|
US5723147A
(en)
*
|
1987-02-23 |
1998-03-03 |
Depotech Corporation |
Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
|
|
US5925375A
(en)
*
|
1987-05-22 |
1999-07-20 |
The Liposome Company, Inc. |
Therapeutic use of multilamellar liposomal prostaglandin formulations
|
|
US5807572A
(en)
*
|
1988-02-18 |
1998-09-15 |
Depotech Corporation |
Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
|
|
WO1989008499A1
(fr)
*
|
1988-03-17 |
1989-09-21 |
Nippon Fine Chemical Co., Ltd. |
Liposome
|
|
US5422120A
(en)
*
|
1988-05-30 |
1995-06-06 |
Depotech Corporation |
Heterovesicular liposomes
|
|
US5230900A
(en)
*
|
1988-07-01 |
1993-07-27 |
The Biomembrane Institute |
Antibody-mediated and ligand-mediated targeting of differentiation-inducers to tumor cells
|
|
JPH0720857B2
(ja)
*
|
1988-08-11 |
1995-03-08 |
テルモ株式会社 |
リポソームおよびその製法
|
|
GB8824593D0
(en)
*
|
1988-10-20 |
1988-11-23 |
Royal Free Hosp School Med |
Liposomes
|
|
US5043164A
(en)
*
|
1989-01-17 |
1991-08-27 |
The University Of Tennessee Research Corporation |
Blood-stable, cholesterol-free liposomes
|
|
US5843473A
(en)
*
|
1989-10-20 |
1998-12-01 |
Sequus Pharmaceuticals, Inc. |
Method of treatment of infected tissues
|
|
US5013556A
(en)
*
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5356633A
(en)
*
|
1989-10-20 |
1994-10-18 |
Liposome Technology, Inc. |
Method of treatment of inflamed tissues
|
|
JP2785981B2
(ja)
*
|
1989-11-20 |
1998-08-13 |
株式会社資生堂 |
乳化組成物
|
|
US5053406A
(en)
*
|
1989-12-13 |
1991-10-01 |
Glycomed, Inc. |
Compositions and methods for preventing and treating rotaviral infections
|
|
US5882678A
(en)
*
|
1990-01-12 |
1999-03-16 |
The Liposome Co, Inc. |
Interdigitation-fusion liposomes containing arachidonic acid metabolites
|
|
US5162361A
(en)
*
|
1990-04-10 |
1992-11-10 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Method of treating diseases associated with elevated levels of interleukin 1
|
|
FR2661331A1
(fr)
*
|
1990-04-30 |
1991-10-31 |
Oreal |
Composition cosmetique ou dermopharmaceutique contenant des vesicules formees par un melange phospholipides/glycolipides.
|
|
DE4107153A1
(de)
*
|
1991-03-06 |
1992-09-10 |
Gregor Cevc |
Praeparat zur wirkstoffapplikation in kleinsttroepfchenform
|
|
DE4107152C2
(de)
*
|
1991-03-06 |
1994-03-24 |
Gregor Cevc |
Präparate zur nichtinvasiven Verabreichung von Antidiabetica
|
|
US5298246A
(en)
*
|
1991-01-09 |
1994-03-29 |
Kanegafuchi Kagaku Kogyo Kabushiki Kaisha |
Stable pharmaceutical composition and method for its production
|
|
CA2120507A1
(en)
*
|
1991-10-18 |
1993-04-29 |
Alban J. Linnenbach |
Soluble variants of type 1 membrane proteins, and methods of using them
|
|
WO1993020802A1
(en)
*
|
1992-04-09 |
1993-10-28 |
Northwestern University |
Acoustically reflective liposomes and methods to make and use the same
|
|
US5858399A
(en)
*
|
1992-04-09 |
1999-01-12 |
Northwestern University |
Acoustically reflective liposomes and methods to make and use the same
|
|
US5573779A
(en)
*
|
1992-04-10 |
1996-11-12 |
Hisamitsu Pharmaceutical Co., Inc. |
Liposome composition
|
|
US5455044A
(en)
*
|
1993-05-14 |
1995-10-03 |
Depotech Corporation |
Method for treating neurological disorders
|
|
US5534241A
(en)
*
|
1993-07-23 |
1996-07-09 |
Torchilin; Vladimir P. |
Amphipathic polychelating compounds and methods of use
|
|
US5863556A
(en)
*
|
1993-08-20 |
1999-01-26 |
Euro-Celtique, S.A. |
Preparations for the external application of antiseptic agents and/or agents promoting the healing of wounds
|
|
US6217849B1
(en)
|
1993-09-29 |
2001-04-17 |
Bracco Research S.A. |
Liposome suspensions as blood pool imaging contrast agents
|
|
DE69424680T2
(de)
*
|
1993-10-25 |
2000-09-28 |
The Liposome Co.,Inc. |
Liposomale defensine
|
|
US5468499A
(en)
*
|
1993-11-15 |
1995-11-21 |
Ohio State University |
Liposomes containing the salt of phosphoramide mustard and related compounds
|
|
RO116341B1
(ro)
*
|
1993-11-16 |
2001-01-30 |
Depotech Corp La Jolia |
Lipozom multivezicular si procedeu de obtinere a acestuia
|
|
FR2712811B1
(fr)
*
|
1993-11-26 |
1996-01-05 |
Oreal |
Procédé pour lutter contre l'adiposite et compositions utilisables à cet effet.
|
|
US5741516A
(en)
*
|
1994-06-20 |
1998-04-21 |
Inex Pharmaceuticals Corporation |
Sphingosomes for enhanced drug delivery
|
|
US5543152A
(en)
*
|
1994-06-20 |
1996-08-06 |
Inex Pharmaceuticals Corporation |
Sphingosomes for enhanced drug delivery
|
|
US5993850A
(en)
*
|
1994-09-13 |
1999-11-30 |
Skyepharma Inc. |
Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
|
|
US5885613A
(en)
*
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5820873A
(en)
*
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
DE69519802T2
(de)
*
|
1994-10-14 |
2001-04-19 |
The Liposome Co.,Inc. |
Etherlipid-liposomen und deren therapeutische verwendung
|
|
ES2165971T3
(es)
*
|
1995-02-24 |
2002-04-01 |
Bracco Research Sa |
Suspensiones de liposomas como agentes de contraste para la imagineria de la sangre.
|
|
US6358915B1
(en)
*
|
1995-03-07 |
2002-03-19 |
George Washington University |
Methods for inhibiting metastasis
|
|
US5990077A
(en)
|
1995-04-14 |
1999-11-23 |
1149336 Ontario Inc. |
Glucagon-like peptide-2 and its therapeutic use
|
|
US6184201B1
(en)
*
|
1995-04-14 |
2001-02-06 |
Nps Allelix Corp. |
Intestinotrophic glucagon-like peptide-2 analogs
|
|
US5834428A
(en)
*
|
1995-04-14 |
1998-11-10 |
1149336 Ontario Inc. |
Glucagon-like peptide-2 and its therapeutic use
|
|
US6673364B1
(en)
|
1995-06-07 |
2004-01-06 |
The University Of British Columbia |
Liposome having an exchangeable component
|
|
US5931809A
(en)
*
|
1995-07-14 |
1999-08-03 |
Depotech Corporation |
Epidural administration of therapeutic compounds with sustained rate of release
|
|
US5855911A
(en)
*
|
1995-08-29 |
1999-01-05 |
Board Of Regents, The University Of Texas System |
Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
|
|
US6107332A
(en)
|
1995-09-12 |
2000-08-22 |
The Liposome Company, Inc. |
Hydrolysis-promoting hydrophobic taxane derivatives
|
|
US6051600A
(en)
*
|
1995-09-12 |
2000-04-18 |
Mayhew; Eric |
Liposomal hydrolysis-promoting hydrophobic taxane derivatives
|
|
US6153736A
(en)
*
|
1995-09-27 |
2000-11-28 |
The Liposome Company, Inc. |
Modified ether glyceroglycolipids
|
|
US5834025A
(en)
*
|
1995-09-29 |
1998-11-10 |
Nanosystems L.L.C. |
Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions
|
|
ATE386506T1
(de)
|
1995-10-17 |
2008-03-15 |
Jagotec Ag |
Verabreichung unlöslicher arzneistoffe
|
|
US6667053B1
(en)
|
1996-02-16 |
2003-12-23 |
Elan Pharmaceuticals, Inc. |
D and L etherlipid stereoisomers and liposomes
|
|
US5965159A
(en)
|
1996-02-16 |
1999-10-12 |
The Liposome Company, Inc. |
Etherlipid-containing multiple lipid liposomes
|
|
US6007839A
(en)
*
|
1996-02-16 |
1999-12-28 |
The Liposome Company, Inc. |
Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes
|
|
US5942246A
(en)
*
|
1996-02-16 |
1999-08-24 |
The Liposome Company, Inc. |
Etherlipid containing multiple lipid liposomes
|
|
USRE39042E1
(en)
*
|
1996-02-16 |
2006-03-28 |
The Liposome Company, Inc. |
Etherlipid-containing multiple lipid liposomes
|
|
AU733212B2
(en)
|
1996-03-28 |
2001-05-10 |
Board Of Trustees Of The University Of Illinois, The |
Material and methods for making improved liposome compositions
|
|
EP2218734B1
(en)
|
1996-04-12 |
2013-06-05 |
1149336 Ontario Inc. |
Glucagon-like peptide-2 analogs
|
|
WO1997039735A1
(en)
*
|
1996-04-24 |
1997-10-30 |
Sdg, Inc. |
Improved masking of liposomes from res recognition
|
|
US6111081A
(en)
*
|
1996-05-31 |
2000-08-29 |
Baylor College Of Medicine |
Lactoferrin variants and uses thereof
|
|
US7309692B1
(en)
*
|
1996-07-08 |
2007-12-18 |
Board Of Regents, The University Of Texas System |
Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
|
|
US7368129B1
(en)
|
1996-08-14 |
2008-05-06 |
Nutrimed Biotech |
Amphiphilic materials and liposome formulations thereof
|
|
US6284267B1
(en)
|
1996-08-14 |
2001-09-04 |
Nutrimed Biotech |
Amphiphilic materials and liposome formulations thereof
|
|
KR100190826B1
(ko)
*
|
1996-08-26 |
1999-06-01 |
강재헌 |
적혈구 용혈 억제용 약제학적 조성물 및 그의제조방법
|
|
US5997899A
(en)
|
1996-10-01 |
1999-12-07 |
Skyepharma Inc. |
Method for producing liposomes with increased percent of compound encapsulated
|
|
US6977244B2
(en)
|
1996-10-04 |
2005-12-20 |
Board Of Regents, The University Of Texas Systems |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
|
US6339069B1
(en)
|
1996-10-15 |
2002-01-15 |
Elan Pharmaceuticalstechnologies, Inc. |
Peptide-lipid conjugates, liposomes and lipsomal drug delivery
|
|
DK0964690T3
(da)
*
|
1996-10-15 |
2003-10-20 |
Liposome Co Inc |
Peptid-lipidkonjugater, liposomer og liposomal lægemiddeladministration
|
|
US6037125A
(en)
*
|
1996-11-05 |
2000-03-14 |
Lexicon Genetics Incorporated |
Disruption of the mammalian RAD51 protein and disruption of proteins that associate with mammalian RAD51 for hindering cell proliferation and/or viability of proliferating cells
|
|
US5827533A
(en)
*
|
1997-02-06 |
1998-10-27 |
Duke University |
Liposomes containing active agents aggregated with lipid surfactants
|
|
US6123956A
(en)
*
|
1997-07-10 |
2000-09-26 |
Keith Baker |
Methods for universally distributing therapeutic agents to the brain
|
|
US20020115609A1
(en)
*
|
1997-07-14 |
2002-08-22 |
Hayat Onyuksel |
Materials and methods for making improved micelle compositions
|
|
US20050025819A1
(en)
*
|
1997-07-14 |
2005-02-03 |
Hayat Onyuksel |
Materials and methods for making improved micelle compositions
|
|
US6217886B1
(en)
|
1997-07-14 |
2001-04-17 |
The Board Of Trustees Of The University Of Illinois |
Materials and methods for making improved micelle compositions
|
|
US6306432B1
(en)
|
1997-09-08 |
2001-10-23 |
Chiron Corporation |
High and low load formulations of IGF-I in multivesicular liposomes
|
|
EP2308470A1
(en)
*
|
1997-09-18 |
2011-04-13 |
Pacira Pharmaceuticals, Inc. |
Sustained-release liposomal anesthetic compositions
|
|
US7704962B1
(en)
|
1997-10-03 |
2010-04-27 |
Board Of Regents, The University Of Texas System |
Small oligonucleotides with anti-tumor activity
|
|
US7285288B1
(en)
|
1997-10-03 |
2007-10-23 |
Board Of Regents, The University Of Texas System |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
|
US6734171B1
(en)
|
1997-10-10 |
2004-05-11 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating nucleic acids in lipid bilayers
|
|
NZ504188A
(en)
*
|
1997-11-14 |
2001-10-26 |
Skyepharma Inc |
Emulsification process for preparing multivesicular liposomes
|
|
US6979456B1
(en)
|
1998-04-01 |
2005-12-27 |
Jagotec Ag |
Anticancer compositions
|
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
|
AU780194B2
(en)
*
|
1999-06-24 |
2005-03-10 |
Kyowa Hakko Kirin Co., Ltd. |
Method of regulating leakage of drug encapsulated in liposomes
|
|
GB9918670D0
(en)
|
1999-08-06 |
1999-10-13 |
Celltech Therapeutics Ltd |
Biological product
|
|
BR0016864A
(pt)
*
|
1999-12-30 |
2002-09-24 |
Judith K Gwathmey |
Sistema de fornecimento de quelante de ferro, e, métodos de preparação de um sistema de fornecimento de quelante de ferro e de tratamento de sobrecarga de ferro em um mamìfero em necessidade de tratamento
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
EP1267946A4
(en)
|
2000-02-28 |
2008-07-02 |
Genesegues Inc |
SYSTEM AND METHOD FOR ENCAPSULATING NANOCAPSULES
|
|
US8088060B2
(en)
|
2000-03-15 |
2012-01-03 |
Orbusneich Medical, Inc. |
Progenitor endothelial cell capturing with a drug eluting implantable medical device
|
|
US9522217B2
(en)
|
2000-03-15 |
2016-12-20 |
Orbusneich Medical, Inc. |
Medical device with coating for capturing genetically-altered cells and methods for using same
|
|
US20070141107A1
(en)
*
|
2000-03-15 |
2007-06-21 |
Orbusneich Medical, Inc. |
Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
|
|
US20070055367A1
(en)
*
|
2000-03-15 |
2007-03-08 |
Orbus Medical Technologies, Inc. |
Medical device with coating that promotes endothelial cell adherence and differentiation
|
|
US8460367B2
(en)
*
|
2000-03-15 |
2013-06-11 |
Orbusneich Medical, Inc. |
Progenitor endothelial cell capturing with a drug eluting implantable medical device
|
|
EP1263484B1
(en)
|
2000-03-15 |
2007-05-16 |
OrbusNeich Medical, Inc. |
Coating which promotes endothelial cell adherence
|
|
US20030229393A1
(en)
*
|
2001-03-15 |
2003-12-11 |
Kutryk Michael J. B. |
Medical device with coating that promotes cell adherence and differentiation
|
|
EP1341800A2
(en)
|
2000-12-11 |
2003-09-10 |
The Research Foundation Of the City university of New York |
C-glucosyl ether lipids
|
|
US8658202B2
(en)
*
|
2001-04-25 |
2014-02-25 |
Western University Of Health Sciences |
Coated drug delivery formulations
|
|
US6759058B1
(en)
*
|
2001-04-25 |
2004-07-06 |
Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences |
Enteric-coated proliposomal formulations for poorly water soluble drugs
|
|
WO2003000707A2
(en)
|
2001-06-21 |
2003-01-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
NZ577565A
(en)
|
2001-10-09 |
2010-10-29 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expressions
|
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
AU2002336867A1
(en)
*
|
2001-11-02 |
2003-05-12 |
Qlt Inc. |
Micelle compositions containing pegylated phospholipids and a photosensitizer
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
EP1460898A4
(en)
*
|
2002-01-03 |
2006-05-24 |
Univ Texas |
WT1 ANTISENSE OLIGOS FOR THE INHIBITION OF BREAST CANCER
|
|
US20040038303A1
(en)
*
|
2002-04-08 |
2004-02-26 |
Unger Gretchen M. |
Biologic modulations with nanoparticles
|
|
WO2003087368A2
(en)
|
2002-04-18 |
2003-10-23 |
Lynkeus Bio Tech Gmbh |
Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification
|
|
US7148342B2
(en)
*
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
|
US20040213837A1
(en)
*
|
2002-08-05 |
2004-10-28 |
Sankaram Mantripragada |
Oil-core compositions for the sustained release of hydrophobic drugs
|
|
BR0314236A
(pt)
|
2002-09-13 |
2005-08-09 |
Replicor Inc |
Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos
|
|
EP1549767A4
(en)
|
2002-09-26 |
2006-06-07 |
Amgen Inc |
MODULATION OF EXPRESSION OF FORKHEAD BOX O1A
|
|
EP2336318B1
(en)
|
2002-11-13 |
2013-04-24 |
Genzyme Corporation |
Antisense modulation of apolipoprotein b expression
|
|
PT2336318E
(pt)
|
2002-11-13 |
2013-06-12 |
Genzyme Corp |
Modulação anti-sentido da expressão de apolipoproteína b
|
|
US8980310B2
(en)
*
|
2002-12-31 |
2015-03-17 |
Bharat Serums and Vaccines, Ltd. |
Non-pegylated long-circulating liposomes
|
|
DK1435231T3
(da)
|
2002-12-31 |
2010-04-26 |
Zydus Bsv Pharma Private Ltd |
Ikke-pegylerede længe cirkulerende liposomer
|
|
EP2251434B1
(en)
|
2003-01-16 |
2014-07-30 |
The Trustees of The University of Pennsylvania |
Compositions and methods for siRNA inhibition of ICAM-1
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
EP1668024A4
(en)
*
|
2003-09-29 |
2008-07-02 |
Topigen Pharma Inc |
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES INCLUDING INFLAMMATORY SUFFERING
|
|
US7960350B2
(en)
|
2003-10-24 |
2011-06-14 |
Ader Enterprises, Inc. |
Composition and method for the treatment of eye disease
|
|
EP2295604B1
(en)
|
2004-02-09 |
2015-04-08 |
Thomas Jefferson University |
Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features
|
|
JP2007535389A
(ja)
*
|
2004-04-30 |
2007-12-06 |
オーバスネイク メディカル インコーポレーテッド |
遺伝子的に改変された細胞を捕捉する被覆を備えた医療デバイスおよびその使用方法
|
|
CN1960707B
(zh)
*
|
2004-06-03 |
2012-11-14 |
博莱科瑞士股份有限公司 |
用于治疗和/或诊断用途的脂质集合体
|
|
WO2006047394A1
(en)
*
|
2004-10-22 |
2006-05-04 |
Benitec, Inc. |
Therapeutic rnai agents for treating psoriasis
|
|
JP5314283B2
(ja)
*
|
2004-10-29 |
2013-10-16 |
トピジェン・ファーマシューティカルズ・インコーポレーテッド |
アレルギーおよび新生物細胞増殖を治療するための、アンチセンスオリゴヌクレオチド
|
|
JP4990786B2
(ja)
*
|
2004-11-05 |
2012-08-01 |
イネックス ファーマシューティカルズ コーポレイション |
薬物リポソーム製剤を安定化するための組成物および方法
|
|
JP5264478B2
(ja)
*
|
2005-04-29 |
2013-08-14 |
ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション，インコーポレーテッド |
活性物質での細胞表面の装飾
|
|
US8287923B2
(en)
*
|
2005-06-10 |
2012-10-16 |
Medical College Of Georgia Research Institute, Inc. |
Compositions and methods for treating immune disorders
|
|
US9446017B2
(en)
|
2005-08-11 |
2016-09-20 |
Augusta University Research Institute, Inc. |
Compositions and methods for treating herpes simplex virus
|
|
ES2523989T3
(es)
|
2005-09-12 |
2014-12-03 |
The Ohio State University Research Foundation |
Composiciones para la terapia de cánceres asociados con BCL2
|
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
|
US20070197460A1
(en)
|
2005-11-01 |
2007-08-23 |
Alnylam Pharmaceuticals, Inc. |
Rnai inhibition of influenza virus replication
|
|
WO2007070705A2
(en)
*
|
2005-12-15 |
2007-06-21 |
The Trustees Of The University Of Pennsylvania |
Cationic lipid-mediated vectors
|
|
EP2221378B1
(en)
*
|
2005-12-22 |
2013-04-17 |
OPKO Pharmaceuticals, LLC |
Compositions and methods for regulating complement system
|
|
EP2479285B1
(en)
|
2006-01-05 |
2014-05-14 |
The Ohio State University Research Foundation |
MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
|
|
CA2635616A1
(en)
|
2006-01-05 |
2007-07-19 |
Carlo M. Croce |
Microrna expression abnormalities in pancreatic endocrine and acinar tumors
|
|
JP5451077B2
(ja)
|
2006-01-05 |
2014-03-26 |
ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション |
肺癌の診断、予後診断及び治療のためのマイクロｒｎａを基盤とした方法及び組成物
|
|
ES2448491T3
(es)
|
2006-03-02 |
2014-03-14 |
The Ohio State University Research Foundation |
Perfil de expresión de microARN asociado con cáncer de páncreas
|
|
US7985584B2
(en)
|
2006-03-20 |
2011-07-26 |
The Ohio State University Research Foundation |
MicroRNA fingerprints during human megakaryocytopoiesis
|
|
US7875288B2
(en)
*
|
2006-03-30 |
2011-01-25 |
The Research Foundation Of State University Of New York |
Method for treating blood coagulation disorders
|
|
NZ572308A
(en)
*
|
2006-03-30 |
2011-09-30 |
Univ New York State Res Found |
Compositions of less immunogenic and long-circulating protein-lipid complexes
|
|
WO2007123691A2
(en)
*
|
2006-03-30 |
2007-11-01 |
The Research Foundation Of State University Of New York |
Method for treating blood coagulation disorders
|
|
CA2873833A1
(en)
|
2006-03-31 |
2007-10-11 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of eg5 gene
|
|
WO2007127919A2
(en)
|
2006-04-28 |
2007-11-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the jc virus
|
|
US20090130212A1
(en)
*
|
2006-05-15 |
2009-05-21 |
Physical Pharmaceutica, Llc |
Composition and improved method for preparation of small particles
|
|
JP2009537153A
(ja)
|
2006-05-19 |
2009-10-29 |
アルニラム ファーマシューティカルズ， インコーポレイテッド |
ＡｈａのＲＮＡｉ調節およびその治療上の使用
|
|
KR20090035662A
(ko)
*
|
2006-05-19 |
2009-04-10 |
토피겐 파마슈티컬스 인코포레이티드 |
포스포디에스테라아제의 발현에 영향을 미치는 올리고누클레오티드
|
|
US7888498B2
(en)
|
2006-05-22 |
2011-02-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of IKK-B gene
|
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
US20080152654A1
(en)
*
|
2006-06-12 |
2008-06-26 |
Exegenics, Inc., D/B/A Opko Health, Inc. |
COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
|
|
ES2447850T3
(es)
|
2006-07-13 |
2014-03-13 |
The Ohio State University Research Foundation |
Métodos y composiciones basados en micro-ARN para el pronóstico y tratamiento de enfermedades relacionadas con el colon
|
|
US7872118B2
(en)
*
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
|
WO2008086807A2
(en)
|
2007-01-19 |
2008-07-24 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
|
WO2008091655A2
(en)
*
|
2007-01-23 |
2008-07-31 |
The Regents Of The University Of California |
Methods, compositions and device for directed and controlled heating and release of agents
|
|
WO2008121604A2
(en)
|
2007-03-29 |
2008-10-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the ebola
|
|
AR066984A1
(es)
|
2007-06-15 |
2009-09-23 |
Novartis Ag |
Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
|
|
EP2190448B1
(en)
|
2007-06-22 |
2016-04-20 |
Children's Medical Center Corporation |
Methods and uses thereof of a fragment of saposin a
|
|
US7910722B2
(en)
|
2007-07-05 |
2011-03-22 |
Florida State University Research Foundation |
RNAi therapeutic for treatment of hepatitis C infection
|
|
CA2695184A1
(en)
|
2007-07-31 |
2009-02-05 |
The Ohio State University Research Foundation |
Methods for reverting methylation by targeting dnmt3a and dnmt3b
|
|
US7960336B2
(en)
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
|
JP2010535473A
(ja)
|
2007-08-03 |
2010-11-25 |
ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン |
ｎｃＲＮＡをコードする超保存領域
|
|
US20110160279A1
(en)
*
|
2007-08-13 |
2011-06-30 |
Board Of Trustees Of Southern Illinois University |
METHODS FOR TREATMENT AND PREVENTION OF OTOTOXICITY BY siRNA
|
|
CA2696887C
(en)
|
2007-08-22 |
2016-06-28 |
The Ohio State University Research Foundation |
Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
|
|
EP2183393B1
(en)
|
2007-09-06 |
2014-06-11 |
The Ohio State University Research Foundation |
Microrna signatures in human ovarian cancer
|
|
US9498493B2
(en)
|
2007-09-27 |
2016-11-22 |
Immunovaccine Technologies Inc. |
Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
|
|
US20100209452A1
(en)
*
|
2007-10-03 |
2010-08-19 |
Immunovaccine Technologies, Inc |
Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
|
|
CA2702241A1
(en)
|
2007-10-11 |
2009-04-16 |
The Ohio State University Research Foundation |
Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas
|
|
EP2848688A1
(en)
|
2007-12-10 |
2015-03-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor VII gene
|
|
CN102014932B
(zh)
|
2008-03-05 |
2015-11-25 |
阿尔尼拉姆医药品有限公司 |
用于抑制Eg5和VEGF基因表达的组合物和方法
|
|
US8314068B2
(en)
|
2008-04-14 |
2012-11-20 |
University Hospitals Of Cleveland |
P2X7 inhibition of epithelial cancers and papillomas
|
|
EP2285961A4
(en)
|
2008-05-15 |
2012-10-17 |
Topigen Pharmaceuticals Inc |
OLIGONUCLEOTIDES FOR THE TREATMENT OF INFLAMMATION AND NEOPLASTIC CELL REPRODUCTION
|
|
JP5715051B2
(ja)
*
|
2008-06-05 |
2015-05-07 |
イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． |
リポソーム、抗原、ポリヌクレオチド及び疎水性物質の連続相を含む担体を含む組成物
|
|
US8252762B2
(en)
|
2008-08-25 |
2012-08-28 |
Excaliard Pharmaceuticals, Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
|
EP2329044B1
(en)
|
2008-08-27 |
2016-05-18 |
Oncotherapy Science, Inc. |
Prmt1 for target genes of cancer therapy and diagnosis
|
|
EP3208337A1
(en)
|
2008-09-02 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions for combined inhibition of mutant egfr and il-6 expression
|
|
CA2738019A1
(en)
|
2008-09-23 |
2010-04-08 |
President And Fellows Of Harvard College |
Sirt4 and uses thereof
|
|
EP3584320A1
(en)
|
2008-09-25 |
2019-12-25 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
|
CA3222620A1
(en)
|
2008-10-20 |
2010-04-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
|
CA2745832A1
(en)
|
2008-12-04 |
2010-06-10 |
Opko Ophthalmics, Llc |
Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms
|
|
AU2009324534B2
(en)
|
2008-12-10 |
2015-07-30 |
Alnylam Pharmaceuticals, Inc. |
GNAQ targeted dsRNA compositions and methods for inhibiting expression
|
|
EP2379720B1
(en)
|
2009-01-20 |
2016-08-17 |
Alona Zilberberg |
Mir-21 promoter driven targeted cancer therapy
|
|
WO2010099341A1
(en)
|
2009-02-26 |
2010-09-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mig-12 gene
|
|
CA2754043A1
(en)
|
2009-03-12 |
2010-09-16 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
|
|
US8524784B2
(en)
*
|
2009-04-30 |
2013-09-03 |
Intezyne Technologies, Incorporated |
Polymer micelles containing anthracylines for the treatment of cancer
|
|
US8524783B2
(en)
|
2009-04-30 |
2013-09-03 |
Intezyne Technologies, Incorporated |
Polymer micelles containing anthracylines for the treatment of cancer
|
|
IT1398857B1
(it)
|
2009-06-10 |
2013-03-21 |
Univ Padova |
Coniugati polimerici fosfolipidi
|
|
WO2011020023A2
(en)
|
2009-08-14 |
2011-02-17 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
|
AU2010288810A1
(en)
|
2009-08-31 |
2012-03-01 |
University Of Bremen |
MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of tumor involving chromosomal rearrangements
|
|
EP2483406A2
(en)
|
2009-09-30 |
2012-08-08 |
President and Fellows of Harvard College |
Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products
|
|
CA2780741C
(en)
|
2009-10-12 |
2023-04-04 |
Smith Holdings, Llc |
Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
|
|
ES2632431T3
(es)
|
2009-10-30 |
2017-09-13 |
Ntf Therapeutics, Inc. |
Moléculas de neurturina mejoradas
|
|
ES2666559T3
(es)
|
2009-12-01 |
2018-05-07 |
Translate Bio, Inc. |
Entrega del mrna para la aumentación de proteínas y enzimas en enfermedades genéticas humanas
|
|
EP2507373A4
(en)
*
|
2009-12-04 |
2013-08-07 |
Opko Pharmaceuticals Llc |
COMPOSITIONS AND METHODS FOR INHIBITING VEGF
|
|
EP3925670A1
(en)
|
2009-12-17 |
2021-12-22 |
Children's Medical Center, Corp. |
Saposin-a derived peptides and uses thereof
|
|
ES2651005T3
(es)
|
2010-03-09 |
2018-01-23 |
Biomedical Research Models, Inc. |
Una nueva estrategia de vacunación mucosa para el virus del herpes simple tipo-2
|
|
ES2893199T3
(es)
|
2010-03-29 |
2022-02-08 |
Alnylam Pharmaceuticals Inc |
Terapia de ARNbc para amiloidosis ocular relacionada con transtiretina (TTR)
|
|
US8507663B2
(en)
|
2010-04-06 |
2013-08-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of CD274/PD-L1 gene
|
|
WO2011123943A1
(en)
|
2010-04-09 |
2011-10-13 |
Mount Sinai Hospital |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
|
WO2011153323A2
(en)
|
2010-06-02 |
2011-12-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
WO2012006552A1
(en)
|
2010-07-09 |
2012-01-12 |
Exelixis, Inc. |
Combinations of kinase inhibitors for the treatment of cancer
|
|
US9339513B2
(en)
|
2010-11-09 |
2016-05-17 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
|
US9072766B2
(en)
|
2010-11-18 |
2015-07-07 |
Beth Israel Deaconess Medical Center, Inc. |
Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
|
|
WO2012075040A2
(en)
|
2010-11-30 |
2012-06-07 |
Shire Human Genetic Therapies, Inc. |
mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
|
|
US20120310140A1
(en)
|
2010-12-01 |
2012-12-06 |
Spinal Modulation, Inc. |
Directed delivery of agents to neural anatomy
|
|
WO2012079046A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
|
US9193973B2
(en)
|
2010-12-10 |
2015-11-24 |
Alynylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (EPO) production
|
|
PT2670411T
(pt)
|
2011-02-02 |
2019-06-18 |
Excaliard Pharmaceuticals Inc |
Compostos anti sentido visando um fator de crescimento do tecido conetivo (ctfg) para utilização num método de tratamento de queloides ou cicatrizes hipertróficas
|
|
CN103813810B
(zh)
|
2011-03-29 |
2021-08-03 |
阿尔尼拉姆医药品有限公司 |
用于抑制tmprss6基因表达的组合物和方法
|
|
WO2012164058A1
(en)
|
2011-06-01 |
2012-12-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for adjusting expression of mitochondrial genome by microrna
|
|
KR20190042747A
(ko)
|
2011-06-02 |
2019-04-24 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
생체외 조직 배양 시스템을 위한 방법 및 용도
|
|
ES2663360T3
(es)
|
2011-06-08 |
2018-04-12 |
Translate Bio, Inc. |
Lípidos escindibles
|
|
BR112013031553A2
(pt)
|
2011-06-08 |
2020-11-10 |
Shire Human Genetic Therapies, Inc. |
composições, mrna que codifica para uma hgla e seu uso, uso de pelo menos uma molécula de mrna e um veículo de transferência e uso de um mrna que codifica para proteína exógena
|
|
JP6081995B2
(ja)
|
2011-06-17 |
2017-02-15 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
癌の処置における治療抗体の標的としてのＦｒｉｚｚｌｅｄ２
|
|
US9068184B2
(en)
|
2011-06-21 |
2015-06-30 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of protein C (PROC) genes
|
|
AU2012272908A1
(en)
|
2011-06-21 |
2013-12-19 |
Alnylam Pharmaceuticals, Inc. |
Assays and methods for determining activity of a therapeutic agent in a subject
|
|
CN120555426A
(zh)
|
2011-06-21 |
2025-08-29 |
阿尔尼拉姆医药品有限公司 |
血管生成素样3（ANGPTL3）iRNA组合物及其使用方法
|
|
KR102540778B1
(ko)
|
2011-06-21 |
2023-06-07 |
알닐람 파마슈티칼스 인코포레이티드 |
아포리포단백질 c-iii(apoc3) 유전자의 발현 억제를 위한 조성물 및 방법
|
|
WO2012178033A2
(en)
|
2011-06-23 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
|
KR20140147797A
(ko)
|
2011-06-27 |
2014-12-30 |
더 잭슨 래보라토리 |
암 및 자가면역 질환의 치료 방법 및 조성물
|
|
EP2543370A1
(en)
|
2011-07-06 |
2013-01-09 |
Georgia Health Sciences University Research Institute, Inc. |
Compositions and Methods for Treating Herpes Simplex Virus
|
|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
JP2014526887A
(ja)
|
2011-08-01 |
2014-10-09 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
造血幹細胞移植の成功率を改善する方法
|
|
AU2012321022B2
(en)
|
2011-10-06 |
2017-03-23 |
Immunovaccine Technologies Inc. |
Liposome compositions comprising an adjuvant that activates or increases the activity of TLR2 and uses thereof
|
|
CN104364390B
(zh)
|
2011-10-14 |
2016-08-24 |
俄亥俄州立大学 |
与卵巢癌相关的方法和材料
|
|
WO2013060894A1
(en)
|
2011-10-27 |
2013-05-02 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment and diagnosis of atherosclerosis
|
|
EP3560509B1
(en)
|
2011-12-22 |
2024-01-31 |
Children's Medical Center Corporation |
Saposin-a derived peptides and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
BR112014024131A2
(pt)
|
2012-03-29 |
2017-07-25 |
Shire Human Genetic Therapies |
lipídios catiônicos ionizáveis
|
|
EP2831232A4
(en)
|
2012-03-30 |
2015-11-04 |
Univ Washington |
METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME
|
|
WO2013153082A1
(en)
|
2012-04-10 |
2013-10-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of nonalcoholic steatohepatitis
|
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
WO2013153139A1
(en)
|
2012-04-11 |
2013-10-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment and diagnosis of acute leukemia
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
EP2859102A4
(en)
|
2012-06-08 |
2016-05-11 |
Shire Human Genetic Therapies |
NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF
|
|
EP3470061A1
(en)
|
2012-11-20 |
2019-04-17 |
Spectrum Pharmaceuticals, Inc. |
Improved method for the preparation of a dosage of liposome encapsulated vincristine for therapeutic use
|
|
SMT201800039T1
(it)
|
2012-12-05 |
2018-03-08 |
Alnylam Pharmaceuticals Inc |
Composizioni di irna di pcsk9 e metodi di uso delle stesse
|
|
EP2929035A1
(en)
|
2012-12-07 |
2015-10-14 |
Shire Human Genetic Therapies, Inc. |
Lipidic nanoparticles for mrna delivering
|
|
CA2897398A1
(en)
|
2013-01-07 |
2014-07-10 |
Biomedical Research Models, Inc. |
Use of vaccines for the treatment of herpes simplex virus type 2 infections
|
|
EP4446413A3
(en)
|
2013-03-14 |
2024-12-18 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
WO2014153052A2
(en)
|
2013-03-14 |
2014-09-25 |
Shire Human Genetic Therapies, Inc. |
Cftr mrna compositions and related methods and uses
|
|
WO2014153236A1
(en)
|
2013-03-14 |
2014-09-25 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating tau expression
|
|
US20160184458A1
(en)
|
2013-03-14 |
2016-06-30 |
Shire Human Genetic Therapies, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
CN120574828A
(zh)
|
2013-03-14 |
2025-09-02 |
阿尔尼拉姆医药品有限公司 |
补体组分C5 iRNA组合物及其使用方法
|
|
ES2795249T3
(es)
|
2013-03-15 |
2020-11-23 |
Translate Bio Inc |
Mejora sinérgica de la administración de ácidos nucleicos a través de formulaciones mezcladas
|
|
EP3708184A1
(en)
|
2013-03-27 |
2020-09-16 |
The General Hospital Corporation |
Methods and agents for treating alzheimer s disease
|
|
AR096203A1
(es)
|
2013-05-06 |
2015-12-16 |
Alnylam Pharmaceuticals Inc |
Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos
|
|
SG10202103166XA
(en)
|
2013-05-22 |
2021-04-29 |
Alnylam Pharmaceuticals Inc |
Tmprss6 irna compositions and methods of use thereof
|
|
PL2999785T3
(pl)
|
2013-05-22 |
2018-09-28 |
Alnylam Pharmaceuticals, Inc. |
Kompozycje iRNA Serpina1 i sposoby ich zastosowania
|
|
WO2015006228A1
(en)
|
2013-07-08 |
2015-01-15 |
The University Of Utah Research Foundation |
Methods for treatment of and prophylaxis against inflammatory disorders
|
|
TW202246503A
(zh)
|
2013-07-19 |
2022-12-01 |
美商百健Ｍａ公司 |
用於調節τ蛋白表現之組合物
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
CA2925107A1
(en)
|
2013-10-02 |
2015-04-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
EP3052628B1
(en)
|
2013-10-04 |
2020-02-26 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the alas1 gene
|
|
ES2707966T3
(es)
|
2013-10-22 |
2019-04-08 |
Translate Bio Inc |
Terapia de ARNm para la deficiencia en síntesis de argininosuccinato
|
|
CN105658242A
(zh)
|
2013-10-22 |
2016-06-08 |
夏尔人类遗传性治疗公司 |
用于苯丙酮尿症的mrna疗法
|
|
SG11201604692UA
(en)
|
2013-12-12 |
2016-07-28 |
Alnylam Pharmaceuticals Inc |
Complement component irna compositions and methods of use thereof
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
EP3079727A1
(en)
|
2013-12-12 |
2016-10-19 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Methods for the prevention and treatment of diabetic cardiomyopathy using mir-424/322
|
|
CN106103718B
(zh)
|
2014-02-11 |
2021-04-02 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
|
CN106164248B
(zh)
|
2014-04-25 |
2019-10-15 |
川斯勒佰尔公司 |
信使rna的纯化方法
|
|
WO2015179724A1
(en)
|
2014-05-22 |
2015-11-26 |
Alnylam Pharmaceuticals, Inc. |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
|
MX388301B
(es)
|
2014-09-03 |
2025-03-19 |
Boehringer Ingelheim Int |
Il-23a y tnf-alfa orientados y compuesto y sus usos.
|
|
SG10201902499VA
(en)
|
2014-09-03 |
2019-04-29 |
Genesegues Inc |
Therapeutic nanoparticles and related compositions, methods and systems
|
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
|
EP3207138B1
(en)
|
2014-10-17 |
2020-07-15 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
|
EP3904519A1
(en)
|
2014-10-30 |
2021-11-03 |
Genzyme Corporation |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
|
JP2017535552A
(ja)
|
2014-11-17 |
2017-11-30 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
|
|
TW201702218A
(zh)
|
2014-12-12 |
2017-01-16 |
美國杰克森實驗室 |
關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
|
|
AU2015364508A1
(en)
|
2014-12-18 |
2017-07-06 |
Alnylam Pharmaceuticals, Inc. |
ReversirTM compounds
|
|
US11400139B2
(en)
|
2015-01-20 |
2022-08-02 |
The Children's Medical Center Corporation |
Anti-NET compounds for treating and preventing fibrosis and for facilitating wound healing
|
|
JP2018510621A
(ja)
|
2015-02-13 |
2018-04-19 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
パタチン様ホスホリパーゼドメイン含有３（ＰＮＰＬＡ３）ｉＲＮＡ組成物およびその使用方法
|
|
WO2016138287A1
(en)
|
2015-02-25 |
2016-09-01 |
Washington University |
METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs
|
|
US10302629B2
(en)
|
2015-03-30 |
2019-05-28 |
University Of Maryland, Baltimore |
Compositions and methods for treating cancer by rational targeting of protein translation
|
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
KR20250107273A
(ko)
|
2015-05-06 |
2025-07-11 |
알닐람 파마슈티칼스 인코포레이티드 |
인자 ＸＩＩ(하게만 인자)(Ｆ12), 칼리크레인 Ｂ, 혈장(플레처 인자) 1(ＫＬＫＢ1) 및 키니노겐 1(ＫＮＧ1) ｉＲＮＡ 조성물 및 그의 이용 방법
|
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
HK1254645A1
(zh)
|
2015-07-02 |
2019-07-26 |
Otsuka Pharmaceutical Co., Ltd. |
冻乾药物组合物
|
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
|
EP3324980B1
(en)
|
2015-07-17 |
2021-11-10 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
TWI678213B
(zh)
|
2015-07-22 |
2019-12-01 |
美商史倍壯製藥公司 |
用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
|
|
TWI861413B
(zh)
|
2015-07-23 |
2024-11-11 |
德商包林格因蓋爾漢國際股份有限公司 |
靶向il-23a與b細胞活化因子(baff)之化合物及其用途
|
|
AU2016315584B2
(en)
|
2015-09-02 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (PD-L1) iRNA compositions and methods of use thereof
|
|
WO2017048843A1
(en)
|
2015-09-14 |
2017-03-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the alas1 gene
|
|
WO2017048620A1
(en)
|
2015-09-14 |
2017-03-23 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
|
|
US10167457B2
(en)
|
2015-10-23 |
2019-01-01 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
US10059949B2
(en)
|
2015-11-16 |
2018-08-28 |
Olix Pharmaceuticals, Inc. |
Treatment of age-related macular degeneration using RNA complexes that target MYD88 or TLR3
|
|
JP2018536689A
(ja)
|
2015-12-10 |
2018-12-13 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
ステロール調節エレメント結合タンパク質（ＳＲＥＢＰ）シャペロン（ＳＣＡＰ）ｉＲＮＡ組成物およびその使用方法
|
|
EP3411480A4
(en)
|
2016-02-02 |
2020-01-22 |
Olix Pharmaceuticals, Inc. |
TREATMENT OF ATOPIC DERMATITIS AND ASTHMA WITH RNA COMPLEXES TARGETED ON LL4R, TRPA1 OR F2RL1
|
|
US10435682B2
(en)
|
2016-02-19 |
2019-10-08 |
University Of South Florida |
Arginine deiminase gene therapy for disordered proteins
|
|
CN109476713A
(zh)
|
2016-06-08 |
2019-03-15 |
儿童医学中心公司 |
工程改造的肉毒杆菌神经毒素
|
|
WO2017214518A1
(en)
|
2016-06-10 |
2017-12-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLETMENT COMPONENT C5 iRNA COMPOSTIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
|
BR112019000278A2
(pt)
|
2016-07-08 |
2019-04-24 |
Children's Medical Center Corporation |
neurotoxina botulínica e seus derivados
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
EP3497214B1
(en)
|
2016-08-09 |
2023-06-28 |
President and Fellows of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
WO2018053142A2
(en)
|
2016-09-14 |
2018-03-22 |
President And Fellows Of Harvard College |
Methods and compositions for modulating erythropoiesis
|
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
|
WO2018067546A1
(en)
|
2016-10-03 |
2018-04-12 |
President And Fellows Of Harvard College |
Delivery of therapeutic rnas via arrdc1-mediated microvesicles
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子Ａ１ ｉＲＮＡ組成物及其使用方法
|
|
KR20190098181A
(ko)
|
2016-12-16 |
2019-08-21 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물을 사용하여 TTR-관련 질병을 치료하거나 예방하는 방법
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
WO2018119354A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Gene editing of pcsk9
|
|
MX2019010155A
(es)
|
2017-02-27 |
2020-12-10 |
Translate Bio Inc |
Arnm de cftr optimizado por codón novedoso.
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
BR112019019655A2
(pt)
|
2017-03-23 |
2020-04-22 |
Harvard College |
editores de nucleobase que compreendem proteínas de ligação a dna programáveis por ácido nucleico
|
|
WO2018195165A1
(en)
|
2017-04-18 |
2018-10-25 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
|
WO2018204918A1
(en)
|
2017-05-05 |
2018-11-08 |
Ardelyx, Inc. |
Treatment of hepatic disorders
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
WO2018213476A1
(en)
|
2017-05-16 |
2018-11-22 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
|
|
WO2019010274A1
(en)
|
2017-07-06 |
2019-01-10 |
Arrowhead Pharmaceuticals, Inc. |
RNAI AGENTS OF INHIBITION OF ALPHA-ENAC GENE EXPRESSION AND METHODS OF USE
|
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
|
SG11202000932XA
(en)
|
2017-08-03 |
2020-02-27 |
Otsuka Pharma Co Ltd |
Drug compound and purification methods thereof
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
CN112105379A
(zh)
|
2017-09-29 |
2020-12-18 |
儿童医学中心公司 |
神经毒素样毒素及其用途
|
|
AU2018352592C1
(en)
|
2017-10-16 |
2025-09-25 |
Beam Therapeutics, Inc. |
Uses of adenosine base editors
|
|
AU2018360697A1
(en)
|
2017-11-01 |
2020-05-14 |
Alnylam Pharmaceuticals, Inc. |
Complement component C3 iRNA compositions and methods of use thereof
|
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019136310A2
(en)
|
2018-01-05 |
2019-07-11 |
University Of South Florida |
Novel compounds for the treatment of neurodegenerative diseases
|
|
WO2019168953A1
(en)
|
2018-02-27 |
2019-09-06 |
President And Fellows Of Harvard College |
Evolved cas9 variants and uses thereof
|
|
US10507226B1
(en)
|
2018-05-02 |
2019-12-17 |
University Of South Florida |
N-amino peptide beta-sheet mimics for the treatment of Alzheimer's disease
|
|
CN112469824A
(zh)
|
2018-05-11 |
2021-03-09 |
比姆医疗股份有限公司 |
利用可编程碱基编辑器系统编辑单核苷酸多态性的方法
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
KR102894715B1
(ko)
|
2018-08-03 |
2025-12-03 |
빔 테라퓨틱스, 인크. |
핵산 표적 서열을 변형시키기 위한 다중-이펙터 핵염기 편집기 및 이를 이용하는 방법
|
|
TW202020157A
(zh)
|
2018-08-16 |
2020-06-01 |
美商艾爾妮蘭製藥公司 |
用於抑制lect2基因表現之組合物及方法
|
|
KR20210060480A
(ko)
|
2018-08-24 |
2021-05-26 |
트랜슬레이트 바이오 인코포레이티드 |
전령 rna의 정제 방법
|
|
CA3109958A1
(en)
*
|
2018-08-24 |
2020-02-27 |
Flagship Pioneering Innovations Vi, Llc |
Modified plant messenger packs and uses thereof
|
|
US20240173430A1
(en)
|
2018-09-05 |
2024-05-30 |
The Broad Institute, Inc. |
Base editing for treating hutchinson-gilford progeria syndrome
|
|
WO2020060986A1
(en)
|
2018-09-18 |
2020-03-26 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
|
WO2020076173A1
(en)
|
2018-09-21 |
2020-04-16 |
Universidade De Coimbra |
Nanodelivery tissue targeting at low systemic exposures and methods thereof
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
|
WO2020102659A1
(en)
|
2018-11-15 |
2020-05-22 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
|
CA3120647A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
|
|
WO2020113135A1
(en)
|
2018-11-29 |
2020-06-04 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating rna
|
|
EP3894559A4
(en)
|
2018-12-03 |
2023-04-05 |
Triplet Therapeutics, Inc. |
METHODS OF TREATMENT OF TRINUCLEOTIDE REPEAT EXPANSION DISORDERS RELATED TO MLH3 ACTIVITY
|
|
JP2022515744A
(ja)
|
2018-12-20 |
2022-02-22 |
プラクシス プレシジョン メディシンズ， インコーポレイテッド |
Ｋｃｎｔ１関連障害の治療のための組成物及び方法
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
|
WO2020181193A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
|
BR112021017864A2
(pt)
|
2019-03-12 |
2021-12-07 |
Harvard College |
Métodos e composições para tratamento do câncer
|
|
CN114127285B
(zh)
|
2019-03-19 |
2024-09-10 |
布罗德研究所股份有限公司 |
编辑核苷酸序列的方法和组合物
|
|
WO2020210751A1
(en)
|
2019-04-12 |
2020-10-15 |
The Broad Institute, Inc. |
System for genome editing
|
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020212586A1
(en)
|
2019-04-18 |
2020-10-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment and prognosis of cancer
|
|
US20220249697A1
(en)
|
2019-05-20 |
2022-08-11 |
The Broad Institute, Inc. |
Aav delivery of nucleobase editors
|
|
WO2020252257A1
(en)
|
2019-06-12 |
2020-12-17 |
President And Fellows Of Harvard College |
Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism
|
|
US20220259617A1
(en)
|
2019-06-13 |
2022-08-18 |
The General Hospital Corporation |
Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
|
|
US20220315906A1
(en)
|
2019-08-08 |
2022-10-06 |
The Broad Institute, Inc. |
Base editors with diversified targeting scope
|
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
|
JP7805286B2
(ja)
|
2019-09-03 |
2026-01-23 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
Ｌｅｃｔ２遺伝子の発現を阻害するための組成物および方法
|
|
EP4028514A1
(en)
|
2019-09-09 |
2022-07-20 |
Beam Therapeutics Inc. |
Novel crispr enzymes, methods, systems and uses thereof
|
|
US12503497B2
(en)
|
2019-09-26 |
2025-12-23 |
President And Fellows Of Harvard College |
Minimal arrestin domain containing protein 1(ARRDC1) constructs
|
|
EP4038189A1
(en)
|
2019-10-04 |
2022-08-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021087325A1
(en)
|
2019-11-01 |
2021-05-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
|
AR120341A1
(es)
|
2019-11-01 |
2022-02-09 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE AGENTES DE ARNi CONTRA LA HUNTINGTINA (HTT) Y SUS MÉTODOS DE USO
|
|
US20230056569A1
(en)
|
2019-11-22 |
2023-02-23 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
|
CA3162908A1
(en)
|
2019-12-03 |
2021-06-10 |
Beam Therapeutics Inc. |
Synthetic guide rna, compositions, methods, and uses thereof
|
|
TWI897902B
(zh)
|
2019-12-13 |
2025-09-21 |
美商阿尼拉製藥公司 |
人類染色體9開讀框72 (C9ORF72) iRNA劑組成物及其使用方法
|
|
WO2021155065A1
(en)
|
2020-01-28 |
2021-08-05 |
The Broad Institute, Inc. |
Base editors, compositions, and methods for modifying the mitochondrial genome
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
WO2021158999A1
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Gene editing methods for treating spinal muscular atrophy
|
|
US20230235309A1
(en)
|
2020-02-05 |
2023-07-27 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
IL295445A
(en)
|
2020-02-10 |
2022-10-01 |
Alnylam Pharmaceuticals Inc |
Preparations and methods for silencing vegf-a expression
|
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
|
JP2023519274A
(ja)
|
2020-03-26 |
2023-05-10 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
コロナウイルスｉＲＮＡ組成物およびその使用方法
|
|
WO2021202443A2
(en)
|
2020-03-30 |
2021-10-07 |
Alnylam Pharmaceucticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
EP4127134A4
(en)
|
2020-04-01 |
2024-07-31 |
Alnylam Pharmaceuticals, Inc. |
COMPOSITIONS OF ALPHA-2A ADRENERGIC RECEPTOR (ADRA2A) ARNI AGENTS AND METHODS OF USE THEREOF
|
|
EP4133078A1
(en)
|
2020-04-06 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing myoc expression
|
|
EP4133077A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
|
EP4133076A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
|
|
KR20230008078A
(ko)
|
2020-04-07 |
2023-01-13 |
알닐람 파마슈티칼스 인코포레이티드 |
Scn9a 발현을 사일런싱하기 위한 조성물 및 방법
|
|
BR112022021813A2
(pt)
|
2020-04-27 |
2023-01-17 |
Alnylam Pharmaceuticals Inc |
Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
|
|
WO2021222318A1
(en)
|
2020-04-28 |
2021-11-04 |
The Broad Institute, Inc. |
Targeted base editing of the ush2a gene
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
|
EP4150089A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rs1)
|
|
EP4150088A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
|
WO2021231673A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
|
EP4150077A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
|
WO2021231680A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
|
WO2021231679A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
EP4157264A4
(en)
|
2020-05-27 |
2024-06-19 |
The Regents of the University of California |
Compositions and methods for transdifferentiating cells
|
|
AR122534A1
(es)
|
2020-06-03 |
2022-09-21 |
Triplet Therapeutics Inc |
Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
|
|
CN116075592A
(zh)
|
2020-06-09 |
2023-05-05 |
阿尔尼拉姆医药品有限公司 |
用于沉默gpam(线粒体甘油-3-磷酸酰基转移酶1)表达的sirna组合物和方法
|
|
EP4162050A1
(en)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
|
US20240018524A1
(en)
|
2020-07-10 |
2024-01-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating epilepsy
|
|
IL300001A
(en)
|
2020-07-24 |
2023-03-01 |
Massachusetts Gen Hospital |
Enhanced virus-like particles and methods of use thereof for delivery to cells
|
|
WO2022056454A2
(en)
|
2020-09-14 |
2022-03-17 |
President And Fellows Of Harvard College |
Methods and compositions for treating hpv-positive cancers
|
|
IL301306A
(en)
|
2020-09-16 |
2023-05-01 |
Harvard College |
Methods of treating an individual that has failed an anti-pd-1/anti-pd-l1 therapy
|
|
WO2022066847A1
(en)
|
2020-09-24 |
2022-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
|
EP4225917A1
(en)
|
2020-10-05 |
2023-08-16 |
Alnylam Pharmaceuticals, Inc. |
G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
|
|
CA3198823A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
|
WO2022087329A1
(en)
|
2020-10-23 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
|
US20240067947A1
(en)
|
2020-10-28 |
2024-02-29 |
Children's Medical Center Corporation |
Truncated modified recombinant adamts13 and uses thereof
|
|
AU2021393417A1
(en)
|
2020-12-01 |
2023-06-29 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
|
US12151024B2
(en)
|
2021-01-22 |
2024-11-26 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
US11278494B1
(en)
|
2021-01-22 |
2022-03-22 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
US11033495B1
(en)
|
2021-01-22 |
2021-06-15 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
US11357727B1
(en)
|
2021-01-22 |
2022-06-14 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
US12129470B2
(en)
|
2021-02-09 |
2024-10-29 |
The Texas A&M University System |
Methods and compositions related to RNA-targeted Rho small GTPase RND3/RhoE therapy
|
|
TW202305131A
(zh)
|
2021-02-12 |
2023-02-01 |
美商艾拉倫製藥股份有限公司 |
用於治療或預防超氧歧化酶１－（ＳＯＤ１－）相關的神經退化疾病的超氧歧化酶１（ＳＯＤ１）ｉＲＮＡ組成物及其使用方法
|
|
KR20230158476A
(ko)
|
2021-02-19 |
2023-11-20 |
빔 테라퓨틱스, 인크. |
유전자 요법을 위한 재조합 광견병 바이러스
|
|
JP2024509783A
(ja)
|
2021-02-25 |
2024-03-05 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
プリオンタンパク質（ｐｒｎｐ）ｉｒｎａ組成物およびその使用方法
|
|
WO2022192519A1
(en)
|
2021-03-12 |
2022-09-15 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
|
CA3211495A1
(en)
|
2021-03-23 |
2022-09-29 |
Bernd ZETSCHE |
Novel crispr enzymes, methods, systems and uses thereof
|
|
EP4314296A2
(en)
|
2021-03-29 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
|
EP4323501A1
(en)
|
2021-04-16 |
2024-02-21 |
Beam Therapeutics Inc. |
Genetic modification of hepatocytes
|
|
EP4330396A1
(en)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
|
WO2022245583A1
(en)
|
2021-05-18 |
2022-11-24 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
|
US20240263177A1
(en)
|
2021-05-20 |
2024-08-08 |
Korro Bio, Inc. |
Methods and Compositions for Adar-Mediated Editing
|
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
|
CA3221008A1
(en)
|
2021-06-02 |
2022-12-08 |
Brian CAFFERTY |
Circular guide rnas for crispr/cas editing systems
|
|
EP4347822A2
(en)
|
2021-06-04 |
2024-04-10 |
Alnylam Pharmaceuticals, Inc. |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
|
WO2022261509A1
(en)
|
2021-06-11 |
2022-12-15 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
|
EP4363574A1
(en)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
|
AU2022316139A1
(en)
|
2021-07-23 |
2024-01-18 |
Alnylam Pharmaceuticals, Inc. |
Beta-catenin (ctnnb1) irna compositions and methods of use thereof
|
|
AU2022313315A1
(en)
|
2021-07-23 |
2024-02-08 |
Beam Therapeutics Inc. |
Guide rnas for crispr/cas editing systems
|
|
EP4395790A2
(en)
|
2021-08-31 |
2024-07-10 |
Alnylam Pharmaceuticals, Inc. |
Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof
|
|
KR20240141708A
(ko)
|
2021-09-08 |
2024-09-27 |
빔 테라퓨틱스, 인크. |
바이러스 가이드 rna 전달
|
|
MX2024003519A
(es)
|
2021-09-24 |
2024-04-01 |
Alnylam Pharmaceuticals Inc |
Composiciones de agentes de acido ribonucleico de interferencia (arni) de proteina tau asociada a microtubulos (mapt) y sus metodos de uso.
|
|
US12285419B2
(en)
|
2021-10-14 |
2025-04-29 |
Pacira Pharmaceuticals, Inc. |
Bupivacaine multivesicular liposome formulations and uses thereof
|
|
US20250352667A1
(en)
|
2021-10-22 |
2025-11-20 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
|
WO2023076898A1
(en)
|
2021-10-25 |
2023-05-04 |
The Broad Institute, Inc. |
Methods and compositions for editing a genome with prime editing and a recombinase
|
|
WO2023076450A2
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
CA3237482A1
(en)
|
2021-11-03 |
2023-05-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Precise genome editing using retrons
|
|
AU2022395500A1
(en)
|
2021-11-23 |
2024-05-23 |
Cellectis Sa |
New tale protein scaffolds with improved on-target/off-target activity ratios
|
|
EP4441073A2
(en)
|
2021-12-03 |
2024-10-09 |
The Broad Institute, Inc. |
Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same
|
|
US20250064979A1
(en)
|
2021-12-03 |
2025-02-27 |
The Broad Institute, Inc. |
Self-assembling virus-like particles for delivery of prime editors and methods of making and using same
|
|
AU2022413670A1
(en)
|
2021-12-17 |
2024-07-04 |
Beam Therapeutics Inc. |
Crispr enzymes, methzods, systems and uses thereof
|
|
EP4453211A1
(en)
|
2021-12-22 |
2024-10-30 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
|
EP4469575A2
(en)
|
2022-01-24 |
2024-12-04 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
CA3247173A1
(en)
|
2022-04-04 |
2023-10-12 |
Trustees Of Boston University |
CAS9 VARIANTS WITH NON-CANONICAL PAM SPECIFICITIES AND THEIR USES
|
|
WO2023196772A1
(en)
|
2022-04-04 |
2023-10-12 |
Beam Therapeutics Inc. |
Novel rna base editing compositions, systems, methods and uses thereof
|
|
WO2023205687A1
(en)
|
2022-04-20 |
2023-10-26 |
The Broad Institute, Inc. |
Improved prime editing methods and compositions
|
|
AU2023259642A1
(en)
|
2022-04-28 |
2024-11-14 |
President And Fellows Of Harvard College |
Aav vectors encoding base editors and uses thereof
|
|
WO2023230613A1
(en)
|
2022-05-27 |
2023-11-30 |
The Broad Institute, Inc. |
Improved mitochondrial base editors and methods for editing mitochondrial dna
|
|
WO2023240137A1
(en)
|
2022-06-08 |
2023-12-14 |
The Board Institute, Inc. |
Evolved cas14a1 variants, compositions, and methods of making and using same in genome editing
|
|
IL317425A
(en)
|
2022-06-10 |
2025-02-01 |
Camp4 Therapeutics Corp |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory RNAs
|
|
EP4573191A1
(en)
|
2022-08-16 |
2025-06-25 |
The Broad Institute, Inc. |
Evolved cytosine deaminases and methods of editing dna using same
|
|
JP2025532593A
(ja)
|
2022-09-15 |
2025-10-01 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
１７ｂ－ヒドロキシステロイドデヒドロゲナーゼ１３型（ｈｓｄ１７ｂ１３）ｉｒｎａ組成物およびその使用方法
|
|
EP4587560A1
(en)
|
2022-09-16 |
2025-07-23 |
Beam Therapeutics Inc. |
Large serine recombinases, systems and uses thereof
|
|
WO2024077267A1
(en)
|
2022-10-07 |
2024-04-11 |
The Broad Institute, Inc. |
Prime editing methods and compositions for treating triplet repeat disorders
|
|
KR20250113490A
(ko)
|
2022-12-01 |
2025-07-25 |
캠프4 테라퓨틱스 코포레이션 |
조절 rna를 표적화하는 안티센스 올리고뉴클레오타이드를 사용하는 syngap1 유전자 전사의 조절
|
|
WO2024138087A2
(en)
|
2022-12-23 |
2024-06-27 |
The Broad Institute, Inc. |
Methods and compositions for modulating cellular factors to increase prime editing efficiencies
|
|
EP4652272A1
(en)
|
2023-01-18 |
2025-11-26 |
The Broad Institute Inc. |
Prime editing-mediated readthrough of premature termination codons (pert)
|
|
EP4652271A1
(en)
|
2023-01-18 |
2025-11-26 |
The Broad Institute, Inc. |
Base editing-mediated readthrough of premature termination codons (bert)
|
|
CN120813691A
(zh)
|
2023-02-09 |
2025-10-17 |
阿尔尼拉姆医药品有限公司 |
Reversir分子及其使用方法
|
|
EP4662306A2
(en)
|
2023-02-09 |
2025-12-17 |
The Broad Institute Inc. |
Evolved recombinases for editing a genome in combination with prime editing
|
|
WO2024206125A1
(en)
|
2023-03-24 |
2024-10-03 |
The Broad Institute, Inc. |
Use of prime editing for treating sickle cell disease
|
|
WO2024243415A1
(en)
|
2023-05-23 |
2024-11-28 |
The Broad Institute, Inc. |
Evolved and engineered prime editors with improved editing efficiency
|
|
WO2025015338A1
(en)
|
2023-07-13 |
2025-01-16 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
AU2024287308A1
(en)
|
2023-07-13 |
2025-12-18 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
WO2025034422A1
(en)
|
2023-08-04 |
2025-02-13 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating ctnnb1-associated disorders
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025059215A1
(en)
|
2023-09-12 |
2025-03-20 |
Aadigen, Llc |
Methods and compositions for treating or preventing cancer
|
|
WO2025061810A1
(en)
|
2023-09-20 |
2025-03-27 |
Institut National de la Santé et de la Recherche Médicale |
Use of a mirna inhibitor for the treatment of osteogenesis imperfecta
|
|
WO2025064678A2
(en)
|
2023-09-20 |
2025-03-27 |
The Broad Institute, Inc. |
Prime editing-mediated readthrough of frameshift mutations (perf)
|
|
WO2025081042A1
(en)
|
2023-10-12 |
2025-04-17 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
AU2024369609A1
(en)
|
2023-10-31 |
2025-12-11 |
Korro Bio, Inc. |
Oligonucleotides comprising phosphoramidate internucleotide linkages
|
|
WO2025106677A1
(en)
|
2023-11-15 |
2025-05-22 |
Slate Bio, Inc. |
Bifunctional il-2 and il-33 proteins for treating autoimmune disease
|
|
WO2025106685A1
(en)
|
2023-11-15 |
2025-05-22 |
Slate Bio, Inc. |
Interleukin-2 superkine and interleukin-33, compositions and uses thereof
|
|
WO2025106663A1
(en)
|
2023-11-15 |
2025-05-22 |
Slate Bio, Inc. |
Interleukin-33 variants, compositions and uses thereof
|
|
WO2025128799A1
(en)
|
2023-12-12 |
2025-06-19 |
Korro Bio, Inc. |
Double-stranded rna-editing oligonucleotides and uses thereof
|
|
WO2025188687A1
(en)
|
2024-03-04 |
2025-09-12 |
Beam Therapeutics Inc. |
Stable rna compositions with stem loop, and methods thereof
|
|
US12280149B1
(en)
|
2024-05-20 |
2025-04-22 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
US12246092B1
(en)
|
2024-05-20 |
2025-03-11 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
US12251472B1
(en)
|
2024-05-20 |
2025-03-18 |
Pacira Pharmaceuticals, Inc. |
Manufacturing of bupivacaine multivesicular liposomes
|
|
WO2025255388A1
(en)
|
2024-06-05 |
2025-12-11 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
|
WO2025259863A1
(en)
|
2024-06-12 |
2025-12-18 |
Orbital Therapeutics, Inc. |
Thermostable ribonuclease r for circular rna purification
|
|
WO2026024856A2
(en)
|
2024-07-23 |
2026-01-29 |
The Broad Institute, Inc. |
Compositions and methods for production of double-stranded dna in cells for programmable gene integration
|