д.Д., Ново Место filed Critical Крка, Товарна Здравил, Д.Д., Ново Место
Publication of EA201000106A1 publication Critical patent/EA201000106A1/ru
Publication of EA017835B1 publication Critical patent/EA017835B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к новым солям периндоприла, в частности к новой кальциевой соли и к новым аминосолям периндоприла, способу их получения и фармацевтическим препаратам, содержащим эти соли.
EA201000106A 2007-06-27 2008-06-27 Кальциевая соль периндоприла, фармацевтическая композиция, содержащая указанную соль, и способ получения такой композиции EA017835B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200700152A SI22543A (sl) 2007-06-27 2007-06-27 Nove soli perindoprila
PCT/EP2008/058258 WO2009000909A2 (en) 2007-06-27 2008-06-27 Salts of perindopril

Publications (2)

Publication Number Publication Date
EA201000106A1 true EA201000106A1 (ru) 2010-06-30
EA017835B1 EA017835B1 (ru) 2013-03-29

Family

ID=40184804

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000106A EA017835B1 (ru) 2007-06-27 2008-06-27 Кальциевая соль периндоприла, фармацевтическая композиция, содержащая указанную соль, и способ получения такой композиции

Country Status (11)

Country Link
US (1) US8470869B2 (ru)
EP (1) EP2162434B1 (ru)
CN (1) CN101754953A (ru)
AU (1) AU2008267198A1 (ru)
EA (1) EA017835B1 (ru)
HR (1) HRP20160616T1 (ru)
RS (1) RS54855B1 (ru)
SI (1) SI22543A (ru)
UA (1) UA105167C2 (ru)
WO (1) WO2009000909A2 (ru)
ZA (1) ZA201000578B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2558099C2 (ru) * 2012-12-11 2015-07-27 Общество с ограниченной ответственностью "Трейдсервис" Комбинированное лекарственное средство для лечения артериальной гипертензии у больных сахарным диабетом
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules
CN118717697B (zh) * 2024-09-04 2025-03-25 杭州沐源生物医药科技有限公司 一种盐酸贝尼地平片组合物及其制备方法和应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2771010B1 (fr) 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
GB2395195A (en) 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
BRPI0411966A (pt) 2003-06-24 2006-08-29 Servier Lab formas cristalinas de perindopril erbumina
AU2003300689B2 (en) * 2003-10-21 2009-01-29 Les Laboratoires Servier Novel method for preparation of crystalline perindopril erbumine
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
SI21704A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
HRP20161602T1 (hr) 2004-03-29 2016-12-30 Les Laboratoires Servier Postupak priprave čvrstog farmaceutskog pripravka
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21801A (sl) 2004-06-21 2005-12-31 Diagen D.O.O. Nov postopek za pripravo perindoprila v novi kristalni obliki
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
JP4547245B2 (ja) 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
RU2280450C1 (ru) 2004-12-29 2006-07-27 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Лекарственное средство, обладающее гипотензивным действием, и способ его изготовления
RU2282443C1 (ru) 2004-12-29 2006-08-27 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Лекарственное средство, обладающее антигипертензивным действием, и способ его изготовления
PL1861367T3 (pl) 2005-03-14 2009-12-31 Servier Lab Ulepszony sposób oczyszczania Perindoprylu
SK50252005A3 (sk) 2005-03-22 2006-10-05 Vúlm, A.S. Farmaceutický prípravok obsahujúci perindopril erbumín, spôsob jeho prípravy a stabilizácie
JP2006290825A (ja) 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2007017894A2 (en) 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
WO2007017893A2 (en) 2005-05-05 2007-02-15 Arch Pharmalabs Limited Preparation of novel crystalline form of perindopril erbumine monohydrate
AU2006278866B2 (en) 2005-07-25 2012-03-15 Lek Pharmaceuticals D.D. Process for the preparation of crystalline perindopril
US20090099370A1 (en) 2005-08-12 2009-04-16 Sandoz Ag Crystalline Form of Perindopril Erbumine
BRPI0614622A2 (pt) 2005-08-12 2011-04-12 Lek Pharmaceuticals processo para a preparação de perindopril erbumina
BRPI0615607A2 (pt) 2005-08-30 2011-05-24 Lek Pharmaceuticals composição farmacêutica compreendendo perindopril ou seus sais
PL1948224T3 (pl) 2005-11-17 2014-10-31 Silverstone Pharma Est Trwały preparat amorficznych soli peryndoprylu, sposób ich wytwarzania, zwłaszcza wytwarzania w skali przemysłowej oraz ich zastosowanie w terapii nadciśnienia
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
SI22542A (sl) 2007-06-04 2008-12-31 Diagen D.O.O. Stabilna formulacija amorfnih soli perindoprila, postopek za njeno pripravo v industrijskem merilu in njena uporaba za zdravljenje hipertenzije

Also Published As

Publication number Publication date
HRP20160616T1 (hr) 2016-07-01
UA105167C2 (ru) 2014-04-25
US8470869B2 (en) 2013-06-25
EP2162434B1 (en) 2016-03-16
SI22543A (sl) 2008-12-31
RS54855B1 (sr) 2016-10-31
WO2009000909A8 (en) 2009-02-12
CN101754953A (zh) 2010-06-23
EP2162434A2 (en) 2010-03-17
ZA201000578B (en) 2010-10-27
US20100298400A1 (en) 2010-11-25
AU2008267198A1 (en) 2008-12-31
EA017835B1 (ru) 2013-03-29
WO2009000909A3 (en) 2010-03-18
WO2009000909A2 (en) 2008-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM