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CR7672A - MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED - Google Patents

MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED

Info

Publication number
CR7672A
CR7672A CR7672A CR7672A CR7672A CR 7672 A CR7672 A CR 7672A CR 7672 A CR7672 A CR 7672A CR 7672 A CR7672 A CR 7672A CR 7672 A CR7672 A CR 7672A
Authority
CR
Costa Rica
Prior art keywords
alfa
substituted
hydroxiesteroids
production
microbiological method
Prior art date
Application number
CR7672A
Other languages
Spanish (es)
Inventor
Zorn Ludwig
Bohlmann Rolf
Gallus Norbert
Kunzer Hermann
Muhn Hans-Peter
Nubbemeyer Reinhard
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10233723A external-priority patent/DE10233723A1/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CR7672A publication Critical patent/CR7672A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se refiere a procedimientos microbiologicos para preparar 11a-hidroxiesteroides 7a-sustituidos, a 11B -halogenesteroides 7a, 17a-sustituidos que se pueden obtener de aquellos, a procedimientos para la preparacion de estos ultimos compuestos y a su uso, asi como a preparaciones farmaceuticas que contienen estos compuestos.It refers to microbiological procedures for preparing 11a-substituted 7a-hydroxysteroids, 11B-7a, 17a-substituted halogenesteroids that can be obtained therefrom, procedures for the preparation of these latter compounds and their use, as well as pharmaceutical preparations containing these compounds.

CR7672A 2002-07-24 2005-02-03 MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED CR7672A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233723A DE10233723A1 (en) 2002-07-24 2002-07-24 Preparation of 7 alpha-substituted 11 alpha-hydroxy-steroids, useful as precursors for new androgenic 7 alpha,17 alpha-substituted 11 beta-halo-steroids, by microbiological conversion of 7 alpha-substituted steroids
US40295302P 2002-08-14 2002-08-14

Publications (1)

Publication Number Publication Date
CR7672A true CR7672A (en) 2006-05-29

Family

ID=31189296

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7672A CR7672A (en) 2002-07-24 2005-02-03 MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED

Country Status (19)

Country Link
EP (1) EP1523568A2 (en)
JP (1) JP4417838B2 (en)
KR (1) KR101041328B1 (en)
CN (1) CN100339486C (en)
BR (1) BR0313210A (en)
CA (1) CA2492079C (en)
CO (1) CO5690563A2 (en)
CR (1) CR7672A (en)
EA (2) EA010572B1 (en)
EC (1) ECSP055630A (en)
HR (1) HRP20050172A2 (en)
IL (1) IL166358A0 (en)
MX (1) MXPA05001024A (en)
NO (1) NO20050980L (en)
NZ (2) NZ549529A (en)
PH (1) PH12005500143B1 (en)
PL (1) PL373808A1 (en)
RS (1) RS51855B (en)
WO (1) WO2004011663A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935838B2 (en) * 2005-10-27 2011-05-03 Sri International Process for production of steroid compound
RU2377309C1 (en) * 2008-04-22 2009-12-27 Валентина Александровна Андрюшина MICROBIOLOGICAL METHOD FOR PREPARATION OF 7α-HYDROXYANDROSTENES
CN103834712B (en) * 2012-11-26 2016-03-30 复旦大学 The optimization method of desogestrel intermediate nanometer liposome bio-transformation
CN103214543B (en) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 New Crategolic acid derivative, its preparation method and the application in antitumor drug thereof
CN104862323B (en) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 Modify the '-hydroxylase gene of diphenol compounds
PL246071B1 (en) * 2022-08-26 2024-11-25 Wrocław University Of Environmental And Life Sciences Method of producing 11α-hydroxy-19-nortestosterone

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE496261A (en) 1949-06-11
US2658023A (en) * 1953-04-21 1953-11-03 Pfizer & Co C Oxygenation of steroids
US2985563A (en) * 1958-11-13 1961-05-23 Schering Corp 11alpha-hydroxylation of steroids by glomerella
US3004047A (en) * 1959-03-13 1961-10-10 Olin Mathieson 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en) * 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
US3203869A (en) * 1962-10-11 1965-08-31 Syntex Corp 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en) 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
GB9525194D0 (en) 1995-12-12 1996-02-07 Zeneca Ltd Pharmaceutical composition
CN1138861C (en) 1995-12-12 2004-02-18 阿克佐诺贝尔公司 Microbial 11 alpha-hydroxylation of steroids
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
EE200200454A (en) 2000-02-15 2003-12-15 Schering Aktiengesellschaft Male contraceptive containing norethisterone
DE10104327A1 (en) 2001-01-24 2002-07-25 Schering Ag New 11beta-halo-testosterone derivatives useful in male hormone replacement therapy and in male fertility control
DE50308933D1 (en) * 2002-07-25 2008-02-14 Bayer Schering Pharma Ag COMPOSITION, CONTAINING AN ANDROGENIC 11-B HALOGEN STEROIDE AND A STATEMENT AND MALE CONTRAZEPTIVUM BASED ON THIS COMPOSITION

Also Published As

Publication number Publication date
MXPA05001024A (en) 2005-05-16
RS20050045A (en) 2007-06-04
CN1671858A (en) 2005-09-21
WO2004011663A9 (en) 2004-05-06
CO5690563A2 (en) 2006-10-31
KR20050026507A (en) 2005-03-15
NO20050980L (en) 2005-02-23
HRP20050172A2 (en) 2005-04-30
RS51855B (en) 2012-02-29
BR0313210A (en) 2005-06-28
ECSP055630A (en) 2005-04-18
EA008147B1 (en) 2007-04-27
JP4417838B2 (en) 2010-02-17
CN100339486C (en) 2007-09-26
CA2492079A1 (en) 2004-02-05
JP2006503813A (en) 2006-02-02
EA010572B1 (en) 2008-10-30
EA200500224A1 (en) 2005-08-25
IL166358A0 (en) 2006-01-16
NZ549529A (en) 2008-04-30
PL373808A1 (en) 2005-09-19
EA200601030A1 (en) 2006-10-27
EP1523568A2 (en) 2005-04-20
HK1081999A1 (en) 2006-05-26
MX260952B (en) 2008-10-01
CA2492079C (en) 2012-01-10
PH12005500143B1 (en) 2011-03-25
WO2004011663A3 (en) 2004-07-15
KR101041328B1 (en) 2011-06-14
AU2003281677A1 (en) 2004-02-16
NZ537871A (en) 2006-10-27
WO2004011663A2 (en) 2004-02-05

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)