DK324380A - Insulinderivater og fremgangsmaade til deres fremstilling - Google Patents

Insulinderivater og fremgangsmaade til deres fremstilling

Info

Publication number: DK324380A
Authority: DK; Denmark
Prior art keywords: insulin; preparation; procedures; derivative; monoalkylpolyethyleneglycol
Prior art date: 1979-07-27

Application number

DK324380A

Other languages

English (en)

Inventor

R Obermeier

R Uhmann

H D Summ

G Regitz

K Geisen

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-27

Filing date

1980-07-25

Publication date

1981-01-28

1980-07-25 Application filed by Hoechst Ag filed Critical Hoechst Ag

1981-01-28 Publication of DK324380A publication Critical patent/DK324380A/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
239000004026 insulin derivative Substances 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
239000002202 Polyethylene glycol Substances 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Polyethers (AREA)

DK324380A 1979-07-27 1980-07-25 Insulinderivater og fremgangsmaade til deres fremstilling DK324380A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19792930542 DE2930542A1 (de)	1979-07-27	1979-07-27	Neue insulinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
DK324380A true DK324380A (da)	1981-01-28

Family

ID=6076963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK324380A DK324380A (da)	1979-07-27	1980-07-25	Insulinderivater og fremgangsmaade til deres fremstilling

Country Status (7)

Country	Link
EP (1)	EP0027161B1 (da)
JP (1)	JPS5622326A (da)
AT (1)	ATE3145T1 (da)
CA (1)	CA1156217A (da)
DE (2)	DE2930542A1 (da)
DK (1)	DK324380A (da)
ES (1)	ES8104202A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1985003934A1 (fr) *	1984-03-06	1985-09-12	Takeda Chemical Industries, Ltd.	Proteine modifiee chimiquement et son procede de preparation
DE3819079A1 (de) *	1988-06-04	1989-12-07	Hoechst Ag	Hirudin-derivate mit verzoegerter wirkung
US5286637A (en) *	1989-08-07	1994-02-15	Debiopharm, S.A.	Biologically active drug polymer derivatives and method for preparing same
US5359030A (en) *	1993-05-10	1994-10-25	Protein Delivery, Inc.	Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5824784A (en)	1994-10-12	1998-10-20	Amgen Inc.	N-terminally chemically modified protein compositions and methods
US6323311B1 (en)	1999-09-22	2001-11-27	University Of Utah Research Foundation	Synthesis of insulin derivatives
EP1613272B1 (en)	2003-04-11	2013-12-18	Antriabio, Inc.	Method for preparation of site-specific protein conjugates
JP4919384B2 (ja) *	2005-12-14	2012-04-18	株式会社フジタ	既存鋼製構造物の補強方法
ES2569066T3 (es)	2006-07-25	2016-05-06	Lipoxen Technologies Limited	Conjugación N-terminal de ácido polisiálico a proteínas
JP4859118B2 (ja) *	2006-08-01	2012-01-25	株式会社フジタ	既存鋼構造部材の補強工法
JP4895284B2 (ja) *	2006-11-10	2012-03-14	株式会社フジタ	既存鋼構造部材の補強構造
WO2015130963A2 (en)	2014-02-27	2015-09-03	Xenetic Biosciences, Inc.	Compositions and methods for administering insulin or insulin-like protein to the brain
CN107446038A (zh) *	2016-06-01	2017-12-08	湖南华腾制药有限公司	聚乙二醇修饰的重组人胰岛素及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2038121A1 (de) *	1970-07-31	1972-02-03	Hoechst Ag	Acylderivate des Insulins und Verfahren zu ihrer Herstellung
DE2047413C3 (de) *	1970-09-26	1980-05-29	F. Hoffmann-La Roche & Co Ag, Basel (Schweiz)	Verfahren zur Herstellung von Peptiden in homogener Phase
DE2433883C2 (de) *	1973-07-20	1986-03-27	Research Corp., New York, N.Y.	Verwendung von physiologisch aktiven Polypeptiden
DE2360794C2 (de) *	1973-12-06	1984-12-06	Hoechst Ag, 6230 Frankfurt	Verfahren zur Herstellung von Peptiden

1979
- 1979-07-27 DE DE19792930542 patent/DE2930542A1/de not_active Withdrawn
1980
- 1980-07-19 AT AT80104267T patent/ATE3145T1/de not_active IP Right Cessation
- 1980-07-19 DE DE8080104267T patent/DE3062890D1/de not_active Expired
- 1980-07-19 EP EP80104267A patent/EP0027161B1/de not_active Expired
- 1980-07-21 ES ES493550A patent/ES8104202A1/es not_active Expired
- 1980-07-25 DK DK324380A patent/DK324380A/da not_active Application Discontinuation
- 1980-07-25 JP JP10137080A patent/JPS5622326A/ja active Pending
- 1980-07-25 CA CA000357096A patent/CA1156217A/en not_active Expired

Also Published As

Publication number	Publication date
EP0027161B1 (de)	1983-04-27
ES493550A0 (es)	1981-04-16
ATE3145T1 (de)	1983-05-15
CA1156217A (en)	1983-11-01
DE3062890D1 (en)	1983-06-01
ES8104202A1 (es)	1981-04-16
JPS5622326A (en)	1981-03-02
EP0027161A1 (de)	1981-04-22
DE2930542A1 (de)	1981-02-12

Publication	Publication Date	Title
DK324380A (da)	1981-01-28	Insulinderivater og fremgangsmaade til deres fremstilling
EP0266099A3 (en)	1990-09-19	Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
DK0400472T3 (da)	1996-05-13	Fremgangsmåde til fremstilling af polyethylenglycolderivater og modificeret protein
EP0181001A3 (en)	1989-04-19	Polypeptide, a process for preparing the same, a pharmaceutical composition containing said polypeptide as well as the use thereof
IL99384A0 (en)	1992-08-18	Process for the purification of insulins by chromatography
AU577928B2 (en)	1988-10-06	Labd-14-en-11-one derivatives
KR830008995A (ko)	1983-12-16	인체 인슐린 및 그의 유도체의 제조방법
ES8400772A1 (es)	1983-11-01	"proceso para preparar insulina humana o los esteres b-30 de la misma".
BG50609A3 (en)	1992-09-15	Method for the preparation of oxophthalazinylacetic acids and their analogues
DK154573C (da)	1989-05-22	Fremgangsmaade til fremstilling af insuliner ud fra tilsvarende praeproinsulinanaloge
DK430280A (da)	1981-04-13	Fremgangsmaade til fremstilling af polyvinylpyrrolidoniod
DK447587D0 (da)	1987-08-27	Oxolabdaner, deres fremstilling og anvendelse
PT83837A (de)	1986-12-01	Verfahren zur herstellung von peptiden unter der verwendung von perchloraten
PT70078A (de)	1979-09-01	Verfahren zur herstellung von alpha-aminophenylessigsaurederivate
JPS5236684A (en)	1977-03-22	Process for preparation of novel penicillins and cephalosporins
DK584489A (da)	1990-05-23	Fremgangsmaade til fremstilling af tripeptider
JPS6470580A (en)	1989-03-16	Langmuir-blogett film and optical modulation element using same
JPS51139684A (en)	1976-12-02	Process for preparing optically active sulfurcontaining amino acids
SE7706567L (sv)	1977-12-08	Biologiskt aktiva peptider
IT1032695B (it)	1979-06-20	Fermaglio elastico a pinza per rinforzare e proteggere il calice dei fiori specialmente garofani

Legal Events

Date	Code	Title	Description
1985-03-25	ATS	Application withdrawn