DK428179A - Fremgangsmaade til fremstilling af metaboliter - Google Patents

Fremgangsmaade til fremstilling af metaboliter

Info

Publication number: DK428179A
Authority: DK; Denmark
Prior art keywords: metabolites; manufacturing; manufacturing metabolites
Prior art date: 1978-10-18

Application number

DK428179A

Other languages

English (en)

Other versions

DK148752B (da

DK148752C (da

Inventor

R P Traber

E Haerri

M Kuhn

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-18

Filing date

1979-10-10

Publication date

1980-04-19

1978-10-18 Priority claimed from CH1077678A external-priority patent/CH637124A5/de

1979-03-22 Priority claimed from CH269679A external-priority patent/CH639961A5/de

1979-08-15 Priority claimed from CH748079A external-priority patent/CH642954A5/de

1979-10-10 Application filed by Sandoz Ag filed Critical Sandoz Ag

1980-04-19 Publication of DK428179A publication Critical patent/DK428179A/da

1985-09-16 Publication of DK148752B publication Critical patent/DK148752B/da

1986-02-10 Application granted granted Critical

1986-02-10 Publication of DK148752C publication Critical patent/DK148752C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/885—Trichoderma
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Mycology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Botany (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK428179A 1978-10-18 1979-10-10 Fremgangsmaade til fremstilling af cyclosporinderivater DK148752C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
CH1077678A CH637124A5 (en)	1978-10-18	1978-10-18	Antibiotic, its preparation and use
CH1077678		1978-10-18
CH269679		1979-03-22
CH269679A CH639961A5 (en)	1979-03-22	1979-03-22	Dihydocyclosporin G, its preparation and use as a medicine
CH748079		1979-08-15
CH748079A CH642954A5 (en)	1979-08-15	1979-08-15	Isocyclosporin G, its preparation and medicaments containing it

Publications (3)

Publication Number	Publication Date
DK428179A true DK428179A (da)	1980-04-19
DK148752B DK148752B (da)	1985-09-16
DK148752C DK148752C (da)	1986-02-10

Family

ID=27173855

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK428179A DK148752C (da)	1978-10-18	1979-10-10	Fremgangsmaade til fremstilling af cyclosporinderivater

Country Status (22)

Country	Link
US (1)	US4288431A (da)
AU (1)	AU530379B2 (da)
CA (1)	CA1129359A (da)
CY (1)	CY1286A (da)
DE (1)	DE2941080A1 (da)
DK (1)	DK148752C (da)
ES (1)	ES485104A1 (da)
FI (1)	FI60032C (da)
FR (1)	FR2439182A1 (da)
GB (1)	GB2033398B (da)
HK (1)	HK48685A (da)
IE (1)	IE49084B1 (da)
IL (1)	IL58465A (da)
IT (1)	IT1164109B (da)
KE (1)	KE3517A (da)
MY (1)	MY8500618A (da)
NL (1)	NL7907609A (da)
NZ (1)	NZ191865A (da)
PH (1)	PH14086A (da)
PT (1)	PT70324A (da)
SE (1)	SE448386B (da)
SG (1)	SG14685G (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4396542A (en) *	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0098457B1 (en) *	1980-02-14	1987-08-05	Sandoz Ag	(1s,2r,3r)- and (1r,2s,3s)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production
EP0056782B1 (en) *	1981-01-09	1984-08-01	Sandoz Ag	Novel cyclosporins
EP0170623B1 (en) *	1984-08-02	1990-11-28	Sandoz Ag	Novel pharmaceutical use of (nva)2-cyclosporine
GB8422253D0 (en) *	1984-09-04	1984-10-10	Sandoz Ltd	Organic compounds
US4727035A (en) *	1984-11-14	1988-02-23	Mahoney Walter C	Immunoassay for cyclosporin
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
US5239057A (en) *	1987-03-27	1993-08-24	Abbott Laboratories	Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5427960A (en) *	1987-03-27	1995-06-27	Abbott Laboratories	Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US4798823A (en) *	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
DE3888357T2 (de) *	1987-06-22	1994-09-15	Merck & Co Inc	Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
GB8717300D0 (en) *	1987-07-22	1987-08-26	Nat Res Dev	Cyclosporins
US5227467A (en) *	1987-08-03	1993-07-13	Merck & Co., Inc.	Immunosuppressive fluorinated cyclosporin analogs
ATE109970T1 (de) *	1987-09-03	1994-09-15	Univ Georgia Res Found	Cyclosporin-augenmittel.
US4839342A (en) *	1987-09-03	1989-06-13	University Of Georgia Research Foundation, Inc.	Method of increasing tear production by topical administration of cyclosporin
US4914188A (en) *	1987-11-16	1990-04-03	Merck & Co., Inc.	Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) *	1987-11-16	1993-08-17	Merck & Co., Inc.	6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
HU201577B (en) *	1988-12-20	1990-11-28	Gyogyszerkutato Intezet	Process for producing cyclosporin antibiotics
US4996193A (en) *	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine
US5540931A (en) *	1989-03-03	1996-07-30	Charles W. Hewitt	Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
FR2649120B1 (fr) *	1989-06-30	1994-01-28	Cayla	Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
GB8916901D0 (en)	1989-07-24	1989-09-06	Sandoz Ltd	Improvements in or relating to organic compounds
US5122511A (en) *	1990-02-27	1992-06-16	Merck & Co., Inc.	Immunosuppressive cyclosporin analogs with modified amino acids at position-8
EP0507968B1 (de) *	1991-04-06	1995-09-06	Arzneimittelwerk Dresden Gmbh	Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme
CA2108886A1 (en) *	1991-05-03	1992-11-04	Thasia G. Woodworth	Interleukin receptor targeted molecules for treatment of inflammatory arthritis
GB9203886D0 (en) *	1992-02-24	1992-04-08	Sandoz Ltd	Improvements in or relating to organic compounds
ES2065273B1 (es) *	1993-05-25	1995-09-16	Biogal Gyogyszergyar	Procedimiento para la purificacion de ciclosporina a.
DE19611094C2 (de)	1996-03-21	1999-06-17	Dresden Arzneimittel	Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
US5747330A (en) *	1996-06-05	1998-05-05	Poli Industria Chimica	Antibiotic producing microbe
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
JP4261049B2 (ja)	1997-10-08	2009-04-30	アイソテクニカインコーポレイテッド	重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用
CA2335903C (fr)	1998-07-01	2009-11-10	Debiopharm S.A.	Nouvelle cyclosporine ayant un profil d'activite ameliore
EP1261732B1 (en) *	2000-02-29	2005-10-12	Biocon Limited	Manufacture and purification of cyclosporin a
EP1406700A1 (en)	2001-07-06	2004-04-14	Sucampo AG	Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent
ES2266564T3 (es)	2001-10-19	2007-03-01	Isotechnika Inc.	Sintesis de analogos de cicloporinas.
EP1458405A1 (en) *	2001-11-21	2004-09-22	Sucampo AG	Use of fk506 and analogues for treating allergic diseases
WO2004082629A2 (en) *	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
EP1804823A4 (en) *	2004-09-29	2010-06-09	Amr Technology Inc	NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
JP2008514701A (ja) *	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
US7361636B2 (en) *	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008036244A1 (en) *	2006-09-18	2008-03-27	The Burham Institute For Medical Research	Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
AU2010208071C1 (en) *	2009-01-30	2013-06-20	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis C infection
US8481483B2 (en) *	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8349312B2 (en) *	2009-07-09	2013-01-08	Enanta Pharmaceuticals, Inc.	Proline substituted cyclosporin analogues
US8367053B2 (en) *	2009-07-09	2013-02-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8623814B2 (en) *	2010-02-23	2014-01-07	Enanta Pharmaceuticals, Inc.	Antiviral agents
PL2651965T3 (pl)	2010-12-15	2019-04-30	Contravir Pharmaceuticals Inc	Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3
WO2012145426A1 (en)	2011-04-18	2012-10-26	The Trustees Of Columbia University In The City Of New York	Methods to treat cancer using cyclosporine and cyclosporine derivatives
EP2705856A1 (en)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Compounds for the treatment of neurodegenerative disorders
WO2014085623A1 (en)	2012-11-28	2014-06-05	Enanta Pharmaceuticals, Inc.	Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
KR20160045136A (ko)	2013-08-26	2016-04-26	이난타 파마슈티칼스, 인코포레이티드	C형 간염을 예방 또는 치료하기 위한 사이클로스포린 유사체
US9669095B2 (en)	2014-11-03	2017-06-06	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis C infection
TW201639873A (zh) *	2015-01-08	2016-11-16	歐樂根公司	Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2463138C2 (de) *	1973-12-06	1984-07-05	Sandoz-Patent-GmbH, 7850 Lörrach	Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung
CH614931A5 (da) *	1975-11-04	1979-12-28	Sandoz Ag
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung

1979
- 1979-10-09 SE SE7908350A patent/SE448386B/sv not_active IP Right Cessation
- 1979-10-10 FI FI793142A patent/FI60032C/fi not_active IP Right Cessation
- 1979-10-10 DK DK428179A patent/DK148752C/da not_active IP Right Cessation
- 1979-10-10 DE DE19792941080 patent/DE2941080A1/de active Granted
- 1979-10-12 US US06/084,100 patent/US4288431A/en not_active Expired - Lifetime
- 1979-10-15 CY CY1286A patent/CY1286A/en unknown
- 1979-10-15 NL NL7907609A patent/NL7907609A/nl not_active Application Discontinuation
- 1979-10-15 GB GB7935689A patent/GB2033398B/en not_active Expired
- 1979-10-16 PT PT70324A patent/PT70324A/pt not_active IP Right Cessation
- 1979-10-16 IE IE1967/79A patent/IE49084B1/en not_active IP Right Cessation
- 1979-10-16 NZ NZ191865A patent/NZ191865A/en unknown
- 1979-10-16 IT IT7950577A patent/IT1164109B/it active
- 1979-10-16 IL IL7958465A patent/IL58465A/xx unknown
- 1979-10-17 FR FR7925780A patent/FR2439182A1/fr active Granted
- 1979-10-17 PH PH23188A patent/PH14086A/en unknown
- 1979-10-17 CA CA337,826A patent/CA1129359A/en not_active Expired
- 1979-10-17 ES ES485104A patent/ES485104A1/es not_active Expired
- 1979-10-18 AU AU51911/79A patent/AU530379B2/en not_active Ceased
1985
- 1985-02-27 SG SG146/85A patent/SG14685G/en unknown
- 1985-03-22 KE KE3517A patent/KE3517A/xx unknown
- 1985-06-20 HK HK486/85A patent/HK48685A/xx not_active IP Right Cessation
- 1985-12-30 MY MY618/85A patent/MY8500618A/xx unknown

Also Published As

Publication number	Publication date
IL58465A (en)	1982-04-30
PT70324A (fr)	1979-11-01
DE2941080A1 (de)	1980-05-08
ES485104A1 (es)	1980-05-16
PH14086A (en)	1981-02-10
DE2941080C2 (da)	1990-03-29
GB2033398A (en)	1980-05-21
KE3517A (en)	1985-04-19
FR2439182B1 (da)	1984-02-10
NL7907609A (nl)	1980-04-22
FI60032B (fi)	1981-07-31
CY1286A (en)	1985-07-05
AU530379B2 (en)	1983-07-14
SE448386B (sv)	1987-02-16
DK148752B (da)	1985-09-16
AU5191179A (en)	1980-04-24
SG14685G (en)	1985-08-16
SE7908350L (sv)	1980-04-19
FI793142A7 (fi)	1980-04-19
DK148752C (da)	1986-02-10
US4288431A (en)	1981-09-08
HK48685A (en)	1985-06-28
FI60032C (fi)	1981-11-10
IL58465A0 (en)	1980-01-31
IT7950577A0 (it)	1979-10-16
FR2439182A1 (fr)	1980-05-16
CA1129359A (en)	1982-08-10
IE791967L (en)	1980-04-18
NZ191865A (en)	1984-05-31
GB2033398B (en)	1982-09-08
MY8500618A (en)	1985-12-31
IE49084B1 (en)	1985-07-24
IT1164109B (it)	1987-04-08

Publication	Publication Date	Title
DK428179A (da)	1980-04-19	Fremgangsmaade til fremstilling af metaboliter
DK150623C (da)	1987-10-12	Fremgangsmaade til fremstilling af fiskemel
DK140480A (da)	1980-10-03	Fremgangsmaade til fremstilling af mercaptoacyldipeptider
DK229980A (da)	1980-11-30	Fremgangsmaade til fremstilling af n-heterocyclyl-thienamyciner
DK156253C (da)	1989-12-11	Fremgangsmaade til fremstilling af pyruvatoxidase
DK150984C (da)	1988-02-22	Fremgangsmaade til kontinuerlig fremstilling af azopigmenter
DK152752C (da)	1988-09-26	Fremgangsmaade til fremstilling af l-sulpirid
DK229479A (da)	1979-12-06	Fremgangsmaade til fremstilling af forbindelser af muramylpeptidtypen
DK226579A (da)	1979-12-09	Fremgangsmaade til fremstilling af metaboliter
DK87079A (da)	1979-09-03	Fremgangsmaade til fremstilling af dialkylphospohorchloridothioter
DK155042C (da)	1989-07-24	Fremgangsmaade til fremstilling af cement
DK511279A (da)	1980-06-02	Fremgangsmaade til fremstilling af steroider
DK168082A (da)	1982-04-14	Fremgangsmaade til fremstilling af metaboliter
DK331479A (da)	1980-02-09	Fremgangsmaade til fremstilling af cycliske diamider
DK258177A (da)	1977-12-12	Fremgangsmade til fremstilling af methicillinalkylaminoalkylestere
DK36379A (da)	1979-07-31	Fremgangsmaade til fremstilling af n-ethylethylendiamin
DK143107C (da)	1981-11-09	Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK147420C (da)	1985-02-18	Fremgangsmaade til fremstilling af acylcyanider
DK341980A (da)	1981-02-10	Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK144280A (da)	1980-10-07	Fremgangsmaade til fremstilling af 2-aminopyraziner
DK274480A (da)	1981-01-10	Fremgangsmaade til fremstilling af pyrenzepin
DK195979A (da)	1979-11-13	Fremgangsmaade til fremstilling af d-homosteroider
DK160294C (da)	1991-08-05	Fremgangsmaade til fremstilling af 3-oxycyclopentener
DK150822C (da)	1988-01-25	Framgangsmaade til fremstilling af cis-2-phenyl-bicyclooctylaminer
DK251679A (da)	1979-12-17	Fremgangsmaade til fremstilling af gipsplader

Legal Events

Date	Code	Title	Description
1999-06-07	PBP	Patent lapsed