DK450187D0 - Fremgangsmaade til fremstilling af proteiner - Google Patents

Fremgangsmaade til fremstilling af proteiner

Info

Publication number: DK450187D0
Authority: DK; Denmark
Prior art keywords: production; amino acid; aprotinin; proteins; procedure
Prior art date: 1987-08-28

Application number

DK450187A

Other languages

Danish (da)

English (en)

Inventor

Kjeld Norris

Fanny Norris

Soeren Erik Bjoern

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-28

Filing date

1987-08-28

Publication date

1987-08-28

1987-08-28 Application filed by Novo Industri As filed Critical Novo Industri As

1987-08-28 Priority to DK450187A priority Critical patent/DK450187D0/da

1987-08-28 Publication of DK450187D0 publication Critical patent/DK450187D0/da

1988-08-26 Priority to PCT/DK1988/000138 priority patent/WO1989001968A1/en

1988-08-26 Priority to DE3852105T priority patent/DE3852105T2/de

1988-08-26 Priority to AT88907646T priority patent/ATE113986T1/de

1988-08-26 Priority to EP88907646A priority patent/EP0375718B1/en

1988-08-26 Priority to JP63507339A priority patent/JP2806958B2/ja

1990-02-27 Priority to FI900991A priority patent/FI104428B/fi

1990-02-27 Priority to NO900920A priority patent/NO177967C/no

1990-02-28 Priority to DK051990A priority patent/DK171239B1/da

1993-06-23 Priority to US08/084,718 priority patent/US5591603A/en

1995-05-18 Priority to US08/443,977 priority patent/US5621074A/en

1995-05-18 Priority to US08/443,976 priority patent/US5618915A/en

Links

102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
108010039627 Aprotinin Proteins 0.000 abstract 3
125000000539 amino acid group Chemical group 0.000 abstract 3
229960004405 aprotinin Drugs 0.000 abstract 3
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 3
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Detergent Compositions (AREA)

DK450187A 1987-08-28 1987-08-28 Fremgangsmaade til fremstilling af proteiner DK450187D0 (da)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
DK450187A DK450187D0 (da)	1987-08-28	1987-08-28	Fremgangsmaade til fremstilling af proteiner
JP63507339A JP2806958B2 (ja)	1987-08-28	1988-08-26	アプロチニン相同体及び酵母におけるアプロチニン及びアプロチニン相同体の生成方法
EP88907646A EP0375718B1 (en)	1987-08-28	1988-08-26	Process for the production of aprotinin and aprotinin homologues in yeast
DE3852105T DE3852105T2 (de)	1987-08-28	1988-08-26	Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
AT88907646T ATE113986T1 (de)	1987-08-28	1988-08-26	Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
PCT/DK1988/000138 WO1989001968A1 (en)	1987-08-28	1988-08-26	Aprotinin homologues and process for the production of aprotinin and aprotinin homologues in yeast
FI900991A FI104428B (fi)	1987-08-28	1990-02-27	Menetelmä aprotiniinin ja aprotiniinihomologien tuottamiseksi hiivassa
NO900920A NO177967C (no)	1987-08-28	1990-02-27	Fremgangsmåte ved fremstilling av aprotinin og aprotinin homologer i gjær, og en gjærstamme som anvendes i fremgangsmåten
DK051990A DK171239B1 (da)	1987-08-28	1990-02-28	Fremgangsmåde til fremstilling af aprotinin eller homologer deraf, vektor der er i stand til at replicere i gær samt gærstamme
US08/084,718 US5591603A (en)	1987-08-28	1993-06-23	Process for preparing aprotinin and aprotinin analogs in yeast cells
US08/443,977 US5621074A (en)	1987-08-28	1995-05-18	Aprotinin analogs
US08/443,976 US5618915A (en)	1987-08-28	1995-05-18	Aprotinin analogs

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK450187A DK450187D0 (da)	1987-08-28	1987-08-28	Fremgangsmaade til fremstilling af proteiner

Publications (1)

Publication Number	Publication Date
DK450187D0 true DK450187D0 (da)	1987-08-28

Family

ID=8134111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK450187A DK450187D0 (da)	1987-08-28	1987-08-28	Fremgangsmaade til fremstilling af proteiner

Country Status (8)

Country	Link
EP (1)	EP0375718B1 (no)
JP (1)	JP2806958B2 (no)
AT (1)	ATE113986T1 (no)
DE (1)	DE3852105T2 (no)
DK (1)	DK450187D0 (no)
FI (1)	FI104428B (no)
NO (1)	NO177967C (no)
WO (1)	WO1989001968A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5591603A (en) *	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
US7413537B2 (en)	1989-09-01	2008-08-19	Dyax Corp.	Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5258302A (en) *	1990-07-03	1993-11-02	The Salk Institute Biotechnology/Industrial Associates, Inc.	DNA for expression of aprotinin in methylotrophic yeast cells
IL99585A0 (en) *	1990-10-01	1992-08-18	Novo Nordisk As	Aprotinin analogues,their production and pharmaceutical compositions containing them
DK1279731T3 (da)	1991-03-01	2007-09-24	Dyax Corp	Fremgangsmåde til udvikling af bindende miniproteiner
DE4417353A1 (de) *	1994-05-18	1996-01-25	Bayer Ag	Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
US5219569A (en) *	1985-04-22	1993-06-15	Genentech, Inc.	Protease resistant urokinase
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1987
- 1987-08-28 DK DK450187A patent/DK450187D0/da not_active Application Discontinuation
1988
- 1988-08-26 DE DE3852105T patent/DE3852105T2/de not_active Expired - Fee Related
- 1988-08-26 JP JP63507339A patent/JP2806958B2/ja not_active Expired - Fee Related
- 1988-08-26 WO PCT/DK1988/000138 patent/WO1989001968A1/en not_active Ceased
- 1988-08-26 EP EP88907646A patent/EP0375718B1/en not_active Expired - Lifetime
- 1988-08-26 AT AT88907646T patent/ATE113986T1/de not_active IP Right Cessation
1990
- 1990-02-27 NO NO900920A patent/NO177967C/no not_active IP Right Cessation
- 1990-02-27 FI FI900991A patent/FI104428B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE113986T1 (de)	1994-11-15
EP0375718A1 (en)	1990-07-04
DE3852105T2 (de)	1995-03-23
NO177967C (no)	1995-12-27
JPH03502519A (ja)	1991-06-13
NO900920L (no)	1990-04-25
FI900991A0 (fi)	1990-02-27
WO1989001968A1 (en)	1989-03-09
EP0375718B1 (en)	1994-11-09
FI104428B (fi)	2000-01-31
NO900920D0 (no)	1990-02-27
NO177967B (no)	1995-09-18
JP2806958B2 (ja)	1998-09-30
DE3852105D1 (de)	1994-12-15

Publication	Publication Date	Title
ES2124685T3 (es)	1999-02-16	Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso.
CA2005502A1 (en)	1990-07-31	Somatotropin analogs
ES2068907T3 (es)	1995-05-01	Secuencias de nucleotidos que codifican una proteina con actividad ureasica.
DK0387231T3 (da)	1995-07-03	Hidtil ukendte inhibitorer for retroviral protease
NZ527053A (en)	2005-04-29	Modified amyloid precursor protein polynucleotides and polypeptides
WO1996017924A3 (en)	1996-09-26	Novel hedgehog-derived polypeptides
DK3688D0 (da)	1988-01-06	Pankreatisk sekretorisk trypsininhibitor og varianter deraf fremstillet af en rekombinant vaert, fremgangsmaade, ekspressionsvektor og rekombinant vaert samt farmaceutisk anvendelse deraf
ES2072918T3 (es)	1995-08-01	Mejoras en la produccion de polipeptidos.
DK0532587T3 (da)	2000-04-17	Fremgangsmåder til trans-destabilisering af specifikke proteiner in vivo
SE8801701D0 (sv)	1988-05-05	Production technology based on enzymic method
BG40815A3 (bg)	1987-02-16	Метод за получаване на пептиди
DK450187D0 (da)	1987-08-28	Fremgangsmaade til fremstilling af proteiner
NO971621D0 (no)	1997-04-09	Keratinocyttvekstfaktoranaloger
DE69018926D1 (de)	1995-06-01	Vakzine gegen Bordetella.
ATE154036T1 (de)	1997-06-15	Retrovirale protease-inhibitoren
NO874905D0 (no)	1987-11-25	Hirudinvariant og fremgangsmaate til dens fremstilling.
ATE166231T1 (de)	1998-06-15	Produktion und verwendung von antihelmintischen substanzen und schützenden immunogenen
FI830813L (fi)	1983-09-14	Foerfarande foer omvandling av pre-proinsulinanaloger till insulin
DK0994187T3 (da)	2001-12-27	Renin-aktivt stof omfattende humant prorenin og antistoffer mod prorenin-profragmentet
DE3873273D1 (de)	1992-09-03	Verfahren zur selektiven spaltung von fusionsproteinen.
DK51990A (da)	1990-04-27	Aprotininhomologer og fremgangsmaade til fremstilling af aprotinin og aprotininhomologer i gaer
DE59004279D1 (de)	1994-03-03	Verfahren zur C-terminalen Modifizierung von Proteinen.
ZA91752B (en)	1991-11-27	Process for the enzymatic cleavage or recombinant proteins using iga proteases
ES2080326T3 (es)	1996-02-01	Proteinas similares a ancrod, su obtencion y empleo.
EP1083497A4 (en)	2003-05-14	METHOD FOR ESTIMATING PROTEIN FUNCTIONS

Legal Events

Date	Code	Title	Description
1988-05-09	AHS	Application shelved for other reasons than non-payment

DK450187D0 - Fremgangsmaade til fremstilling af proteiner - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (12)

Applications Claiming Priority (1)

Publications (1)

Family

ID=8134111

Family Applications (1)

Country Status (8)

Families Citing this family (9)

Family Cites Families (3)

Also Published As

Similar Documents

Legal Events