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EA200300834A1 - Антагонисты фактора, высвобождающего кортикотропин - Google Patents

Антагонисты фактора, высвобождающего кортикотропин

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Publication number
EA200300834A1
EA200300834A1 EA200300834A EA200300834A EA200300834A1 EA 200300834 A1 EA200300834 A1 EA 200300834A1 EA 200300834 A EA200300834 A EA 200300834A EA 200300834 A EA200300834 A EA 200300834A EA 200300834 A1 EA200300834 A1 EA 200300834A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
factor
corticotropin
disorders
releases
Prior art date
Application number
EA200300834A
Other languages
English (en)
Inventor
Юхпинг Лианг Чен
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200300834A1 publication Critical patent/EA200300834A1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Описываются антагонисты фактора, высвобождающего кортикотропин (CRF), имеющие формулу (I), где A, B, Z, R, R, Rимеют значения, указанные в описании заявки, и способы их получения. Указанные соединения и их фармацевтически приемлемые соли полезны для лечения расстройств, в том числе расстройств ЦНС и расстройств, связанных со стрессом.
EA200300834A 2000-01-18 2001-01-05 Антагонисты фактора, высвобождающего кортикотропин EA200300834A1 (ru)

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CN1395566A (zh) 2003-02-05
AU2390501A (en) 2001-07-31
NO20023424L (no) 2002-09-10
PE20011166A1 (es) 2001-11-13
PA8510001A1 (es) 2002-12-11
YU54402A (sh) 2005-11-28
MA26864A1 (fr) 2004-12-20
EA200200688A1 (ru) 2003-02-27
PL357589A1 (en) 2004-07-26
IL150632A0 (en) 2003-02-12
HUP0204272A3 (en) 2005-03-29
EP1263732A1 (en) 2002-12-11
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BG106853A (bg) 2003-01-31
JP2003520272A (ja) 2003-07-02
IS6445A (is) 2002-06-25
AR027221A1 (es) 2003-03-19
HRP20020599A2 (en) 2004-08-31
OA12157A (en) 2006-05-08
EE200200400A (et) 2003-10-15
KR20020063934A (ko) 2002-08-07
US6833378B2 (en) 2004-12-21
WO2001053263A1 (en) 2001-07-26
AU779995B2 (en) 2005-02-24
ZA200205660B (en) 2003-10-09
US20020016328A1 (en) 2002-02-07
CO5271658A1 (es) 2003-04-30
BR0107662A (pt) 2002-11-19
MXPA02007047A (es) 2002-12-13
CZ20022390A3 (cs) 2003-08-13
CR6698A (es) 2004-01-14
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