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EA200601030A1 - 7α, 17α-SUBSTITUTED 11β-HALOGENOSTEROIDS, METHODS FOR THEIR RECEPTION, APPLICATION AND PHARMACEUTICAL PREPARATION ON THEIR BASIS - Google Patents

7α, 17α-SUBSTITUTED 11β-HALOGENOSTEROIDS, METHODS FOR THEIR RECEPTION, APPLICATION AND PHARMACEUTICAL PREPARATION ON THEIR BASIS

Info

Publication number
EA200601030A1
EA200601030A1 EA200601030A EA200601030A EA200601030A1 EA 200601030 A1 EA200601030 A1 EA 200601030A1 EA 200601030 A EA200601030 A EA 200601030A EA 200601030 A EA200601030 A EA 200601030A EA 200601030 A1 EA200601030 A1 EA 200601030A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
methods
pharmaceutical preparation
halogenosteroids
reception
Prior art date
Application number
EA200601030A
Other languages
Russian (ru)
Other versions
EA010572B1 (en
Inventor
Людвиг Цорн
Рольф Больманн
Норберт Галлус
Германн Кюнцер
Ханс-Петер Мун
Райнхард Нуббемейер
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10233723A external-priority patent/DE10233723A1/en
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of EA200601030A1 publication Critical patent/EA200601030A1/en
Publication of EA010572B1 publication Critical patent/EA010572B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

В заявке описываются новые соединения, представляющие собой 7α,17α-замещенные 11β-галогенстероиды общей формулы (8,10,12)способы их получения, применение и фармацевтический препарат на их основе.The application describes new compounds, which are 7α, 17α-substituted 11β-halogen steroids of the general formula (8,10,12), methods for their preparation, use and pharmaceutical preparation based on them.

EA200601030A 2002-07-24 2003-07-24 7 alpha, 17 alpha substituted 11 beta halogen steroids, processes for production thereof, use thereof and pharmaceutical preparation based thereon EA010572B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233723A DE10233723A1 (en) 2002-07-24 2002-07-24 Preparation of 7 alpha-substituted 11 alpha-hydroxy-steroids, useful as precursors for new androgenic 7 alpha,17 alpha-substituted 11 beta-halo-steroids, by microbiological conversion of 7 alpha-substituted steroids
US40295302P 2002-08-14 2002-08-14

Publications (2)

Publication Number Publication Date
EA200601030A1 true EA200601030A1 (en) 2006-10-27
EA010572B1 EA010572B1 (en) 2008-10-30

Family

ID=31189296

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200500224A EA008147B1 (en) 2002-07-24 2003-07-24 Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids
EA200601030A EA010572B1 (en) 2002-07-24 2003-07-24 7 alpha, 17 alpha substituted 11 beta halogen steroids, processes for production thereof, use thereof and pharmaceutical preparation based thereon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200500224A EA008147B1 (en) 2002-07-24 2003-07-24 Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids

Country Status (19)

Country Link
EP (1) EP1523568A2 (en)
JP (1) JP4417838B2 (en)
KR (1) KR101041328B1 (en)
CN (1) CN100339486C (en)
BR (1) BR0313210A (en)
CA (1) CA2492079C (en)
CO (1) CO5690563A2 (en)
CR (1) CR7672A (en)
EA (2) EA008147B1 (en)
EC (1) ECSP055630A (en)
HR (1) HRP20050172A2 (en)
IL (1) IL166358A0 (en)
MX (1) MXPA05001024A (en)
NO (1) NO20050980L (en)
NZ (2) NZ549529A (en)
PH (1) PH12005500143B1 (en)
PL (1) PL373808A1 (en)
RS (1) RS51855B (en)
WO (1) WO2004011663A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4926071B2 (en) * 2005-10-27 2012-05-09 エスアールアイ インターナショナル Method for producing steroid compounds
RU2377309C1 (en) * 2008-04-22 2009-12-27 Валентина Александровна Андрюшина MICROBIOLOGICAL METHOD FOR PREPARATION OF 7α-HYDROXYANDROSTENES
CN103834712B (en) * 2012-11-26 2016-03-30 复旦大学 The optimization method of desogestrel intermediate nanometer liposome bio-transformation
CN103214543B (en) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 New Crategolic acid derivative, its preparation method and the application in antitumor drug thereof
CN104862323B (en) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 Modify the '-hydroxylase gene of diphenol compounds
PL246071B1 (en) * 2022-08-26 2024-11-25 Wrocław University Of Environmental And Life Sciences Method of producing 11α-hydroxy-19-nortestosterone

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE496261A (en) 1949-06-11
US2658023A (en) * 1953-04-21 1953-11-03 Pfizer & Co C Oxygenation of steroids
US2985563A (en) * 1958-11-13 1961-05-23 Schering Corp 11alpha-hydroxylation of steroids by glomerella
US3004047A (en) * 1959-03-13 1961-10-10 Olin Mathieson 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en) * 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
US3203869A (en) * 1962-10-11 1965-08-31 Syntex Corp 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en) 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
PT900283E (en) * 1995-12-12 2002-09-30 Akzo Nobel Nv 11ALFA-HYDROXYLACAO MICROBIAL STEROIDS
GB9525194D0 (en) 1995-12-12 1996-02-07 Zeneca Ltd Pharmaceutical composition
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
SI1267885T1 (en) 2000-02-15 2007-08-31 Bayer Schering Pharma Ag Male contraceptive formulation comprising norethisterone and testosterone undecanoate
DE10104327A1 (en) * 2001-01-24 2002-07-25 Schering Ag New 11beta-halo-testosterone derivatives useful in male hormone replacement therapy and in male fertility control
PL374317A1 (en) * 2002-07-25 2005-10-03 Schering Aktiengesellschaft Composition containing an androgenous 11beta-halogen steroid and a progestational hormone, and male contraceptive based on said composition

Also Published As

Publication number Publication date
CA2492079A1 (en) 2004-02-05
MX260952B (en) 2008-10-01
PL373808A1 (en) 2005-09-19
CN100339486C (en) 2007-09-26
IL166358A0 (en) 2006-01-16
JP2006503813A (en) 2006-02-02
HRP20050172A2 (en) 2005-04-30
HK1081999A1 (en) 2006-05-26
WO2004011663A3 (en) 2004-07-15
CO5690563A2 (en) 2006-10-31
NZ537871A (en) 2006-10-27
BR0313210A (en) 2005-06-28
PH12005500143B1 (en) 2011-03-25
EA008147B1 (en) 2007-04-27
CN1671858A (en) 2005-09-21
EA200500224A1 (en) 2005-08-25
NO20050980L (en) 2005-02-23
KR101041328B1 (en) 2011-06-14
AU2003281677A1 (en) 2004-02-16
JP4417838B2 (en) 2010-02-17
KR20050026507A (en) 2005-03-15
RS20050045A (en) 2007-06-04
CA2492079C (en) 2012-01-10
EP1523568A2 (en) 2005-04-20
ECSP055630A (en) 2005-04-18
MXPA05001024A (en) 2005-05-16
WO2004011663A2 (en) 2004-02-05
RS51855B (en) 2012-02-29
EA010572B1 (en) 2008-10-30
WO2004011663A9 (en) 2004-05-06
CR7672A (en) 2006-05-29
NZ549529A (en) 2008-04-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU