DK355287D0 - 2-oxoindolin-1-alkansyre-forbindelser og farmaceutiske praeparater indeholdende disse - Google Patents
2-oxoindolin-1-alkansyre-forbindelser og farmaceutiske praeparater indeholdende disseInfo
- Publication number
- DK355287D0 DK355287D0 DK355287A DK355287A DK355287D0 DK 355287 D0 DK355287 D0 DK 355287D0 DK 355287 A DK355287 A DK 355287A DK 355287 A DK355287 A DK 355287A DK 355287 D0 DK355287 D0 DK 355287D0
- Authority
- DK
- Denmark
- Prior art keywords
- indoline
- oxo
- acetic acid
- dichlorobenzyl
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000002253 acid Substances 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- JKJISQOWTFXMRR-UHFFFAOYSA-N 2-(2-oxo-3h-indol-1-yl)acetic acid Chemical compound C1=CC=C2N(CC(=O)O)C(=O)CC2=C1 JKJISQOWTFXMRR-UHFFFAOYSA-N 0.000 abstract 1
- AJPROLABJSJVQL-UHFFFAOYSA-N 2-[3-[(3,4-dichlorophenyl)methyl]-2-oxo-3h-indol-1-yl]acetic acid Chemical compound C12=CC=CC=C2N(CC(=O)O)C(=O)C1CC1=CC=C(Cl)C(Cl)=C1 AJPROLABJSJVQL-UHFFFAOYSA-N 0.000 abstract 1
- KSWZALKIOKZGJX-UHFFFAOYSA-N 2-[3-[(3,4-dichlorophenyl)methyl]-6-hydroxy-2-oxo-3h-indol-1-yl]acetic acid Chemical compound C12=CC=C(O)C=C2N(CC(=O)O)C(=O)C1CC1=CC=C(Cl)C(Cl)=C1 KSWZALKIOKZGJX-UHFFFAOYSA-N 0.000 abstract 1
- QYCLUYBUTDMHJI-UHFFFAOYSA-N 2-[3-[(3,4-dichlorophenyl)methyl]-6-methoxy-2-oxo-3h-indol-1-yl]acetic acid Chemical compound O=C1N(CC(O)=O)C2=CC(OC)=CC=C2C1CC1=CC=C(Cl)C(Cl)=C1 QYCLUYBUTDMHJI-UHFFFAOYSA-N 0.000 abstract 1
- BGEMJGYOGOPLHL-UHFFFAOYSA-N 2-[3-[1-(3,4-dichlorophenyl)ethyl]-2-oxo-3h-indol-1-yl]acetic acid Chemical compound O=C1N(CC(O)=O)C2=CC=CC=C2C1C(C)C1=CC=C(Cl)C(Cl)=C1 BGEMJGYOGOPLHL-UHFFFAOYSA-N 0.000 abstract 1
- RFKBMPCMUIGTCJ-UHFFFAOYSA-N 2-[5-chloro-3-[(3,4-dichlorophenyl)methyl]-2-oxo-3h-indol-1-yl]acetic acid Chemical compound C12=CC(Cl)=CC=C2N(CC(=O)O)C(=O)C1CC1=CC=C(Cl)C(Cl)=C1 RFKBMPCMUIGTCJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 3,4-dichloro- alpha -methylbenzyl moiety Chemical group 0.000 abstract 1
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1986/001429 WO1993012786A1 (en) | 1986-07-10 | 1986-07-10 | Indolinone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK355287D0 true DK355287D0 (da) | 1987-07-09 |
| DK355287A DK355287A (da) | 1988-04-08 |
Family
ID=22195566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK355287A DK355287A (da) | 1986-07-10 | 1987-07-09 | 2-oxoindolin-1-alkansyre-forbindelser og farmaceutiske praeparater indeholdende disse |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0252713B1 (da) |
| JP (1) | JPH0643393B2 (da) |
| AT (1) | ATE56435T1 (da) |
| DE (1) | DE3764886D1 (da) |
| DK (1) | DK355287A (da) |
| ES (1) | ES2031506T3 (da) |
| GR (1) | GR3000854T3 (da) |
| IE (1) | IE59995B1 (da) |
| PT (1) | PT85294B (da) |
| WO (1) | WO1993012786A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5064852A (en) * | 1988-12-16 | 1991-11-12 | Pfizer Inc. | Indolinone derivatives |
| JPH04217684A (ja) * | 1990-05-30 | 1992-08-07 | Shionogi & Co Ltd | アルド−ス還元酵素阻害物質 |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| US6214991B1 (en) * | 1998-03-31 | 2001-04-10 | The Institute For Pharmaceutical Discovery, Inc. | Substituted indolealkanoic acids |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| PT1255752E (pt) | 2000-02-15 | 2007-10-17 | Pharmacia & Upjohn Co Llc | Inibidores de proteína quinases: 2-indolinonas substituídas com pirrolo |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| EP1294688A2 (en) | 2000-06-02 | 2003-03-26 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| PE20030062A1 (es) | 2001-05-30 | 2003-02-08 | Sugen Inc | Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas |
| MXPA04003385A (es) | 2001-10-10 | 2005-04-11 | Sugen Inc | Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa. |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| EP1791843B1 (en) * | 2004-09-08 | 2012-08-29 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam cgrp receptor antagonists |
| WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| AR063280A1 (es) | 2006-10-12 | 2009-01-21 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos |
| CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| NZ599334A (en) | 2009-10-14 | 2014-03-28 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| RU2596488C2 (ru) | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| TW202502735A (zh) * | 2023-03-02 | 2025-01-16 | 印度商吉德斯生命科學有限公司 | 新穎atx抑制劑 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3393208A (en) * | 1965-10-22 | 1968-07-16 | Mcneilab Inc | 6h-benzo[5, 6] cyclohept[1, 2, 3-cd]indolin-1, 6-diones |
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| US4053613A (en) * | 1975-09-17 | 1977-10-11 | E. R. Squibb & Sons, Inc. | 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones |
| FR2355006A1 (fr) * | 1976-06-17 | 1978-01-13 | Labaz | Nouveaux derives d'indole et procedes pour les preparer |
| DE3064910D1 (en) * | 1979-06-12 | 1983-10-27 | Fujisawa Pharmaceutical Co | 2-oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives |
-
1986
- 1986-07-10 WO PCT/US1986/001429 patent/WO1993012786A1/en not_active Ceased
-
1987
- 1987-07-07 EP EP87305984A patent/EP0252713B1/en not_active Expired - Lifetime
- 1987-07-07 ES ES198787305984T patent/ES2031506T3/es not_active Expired - Lifetime
- 1987-07-07 DE DE8787305984T patent/DE3764886D1/de not_active Expired - Lifetime
- 1987-07-07 AT AT87305984T patent/ATE56435T1/de not_active IP Right Cessation
- 1987-07-09 PT PT85294A patent/PT85294B/pt not_active IP Right Cessation
- 1987-07-09 DK DK355287A patent/DK355287A/da not_active Application Discontinuation
- 1987-07-09 JP JP62172054A patent/JPH0643393B2/ja not_active Expired - Lifetime
- 1987-07-09 IE IE184387A patent/IE59995B1/en not_active IP Right Cessation
-
1990
- 1990-09-20 GR GR90400685T patent/GR3000854T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK355287A (da) | 1988-04-08 |
| DE3764886D1 (de) | 1990-10-18 |
| PT85294B (pt) | 1990-04-30 |
| GR3000854T3 (en) | 1991-11-15 |
| JPS6323863A (ja) | 1988-02-01 |
| IE59995B1 (en) | 1994-05-18 |
| IE871843L (en) | 1988-01-10 |
| ES2031506T3 (es) | 1992-12-16 |
| WO1993012786A1 (en) | 1993-07-08 |
| PT85294A (en) | 1987-08-01 |
| JPH0643393B2 (ja) | 1994-06-08 |
| EP0252713A1 (en) | 1988-01-13 |
| EP0252713B1 (en) | 1990-09-12 |
| ATE56435T1 (de) | 1990-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |