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EA200701164A1 - Способ получения аннелированных производных пиперазин-2-она и соответствующие промежуточные продукты - Google Patents

Способ получения аннелированных производных пиперазин-2-она и соответствующие промежуточные продукты

Info

Publication number
EA200701164A1
EA200701164A1 EA200701164A EA200701164A EA200701164A1 EA 200701164 A1 EA200701164 A1 EA 200701164A1 EA 200701164 A EA200701164 A EA 200701164A EA 200701164 A EA200701164 A EA 200701164A EA 200701164 A1 EA200701164 A1 EA 200701164A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
obtaining
intermediate products
related intermediate
annelated
Prior art date
Application number
EA200701164A
Other languages
English (en)
Other versions
EA012624B1 (ru
Inventor
Адил Дуран
Гюнтер Линц
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35923724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200701164(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200701164A1 publication Critical patent/EA200701164A1/ru
Publication of EA012624B1 publication Critical patent/EA012624B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В заявке описан способ получения аннелированных производных пиперазин-2-она общей формулы (I)в которой остатки R-R, Aи Аимеют указанные в формуле изобретения и в описании значения, прежде всего способ получения производных 7,8-дигидро-5Н-птеридин-6-она.
EA200701164A 2004-12-02 2005-11-29 Способ получения аннелированных производных пиперазин-2-она и соответствующие промежуточные продукты EA012624B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
PCT/EP2005/056291 WO2006058876A1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens

Publications (2)

Publication Number Publication Date
EA200701164A1 true EA200701164A1 (ru) 2007-12-28
EA012624B1 EA012624B1 (ru) 2009-10-30

Family

ID=35923724

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701164A EA012624B1 (ru) 2004-12-02 2005-11-29 Способ получения аннелированных производных пиперазин-2-она и соответствующие промежуточные продукты

Country Status (34)

Country Link
US (9) US7238807B2 (ru)
EP (2) EP2436685B1 (ru)
JP (1) JP5164574B2 (ru)
KR (2) KR101395591B1 (ru)
CN (3) CN102093361B (ru)
AR (1) AR053100A1 (ru)
AU (1) AU2005311308B2 (ru)
BR (1) BRPI0518601A2 (ru)
CA (1) CA2588857C (ru)
CL (1) CL2013002895A1 (ru)
CY (1) CY1113625T1 (ru)
DE (1) DE102004058337A1 (ru)
DK (2) DK1819706T3 (ru)
EA (1) EA012624B1 (ru)
ES (2) ES2548680T3 (ru)
HR (1) HRP20120980T1 (ru)
HU (1) HUE027689T2 (ru)
IL (1) IL183568A (ru)
ME (1) ME01470B (ru)
MX (1) MX2007006549A (ru)
MY (1) MY147459A (ru)
NO (1) NO20072283L (ru)
NZ (1) NZ556182A (ru)
PE (2) PE20090488A1 (ru)
PL (2) PL1819706T3 (ru)
PT (1) PT1819706E (ru)
RS (1) RS52533B (ru)
SG (2) SG158848A1 (ru)
SI (1) SI1819706T1 (ru)
TW (1) TWI362391B (ru)
UA (1) UA89390C2 (ru)
UY (1) UY29233A1 (ru)
WO (1) WO2006058876A1 (ru)
ZA (1) ZA200703368B (ru)

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EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
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CN103492391A (zh) 2009-09-25 2014-01-01 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
WO2011036566A1 (en) 2009-09-25 2011-03-31 Vertex Pharmaceuticals Incorporated Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
EP2678342B1 (en) 2011-02-25 2015-01-07 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
UY34893A (es) 2012-07-10 2014-02-28 Takeda Pharmaceutical Derivados de azaindol
US20150031699A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
TW201620904A (zh) 2014-01-09 2016-06-16 武田藥品工業有限公司 氮雜吲哚衍生物
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Also Published As

Publication number Publication date
HK1158199A1 (en) 2012-07-13
EA012624B1 (ru) 2009-10-30
AU2005311308A1 (en) 2006-06-08
TWI362391B (en) 2012-04-21
DK2436685T3 (en) 2015-09-14
ZA200703368B (en) 2008-09-25
DK1819706T3 (da) 2013-01-02
US20070213528A1 (en) 2007-09-13
EP1819706A1 (de) 2007-08-22
CL2013002895A1 (es) 2014-03-14
US20060122393A1 (en) 2006-06-08
UY29233A1 (es) 2006-07-31
US20070213531A1 (en) 2007-09-13
JP2008521861A (ja) 2008-06-26
JP5164574B2 (ja) 2013-03-21
HUE027689T2 (hu) 2021-12-28
PL1819706T3 (pl) 2013-03-29
CA2588857A1 (en) 2006-06-08
ME01470B (me) 2014-04-20
KR20120136414A (ko) 2012-12-18
AR053100A1 (es) 2007-04-25
UA89390C2 (ru) 2010-01-25
CN102093361A (zh) 2011-06-15
CN102093361B (zh) 2014-05-07
US7238807B2 (en) 2007-07-03
CY1113625T1 (el) 2016-06-22
US20070208027A1 (en) 2007-09-06
HK1158200A1 (en) 2012-07-13
NO20072283L (no) 2007-06-28
MX2007006549A (es) 2007-06-18
NZ556182A (en) 2009-08-28
HK1113489A1 (en) 2008-10-03
DE102004058337A1 (de) 2006-06-14
KR101395591B1 (ko) 2014-05-16
TW200628471A (en) 2006-08-16
KR20070092252A (ko) 2007-09-12
PL2436685T3 (pl) 2015-11-30
AU2005311308B2 (en) 2012-04-12
CN102070637B (zh) 2012-09-26
HRP20120980T1 (hr) 2012-12-31
EP1819706B1 (de) 2012-09-19
IL183568A0 (en) 2007-09-20
SG158848A1 (en) 2010-02-26
US20070213534A1 (en) 2007-09-13
USRE43115E1 (en) 2012-01-17
KR101362131B1 (ko) 2014-02-19
US7626019B2 (en) 2009-12-01
RS52533B (sr) 2013-04-30
CN101065381B (zh) 2011-03-30
CN102070637A (zh) 2011-05-25
PE20061061A1 (es) 2006-11-10
BRPI0518601A2 (pt) 2008-11-25
MY147459A (en) 2012-12-14
US20070219369A1 (en) 2007-09-20
EP2436685B1 (de) 2015-07-01
EP2436685A1 (de) 2012-04-04
US20070213530A1 (en) 2007-09-13
ES2548680T3 (es) 2015-10-20
IL183568A (en) 2015-02-26
SI1819706T1 (sl) 2013-01-31
SG141461A1 (en) 2008-04-28
PE20090488A1 (es) 2009-05-27
CA2588857C (en) 2013-10-08
PT1819706E (pt) 2012-12-06
US20070213529A1 (en) 2007-09-13
WO2006058876A1 (de) 2006-06-08
CN101065381A (zh) 2007-10-31
ES2395829T3 (es) 2013-02-15

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