MX2011008348A - Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion. - Google Patents
Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion.Info
- Publication number
- MX2011008348A MX2011008348A MX2011008348A MX2011008348A MX2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A
- Authority
- MX
- Mexico
- Prior art keywords
- coupling
- transition metal
- metal catalyst
- substituted heterocyclic
- heterocyclic derivative
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000010168 coupling process Methods 0.000 title abstract 2
- 238000005859 coupling reaction Methods 0.000 title abstract 2
- 239000003054 catalyst Substances 0.000 title 1
- 230000008878 coupling Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical class 0.000 title 1
- 229910052723 transition metal Inorganic materials 0.000 title 1
- 150000003624 transition metals Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000001431 Hyperuricemia Diseases 0.000 abstract 1
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 150000003623 transition metal compounds Chemical class 0.000 abstract 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un proceso para producir eficientemente, a través de pocos pasos, ya sea un inhibidor de xantina oxidasa, que sea un agente terapéutico para hiperuricemia, o un intermediario del mismo. El proceso es un proceso novedoso de acoplamiento que comprende someter un compuesto representado por la fórmula (1) a reacción de acoplamiento con un compuesto representado por la fórmula (2) en presencia de un compuesto de metal de transición para así obtener un compuesto representado por la fórmula (3).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009046003 | 2009-02-27 | ||
| JP2009153770 | 2009-06-29 | ||
| PCT/JP2010/053043 WO2010098428A1 (ja) | 2009-02-27 | 2010-02-26 | 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011008348A true MX2011008348A (es) | 2011-09-01 |
Family
ID=42665632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011008348A MX2011008348A (es) | 2009-02-27 | 2010-02-26 | Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8952174B2 (es) |
| EP (2) | EP2404908B1 (es) |
| JP (1) | JP5312570B2 (es) |
| KR (1) | KR101639834B1 (es) |
| CN (1) | CN102333765B (es) |
| AU (1) | AU2010218748B2 (es) |
| BR (1) | BRPI1008308B8 (es) |
| CA (1) | CA2752485C (es) |
| DK (1) | DK2404908T3 (es) |
| ES (1) | ES2459722T3 (es) |
| IL (1) | IL214302A (es) |
| MX (1) | MX2011008348A (es) |
| PL (1) | PL2404908T3 (es) |
| PT (1) | PT2404908E (es) |
| RU (1) | RU2510393C9 (es) |
| SG (1) | SG173884A1 (es) |
| TW (1) | TWI466874B (es) |
| WO (1) | WO2010098428A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101800054B1 (ko) * | 2010-08-27 | 2017-11-21 | 데이진 화-마 가부시키가이샤 | 팔라듐 화합물을 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법 |
| CN102234253B (zh) * | 2011-06-02 | 2013-07-03 | 重庆莱美药业股份有限公司 | 一种制备非布索坦中间体的方法 |
| CN103910694B (zh) * | 2012-12-29 | 2016-08-24 | 广东东阳光药业有限公司 | 一种2-芳基腈噻唑衍生物的制备方法 |
| US20170144987A1 (en) * | 2014-05-13 | 2017-05-25 | Teijin Pharma Limited | Novel crystalline polymorphs of pyridine derivative and method for producing the same |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| CN110066258A (zh) * | 2018-01-23 | 2019-07-30 | 湘北威尔曼制药股份有限公司 | 噻唑-5-甲酸衍生物及其制备方法与应用 |
| CN109293597B (zh) * | 2018-10-29 | 2022-05-10 | 安徽省庆云医药股份有限公司 | 一种非布索坦的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346094A (en) | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4495195A (en) | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| JP2591632B2 (ja) | 1987-12-18 | 1997-03-19 | 株式会社トプコン | 真空吸引装置 |
| DK0513379T3 (da) | 1990-11-30 | 1996-09-30 | Teijin Ltd | 2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne |
| JP3399559B2 (ja) | 1992-08-12 | 2003-04-21 | 帝人株式会社 | ２−フェニル複素環式化合物 |
| JP3113110B2 (ja) | 1993-01-19 | 2000-11-27 | 帝人株式会社 | イソキサゾールおよびイソチアゾール誘導体 |
| JP3169735B2 (ja) | 1993-04-08 | 2001-05-28 | 帝人株式会社 | （アルコキシシアノフェニル）チアゾール誘導体の製造方法 |
| JP2706037B2 (ja) | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
| JP2834971B2 (ja) | 1993-05-25 | 1998-12-14 | 帝人株式会社 | ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法およびその新規製造中間体 |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JPH10139770A (ja) | 1996-11-08 | 1998-05-26 | Teijin Ltd | ２−（３−シアノフェニル）チアゾール誘導体の製造法 |
| JPH10310578A (ja) | 1996-11-13 | 1998-11-24 | Yoshitomi Pharmaceut Ind Ltd | ３−フェニルピラゾール化合物 |
| JP3440196B2 (ja) | 1997-08-13 | 2003-08-25 | 帝人株式会社 | チオベンズアミド誘導体の製造方法 |
| AU780205B2 (en) | 2000-02-23 | 2005-03-10 | Alteon Inc. | Thiazolium compounds and treatments of disorders associated with protein aging |
| WO2002051849A1 (en) | 2000-12-26 | 2002-07-04 | Daiichi Pharmaceutical Co., Ltd. | Cdk4 inhibitors |
| TWI314928B (en) * | 2002-02-28 | 2009-09-21 | Novartis A | 5-phenylthiazole derivatives and use as pi3 kinase inhibitors |
| CA2755297A1 (en) * | 2003-02-10 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Processes for the preparation of n-heteroaryl-n-aryl-amines by reacting an n-aryl carbamic acid ester with a halo-heteroaryl and analogous processes |
| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
| AU2005210474B2 (en) | 2004-01-30 | 2011-07-07 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding cassette transporters |
| EP1783116B1 (en) | 2004-08-27 | 2009-08-26 | Astellas Pharma Inc. | 2-phenylpyridine derivative |
| JP5040656B2 (ja) | 2005-10-07 | 2012-10-03 | アステラス製薬株式会社 | トリアリールカルボン酸誘導体 |
| PL1992361T3 (pl) | 2006-02-24 | 2012-10-31 | Astellas Pharma Inc | Środek do leczenia lub zapobiegania wrzodowi trawiennemu |
| JP2012096999A (ja) | 2009-02-27 | 2012-05-24 | Nagoya Univ | ニッケル触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
| KR101800054B1 (ko) | 2010-08-27 | 2017-11-21 | 데이진 화-마 가부시키가이샤 | 팔라듐 화합물을 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법 |
-
2010
- 2010-02-26 CN CN201080009880.9A patent/CN102333765B/zh active Active
- 2010-02-26 EP EP10746307.7A patent/EP2404908B1/en active Active
- 2010-02-26 MX MX2011008348A patent/MX2011008348A/es active IP Right Grant
- 2010-02-26 US US13/148,820 patent/US8952174B2/en active Active
- 2010-02-26 DK DK10746307.7T patent/DK2404908T3/da active
- 2010-02-26 PL PL10746307T patent/PL2404908T3/pl unknown
- 2010-02-26 CA CA2752485A patent/CA2752485C/en active Active
- 2010-02-26 BR BRPI1008308A patent/BRPI1008308B8/pt not_active IP Right Cessation
- 2010-02-26 SG SG2011062122A patent/SG173884A1/en unknown
- 2010-02-26 PT PT107463077T patent/PT2404908E/pt unknown
- 2010-02-26 AU AU2010218748A patent/AU2010218748B2/en not_active Ceased
- 2010-02-26 JP JP2011501659A patent/JP5312570B2/ja active Active
- 2010-02-26 WO PCT/JP2010/053043 patent/WO2010098428A1/ja not_active Ceased
- 2010-02-26 EP EP14163761.1A patent/EP2754658A1/en not_active Withdrawn
- 2010-02-26 ES ES10746307.7T patent/ES2459722T3/es active Active
- 2010-02-26 KR KR1020117019476A patent/KR101639834B1/ko not_active Expired - Fee Related
- 2010-02-26 TW TW99105657A patent/TWI466874B/zh not_active IP Right Cessation
- 2010-02-26 RU RU2011139307/04A patent/RU2510393C9/ru active
-
2011
- 2011-07-26 IL IL214302A patent/IL214302A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010218748B2 (en) | 2015-03-26 |
| RU2011139307A (ru) | 2013-04-10 |
| CN102333765A (zh) | 2012-01-25 |
| AU2010218748A1 (en) | 2011-08-11 |
| BRPI1008308B1 (pt) | 2020-03-31 |
| RU2510393C2 (ru) | 2014-03-27 |
| KR20110120896A (ko) | 2011-11-04 |
| IL214302A0 (en) | 2011-09-27 |
| EP2404908A4 (en) | 2012-08-15 |
| PT2404908E (pt) | 2014-06-23 |
| TW201041859A (en) | 2010-12-01 |
| JPWO2010098428A1 (ja) | 2012-09-06 |
| KR101639834B1 (ko) | 2016-07-14 |
| CN102333765B (zh) | 2015-01-14 |
| DK2404908T3 (da) | 2014-04-28 |
| US20110313169A1 (en) | 2011-12-22 |
| HK1162501A1 (en) | 2012-08-31 |
| BRPI1008308B8 (pt) | 2021-05-25 |
| JP5312570B2 (ja) | 2013-10-09 |
| WO2010098428A1 (ja) | 2010-09-02 |
| US8952174B2 (en) | 2015-02-10 |
| SG173884A1 (en) | 2011-10-28 |
| TWI466874B (zh) | 2015-01-01 |
| PL2404908T3 (pl) | 2014-12-31 |
| EP2404908B1 (en) | 2014-04-09 |
| EP2404908A1 (en) | 2012-01-11 |
| CA2752485C (en) | 2017-01-03 |
| EP2754658A1 (en) | 2014-07-16 |
| RU2510393C9 (ru) | 2014-08-27 |
| ES2459722T3 (es) | 2014-05-12 |
| BRPI1008308A2 (pt) | 2016-02-23 |
| CA2752485A1 (en) | 2010-09-02 |
| IL214302A (en) | 2014-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |