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EA200800975A1 - ПИРИМИДИНИЛАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ВКЛЮЧАЮЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО α4-ИНТЕГРИНАМИ - Google Patents

ПИРИМИДИНИЛАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ВКЛЮЧАЮЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО α4-ИНТЕГРИНАМИ

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Publication number
EA200800975A1
EA200800975A1 EA200800975A EA200800975A EA200800975A1 EA 200800975 A1 EA200800975 A1 EA 200800975A1 EA 200800975 A EA200800975 A EA 200800975A EA 200800975 A EA200800975 A EA 200800975A EA 200800975 A1 EA200800975 A1 EA 200800975A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
treatment
pyrimidinylamide
integrin
variants
Prior art date
Application number
EA200800975A
Other languages
English (en)
Other versions
EA015388B1 (ru
Inventor
Кристофер Майкл Сэмкоу
Ин-цзы Сюй
Фрэнк Стэпэнбэк
Дженифер Ли Смит
Кассандра Инес Росситер
Джури И. Фукуда
Андрей В. Конрэди
Original Assignee
Элан Фамэсьютикэлс, Инк.
Виет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фамэсьютикэлс, Инк., Виет filed Critical Элан Фамэсьютикэлс, Инк.
Publication of EA200800975A1 publication Critical patent/EA200800975A1/ru
Publication of EA015388B1 publication Critical patent/EA015388B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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Abstract

Настоящее изобретение относится к соединениям, которые связывают VLA-4. Некоторые из этих соединений ингибируют также адгезию лейкоцитов и, в частности, адгезию лейкоцитов, опосредованную VLA-4. Такие соединения можно использовать для лечения воспалительных заболеваний у человека и животных, таких как астма, болезнь Альцгеймера, атеросклероз, вызванная СПИДом деменция, диабет, воспалительное заболевание кишечника, ревматоидный артрит, последствия трансплантации тканей, метастазы опухолей и миокардиальная ишемия. Соединения могут назначаться также для лечения воспалительных заболеваний мозга, например, рассеянного склероза (формула I).
EA200800975A 2005-09-29 2006-09-28 ПИРИМИДИНИЛАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ВКЛЮЧАЮЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО α4-ИНТЕГРИНАМИ EA015388B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72235805P 2005-09-29 2005-09-29
PCT/US2006/038009 WO2007041270A1 (en) 2005-09-29 2006-09-28 Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
EA200800975A1 true EA200800975A1 (ru) 2008-08-29
EA015388B1 EA015388B1 (ru) 2011-08-30

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EA200800975A EA015388B1 (ru) 2005-09-29 2006-09-28 ПИРИМИДИНИЛАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ВКЛЮЧАЮЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО α4-ИНТЕГРИНАМИ

Country Status (17)

Country Link
US (2) US7511052B2 (ru)
EP (1) EP1940826B1 (ru)
JP (1) JP5101512B2 (ru)
KR (1) KR20080059268A (ru)
CN (1) CN101273034B (ru)
AT (1) ATE493405T1 (ru)
AU (1) AU2006297220B8 (ru)
BR (1) BRPI0616687A2 (ru)
CA (1) CA2624450C (ru)
DE (1) DE602006019296D1 (ru)
DK (1) DK1940826T3 (ru)
EA (1) EA015388B1 (ru)
IL (1) IL190084A (ru)
NO (1) NO20082002L (ru)
NZ (1) NZ567270A (ru)
WO (1) WO2007041270A1 (ru)
ZA (2) ZA200803280B (ru)

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JP5101512B2 (ja) 2012-12-19
ATE493405T1 (de) 2011-01-15
AU2006297220C1 (en) 2012-11-29
ZA200803280B (en) 2009-11-25
US20090192181A1 (en) 2009-07-30
AU2006297220A1 (en) 2007-04-12
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CA2624450A1 (en) 2007-04-12
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AU2006297220B8 (en) 2013-01-31
US7763632B2 (en) 2010-07-27
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CN101273034A (zh) 2008-09-24
AU2006297220B2 (en) 2012-04-26
EP1940826A1 (en) 2008-07-09
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