DK3201230T3 - Canine pd-l1-bindende pd-l1-antistoffer - Google Patents
Canine pd-l1-bindende pd-l1-antistoffer Download PDFInfo
- Publication number
- DK3201230T3 DK3201230T3 DK15771582.2T DK15771582T DK3201230T3 DK 3201230 T3 DK3201230 T3 DK 3201230T3 DK 15771582 T DK15771582 T DK 15771582T DK 3201230 T3 DK3201230 T3 DK 3201230T3
- Authority
- DK
- Denmark
- Prior art keywords
- canine
- antibodies
- binding
- Prior art date
Links
- 102000008096 B7-H1 Antigen Human genes 0.000 title 2
- 108010074708 B7-H1 Antigen Proteins 0.000 title 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462057541P | 2014-09-30 | 2014-09-30 | |
| US201562172511P | 2015-06-08 | 2015-06-08 | |
| PCT/EP2015/072324 WO2016050721A1 (en) | 2014-09-30 | 2015-09-29 | Pd-l1 antibodies binding canine pd-l1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3201230T3 true DK3201230T3 (da) | 2021-02-15 |
Family
ID=54207505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15771582.2T DK3201230T3 (da) | 2014-09-30 | 2015-09-29 | Canine pd-l1-bindende pd-l1-antistoffer |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10550194B2 (da) |
| EP (1) | EP3201230B1 (da) |
| JP (1) | JP6797111B2 (da) |
| CN (2) | CN112851816B (da) |
| AU (2) | AU2015326996B2 (da) |
| CA (1) | CA2961987A1 (da) |
| DK (1) | DK3201230T3 (da) |
| ES (1) | ES2853823T3 (da) |
| RU (1) | RU2722562C2 (da) |
| WO (1) | WO2016050721A1 (da) |
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| CN106029697B (zh) | 2013-12-20 | 2021-06-04 | 英特维特国际股份有限公司 | 具有经修饰的ch2-ch3序列的犬抗体 |
| SG10201913297TA (en) | 2015-03-13 | 2020-02-27 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| JP6938383B2 (ja) | 2015-04-02 | 2021-09-22 | インターベット インターナショナル ベー． フェー． | イヌインターロイキン４受容体アルファに対する抗体 |
| WO2017102920A1 (en) | 2015-12-18 | 2017-06-22 | Intervet International B.V. | Caninized human antibodies to human and canine il-4r alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| BR112018076281A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | imunocitocina, uso de uma imunocitocina, método, composição farmacêutica, método para tratar uma doença proliferativa em um animal, ácido nucleico, vetor, hospedeiro e anticorpo ou fragmento do mesmo |
| CN110267674A (zh) * | 2016-07-08 | 2019-09-20 | 奥美药业有限公司 | 包含瘦素的融合蛋白及其生产和使用方法 |
| EP3369745B1 (en) * | 2016-08-04 | 2021-09-29 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-pd-l1 nanobody and use thereof |
| CA3033896A1 (en) * | 2016-08-15 | 2018-02-22 | National University Corporation Hokkaido University | Anti-pd-l1 antibody |
| CA3040823A1 (en) * | 2016-10-17 | 2018-04-26 | Vetoquinol Sa | Modified antibody constant region |
| WO2018181064A1 (ja) | 2017-03-27 | 2018-10-04 | 国立大学法人北海道大学 | Ｐｄ－ｌ１検出用抗ｐｄ－ｌ１抗体 |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| WO2019035010A1 (en) | 2017-08-15 | 2019-02-21 | Kindred Biosciences, Inc. | IGG VARIANTS FOR VETERINARY USE |
| US20190100587A1 (en) * | 2017-10-02 | 2019-04-04 | Covagen Ag | IgG1 Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS |
| CN111344305B (zh) * | 2017-11-27 | 2022-09-16 | 山东博安生物技术股份有限公司 | 抗pd-l1的抗体及其用途 |
| CN113194984A (zh) * | 2018-10-18 | 2021-07-30 | 金德雷德生物科学股份有限公司 | 兽用的与新生儿Fc受体(FcRn)结合改变的Fc变体 |
| CN109452229B (zh) * | 2018-11-19 | 2021-10-22 | 百奥赛图(北京)医药科技股份有限公司 | 狗源化pd-1基因改造动物模型的制备方法及应用 |
| CN120904316A (zh) * | 2018-12-27 | 2025-11-07 | 伊兰科美国公司 | 兽用IgG Fc变体 |
| CN110194799B (zh) * | 2019-06-03 | 2021-07-23 | 北京希诺谷生物科技有限公司 | 结合犬pd-1的抗犬pd-1抗体 |
| AU2020312686A1 (en) * | 2019-07-15 | 2022-02-03 | Intervet International B.V. | Caninized antibodies against canine CTLA-4 |
| CA3145347A1 (en) | 2019-07-15 | 2021-01-21 | Intervet International B.V. | Caninized antibodies to human and canine ctla-4 |
| CN110590959B (zh) * | 2019-09-19 | 2021-01-05 | 北京伟杰信生物科技有限公司 | 重组犬pd-1融合蛋白及其制备方法与应用 |
| WO2021225954A1 (en) * | 2020-05-04 | 2021-11-11 | The Regents Of The University Of California | Inhibiting anti-enpp1 antibodies |
| AU2021266688A1 (en) * | 2020-05-04 | 2022-12-08 | Inhibrx Biosciences, Inc. | Canine PD-1-binding polypeptides and uses thereof |
| KR20240042005A (ko) * | 2021-08-06 | 2024-04-01 | 펫메딕스 리미티드 | 항체 Fc 변이체 |
| IL320868A (en) * | 2022-11-15 | 2025-07-01 | Purdue Research Foundation | Canine PD-L1 antibody, antigen-binding fragments thereof, and methods of using them |
| WO2024145278A2 (en) | 2022-12-27 | 2024-07-04 | Invetx, Inc. | Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use |
| AU2024210302A1 (en) | 2023-01-20 | 2025-09-04 | Invetx, Inc. | Bispecific binding agents for use in companion animals |
| WO2024160721A1 (en) | 2023-01-30 | 2024-08-08 | Kymab Limited | Antibodies |
| EP4665459A1 (en) * | 2023-02-13 | 2025-12-24 | Intervet International B.V. | Canine antibodies to canine il-13 |
| WO2025113570A1 (en) * | 2023-11-29 | 2025-06-05 | Vetigenics, Inc. | Fully canine antibodies and uses thereof |
| CN117343185B (zh) * | 2023-12-06 | 2024-03-01 | 北京伟杰信生物科技有限公司 | 一种抗犬pd-1抗体及其用途 |
| KR20250091367A (ko) * | 2023-12-13 | 2025-06-23 | 주식회사 노드큐어 | 개 pdl-1 항체 및 이의 용도 |
| WO2025128263A1 (en) * | 2023-12-15 | 2025-06-19 | Pharmaessentia Corporation | Anti-pd-1 monoclonal antibody and methods of preparation thereof |
| EP4669757A1 (en) | 2024-03-21 | 2025-12-31 | Akston Biosciences Corporation | PD-L1 ANALOGUE FUSION PROTEINS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY AND METHODS OF USE |
| CN119591713B (zh) * | 2024-12-12 | 2025-10-14 | 扬州大学 | 猫pd-l1单克隆抗体、分泌猫pd-l1单克隆抗体的杂交瘤细胞株及其应用 |
Family Cites Families (28)
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| DK1068241T3 (da) | 1998-04-02 | 2008-02-04 | Genentech Inc | Antistofvarianter og fragmenter deraf |
| WO2001077332A2 (en) | 2000-04-07 | 2001-10-18 | Heska Corporation | Compositions and methods related to canine igg and canine il-13 receptors |
| EP2243493A1 (en) | 2002-07-03 | 2010-10-27 | Ono Pharmaceutical Co., Ltd. | Immunopotentiative composition |
| TW200902555A (en) | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
| MX2007013978A (es) | 2005-05-09 | 2008-02-22 | Ono Pharmaceutical Co | Anticuerpos monoclonales humanos a muerte programada 1 (pd-1) y metodos para tratamiento de cancer utilizando anticuerpos anti-pd-1 solos o en combinacion con otros inmunoterapeuticos. |
| CN105330741B (zh) * | 2005-07-01 | 2023-01-31 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| KR101562580B1 (ko) | 2007-06-18 | 2015-10-22 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체 |
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| US20130017199A1 (en) * | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
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| GB201114858D0 (en) | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| KR20170070272A (ko) | 2011-05-06 | 2017-06-21 | 넥스베트 오스트레일리아 피티와이 리미티드 | 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법 |
| CA2835094C (en) | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| CA2834983C (en) | 2011-05-06 | 2020-11-17 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB2528401A (en) | 2011-05-06 | 2016-01-20 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| US20140294815A1 (en) | 2011-08-30 | 2014-10-02 | Nvip Pty Ltd | Caninised tumour necrosis factor antibodies and methods of using the same |
| JP6316195B2 (ja) | 2011-10-26 | 2018-04-25 | エランコ ティーアゲズンタイト アーゲー | モノクローナル抗体および使用の方法 |
| EP2785375B1 (en) * | 2011-11-28 | 2020-07-22 | Merck Patent GmbH | Anti-pd-l1 antibodies and uses thereof |
| CN106029697B (zh) | 2013-12-20 | 2021-06-04 | 英特维特国际股份有限公司 | 具有经修饰的ch2-ch3序列的犬抗体 |
| WO2016006241A1 (ja) | 2014-07-09 | 2016-01-14 | 日本全薬工業株式会社 | 抗イヌｐｄ－１抗体又は抗イヌｐｄ－ｌ１抗体 |
| JP6945444B2 (ja) * | 2014-08-08 | 2021-10-06 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 高親和性ｐｄ−１薬剤とその使用方法 |
| US20160129097A1 (en) * | 2014-11-06 | 2016-05-12 | Jeremy Delk | Method of processing a veterinary tumor vaccine and a veterinary tumor vaccine processing kit |
-
2015
- 2015-09-29 DK DK15771582.2T patent/DK3201230T3/da active
- 2015-09-29 RU RU2017114341A patent/RU2722562C2/ru active
- 2015-09-29 WO PCT/EP2015/072324 patent/WO2016050721A1/en not_active Ceased
- 2015-09-29 ES ES15771582T patent/ES2853823T3/es active Active
- 2015-09-29 JP JP2017516842A patent/JP6797111B2/ja active Active
- 2015-09-29 CN CN202110355046.5A patent/CN112851816B/zh active Active
- 2015-09-29 AU AU2015326996A patent/AU2015326996B2/en active Active
- 2015-09-29 US US15/514,920 patent/US10550194B2/en active Active
- 2015-09-29 CN CN201580052709.9A patent/CN107074952B/zh active Active
- 2015-09-29 EP EP15771582.2A patent/EP3201230B1/en active Active
- 2015-09-29 CA CA2961987A patent/CA2961987A1/en active Pending
-
2019
- 2019-12-18 US US16/718,729 patent/US11447561B2/en active Active
-
2021
- 2021-08-18 AU AU2021218094A patent/AU2021218094B2/en active Active
-
2022
- 2022-08-15 US US17/819,745 patent/US20220389114A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200109212A1 (en) | 2020-04-09 |
| US10550194B2 (en) | 2020-02-04 |
| JP6797111B2 (ja) | 2020-12-09 |
| US20180237535A1 (en) | 2018-08-23 |
| JP2017534267A (ja) | 2017-11-24 |
| RU2020117210A (ru) | 2020-06-16 |
| CA2961987A1 (en) | 2016-04-07 |
| EP3201230B1 (en) | 2020-12-23 |
| WO2016050721A1 (en) | 2016-04-07 |
| BR112017006203A2 (pt) | 2018-05-02 |
| AU2021218094A1 (en) | 2021-09-09 |
| AU2015326996B2 (en) | 2021-05-20 |
| RU2722562C2 (ru) | 2020-06-01 |
| AU2021218094B2 (en) | 2023-04-20 |
| RU2017114341A3 (da) | 2019-07-17 |
| ES2853823T3 (es) | 2021-09-17 |
| CN107074952A (zh) | 2017-08-18 |
| CN112851816B (zh) | 2024-03-08 |
| US11447561B2 (en) | 2022-09-20 |
| CN112851816A (zh) | 2021-05-28 |
| RU2017114341A (ru) | 2018-11-09 |
| US20220389114A1 (en) | 2022-12-08 |
| EP3201230A1 (en) | 2017-08-09 |
| CN107074952B (zh) | 2021-04-09 |
| AU2015326996A1 (en) | 2017-03-23 |
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