FI900991A0 - Aprotinhomologer och ett foerfarande foer producering av aprotin och aprotinhomologer i jaest. - Google Patents

Aprotinhomologer och ett foerfarande foer producering av aprotin och aprotinhomologer i jaest.

Info

Publication number: FI900991A0
Authority: FI; Finland
Prior art keywords: aprotinhomologer; och; jaest; aprotin; foerfarande foer
Prior art date: 1987-08-28

Application number

FI900991A

Other languages

English (en)

Other versions

FI104428B (fi

Inventor

Kjeld Norris

Fanny Norris

Soeren Erik Bjoern

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-28

Filing date

1990-02-27

Publication date

1990-02-27

1990-02-27 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1990-02-27 Publication of FI900991A0 publication Critical patent/FI900991A0/fi

2000-01-31 Application granted granted Critical

2000-01-31 Publication of FI104428B publication Critical patent/FI104428B/fi

Links

108010039627 Aprotinin Proteins 0.000 abstract 3
125000000539 amino acid group Chemical group 0.000 abstract 3
229960004405 aprotinin Drugs 0.000 abstract 3
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 3
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Detergent Compositions (AREA)

FI900991A 1987-08-28 1990-02-27 Menetelmä aprotiniinin ja aprotiniinihomologien tuottamiseksi hiivassa FI104428B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK450187A DK450187D0 (da)	1987-08-28	1987-08-28	Fremgangsmaade til fremstilling af proteiner
DK450187		1987-08-28
DK8800138		1988-08-26
PCT/DK1988/000138 WO1989001968A1 (en)	1987-08-28	1988-08-26	Aprotinin homologues and process for the production of aprotinin and aprotinin homologues in yeast

Publications (2)

Publication Number	Publication Date
FI900991A0 true FI900991A0 (fi)	1990-02-27
FI104428B FI104428B (fi)	2000-01-31

Family

ID=8134111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI900991A FI104428B (fi)	1987-08-28	1990-02-27	Menetelmä aprotiniinin ja aprotiniinihomologien tuottamiseksi hiivassa

Country Status (8)

Country	Link
EP (1)	EP0375718B1 (fi)
JP (1)	JP2806958B2 (fi)
AT (1)	ATE113986T1 (fi)
DE (1)	DE3852105T2 (fi)
DK (1)	DK450187D0 (fi)
FI (1)	FI104428B (fi)
NO (1)	NO177967C (fi)
WO (1)	WO1989001968A1 (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5591603A (en) *	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
US7413537B2 (en)	1989-09-01	2008-08-19	Dyax Corp.	Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5258302A (en) *	1990-07-03	1993-11-02	The Salk Institute Biotechnology/Industrial Associates, Inc.	DNA for expression of aprotinin in methylotrophic yeast cells
IL99585A0 (en) *	1990-10-01	1992-08-18	Novo Nordisk As	Aprotinin analogues,their production and pharmaceutical compositions containing them
DK1279731T3 (da)	1991-03-01	2007-09-24	Dyax Corp	Fremgangsmåde til udvikling af bindende miniproteiner
DE4417353A1 (de) *	1994-05-18	1996-01-25	Bayer Ag	Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
US5219569A (en) *	1985-04-22	1993-06-15	Genentech, Inc.	Protease resistant urokinase
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1987
- 1987-08-28 DK DK450187A patent/DK450187D0/da not_active Application Discontinuation
1988
- 1988-08-26 DE DE3852105T patent/DE3852105T2/de not_active Expired - Fee Related
- 1988-08-26 JP JP63507339A patent/JP2806958B2/ja not_active Expired - Fee Related
- 1988-08-26 WO PCT/DK1988/000138 patent/WO1989001968A1/en not_active Ceased
- 1988-08-26 EP EP88907646A patent/EP0375718B1/en not_active Expired - Lifetime
- 1988-08-26 AT AT88907646T patent/ATE113986T1/de not_active IP Right Cessation
1990
- 1990-02-27 NO NO900920A patent/NO177967C/no not_active IP Right Cessation
- 1990-02-27 FI FI900991A patent/FI104428B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE113986T1 (de)	1994-11-15
EP0375718A1 (en)	1990-07-04
DE3852105T2 (de)	1995-03-23
NO177967C (no)	1995-12-27
JPH03502519A (ja)	1991-06-13
NO900920L (no)	1990-04-25
WO1989001968A1 (en)	1989-03-09
DK450187D0 (da)	1987-08-28
EP0375718B1 (en)	1994-11-09
FI104428B (fi)	2000-01-31
NO900920D0 (no)	1990-02-27
NO177967B (no)	1995-09-18
JP2806958B2 (ja)	1998-09-30
DE3852105D1 (de)	1994-12-15

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Legal Events

Date	Code	Title	Description
2004-08-31	FG	Patent granted	Owner name: NOVO NORDISK A/S
2005-02-28	MA	Patent expired