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EA200901161A1 - Вакцина против гриппа в виде эмульсии типа "масло в воде" - Google Patents

Вакцина против гриппа в виде эмульсии типа "масло в воде"

Info

Publication number
EA200901161A1
EA200901161A1 EA200901161A EA200901161A EA200901161A1 EA 200901161 A1 EA200901161 A1 EA 200901161A1 EA 200901161 A EA200901161 A EA 200901161A EA 200901161 A EA200901161 A EA 200901161A EA 200901161 A1 EA200901161 A1 EA 200901161A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oil
level below
flu
emulsion
water
Prior art date
Application number
EA200901161A
Other languages
English (en)
Other versions
EA024250B1 (ru
Inventor
Уилльям Рипли Баллоу
Эммануэль Жюль Ханон
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0707697A external-priority patent/GB0707697D0/en
Priority claimed from GB0711357A external-priority patent/GB0711357D0/en
Priority claimed from GB0712062A external-priority patent/GB0712062D0/en
Priority claimed from PCT/EP2007/060743 external-priority patent/WO2008043774A1/en
Priority claimed from GB0724651A external-priority patent/GB0724651D0/en
Application filed by Глаксосмитклайн Байолоджикалс С.А. filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA200901161A1 publication Critical patent/EA200901161A1/ru
Publication of EA024250B1 publication Critical patent/EA024250B1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Согласно настоящему изобретению предложена иммуногенная композиция против гриппа в дозовом объеме, подходящем для применения у человека, содержащая антиген или антигенный препарат вируса гриппа в комбинации с адъювантом в виде эмульсии типа "масло в воде", где указанный адъювант в виде эмульсии типа "масло в воде" содержит метаболизируемое масло на уровне ниже 11 мг и эмульгатор на уровне ниже 5 мг, и возможно токол и/или стерол на уровне ниже 12 мг. Предпочтительно, количество антигена вируса гриппа на штамм на дозу составляет 15 мкг НА или низкое количество, такое как менее 15 мкг НА.
EA200901161A 2007-04-20 2008-04-16 Дозированная форма иммуногенного препарата против гриппа для применения у человека и содержащая её вакцина, способы их приготовления и их применение для лечения или предупреждения заболеваний, вызываемых вирусом гриппа у людей EA024250B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0707697A GB0707697D0 (en) 2007-04-20 2007-04-20 Vaccine
GB0711357A GB0711357D0 (en) 2007-06-12 2007-06-12 Vaccine
GB0712062A GB0712062D0 (en) 2007-06-21 2007-06-21 Vaccine
PCT/EP2007/060743 WO2008043774A1 (en) 2006-10-12 2007-10-10 Vaccine comprising an oil in water emulsion adjuvant
GB0724651A GB0724651D0 (en) 2007-12-18 2007-12-18 Vaccine
PCT/EP2008/054614 WO2008128939A1 (en) 2007-04-20 2008-04-16 Oil-in-water emulsion influenza vaccine

Publications (2)

Publication Number Publication Date
EA200901161A1 true EA200901161A1 (ru) 2010-06-30
EA024250B1 EA024250B1 (ru) 2016-08-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901161A EA024250B1 (ru) 2007-04-20 2008-04-16 Дозированная форма иммуногенного препарата против гриппа для применения у человека и содержащая её вакцина, способы их приготовления и их применение для лечения или предупреждения заболеваний, вызываемых вирусом гриппа у людей

Country Status (21)

Country Link
US (4) US9452209B2 (ru)
EP (2) EP2136837B1 (ru)
JP (1) JP2010524883A (ru)
KR (1) KR101188382B1 (ru)
CN (2) CN105311629A (ru)
AR (1) AR066405A1 (ru)
AT (1) ATE537841T1 (ru)
AU (1) AU2008240761B2 (ru)
BR (1) BRPI0810015B1 (ru)
CA (1) CA2683075C (ru)
CO (1) CO6251369A2 (ru)
CR (1) CR11122A (ru)
DO (1) DOP2009000239A (ru)
EA (1) EA024250B1 (ru)
ES (1) ES2377761T3 (ru)
IL (1) IL200859A (ru)
MA (1) MA31381B1 (ru)
PE (1) PE20090146A1 (ru)
TW (1) TW200908994A (ru)
WO (1) WO2008128939A1 (ru)
ZA (1) ZA200906753B (ru)

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