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EA200801892A1 - Способ получения 1-галоген-2,7-нафтиридинилпроизводных - Google Patents

Способ получения 1-галоген-2,7-нафтиридинилпроизводных

Info

Publication number
EA200801892A1
EA200801892A1 EA200801892A EA200801892A EA200801892A1 EA 200801892 A1 EA200801892 A1 EA 200801892A1 EA 200801892 A EA200801892 A EA 200801892A EA 200801892 A EA200801892 A EA 200801892A EA 200801892 A1 EA200801892 A1 EA 200801892A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
derivatives
naftyridinyl
halogen
Prior art date
Application number
EA200801892A
Other languages
English (en)
Other versions
EA014497B1 (ru
Inventor
Николас Дейвид Тиррелл
Нил Тремейн
Грэм Роберт Эванс
Original Assignee
Юсб Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юсб Фарма С.А. filed Critical Юсб Фарма С.А.
Publication of EA200801892A1 publication Critical patent/EA200801892A1/ru
Publication of EA014497B1 publication Critical patent/EA014497B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описан способ получения производных 1-галоген-2,7-нафтиридинила формулы (I)где X означает Cl или Br, причем указанный способ включает следующие стадии: (1) взаимодействие производного 3-циано-4-метилпиридина формулы (А)с соединением формулы (II)в присутствии ди(С-С)алкилацеталя N,N-диметилформамида, с образованием енамина формулы (III)(2) циклизацию енамина формулы (III) с образованием соединения формулы (IV)(3) реакцию соединения формулы (IV) с галогенирующим агентом с образованием соединения формулы (I).
EA200801892A 2006-03-22 2007-03-21 Способ получения 1-галоген-2,7-нафтиридинилпроизводных EA014497B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0605766.5A GB0605766D0 (en) 2006-03-22 2006-03-22 Process
PCT/EP2007/002485 WO2007107345A2 (en) 2006-03-22 2007-03-21 PROCESS FOR PREPARING l-HALO-2,7-NAPHTHYRIDINYL DERIVATIVES

Publications (2)

Publication Number Publication Date
EA200801892A1 true EA200801892A1 (ru) 2009-04-28
EA014497B1 EA014497B1 (ru) 2010-12-30

Family

ID=36383981

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801892A EA014497B1 (ru) 2006-03-22 2007-03-21 Способ получения 1-галоген-2,7-нафтиридинилпроизводных

Country Status (19)

Country Link
US (1) US20090221828A1 (ru)
EP (1) EP1999110B1 (ru)
JP (1) JP2009530336A (ru)
KR (1) KR20090028682A (ru)
CN (1) CN101405267A (ru)
AT (1) ATE443045T1 (ru)
AU (1) AU2007228939A1 (ru)
BR (1) BRPI0708560A2 (ru)
CA (1) CA2642452A1 (ru)
DE (1) DE602007002486D1 (ru)
EA (1) EA014497B1 (ru)
ES (1) ES2333628T3 (ru)
GB (1) GB0605766D0 (ru)
IL (1) IL193276A0 (ru)
MX (1) MX2008011858A (ru)
NZ (1) NZ570482A (ru)
PL (1) PL1999110T3 (ru)
WO (1) WO2007107345A2 (ru)
ZA (1) ZA200806896B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2729463B1 (en) * 2011-07-08 2015-07-29 Sanofi Substituted phenyl compounds
WO2019236879A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
EP4136066A1 (en) * 2020-04-17 2023-02-22 DSM IP Assets B.V. A process for preparation of substituted enamine compounds
CN111961047A (zh) * 2020-08-19 2020-11-20 南通大学 一种6-乙氧基-3,4-二氢-2,7-萘啶-1（2h）-酮及其合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859671A (en) * 1988-07-08 1989-08-22 American Home Products Corporation 2-substituted 1,2-benzisothiazol-3(2H)-one 1,1-dioxide useful as an anxiolytic agent
CN1285601C (zh) * 2000-11-30 2006-11-22 佳能株式会社 发光器件和显示器
GB0216571D0 (en) * 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1999110B1 (en) 2009-09-16
KR20090028682A (ko) 2009-03-19
EP1999110A2 (en) 2008-12-10
ZA200806896B (en) 2009-11-25
IL193276A0 (en) 2009-08-03
NZ570482A (en) 2010-07-30
WO2007107345A2 (en) 2007-09-27
CA2642452A1 (en) 2007-09-27
EA014497B1 (ru) 2010-12-30
AU2007228939A1 (en) 2007-09-27
ATE443045T1 (de) 2009-10-15
MX2008011858A (es) 2008-11-04
GB0605766D0 (en) 2006-05-03
PL1999110T3 (pl) 2010-02-26
JP2009530336A (ja) 2009-08-27
US20090221828A1 (en) 2009-09-03
BRPI0708560A2 (pt) 2011-06-07
CN101405267A (zh) 2009-04-08
DE602007002486D1 (de) 2009-10-29
ES2333628T3 (es) 2010-02-24
WO2007107345A3 (en) 2008-04-10

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU