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DK536486A - Derivater af 4-benzyl-1-(2h)-phthalazinon - Google Patents

Derivater af 4-benzyl-1-(2h)-phthalazinon

Info

Publication number
DK536486A
DK536486A DK536486A DK536486A DK536486A DK 536486 A DK536486 A DK 536486A DK 536486 A DK536486 A DK 536486A DK 536486 A DK536486 A DK 536486A DK 536486 A DK536486 A DK 536486A
Authority
DK
Denmark
Prior art keywords
alkylamino
alkyl
benzyl
alkanoyloxy
alkoxy
Prior art date
Application number
DK536486A
Other languages
English (en)
Other versions
DK536486D0 (da
DK172076B1 (da
Inventor
Juergen Engel
Gerhard Scheffler
Original Assignee
Asta Werke Ag Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke Ag Chem Fab filed Critical Asta Werke Ag Chem Fab
Publication of DK536486D0 publication Critical patent/DK536486D0/da
Publication of DK536486A publication Critical patent/DK536486A/da
Application granted granted Critical
Publication of DK172076B1 publication Critical patent/DK172076B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK536486A 1985-11-11 1986-11-10 Derivater af 4-benzyl-1-(2H)-phthalazinon, fremgangsmåde til fremstilling heraf, forbindelserne til terapeutisk anvendelse, anvendelse af forbindelserne til fremstilling af lægemidler, lægemidler indeholdende forbindelserne samt fremgangsmåde til fremstilling af sådanne lægemidler DK172076B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3539873 1985-11-11
DE3539873 1985-11-11

Publications (3)

Publication Number Publication Date
DK536486D0 DK536486D0 (da) 1986-11-10
DK536486A true DK536486A (da) 1987-05-12
DK172076B1 DK172076B1 (da) 1997-10-13

Family

ID=6285623

Family Applications (1)

Application Number Title Priority Date Filing Date
DK536486A DK172076B1 (da) 1985-11-11 1986-11-10 Derivater af 4-benzyl-1-(2H)-phthalazinon, fremgangsmåde til fremstilling heraf, forbindelserne til terapeutisk anvendelse, anvendelse af forbindelserne til fremstilling af lægemidler, lægemidler indeholdende forbindelserne samt fremgangsmåde til fremstilling af sådanne lægemidler

Country Status (20)

Country Link
US (1) US4841047A (da)
EP (1) EP0222191B1 (da)
JP (1) JPH0780871B2 (da)
CN (1) CN86107627A (da)
AT (1) ATE60598T1 (da)
AU (1) AU593593B2 (da)
CA (1) CA1295613C (da)
DD (1) DD263058A5 (da)
DE (1) DE3677322D1 (da)
DK (1) DK172076B1 (da)
ES (1) ES2031813T3 (da)
FI (1) FI88504C (da)
GR (1) GR3001412T3 (da)
HU (1) HU196793B (da)
IE (1) IE59056B1 (da)
IL (1) IL80560A0 (da)
NO (1) NO864474L (da)
PT (1) PT83713B (da)
SU (1) SU1454251A3 (da)
ZA (1) ZA868531B (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88984B (pt) * 1987-11-13 1993-01-29 Asta Medica Ag Processo para a preparação de embonato de azelastina e de composições earmacâutxcas que 0 contêm como ingrediente activo
EP0322153A3 (en) * 1987-12-21 1990-08-16 Pfizer Inc. Heterocyclic oxophtalazinyl acetic acids
FR2643373B1 (fr) * 1989-01-10 1993-12-31 Adir Cie Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DE59006184D1 (de) * 1989-05-05 1994-07-28 Asta Medica Ag Salze des Azelastins mit verbesserter Löslichkeit.
JPH04198180A (ja) * 1990-11-28 1992-07-17 Eezai Kagaku Kk ベンジルフタラゾン誘導体の製造方法
DE4207234A1 (de) * 1992-03-07 1993-09-09 Asta Medica Ag Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung
EP0561166A1 (de) * 1992-03-17 1993-09-22 ASTA Medica Aktiengesellschaft Dosieraerosole enthaltend den Wirkstoff D-18024 und verwandte Strukturen
CZ199593A3 (en) * 1992-10-02 1994-04-13 Asta Medica Ag Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
ES2357057T3 (es) * 2002-04-30 2011-04-15 Kudos Pharmaceuticals Limited Derivados de ftalazinona.
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
PL2522365T3 (pl) 2004-11-24 2017-05-31 Meda Pharmaceuticals Inc. Kompozycje zawierające azelastynę i sposoby ich zastosowania
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
GB0521373D0 (en) * 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
PE20080360A1 (es) * 2006-04-20 2008-05-22 Glaxo Group Ltd Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3
WO2007144637A1 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited 2 -oxyheteroarylamide derivatives as parp inhibitors
EP2035380A2 (en) * 2006-06-15 2009-03-18 Kudos Pharmaceuticals Limited Parp inhibitors
CN101484421A (zh) * 2006-06-15 2009-07-15 库多斯药物有限公司 作为parp抑制剂的2-氧基苯甲酰胺衍生物
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
JP2010513393A (ja) * 2006-12-20 2010-04-30 グラクソ グループ リミテッド Ｈ１受容体アンタゴニストとしての４−ベンジル−ｌ（２ｈ）−フタラジノン
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
WO2009034326A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
EP2215082B1 (en) * 2007-10-11 2011-09-21 Glaxo Group Limited Phthalazine and pyrido[3,4-d]pyridazine compounds as h1 receptor antagonists
KR101598231B1 (ko) * 2007-10-17 2016-02-26 쿠도스 파마슈티칼스 리미티드 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
DK2346495T4 (da) 2008-10-07 2023-08-28 Kudos Pharm Ltd Farmaceutisk formulering 514
UY32790A (es) * 2009-07-15 2011-02-28 Astrazeneca Ab Compuesto de ftalazinona
CN113956239A (zh) * 2021-10-28 2022-01-21 昆明源瑞制药有限公司 一种盐酸氮卓斯汀及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3017411A (en) * 1962-01-16 New substituted phthalazones and proc-
DE2114884A1 (de) * 1971-03-27 1972-10-12 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Basisch substituierte Derivate des 1(2H)-Phthalazinons
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
ATE49205T1 (de) * 1984-09-14 1990-01-15 Asta Pharma Ag Substituierte benzylphthalazinon-derivate.
DE3530793A1 (de) * 1984-09-14 1986-03-27 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld Substituierte benzylphthalazinon-derivate

Also Published As

Publication number Publication date
DK536486D0 (da) 1986-11-10
US4841047A (en) 1989-06-20
FI864555A7 (fi) 1987-05-12
ATE60598T1 (de) 1991-02-15
HUT42084A (en) 1987-06-29
FI88504C (fi) 1993-05-25
NO864474L (no) 1987-05-12
DD263058A5 (de) 1988-12-21
JPH0780871B2 (ja) 1995-08-30
NO864474D0 (no) 1986-11-10
CN86107627A (zh) 1987-07-15
ZA868531B (en) 1987-07-29
DK172076B1 (da) 1997-10-13
DE3677322D1 (de) 1991-03-07
IE862960L (en) 1987-05-11
GR3001412T3 (en) 1992-09-25
AU593593B2 (en) 1990-02-15
ES2031813T3 (es) 1993-01-01
FI88504B (fi) 1993-02-15
EP0222191B1 (de) 1991-01-30
EP0222191A1 (de) 1987-05-20
JPS62114987A (ja) 1987-05-26
HU196793B (en) 1989-01-30
FI864555A0 (fi) 1986-11-10
AU6498286A (en) 1987-05-14
PT83713A (de) 1986-12-01
CA1295613C (en) 1992-02-11
SU1454251A3 (ru) 1989-01-23
IL80560A0 (en) 1987-02-27
PT83713B (pt) 1989-06-30
IE59056B1 (en) 1993-12-15

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