DK605786D0 - Stabiliserede human-vaevsplasminogenaktivator-praeparater - Google Patents

Stabiliserede human-vaevsplasminogenaktivator-praeparater

Info

Publication number: DK605786D0
Authority: DK; Denmark
Prior art keywords: plasminogen activator; human tissue; tissue plasminogen; stabilized human; activator preparations
Prior art date: 1985-12-17

Application number

DK605786A

Other languages

English (en)

Other versions

DK174203B1 (da

DK605786A (da

Inventor

William Franklin Bennett

Stuart Elliot Builder

Larry Alan Gatlin

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-17

Filing date

1986-12-16

Publication date

1986-12-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25205495&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK605786(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-12-16 Application filed by Genentech Inc filed Critical Genentech Inc

1986-12-16 Publication of DK605786D0 publication Critical patent/DK605786D0/da

1987-06-18 Publication of DK605786A publication Critical patent/DK605786A/da

2002-09-16 Application granted granted Critical

2002-09-16 Publication of DK174203B1 publication Critical patent/DK174203B1/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

DK198606057A 1985-12-17 1986-12-16 Stabiliserede human-vævsplasminogenaktivator-præparater DK174203B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US81108185		1985-12-17
US06/811,081 US4777043A (en)	1985-12-17	1985-12-17	Stabilized human tissue plasminogen activator compositions

Publications (3)

Publication Number	Publication Date
DK605786D0 true DK605786D0 (da)	1986-12-16
DK605786A DK605786A (da)	1987-06-18
DK174203B1 DK174203B1 (da)	2002-09-16

Family

ID=25205495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198606057A DK174203B1 (da)	1985-12-17	1986-12-16	Stabiliserede human-vævsplasminogenaktivator-præparater

Country Status (23)

Country	Link
US (2)	US4777043A (da)
EP (1)	EP0228862B1 (da)
JP (2)	JPH0714886B2 (da)
KR (1)	KR950010322B1 (da)
AT (1)	ATE79273T1 (da)
AU (1)	AU600246B2 (da)
DD (1)	DD255477A5 (da)
DE (2)	DE3686410T2 (da)
DK (1)	DK174203B1 (da)
ES (1)	ES2044840T3 (da)
FI (1)	FI88873C (da)
FR (1)	FR2591485B1 (da)
GB (1)	GB2184354B (da)
GR (1)	GR3006078T3 (da)
HU (1)	HU200101B (da)
IE (1)	IE59060B1 (da)
IL (1)	IL80904A (da)
MY (1)	MY102185A (da)
NO (1)	NO168988C (da)
NZ (1)	NZ218612A (da)
PH (1)	PH24716A (da)
PT (1)	PT83933B (da)
ZA (1)	ZA869457B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE83153T1 (de) *	1985-09-10	1992-12-15	Eisai Co Ltd	Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
JPH0672105B2 (ja) *	1985-10-02	1994-09-14	持田製薬株式会社	血栓溶解剤及びその製法
US5453363A (en) *	1985-10-23	1995-09-26	Boehringer Mannheim Gmbh	Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US5034225A (en) *	1985-12-17	1991-07-23	Genentech Inc.	Stabilized human tissue plasminogen activator compositions
JP2708749B2 (ja) *	1987-08-10	1998-02-04	エーザイ株式会社	修飾型ｔＰＡ含有注射用組成物
EP0317376B2 (fr) *	1987-10-23	1996-04-03	Centre Regional De Transfusion Sanguine De Lille	Préparation de concentré de facteur IX humain de haute pureté et d'autres protéines plasmatiques
US4898826A (en) *	1987-12-10	1990-02-06	Invitron Corporation	Method to solubilize tissue plasminogen activator
HU206367B (en) *	1988-04-30	1992-10-28	Sandoz Ag	Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
US4980165A (en) *	1989-01-27	1990-12-25	Genetics Institute, Inc.	Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) *	1989-02-07	1990-08-16	Boehringer Mannheim Gmbh	Gewebs-plasminogenaktivator-derivat
US6207151B1 (en) *	1989-09-21	2001-03-27	Mitsui Chemicals Inc.	Aqueous solution of t-PA
JP2520975B2 (ja) *	1989-09-21	1996-07-31	三井東圧化学株式会社	組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
DE3942144A1 (de) *	1989-12-20	1991-06-27	Boehringer Mannheim Gmbh	Stabilisierung von k1k2p pro
DE3942145A1 (de) *	1989-12-20	1991-06-27	Boehringer Mannheim Gmbh	T-pa-solubilisierung
DE3942143A1 (de) *	1989-12-20	1991-06-27	Boehringer Mannheim Gmbh	T-pa pro stabilisierung
DE3942141A1 (de) *	1989-12-20	1991-06-27	Boehringer Mannheim Gmbh	K2p pro-stabilisierung
DE3942142A1 (de) *	1989-12-20	1991-06-27	Boehringer Mannheim Gmbh	Stabilisierung von glykosyliertem t-pa
US5358708A (en) *	1993-01-29	1994-10-25	Schering Corporation	Stabilization of protein formulations
US5656730A (en) *	1995-04-07	1997-08-12	Enzon, Inc.	Stabilized monomeric protein compositions
DE19606551C2 (de) *	1996-02-22	2000-06-08	Basotherm Gmbh	rt-PA zur Prävention des Nachstars nach Kataraktoperation
US5972912A (en) *	1998-12-17	1999-10-26	S.P. Pharmaceuticals	Method for lyophilizing ifosfamide
US6586574B1 (en)	1999-08-17	2003-07-01	Nn A/S	Stabilization of freeze-dried cake
DE60009926T2 (de) *	1999-08-17	2005-04-07	Novo Nordisk Health Care Ag	Stabilisierung von gefriergetrocknetem kuchen
WO2001032915A2 (en) *	1999-11-04	2001-05-10	Genentech, Inc.	Reversed-phase hplc assay for plasminogen activators
US7282219B2 (en)	2000-03-31	2007-10-16	Kirin Beer Kabushiki Kaisha	Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability
WO2003022997A2 (en) *	2001-09-07	2003-03-20	Global Biotech Inc.	Human tissue urokinase type plasminogen activator formulation
US20110179558A1 (en) *	2009-07-29	2011-07-28	International Enviroguard Systems, Inc.	Breathable Protective Fabric and Garment
CN105188759A (zh) *	2013-03-14	2015-12-23	阿勒根公司	持续释放递送的组合物以及在制造过程中稳定蛋白质的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK98833C (da) *	1961-04-25	1964-05-25	Novo Terapeutisk Labor As	Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger.
EP0112940B1 (en) *	1982-12-30	1986-10-15	Kowa Company, Ltd.	Method of producing a tissue plasminogen activator and composition comprising same
JPS59196824A (ja) *	1983-04-21	1984-11-08	Kowa Co	吸着防止剤
EP0156169B1 (en) *	1984-02-29	1991-12-18	Asahi Kasei Kogyo Kabushiki Kaisha	An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
GB2173804B (en) *	1985-04-22	1989-07-05	Genentech Inc	Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
IL78937A (en) *	1985-05-28	1990-11-29	Wellcome Found	Pharmaceutical compositions containing tissue-plasminogen activator
US4929444A (en) *	1985-05-28	1990-05-29	Burroughs Wellcome Co.	Low pH pharmaceutical formulation containing t-PA
ZW14486A1 (en) *	1985-07-29	1986-10-22	Smithkline Beckman Corp	Pharmaceutical dosage unit
ATE83153T1 (de) *	1985-09-10	1992-12-15	Eisai Co Ltd	Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
JPH0672105B2 (ja) *	1985-10-02	1994-09-14	持田製薬株式会社	血栓溶解剤及びその製法
DE3537708A1 (de) *	1985-10-23	1987-04-23	Boehringer Mannheim Gmbh	Verfahren zur aktivierung von t-pa nach expression in prokaryonten
JPS62120321A (ja) *	1985-11-20	1987-06-01	Eisai Co Ltd	ｔＰＡ含有医薬組成物
JPS62283932A (ja) *	1986-05-29	1987-12-09	Green Cross Corp:The	組織プラスミノ−ゲンアクチベ−タの乾燥製剤

1985
- 1985-12-17 US US06/811,081 patent/US4777043A/en not_active Expired - Lifetime
1986
- 1986-12-08 IL IL80904A patent/IL80904A/xx not_active IP Right Cessation
- 1986-12-12 NZ NZ218612A patent/NZ218612A/xx unknown
- 1986-12-15 PT PT83933A patent/PT83933B/pt unknown
- 1986-12-16 HU HU865225A patent/HU200101B/hu unknown
- 1986-12-16 GB GB8629981A patent/GB2184354B/en not_active Expired - Lifetime
- 1986-12-16 DE DE8686309811T patent/DE3686410T2/de not_active Expired - Lifetime
- 1986-12-16 KR KR1019860010747A patent/KR950010322B1/ko not_active Expired - Lifetime
- 1986-12-16 EP EP86309811A patent/EP0228862B1/en not_active Expired - Lifetime
- 1986-12-16 AT AT86309811T patent/ATE79273T1/de not_active IP Right Cessation
- 1986-12-16 ES ES86309811T patent/ES2044840T3/es not_active Expired - Lifetime
- 1986-12-16 DK DK198606057A patent/DK174203B1/da not_active IP Right Cessation
- 1986-12-16 PH PH34602A patent/PH24716A/en unknown
- 1986-12-16 FR FR8617593A patent/FR2591485B1/fr not_active Expired
- 1986-12-16 DE DE19863642960 patent/DE3642960A1/de not_active Ceased
- 1986-12-16 NO NO865079A patent/NO168988C/no not_active IP Right Cessation
- 1986-12-16 DD DD86297695A patent/DD255477A5/de unknown
- 1986-12-16 AU AU66610/86A patent/AU600246B2/en not_active Expired
- 1986-12-16 IE IE327986A patent/IE59060B1/en not_active IP Right Cessation
- 1986-12-17 FI FI865159A patent/FI88873C/fi not_active IP Right Cessation
- 1986-12-17 ZA ZA869457A patent/ZA869457B/xx unknown
- 1986-12-17 JP JP61302767A patent/JPH0714886B2/ja not_active Expired - Lifetime
1987
- 1987-10-01 MY MYPI87002760A patent/MY102185A/en unknown
1988
- 1988-03-28 US US07/173,854 patent/US4908205A/en not_active Expired - Lifetime
1992
- 1992-10-26 GR GR920402407T patent/GR3006078T3/el unknown
1994
- 1994-08-04 JP JP6183274A patent/JPH07173076A/ja active Pending

Also Published As

Publication number	Publication date
GB8629981D0 (en)	1987-01-28
EP0228862B1 (en)	1992-08-12
ES2044840T3 (es)	1994-01-16
DE3642960A1 (de)	1987-06-19
US4908205A (en)	1990-03-13
IL80904A (en)	1992-01-15
FI865159A0 (fi)	1986-12-17
JPH07173076A (ja)	1995-07-11
AU6661086A (en)	1987-06-18
IE59060B1 (en)	1993-12-15
FI88873C (fi)	1993-07-26
JPS62164632A (ja)	1987-07-21
NO865079L (no)	1987-06-18
DK174203B1 (da)	2002-09-16
GB2184354A (en)	1987-06-24
AU600246B2 (en)	1990-08-09
FI88873B (fi)	1993-04-15
PT83933B (pt)	1989-01-17
GB2184354B (en)	1990-04-11
NO865079D0 (no)	1986-12-16
IL80904A0 (en)	1987-03-31
ATE79273T1 (de)	1992-08-15
DE3686410T2 (de)	1993-02-18
PT83933A (en)	1987-01-01
ZA869457B (en)	1988-08-31
DE3686410D1 (de)	1992-09-17
KR870005647A (ko)	1987-07-06
GR3006078T3 (da)	1993-06-21
DD255477A5 (de)	1988-04-06
PH24716A (en)	1990-10-01
NO168988C (no)	1992-04-29
JPH0714886B2 (ja)	1995-02-22
FR2591485B1 (fr)	1989-07-28
NO168988B (no)	1992-01-20
HUT42955A (en)	1987-09-28
IE863279L (en)	1987-06-17
MY102185A (en)	1992-04-30
FI865159L (fi)	1987-06-18
EP0228862A3 (en)	1988-09-28
DK605786A (da)	1987-06-18
FR2591485A1 (fr)	1987-06-19
US4777043A (en)	1988-10-11
NZ218612A (en)	1989-07-27
HU200101B (en)	1990-04-28
EP0228862A2 (en)	1987-07-15
KR950010322B1 (ko)	1995-09-14

Publication	Publication Date	Title
DK605786A (da)	1987-06-18	Stabiliserede human-vaevsplasminogenaktivator-praeparater
ZA895090B (en)	1990-05-30	Novel benzopyran derivatives,processes for their preparation and their use and preparations containing the compounds
IT8920207A0 (it)	1989-04-20	Procedimento per la preparazione di perfluoropolieteri perossidici.
NO862096L (no)	1986-12-01	Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende vevsplasminogenaktivator.
DK261490D0 (da)	1990-10-31	New pharmaceutical compound
NO921382D0 (no)	1992-04-08	Amidinofenylalaninderivater, samt fremstilling, anvendelse og preparater inneholdende forbindelsene
DK0482097T3 (da)	2001-09-17	Tensidpræparater og fremgangsmåder
IL85189A (en)	1992-06-21	Beta-alkyl substituted melatonins,their preparation and pharmaceutical compositions containing them
ES2019634B3 (es)	1991-07-01	Terapia con clorfeniramina.
PT89742A (pt)	1989-10-04	Processo de preparacao de 24r-cimnol e de suas composicoes farmaceuticas
MY102026A (en)	1992-02-29	Antiasthmatic.
DK630088A (da)	1989-05-14	Azelastinembonat, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater med indhold af denne forbindelse som aktivt middel
GR3005231T3 (da)	1993-05-24
AU1235288A (en)	1988-09-01	Antidepressant compositions
TR22867A (tr)	1988-09-19	Birden fazla aktif bilesen ihtiva eden insektisid terkibi
DE3773322D1 (de)	1991-10-31	Pharmazeutische zubereitungen mit heilender aktivitaet.
SE8503513L (sv)	1986-01-20	Farmaceutiska och kosmetiska kompositioner, vilka som verksam bestandsdel innehaller acetyl-10-triacetoxi-1,8,9-antracen
ES8706441A1 (es)	1987-07-01	Procedimiento para preparar una composicion farmaceutica a base de sulpirida y un progestageno.
MX9704551A (es)	1997-10-31	Formulaciones en polvo que contienen melecitosa como un diluyente.
DK98788A (da)	1988-08-27	Benzylaminoaryl-dihydropyridinlactoner, fremgangmsaade til deres fremstilling samt deres anvendelse som laegemidler

Legal Events

Date	Code	Title	Description
2002-09-16	B1	Patent granted (law 1993)
2007-01-02	PUP	Patent expired